ES2049700T1 - Sal cristalina de la s-carboximetilcisteina lisina monohidratada y procedimiento para su fabricacion. - Google Patents

Sal cristalina de la s-carboximetilcisteina lisina monohidratada y procedimiento para su fabricacion.

Info

Publication number
ES2049700T1
ES2049700T1 ES92117267T ES92117267T ES2049700T1 ES 2049700 T1 ES2049700 T1 ES 2049700T1 ES 92117267 T ES92117267 T ES 92117267T ES 92117267 T ES92117267 T ES 92117267T ES 2049700 T1 ES2049700 T1 ES 2049700T1
Authority
ES
Spain
Prior art keywords
monohidratada
carboximetilcisteina
lisina
procedure
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES92117267T
Other languages
English (en)
Other versions
ES2049700T3 (es
Inventor
Maria Argese
Enrico Bosone
Gaetano Clavenna
Roberto Giani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dompe Farmaceutici SpA
Original Assignee
Dompe Farmaceutici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11361322&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2049700(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dompe Farmaceutici SpA filed Critical Dompe Farmaceutici SpA
Publication of ES2049700T1 publication Critical patent/ES2049700T1/es
Application granted granted Critical
Publication of ES2049700T3 publication Critical patent/ES2049700T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

MONOHIDRATO DE SAL DE LISINA DE S-CARBOXIMETILCISTEINA PARA LA PREPARACION DE UN MEDICAMENTO QUE TIENE ACTIVIDADES MUCOLITICAS, BROCOSECRETOLITICAS Y ANTIBRONCOESPASTICAS Y UN PROCESO PARA LA PREPARACION DEL MISMO QUE SE CARACTERIZA PORQUE SE HACER REACCIONAR A LA L(R)-S-CARBOXIMETILCISTEINA CON UNA SOLUCION ACUOSA DE L(S)-LISINA, DILUYENDOSE LA SOLUCION OBTENIDA CON ETANOL Y CRISTALIZANDO EL PRODUCTO MEDIANTE AGITACION.
ES92117267T 1991-12-12 1992-10-09 Sal de la s-carboximetilcisteina lisina monohidratada y procedimiento para su fabricacion. Expired - Lifetime ES2049700T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI913338A IT1252201B (it) 1991-12-12 1991-12-12 S-carbossimetilcisteina sale di lisina monoidrato e procedimento per la sua preparazione.

Publications (2)

Publication Number Publication Date
ES2049700T1 true ES2049700T1 (es) 1994-05-01
ES2049700T3 ES2049700T3 (es) 1996-04-16

Family

ID=11361322

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92117267T Expired - Lifetime ES2049700T3 (es) 1991-12-12 1992-10-09 Sal de la s-carboximetilcisteina lisina monohidratada y procedimiento para su fabricacion.

Country Status (9)

Country Link
EP (1) EP0546272B1 (es)
JP (1) JPH05310686A (es)
AT (1) ATE134613T1 (es)
DE (2) DE546272T1 (es)
DK (1) DK0546272T3 (es)
ES (1) ES2049700T3 (es)
GR (2) GR930300083T1 (es)
IT (1) IT1252201B (es)
MX (1) MX9207225A (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101851185A (zh) * 2009-10-20 2010-10-06 西华大学 一种福多司坦的制备与纯化方法
CN102863364B (zh) * 2011-07-07 2014-06-25 广州白云山制药股份有限公司广州白云山制药总厂 S-(羧甲基)-半胱氨酸药物化合物及其制备方法和用途
CN102775334B (zh) * 2012-06-12 2013-12-18 宁波市镇海海德生化科技有限公司 L-赖氨酸-s-羧甲基-l-半胱氨酸盐的生产工艺
WO2014005543A1 (zh) * 2012-07-06 2014-01-09 广州白云山制药股份有限公司广州白云山制药总厂 一种s-(羧甲基)-半胱氨酸药物化合物及其制备方法和用途
CN108715582A (zh) * 2018-08-30 2018-10-30 浙江三门恒康制药有限公司 一种赖氨酸羧甲司坦的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2147812A1 (en) * 1971-07-30 1973-03-11 Rech Pharmaceut Scient Hemisalts of s-carboxymethylcysteine - for treating respiratory infections,hepatic and skin disorders atherosclerosis,and
DE2530953C2 (de) * 1975-07-11 1994-07-07 Dr. Madaus & Co, 5000 Köln Verfahren zur Herstellung von röntgenamorphem Aescin, nach diesem Verfahren erhältliches röntgenamorphes Aescin und dieses enthaltende Arzneimittel
IT1130972B (it) * 1980-03-17 1986-06-18 Franco Bolasco Composizioni farmaceutiche ad attivita' mucolitica,broncosecretolitica e antibroncospastica

Also Published As

Publication number Publication date
DK0546272T3 (da) 1996-06-10
DE69208605D1 (de) 1996-04-04
ITMI913338A0 (it) 1991-12-12
IT1252201B (it) 1995-06-05
EP0546272B1 (en) 1996-02-28
ITMI913338A1 (it) 1993-06-12
GR3019589T3 (en) 1996-07-31
ES2049700T3 (es) 1996-04-16
DE69208605T2 (de) 1996-07-11
MX9207225A (es) 1993-07-01
JPH05310686A (ja) 1993-11-22
DE546272T1 (de) 1993-10-14
ATE134613T1 (de) 1996-03-15
EP0546272A1 (en) 1993-06-16
GR930300083T1 (en) 1993-10-31

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