DK0586376T3 - Fremgangsmåde og mellemprodukter til fremstilling af anxiolytiske perhydro-1H-pyrido 1,2-a pyraziner - Google Patents

Fremgangsmåde og mellemprodukter til fremstilling af anxiolytiske perhydro-1H-pyrido 1,2-a pyraziner

Info

Publication number: DK0586376T3
Authority: DK; Denmark
Prior art keywords: pyrido; intermediates; phthalimido; pyrazines; perhydro
Prior art date: 1991-02-27

Application number

DK92900722.7T

Other languages

Danish (da)

English (en)

Inventor

Dennis Michael Godek

Charles William Murtiashaw

Frank John Urban

Brian Clement Vanderplas

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-02-27

Filing date

1991-11-19

Publication date

1997-10-27

1991-11-19 Application filed by Pfizer filed Critical Pfizer

1997-10-27 Application granted granted Critical

1997-10-27 Publication of DK0586376T3 publication Critical patent/DK0586376T3/da

Links

239000000543 intermediate Substances 0.000 title abstract 3
239000002249 anxiolytic agent Substances 0.000 title abstract 2
230000000949 anxiolytic effect Effects 0.000 title abstract 2
150000003216 pyrazines Chemical class 0.000 title 1
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
239000002243 precursor Substances 0.000 abstract 2
239000007858 starting material Substances 0.000 abstract 2
LMRDBJZQDUVCQH-UHFFFAOYSA-N 2-(1,3-dioxoisoindol-2-yl)acetaldehyde Chemical compound C1=CC=C2C(=O)N(CC=O)C(=O)C2=C1 LMRDBJZQDUVCQH-UHFFFAOYSA-N 0.000 abstract 1
HIXUMZQBGZEFIF-UHFFFAOYSA-N 2-(1,3-dioxoisoindol-2-yl)ethyl trifluoromethanesulfonate Chemical compound C1=CC=C2C(=O)N(CCOS(=O)(=O)C(F)(F)F)C(=O)C2=C1 HIXUMZQBGZEFIF-UHFFFAOYSA-N 0.000 abstract 1
229940005530 anxiolytics Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Reinforced Plastic Materials (AREA)

DK92900722.7T 1991-02-27 1991-11-19 Fremgangsmåde og mellemprodukter til fremstilling af anxiolytiske perhydro-1H-pyrido 1,2-a pyraziner DK0586376T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/661,730 US5185449A (en)	1991-02-27	1991-02-27	Process and intermediate for certain bis-aza-bicyclic anxiolytic agents

Publications (1)

Publication Number	Publication Date
DK0586376T3 true DK0586376T3 (da)	1997-10-27

Family

ID=24654869

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92900722.7T DK0586376T3 (da)	1991-02-27	1991-11-19	Fremgangsmåde og mellemprodukter til fremstilling af anxiolytiske perhydro-1H-pyrido 1,2-a pyraziner

Country Status (23)

Country	Link
US (1)	US5185449A (de)
EP (1)	EP0586376B1 (de)
JP (1)	JPH0784467B2 (de)
KR (1)	KR100189044B1 (de)
AT (1)	ATE153662T1 (de)
AU (1)	AU647562B2 (de)
CA (1)	CA2101433C (de)
DE (1)	DE69126326T2 (de)
DK (1)	DK0586376T3 (de)
ES (1)	ES2101831T3 (de)
FI (1)	FI107153B (de)
GR (1)	GR3024125T3 (de)
HU (2)	HUT67440A (de)
IE (1)	IE920600A1 (de)
IL (1)	IL101022A (de)
MX (1)	MX9200802A (de)
MY (1)	MY110167A (de)
NO (1)	NO302947B1 (de)
NZ (1)	NZ241738A (de)
PT (1)	PT100161B (de)
TW (1)	TW268949B (de)
WO (1)	WO1992015575A1 (de)
ZA (1)	ZA921406B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI933755L (fi) *	1991-02-27	1993-08-26	Pfizer	Foerfarande foer framstaellning av trans-piperidin-2,5-dikarboxylater
SI9520096A (sl) *	1994-09-30	1998-04-30	Pfizer Inc.	Derivati 2,7-substituiranega oktahidro-1H-pirido /1,2-a/ pirazina
WO1996010570A1 (en) *	1994-09-30	1996-04-11	Pfizer Inc.	NEUROLEPTIC 2,7-DISUBSTITUTED PERHYDRO-1H-PYRIDO[1,2-a]PYRAZINES
US6670476B2 (en)	2000-11-29	2003-12-30	Pfizer Inc.	Resolution of trans-7-(hydroxy-methyl)octa-hydro-2H-pyrido[1,2-a]pyrazine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3388128A (en) *	1965-09-03	1968-06-11	Allan R. Day	Substituted 1, 4-diazabicyclo [4. 4. 9] decanes
MX19222A (es) *	1989-01-23	1993-12-01	Pfizer	Agentes ansioliticos bis-aza-biciclicos
FI933755L (fi) *	1991-02-27	1993-08-26	Pfizer	Foerfarande foer framstaellning av trans-piperidin-2,5-dikarboxylater

1991
- 1991-02-27 US US07/661,730 patent/US5185449A/en not_active Expired - Lifetime
- 1991-11-19 WO PCT/US1991/008400 patent/WO1992015575A1/en not_active Ceased
- 1991-11-19 ES ES92900722T patent/ES2101831T3/es not_active Expired - Lifetime
- 1991-11-19 HU HU9302428A patent/HUT67440A/hu unknown
- 1991-11-19 CA CA002101433A patent/CA2101433C/en not_active Expired - Fee Related
- 1991-11-19 DK DK92900722.7T patent/DK0586376T3/da active
- 1991-11-19 EP EP92900722A patent/EP0586376B1/de not_active Expired - Lifetime
- 1991-11-19 AT AT92900722T patent/ATE153662T1/de not_active IP Right Cessation
- 1991-11-19 DE DE69126326T patent/DE69126326T2/de not_active Expired - Fee Related
- 1991-11-19 AU AU90666/91A patent/AU647562B2/en not_active Ceased
- 1991-11-19 KR KR1019930702557A patent/KR100189044B1/ko not_active Expired - Fee Related
- 1991-11-19 HU HU9302428A patent/HU223138B1/hu not_active IP Right Cessation
- 1991-11-19 JP JP4501915A patent/JPH0784467B2/ja not_active Expired - Fee Related
1992
- 1992-02-20 IL IL10102292A patent/IL101022A/en not_active IP Right Cessation
- 1992-02-25 MX MX9200802A patent/MX9200802A/es not_active IP Right Cessation
- 1992-02-25 PT PT100161A patent/PT100161B/pt not_active IP Right Cessation
- 1992-02-26 NZ NZ241738A patent/NZ241738A/xx not_active IP Right Cessation
- 1992-02-26 IE IE060092A patent/IE920600A1/en not_active IP Right Cessation
- 1992-02-26 ZA ZA921406A patent/ZA921406B/xx unknown
- 1992-02-26 MY MYPI92000314A patent/MY110167A/en unknown
- 1992-03-14 TW TW081101935A patent/TW268949B/zh active
1993
- 1993-08-26 NO NO933048A patent/NO302947B1/no unknown
- 1993-08-26 FI FI933754A patent/FI107153B/fi not_active IP Right Cessation
1997
- 1997-07-16 GR GR970401775T patent/GR3024125T3/el unknown

Also Published As

Publication number	Publication date
JPH0784467B2 (ja)	1995-09-13
NO302947B1 (no)	1998-05-11
PT100161B (pt)	1999-09-30
ES2101831T3 (es)	1997-07-16
IE920600A1 (en)	1992-09-09
AU9066691A (en)	1992-10-06
KR100189044B1 (ko)	1999-06-01
FI933754A0 (fi)	1993-08-26
MY110167A (en)	1998-02-28
NO933048L (no)	1993-08-26
FI107153B (fi)	2001-06-15
GR3024125T3 (en)	1997-10-31
HUT67440A (en)	1995-04-28
CA2101433C (en)	1999-07-27
EP0586376B1 (de)	1997-05-28
ZA921406B (en)	1993-08-26
JPH06501021A (ja)	1994-01-27
DE69126326T2 (de)	1997-09-04
TW268949B (de)	1996-01-21
US5185449A (en)	1993-02-09
NO933048D0 (no)	1993-08-26
ATE153662T1 (de)	1997-06-15
EP0586376A1 (de)	1994-03-16
AU647562B2 (en)	1994-03-24
NZ241738A (en)	1993-05-26
WO1992015575A1 (en)	1992-09-17
IL101022A (en)	1996-06-18
HU223138B1 (hu)	2004-03-29
FI933754L (fi)	1993-08-26
PT100161A (pt)	1993-05-31
DE69126326D1 (de)	1997-07-03
IL101022A0 (en)	1992-11-15
HU9302428D0 (en)	1993-11-29
CA2101433A1 (en)	1992-08-28
MX9200802A (es)	1992-08-01

Publication	Publication Date	Title
ATE294182T1 (de)	2005-05-15	Zwischenprodukte zur herstellung von camptothecin und analogen
DK0645389T3 (da)	1997-03-10	Fremgangsmåde til fremstilling af imidazopyridinderivater
DK0556080T3 (da)	2002-08-19	Biocykliske pyridinderivater, fremgangsmåde til deres fremstilling, mellemprodukter, deres anvendelse som lægemidler og farmaceutiske præparater med indhold deraf
ATE54913T1 (de)	1990-08-15	Industrielle verbindungen anwendbar als zwischenprodukte in der herstellung von in stellung 2 substituierten 4-hydroxy 3quinolincarboxamid-derivaten und die herstellung von diesen zwischenprodukten.
FI924110A0 (fi)	1992-09-14	Menetelmä dihydropyridiinijohdannaisten valmistamiseksi, jotka ovat käyttökelpoisia kasvainten vastaisessa terapiassa
DK0586376T3 (da)	1997-10-27	Fremgangsmåde og mellemprodukter til fremstilling af anxiolytiske perhydro-1H-pyrido 1,2-a pyraziner
ATE51617T1 (de)	1990-04-15	Verfahren zur herstellung von 4-phenyl-pyrrolderivaten.
FI832739A0 (fi)	1983-07-28	5-alkyl-1,6-naftyridin-2(1h)-oner, mellanprodukter deras framstaellning och anvaendning som hjaertlaekemedel
NO940227L (no)	1994-01-21	Fremgangsmaate for fremstilling av mellomprodukter for syntese av chirale tiazolidin-2,4-dion-derivater
DK18186A (da)	1986-07-17	Aminoacrylsyre-derivater, deres fremstilling og anvendelse, samt vedfremstillingen anvendelige mellemprodukter og fremstillingderaf
DK0573464T3 (da)	1997-09-01	Fremgangsmåde til fremstilling af trans-piperidin-2,5-dicarboxylater
NO895165L (no)	1989-12-21	Pyrazolopyridin-type mevalono-laktoner.
CZ281393B6 (cs)	1996-09-11	Způsob výroby 6-(substituovaných amino)-propionyl derivátů forskolinu
DE3864286D1 (de)	1991-09-26	Herstellungsverfahren von trifluormethylverbindungen.
PT84061A (en)	1987-02-01	Process for the preparation of monosulfactams
JPS5735573A (en)	1982-02-26	Novel 3-alkyl substituted 2,4(1h,3h)-quinazolinedione derivative
IT1254201B (it)	1995-09-14	Procedimento per la preparazione di derivati del glicerolo otticamente attivi.