DK0576228T3 - Fremgangsmåde til fremstilling af beta-anomer-berigede 2-deoxy-2,2-difluor-D-ribofuranosyl-arylsulfonater - Google Patents

Fremgangsmåde til fremstilling af beta-anomer-berigede 2-deoxy-2,2-difluor-D-ribofuranosyl-arylsulfonater

Info

Publication number
DK0576228T3
DK0576228T3 DK93304816T DK93304816T DK0576228T3 DK 0576228 T3 DK0576228 T3 DK 0576228T3 DK 93304816 T DK93304816 T DK 93304816T DK 93304816 T DK93304816 T DK 93304816T DK 0576228 T3 DK0576228 T3 DK 0576228T3
Authority
DK
Denmark
Prior art keywords
ribofuranosyl
deoxy
difluoro
beta
arylsulfonates
Prior art date
Application number
DK93304816T
Other languages
Danish (da)
English (en)
Inventor
Charles David Jones
Ta-Sen Chou
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK0576228T3 publication Critical patent/DK0576228T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK93304816T 1992-06-22 1993-06-21 Fremgangsmåde til fremstilling af beta-anomer-berigede 2-deoxy-2,2-difluor-D-ribofuranosyl-arylsulfonater DK0576228T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/902,143 US5252756A (en) 1992-06-22 1992-06-22 Process for preparing beta-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl-arylsulfonates

Publications (1)

Publication Number Publication Date
DK0576228T3 true DK0576228T3 (da) 1999-09-20

Family

ID=25415363

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93304816T DK0576228T3 (da) 1992-06-22 1993-06-21 Fremgangsmåde til fremstilling af beta-anomer-berigede 2-deoxy-2,2-difluor-D-ribofuranosyl-arylsulfonater

Country Status (9)

Country Link
US (1) US5252756A (de)
EP (1) EP0576228B1 (de)
JP (1) JPH0656864A (de)
AT (1) ATE176479T1 (de)
CA (1) CA2098885C (de)
DE (1) DE69323352T2 (de)
DK (1) DK0576228T3 (de)
ES (1) ES2127249T3 (de)
GR (1) GR3029572T3 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9303713A (es) * 1992-06-22 1994-05-31 Lilly Co Eli Proceso estereoselectivo para preparar un derivadoribofuranosilo enriquecido con alfa anomero.
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
BRPI0513783A (pt) * 2004-07-29 2008-05-13 Hanmi Pharm Ind Co Ltd derivados 1-(alfa)-halo-2, 2-diflúor-2-desóxi-d-ribofuranose e processo para a sua preparação
AT502221A1 (de) * 2005-07-20 2007-02-15 Pharmacon Forschung & Beratung Gmbh Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung
US8207359B2 (en) * 2006-04-27 2012-06-26 Sumitomo Chemical Company, Limited Method for producing epoxy compound
KR100908363B1 (ko) 2007-02-28 2009-07-20 한미약품 주식회사 트라이-Ｏ-아세틸-5-데옥시-β-Ｄ-라이보퓨라노즈의입체선택적 제조방법 및 이의 분리방법

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
DE3856477T2 (de) * 1987-08-28 2001-11-08 Eli Lilly And Co., Indianapolis Verfahren zur Herstellung von 2'-deoxy-2',2'-difluornukleosiden
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides

Also Published As

Publication number Publication date
JPH0656864A (ja) 1994-03-01
ES2127249T3 (es) 1999-04-16
ATE176479T1 (de) 1999-02-15
EP0576228A1 (de) 1993-12-29
CA2098885A1 (en) 1993-12-23
CA2098885C (en) 2003-07-29
GR3029572T3 (en) 1999-06-30
US5252756A (en) 1993-10-12
EP0576228B1 (de) 1999-02-03
DE69323352T2 (de) 1999-06-24
DE69323352D1 (de) 1999-03-18

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