DK0551182T3 - Fremgangsmåde til behandling af hyperproliferative karsygdomme under anvendelse af rapamycin, eventuelt i komb. med mycophe - Google Patents

Fremgangsmåde til behandling af hyperproliferative karsygdomme under anvendelse af rapamycin, eventuelt i komb. med mycophe

Info

Publication number: DK0551182T3
Authority: DK; Denmark
Prior art keywords: vascular disease; rapamycin; mycophe; comb; optionally
Prior art date: 1992-01-09

Application number

DK93300052T

Other languages

English (en)

Inventor

Randall Ellis Morris

Clare Robert Gregory

Original Assignee

American Home Prod

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-01-09

Filing date

1993-01-06

Publication date

2000-10-09

1993-01-06 Application filed by American Home Prod filed Critical American Home Prod

2000-10-09 Application granted granted Critical

2000-10-09 Publication of DK0551182T3 publication Critical patent/DK0551182T3/da

Links

ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 title abstract 2
229960002930 sirolimus Drugs 0.000 title abstract 2
QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title abstract 2
208000019553 vascular disease Diseases 0.000 title abstract 2
230000003463 hyperproliferative effect Effects 0.000 title 1
241000124008 Mammalia Species 0.000 abstract 1
230000001028 anti-proliverative effect Effects 0.000 abstract 1
HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 abstract 1
229960000951 mycophenolic acid Drugs 0.000 abstract 1
HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Steroid Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Compounds Of Unknown Constitution (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

DK93300052T 1992-01-09 1993-01-06 Fremgangsmåde til behandling af hyperproliferative karsygdomme under anvendelse af rapamycin, eventuelt i komb. med mycophe DK0551182T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US81931492A	1992-01-09	1992-01-09

Publications (1)

Publication Number	Publication Date
DK0551182T3 true DK0551182T3 (da)	2000-10-09

Family

ID=25227805

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK93300052T DK0551182T3 (da)	1992-01-09	1993-01-06	Fremgangsmåde til behandling af hyperproliferative karsygdomme under anvendelse af rapamycin, eventuelt i komb. med mycophe

Country Status (14)

Country	Link
EP (1)	EP0551182B1 (da)
JP (1)	JP2644955B2 (da)
KR (1)	KR100276142B1 (da)
AT (1)	ATE194493T1 (da)
AU (1)	AU665041B2 (da)
CA (1)	CA2086642C (da)
DE (1)	DE69328981T2 (da)
DK (1)	DK0551182T3 (da)
ES (1)	ES2147740T3 (da)
GR (1)	GR3034479T3 (da)
LV (1)	LV12603B (da)
NZ (1)	NZ245630A (da)
PT (1)	PT551182E (da)
SG (1)	SG47639A1 (da)

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US5811447A (en)	1993-01-28	1998-09-22	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en) *	1991-09-27	2003-02-04	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US5516781A (en) *	1992-01-09	1996-05-14	American Home Products Corporation	Method of treating restenosis with rapamycin
US5283257A (en) *	1992-07-10	1994-02-01	The Board Of Trustees Of The Leland Stanford Junior University	Method of treating hyperproliferative vascular disease
US6663881B2 (en)	1993-01-28	2003-12-16	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US5981568A (en)	1993-01-28	1999-11-09	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US6491938B2 (en)	1993-05-13	2002-12-10	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
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US5527907A (en) *	1993-11-19	1996-06-18	Abbott Laboratories	Macrolide immunomodulators
WO1995014023A1 (en) *	1993-11-19	1995-05-26	Abbott Laboratories	Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
US5519042A (en) *	1994-01-13	1996-05-21	Hoechst Aktiengesellschaft	Method of treating hyperproliferative vascular disease
US5444072A (en) *	1994-02-18	1995-08-22	Syntex (U.S.A.) Inc.	6-substituted mycophenolic acid and derivatives
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IL122212A (en)	1995-06-09	2001-08-26	Novartis Ag	Rapamycin derivatives, pharmaceutical compositions comprising them and their preparation
KR100616020B1 (ko) *	1996-03-27	2007-01-31	노파르티스 아게	맥관장애및이종이식술에서의라파마이신유도체의용도
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US6515016B2 (en)	1996-12-02	2003-02-04	Angiotech Pharmaceuticals, Inc.	Composition and methods of paclitaxel for treating psoriasis
IT1289815B1 (it)	1996-12-30	1998-10-16	Sorin Biomedica Cardio Spa	Stent per angioplastica e relativo procedimento di produzione
US6273913B1 (en) †	1997-04-18	2001-08-14	Cordis Corporation	Modified stent useful for delivery of drugs along stent strut
US6241762B1 (en)	1998-03-30	2001-06-05	Conor Medsystems, Inc.	Expandable medical device with ductile hinges
US7208010B2 (en)	2000-10-16	2007-04-24	Conor Medsystems, Inc.	Expandable medical device for delivery of beneficial agent
US7208011B2 (en)	2001-08-20	2007-04-24	Conor Medsystems, Inc.	Implantable medical device with drug filled holes
WO1999055396A1 (en)	1998-04-27	1999-11-04	Surmodics, Inc.	Bioactive agent release coating
US6120847A (en) *	1999-01-08	2000-09-19	Scimed Life Systems, Inc.	Surface treatment method for stent coating
US6419692B1 (en)	1999-02-03	2002-07-16	Scimed Life Systems, Inc.	Surface protection method for stents and balloon catheters for drug delivery
US6156373A (en)	1999-05-03	2000-12-05	Scimed Life Systems, Inc.	Medical device coating methods and devices
US6258121B1 (en)	1999-07-02	2001-07-10	Scimed Life Systems, Inc.	Stent coating
US6251136B1 (en)	1999-12-08	2001-06-26	Advanced Cardiovascular Systems, Inc.	Method of layering a three-coated stent using pharmacological and polymeric agents
US6702849B1 (en)	1999-12-13	2004-03-09	Advanced Cardiovascular Systems, Inc.	Method of processing open-celled microcellular polymeric foams with controlled porosity for use as vascular grafts and stent covers
ATE300255T1 (de)	2000-10-16	2005-08-15	Conor Medsystems Inc	Expandierbare medizinische vorrichtung zum zuführen eines heilmittels
DE10115740A1 (de)	2001-03-26	2002-10-02	Ulrich Speck	Zubereitung für die Restenoseprophylaxe
US6613083B2 (en)	2001-05-02	2003-09-02	Eckhard Alt	Stent device and method
US7842083B2 (en)	2001-08-20	2010-11-30	Innovational Holdings, Llc.	Expandable medical device with improved spatial distribution
US7056338B2 (en)	2003-03-28	2006-06-06	Conor Medsystems, Inc.	Therapeutic agent delivery device with controlled therapeutic agent release rates
US6939376B2 (en)	2001-11-05	2005-09-06	Sun Biomedical, Ltd.	Drug-delivery endovascular stent and method for treating restenosis
US7682387B2 (en)	2002-04-24	2010-03-23	Biosensors International Group, Ltd.	Drug-delivery endovascular stent and method for treating restenosis
US7097850B2 (en)	2002-06-18	2006-08-29	Surmodics, Inc.	Bioactive agent release coating and controlled humidity method
DE10244847A1 (de)	2002-09-20	2004-04-01	Ulrich Prof. Dr. Speck	Medizinische Vorrichtung zur Arzneimittelabgabe
EP1449546B1 (en)	2003-02-21	2010-10-27	Sorin Biomedica Cardio S.R.L.	A process for producing stents and corresponding stent
AR045957A1 (es) *	2003-10-03	2005-11-16	Novartis Ag	Composicion farmaceutica y combinacion
US7303758B2 (en) *	2004-01-20	2007-12-04	Cordis Corporation	Local vascular delivery of mycophenolic acid in combination with rapamycin to prevent restenosis following vascular injury
CN1964748A (zh)	2004-04-06	2007-05-16	苏莫迪克斯公司	用于生物活性剂的涂料组合物
USD516723S1 (en)	2004-07-06	2006-03-07	Conor Medsystems, Inc.	Stent wall structure
WO2007040249A1 (ja)	2005-10-06	2007-04-12	Kaneka Corporation	生体留置用ステント
AU2007271554B2 (en)	2006-07-03	2011-02-10	Hemoteq Ag	Manufacture, method, and use of active substance-releasing medical products for permanently keeping blood vessels open
BRPI0806727B8 (pt)	2007-01-21	2021-06-22	Hemoteq Ag	método para o revestimento de um cateter de balão
US9192697B2 (en)	2007-07-03	2015-11-24	Hemoteq Ag	Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
CA2711765A1 (en)	2008-01-11	2009-07-16	Massachusetts Eye & Ear Infirmary	Conditional-stop dimerizable caspase transgenic animals
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WO2012031236A1 (en)	2010-09-02	2012-03-08	Boston Scientific Scimed, Inc.	Coating process for drug delivery balloons using heat-induced rewrap memory
US8669360B2 (en)	2011-08-05	2014-03-11	Boston Scientific Scimed, Inc.	Methods of converting amorphous drug substance into crystalline form
WO2013028208A1 (en)	2011-08-25	2013-02-28	Boston Scientific Scimed, Inc.	Medical device with crystalline drug coating
JP6278332B2 (ja)	2013-04-22	2018-02-14	スズキ株式会社	変速機の制御装置

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US5078999A (en) *	1991-02-22	1992-01-07	American Home Products Corporation	Method of treating systemic lupus erythematosus

1993
- 1993-01-04 CA CA002086642A patent/CA2086642C/en not_active Expired - Lifetime
- 1993-01-06 SG SG1996003304A patent/SG47639A1/en unknown
- 1993-01-06 DE DE69328981T patent/DE69328981T2/de not_active Expired - Lifetime
- 1993-01-06 PT PT93300052T patent/PT551182E/pt unknown
- 1993-01-06 AT AT93300052T patent/ATE194493T1/de active
- 1993-01-06 EP EP93300052A patent/EP0551182B1/en not_active Expired - Lifetime
- 1993-01-06 ES ES93300052T patent/ES2147740T3/es not_active Expired - Lifetime
- 1993-01-06 DK DK93300052T patent/DK0551182T3/da active
- 1993-01-07 NZ NZ245630A patent/NZ245630A/en not_active IP Right Cessation
- 1993-01-07 AU AU31079/93A patent/AU665041B2/en not_active Expired
- 1993-01-08 KR KR1019930000174A patent/KR100276142B1/ko not_active Expired - Lifetime
- 1993-01-08 JP JP5001773A patent/JP2644955B2/ja not_active Expired - Lifetime
2000
- 2000-09-26 GR GR20000402168T patent/GR3034479T3/el unknown
- 2000-10-06 LV LVP-00-134A patent/LV12603B/en unknown

Also Published As

Publication number	Publication date
HK1010332A1 (en)	1999-06-17
AU665041B2 (en)	1995-12-14
SG47639A1 (en)	1998-04-17
JPH069390A (ja)	1994-01-18
PT551182E (pt)	2000-12-29
DE69328981T2 (de)	2000-11-16
ATE194493T1 (de)	2000-07-15
EP0551182A1 (en)	1993-07-14
KR930016102A (ko)	1993-08-26
DE69328981D1 (de)	2000-08-17
CA2086642C (en)	2004-06-15
GR3034479T3 (en)	2000-12-29
KR100276142B1 (ko)	2001-02-01
LV12603B (en)	2001-04-20
ES2147740T3 (es)	2000-10-01
NZ245630A (en)	1997-07-27
JP2644955B2 (ja)	1997-08-25
EP0551182B1 (en)	2000-07-12
CA2086642A1 (en)	1993-07-10
LV12603A (en)	2001-01-20
AU3107993A (en)	1993-07-15

Publication	Publication Date	Title
DK0551182T3 (da)	2000-10-09	Fremgangsmåde til behandling af hyperproliferative karsygdomme under anvendelse af rapamycin, eventuelt i komb. med mycophe
PY0101639A (es)	2001-12-03	Method of treating restenosis with rapamycin
DK0583925T3 (da)	1998-10-12	Rapamycin til behandling af Crohn's sygdom, ulcerøs colitis og ulcerøs proctitis
DK0665013T3 (da)	2002-02-18	Behandling af hyperproliferative karsygdomme
FI941133L (fi)	1994-03-10	Koostumus ja menetelmä hepatiitti C:n hoitamiseksi
DK0568310T3 (da)	1996-07-29	Sammensætning indeholdende heparin og rapamycin
UA27911C2 (uk)	2000-10-16	Засіб для лікування або запобігання фізіологічних розладів, які викликані надлишком тахікініну
DE3789425D1 (de)	1994-04-28	Verfahren zur Kettspannungskontrolle.
DK447489D0 (da)	1989-09-11	Metode til stabilisering af blod
ATE147977T1 (de)	1997-02-15	Verwendung von kompetitiven nmda- rezeptorantagonisten zur behandlung der harninkontinenz
DE69431638D1 (de)	2002-12-12	Automatische Fokusausgleicheinstellvorrichtung und Verfahren
ATE138807T1 (de)	1996-06-15	29-demethoxyrapamycin zur induktion der immunosuppression
FI910421A7 (fi)	1991-07-31	Menetelmä rikin binääristen yhdisteiden käsittelemiseksi
DK234590D0 (da)	1990-09-28	Fremgangsmaade til behandling af retrovirusinfektioner
FI963638L (fi)	1996-11-13	Menetelmiä HIV-1-injektion diagnosoimiseksi ja hoitamiseksi
FI911269A7 (fi)	1991-09-16	Menetelmä ja koostumus aktiivisten aineiden lisääntyneen pitoisuuden aikaansaamiseksi iholla iontoforeesin avulla
DE68913995D1 (de)	1994-04-21	Zusammensetzung zur behandlung progressiver myopie.
DE3785550D1 (de)	1993-05-27	Photosensible zusammensetzung mit verbesserter haftung, gegenstaende und verfahren.
IT1266849B1 (it)	1997-01-21	Programmatore analogico perfezionato per forni.
DE3669159D1 (de)	1990-04-05	Triazinderivate, verfahren zur herstellung dieser derivate und herbizide, welche diese derivate als wirksame komponente enthalten.
ES1023268Y (es)	1994-04-16	Pieza perfeccionada parajuegos de construccion.
DE58906954D1 (de)	1994-03-24	Wässrige lösung zur oxidation, entkeimung und desodorierung sowie verfahren zur herstellung dieser lösung.
ITRM920323A1 (it)	1993-10-28	Pettine, fiancate dell'elevatore e punte sparticampo migliorate per macchina da raccolta pomodoro.
DK224390D0 (da)	1990-09-18	Apparat til faeldning af mindre traeer
DE68914450D1 (de)	1994-05-11	Verfahren zur bekämpfung von fichtenborkenkäfern und zusammensetzung dafür.