DK0546272T3 - S-carboxylmethylcysteinlysinsalt-monohydrat og fremgangsmåde til fremstilling deraf - Google Patents

S-carboxylmethylcysteinlysinsalt-monohydrat og fremgangsmåde til fremstilling deraf

Info

Publication number: DK0546272T3
Authority: DK; Denmark
Prior art keywords: preparation; carboxylmethylcysteine; salt monohydrate; lysine salt; carboxymethylcysteine
Prior art date: 1991-12-12

Application number

DK92117267.2T

Other languages

English (en)

Inventor

Maria Argese

Enrico Bosone

Gaetano Clavenna

Roberto Giani

Original Assignee

Dompe Farmaceutici Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-12-12

Filing date

1992-10-09

Publication date

1996-06-10

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11361322&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0546272(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-10-09 Application filed by Dompe Farmaceutici Spa filed Critical Dompe Farmaceutici Spa

1996-06-10 Application granted granted Critical

1996-06-10 Publication of DK0546272T3 publication Critical patent/DK0546272T3/da

Links

238000002360 preparation method Methods 0.000 title abstract 3
QVJUWKMADMJHJZ-PBUQCQDLSA-N (2r)-2-amino-3-(carboxymethylsulfanyl)propanoic acid;(2s)-2,6-diaminohexanoic acid;hydrate Chemical compound O.NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CSCC(O)=O QVJUWKMADMJHJZ-PBUQCQDLSA-N 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 2
230000002562 anti-bronchospastic effect Effects 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000000510 mucolytic effect Effects 0.000 abstract 1
239000000243 solution Substances 0.000 abstract 1
238000003756 stirring Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

DK92117267.2T 1991-12-12 1992-10-09 S-carboxylmethylcysteinlysinsalt-monohydrat og fremgangsmåde til fremstilling deraf DK0546272T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITMI913338A IT1252201B (it)	1991-12-12	1991-12-12	S-carbossimetilcisteina sale di lisina monoidrato e procedimento per la sua preparazione.

Publications (1)

Publication Number	Publication Date
DK0546272T3 true DK0546272T3 (da)	1996-06-10

Family

ID=11361322

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92117267.2T DK0546272T3 (da)	1991-12-12	1992-10-09	S-carboxylmethylcysteinlysinsalt-monohydrat og fremgangsmåde til fremstilling deraf

Country Status (9)

Country	Link
EP (1)	EP0546272B1 (da)
JP (1)	JPH05310686A (da)
AT (1)	ATE134613T1 (da)
DE (2)	DE546272T1 (da)
DK (1)	DK0546272T3 (da)
ES (1)	ES2049700T3 (da)
GR (2)	GR930300083T1 (da)
IT (1)	IT1252201B (da)
MX (1)	MX9207225A (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN101851185A (zh) *	2009-10-20	2010-10-06	西华大学	一种福多司坦的制备与纯化方法
CN102863365B (zh) *	2011-07-07	2014-04-16	广州白云山制药股份有限公司广州白云山制药总厂	一种结晶药物化合物及其制备方法和用途
CN102775334B (zh) *	2012-06-12	2013-12-18	宁波市镇海海德生化科技有限公司	L-赖氨酸-s-羧甲基-l-半胱氨酸盐的生产工艺
WO2014005543A1 (zh) *	2012-07-06	2014-01-09	广州白云山制药股份有限公司广州白云山制药总厂	一种s-(羧甲基)-半胱氨酸药物化合物及其制备方法和用途
CN108715582A (zh) *	2018-08-30	2018-10-30	浙江三门恒康制药有限公司	一种赖氨酸羧甲司坦的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2147812A1 (en) *	1971-07-30	1973-03-11	Rech Pharmaceut Scient	Hemisalts of s-carboxymethylcysteine - for treating respiratory infections,hepatic and skin disorders atherosclerosis,and
DE2530953C2 (de) *	1975-07-11	1994-07-07	Dr. Madaus & Co, 5000 Köln	Verfahren zur Herstellung von röntgenamorphem Aescin, nach diesem Verfahren erhältliches röntgenamorphes Aescin und dieses enthaltende Arzneimittel
IT1130972B (it) *	1980-03-17	1986-06-18	Franco Bolasco	Composizioni farmaceutiche ad attivita' mucolitica,broncosecretolitica e antibroncospastica

1991
- 1991-12-12 IT ITMI913338A patent/IT1252201B/it active IP Right Grant
1992
- 1992-10-09 ES ES92117267T patent/ES2049700T3/es not_active Expired - Lifetime
- 1992-10-09 DK DK92117267.2T patent/DK0546272T3/da active
- 1992-10-09 EP EP92117267A patent/EP0546272B1/en not_active Expired - Lifetime
- 1992-10-09 AT AT92117267T patent/ATE134613T1/de active
- 1992-10-09 DE DE92117267T patent/DE546272T1/de active Pending
- 1992-10-09 DE DE69208605T patent/DE69208605T2/de not_active Expired - Lifetime
- 1992-12-10 JP JP4352125A patent/JPH05310686A/ja active Pending
- 1992-12-11 MX MX9207225A patent/MX9207225A/es unknown
1993
- 1993-10-31 GR GR930300083T patent/GR930300083T1/el unknown
1996
- 1996-04-09 GR GR960400981T patent/GR3019589T3/el unknown

Also Published As

Publication number	Publication date
IT1252201B (it)	1995-06-05
ITMI913338A1 (it)	1993-06-12
EP0546272A1 (en)	1993-06-16
EP0546272B1 (en)	1996-02-28
JPH05310686A (ja)	1993-11-22
ATE134613T1 (de)	1996-03-15
GR3019589T3 (en)	1996-07-31
DE546272T1 (de)	1993-10-14
GR930300083T1 (en)	1993-10-31
ES2049700T3 (es)	1996-04-16
MX9207225A (es)	1993-07-01
ITMI913338A0 (it)	1991-12-12
ES2049700T1 (es)	1994-05-01
DE69208605T2 (de)	1996-07-11
DE69208605D1 (de)	1996-04-04

Publication	Publication Date	Title
HUT64314A (en)	1993-12-28	Process for production isoxazole-4-carboxylic acid amides and hydroxi-alkylidene-cyanic-acetic acid amides and pharmaceutical preparations having these compounds
IE901040L (en)	1990-09-22	N-(3-hydroxy-4-piperidinyl)(dihydro-benzofuran,¹dihydro-2h-benzopyran or dihydrobenzodioxin)carboxamide¹derivatives
EP0314098A3 (en)	1990-01-03	Imide derivatives, their production and use
DK383788D0 (da)	1988-07-08	Hydroxyalkyl-azolyl-derivater, deres fremstilling og anvendelse som fungicider og plandtevaekstregulatorer
DK0546272T3 (da)	1996-06-10	S-carboxylmethylcysteinlysinsalt-monohydrat og fremgangsmåde til fremstilling deraf
EP0103320A3 (en)	1984-09-05	Acetylsalicylic acid thioesters, a process for their preparation and pharmaceutical compositions containing them
DK217983A (da)	1983-11-18	(-)-15-deoxyspergualin, dets fremstilling og anvendelse
BR9200646A (pt)	1992-11-10	Gliceradeido-3-pentanida e processo para a sua preparacao
ES8800144A1 (es)	1987-11-01	Procedimiento de obtencion de un tioester de la n-acetilcisteina y de sus sales de interes terapeutico
JPS6470479A (en)	1989-03-15	Heterocylic carboxylic acid derivative, production thereof and agricultural and horticultural germicide containing said derivative as active ingredient
HRP930613A2 (en)	1998-06-30	4-oxo-azetidine-2-sulphonic acids amides and their salts, process for their production and their use
IT1217589B (it)	1990-03-30	Agente antiinfiammatorio per la terapia dell'ipertrofia prostatica,sua preparazione e relative composizioni farmaceutiche
GB1492180A (en)	1977-11-16	Pharmaceutical composition for the treatment of hyperammoniemia
TH34889A (th)	1999-09-14	การเตรียม 2-(10, 11-ไดไฮโดร-10-ออกโซไดเบนโซ [b,f] ไธเอพิน-2-อิล) กรดโพรพิโอนิค
GB935282A (en)	1963-08-28	Improvements in and relating to sulphonyl ureas and their manufacture