DK0537492T3 - Stabile salte af 5,10-methylentetrahydrofolsyre - Google Patents

Stabile salte af 5,10-methylentetrahydrofolsyre

Info

Publication number
DK0537492T3
DK0537492T3 DK92115888.7T DK92115888T DK0537492T3 DK 0537492 T3 DK0537492 T3 DK 0537492T3 DK 92115888 T DK92115888 T DK 92115888T DK 0537492 T3 DK0537492 T3 DK 0537492T3
Authority
DK
Denmark
Prior art keywords
stable salts
methylenetetrahydrofolic acid
acid
salts
stable
Prior art date
Application number
DK92115888.7T
Other languages
English (en)
Inventor
Hans Rudolf Mueller
Martin Ulmann
Josef Conti
Original Assignee
Eprova Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eprova Ag filed Critical Eprova Ag
Application granted granted Critical
Publication of DK0537492T3 publication Critical patent/DK0537492T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Treatment Of Fiber Materials (AREA)
DK92115888.7T 1991-10-15 1992-09-17 Stabile salte af 5,10-methylentetrahydrofolsyre DK0537492T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH3019/91A CH682664A5 (en) 1991-10-15 1991-10-15 Stable salts of 5,10-methylene tetrahydrofolate.

Publications (1)

Publication Number Publication Date
DK0537492T3 true DK0537492T3 (da) 1995-07-17

Family

ID=4246816

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92115888.7T DK0537492T3 (da) 1991-10-15 1992-09-17 Stabile salte af 5,10-methylentetrahydrofolsyre

Country Status (9)

Country Link
US (1) US5300505A (da)
EP (1) EP0537492B1 (da)
JP (1) JPH0742288B2 (da)
AT (1) ATE122675T1 (da)
CA (1) CA2078939C (da)
CH (1) CH682664A5 (da)
DE (1) DE59202227D1 (da)
DK (1) DK0537492T3 (da)
ES (1) ES2073222T3 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH683690A5 (de) * 1991-12-21 1994-04-29 Sapec Fine Chemicals Verfahren zur Herstellung von diastereoisomerenreinen Tetrahydrofolaten.
US5710271A (en) * 1994-06-08 1998-01-20 Dibra S.P.A. Process for the preparation and separation of diastereomeric salts of folinic acid
CH693255A5 (de) * 1997-06-13 2003-05-15 Eprova Ag Verwendung von Tetrahydrofolaten in der natürlichenstereoisomeren Form zur Herstellung einer pharmazeutischenZubereitung geeignet zur Beeinflussung des Homocystein-Spiegels.
CH693905A5 (de) 1999-04-15 2004-04-15 Eprova Ag Stabile kristalline Salze von 5-Methyltetrahydrofolsäure.
CH695217A5 (de) 1999-07-14 2006-01-31 Merck Eprova Ag Verfahren zur Trennung optischer Isomeren von Tetrahydrofolsäureestersalzen und Tetrahydrofolsäure.
ITMI20020132A1 (it) 2002-01-25 2003-07-25 Gmt Fine Chemicals Sa Processo per l'ottenimento dell'acido (6s)-5,6,7,8-tetraidrofolico
EP2837631A1 (en) * 2013-08-14 2015-02-18 Merck & Cie New stable salt of 5,10-methylene-(6R)-tetrahydrofolic acid
US10059710B2 (en) 2016-02-17 2018-08-28 Merck & Cie Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid
JP7232815B2 (ja) 2017-08-16 2023-03-03 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング ５，１０－メチレン－（６ｒ）－テトラヒドロ葉酸を含む安定な凍結乾燥物
PT3817812T (pt) 2018-07-06 2023-12-28 Merck Patent Gmbh Sal cristalino de acido 5-metil-(68)-tetra-hidrofólico e éster etílico de l-isoleucina
EP4536188A1 (en) 2022-06-08 2025-04-16 Merck Patent GmbH Stable lyophilisates comprising 5,10-methylene-(6r)-tetrahydrofolic acid
AU2023282347A1 (en) 2022-06-08 2025-01-16 Merck Patent Gmbh Compositions comprising disodium 5,10-methylene-(6r)-tetrahydrofolate
CA3258607A1 (en) 2022-06-08 2023-12-14 Merck Patent Gmbh STABLE PHARMACEUTICAL COMPOSITIONS COMPRISING 5,10-METHYLENE-(6R)-TETRAHYDROFOLIC ACID AND NACL
EP4536184A1 (en) 2022-06-08 2025-04-16 Merck Patent GmbH Concentrated solutions comprising sodium 5,10-methylene-(6r)- tetrahydrofolate
EP4536186A1 (en) 2022-06-08 2025-04-16 Merck Patent GmbH Concentrated solutions comprising 5,10-methylene-(6r)-tetrahydrofolic acid

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3468886A (en) * 1967-10-23 1969-09-23 Us Health Education & Welfare Tetrahydrohomofolic acid sulfate and synthesis thereof
DE3821875C1 (da) * 1988-06-29 1990-02-15 Eprova Ag, Forschungsinstitut, Schaffhausen, Ch
CH681303A5 (da) * 1991-01-16 1993-02-26 Eprova Ag

Also Published As

Publication number Publication date
EP0537492A3 (en) 1993-06-23
EP0537492B1 (de) 1995-05-17
DE59202227D1 (de) 1995-06-22
CA2078939A1 (en) 1993-04-16
EP0537492A2 (de) 1993-04-21
CH682664A5 (en) 1993-10-29
CA2078939C (en) 1998-08-18
JPH0742288B2 (ja) 1995-05-10
ES2073222T3 (es) 1995-08-01
US5300505A (en) 1994-04-05
JPH05294968A (ja) 1993-11-09
ATE122675T1 (de) 1995-06-15

Similar Documents

Publication Publication Date Title
DK0537492T3 (da) Stabile salte af 5,10-methylentetrahydrofolsyre
PT91553A (pt) Processo de preparacao de uma composicao contendo morfina
DK1044975T3 (da) Stabilt krystallinsk salt af 5-mehtyl-(6S)-tetrahydrofolsyre
SE8701348D0 (sv) Improvements in pharmaceutically acceptable salts
DK354785A (da) Stabile salte af s-adenosyl-l-methionin med polyanioner
YU174490A (sh) Novi estri tienil-karboksilne kiseline sa aminoalkoholima, njihova kvaterna jedinjenja kao i pripremanje i primena tih jedinjenja
NO923533D0 (no) Nye 5-amino-4-hydroksyheksansyrederivater som terapeutika
AU564910B2 (en) Diazabicyclo-(3.3.1)nonanes
NZ224228A (en) 16-substituted 2b-morpholino-androstane derivatives and pharmaceutical compositions
IE820856L (en) Omega-cyano-1,omega-diphenyl-azaalkane derivatives.
IT8348006A0 (it) Loro produzione derivati cefalosporinici e composizioni antibatteriche che li contengono, nonche' procedimento per la
DE59507591D1 (de) Stabile kristalline (6S)- und (6R)-Tetrahydrofolsäure
DK0598770T3 (da) Pyrazinderivater samt fremstilling og anvendelse deraf
IL84359A0 (en) Substituted cephalosporin sulfones,their preparation and pharmaceutical compositions containing them
GR850309B (da)
ATE22532T1 (de) Pharmazeutische zusammensetzung.
DK0416773T3 (da) Vitamin B12 præparat
ES8701752A1 (es) Un procedimiento para preparar derivados de bencimidazol
PT100329A (pt) Composicoes a base de di-hidro-4-(3,5-di-terc-butil-4-hidroxi-benzilideno)-metil-2h-1,2-oxazin-3(4h)-ona sob forma micronizada
EP0331092A3 (en) Alpha-amino-carboxylic-acid derivatives, their preparation and use
IT1209945B (it) Derivati piridinici e procedimenti per la loro preparazione
IT1190401B (it) Derivati di vitamina d,composizioni farmaceutiche che li contengono e loro precursori
SE8306225D0 (sv) 2-piperazinyl-quinazoline derivatives, their production and pharmaceutical compositions containing them
ATE19855T1 (de) Pharmazeutische und diaetetische zusammensetzung.
ATE36853T1 (de) Beta-carbolin-3-carbonsaeurederivate und methode zu ihrer herstellung.