ZA921406B - Improved process and intermediate for certain bis-aza-bicyclic anxiolytic agents. - Google Patents

Improved process and intermediate for certain bis-aza-bicyclic anxiolytic agents.

Info

Publication number: ZA921406B
Authority: ZA; South Africa
Prior art keywords: aza; phthalimido; improved process; certain bis; bicyclic
Prior art date: 1991-02-27

Application number

ZA921406A

Other languages

English (en)

Inventor

Dennis Michael Godek

Charles William Murtiashaw

Frak John Urban

Brian Clement Vanderpalas

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-02-27

Filing date

1992-02-26

Publication date

1993-08-26

1992-02-26 Application filed by Pfizer filed Critical Pfizer

1993-08-26 Publication of ZA921406B publication Critical patent/ZA921406B/xx

Links

239000002249 anxiolytic agent Substances 0.000 title abstract 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
239000000543 intermediate Substances 0.000 abstract 2
239000002243 precursor Substances 0.000 abstract 2
239000007858 starting material Substances 0.000 abstract 2
LMRDBJZQDUVCQH-UHFFFAOYSA-N 2-(1,3-dioxoisoindol-2-yl)acetaldehyde Chemical compound C1=CC=C2C(=O)N(CC=O)C(=O)C2=C1 LMRDBJZQDUVCQH-UHFFFAOYSA-N 0.000 abstract 1
HIXUMZQBGZEFIF-UHFFFAOYSA-N 2-(1,3-dioxoisoindol-2-yl)ethyl trifluoromethanesulfonate Chemical compound C1=CC=C2C(=O)N(CCOS(=O)(=O)C(F)(F)F)C(=O)C2=C1 HIXUMZQBGZEFIF-UHFFFAOYSA-N 0.000 abstract 1
230000000949 anxiolytic effect Effects 0.000 abstract 1
229940005530 anxiolytics Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Reinforced Plastic Materials (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

ZA921406A 1991-02-27 1992-02-26 Improved process and intermediate for certain bis-aza-bicyclic anxiolytic agents. ZA921406B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/661,730 US5185449A (en)	1991-02-27	1991-02-27	Process and intermediate for certain bis-aza-bicyclic anxiolytic agents

Publications (1)

Publication Number	Publication Date
ZA921406B true ZA921406B (en)	1993-08-26

Family

ID=24654869

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA921406A ZA921406B (en)	1991-02-27	1992-02-26	Improved process and intermediate for certain bis-aza-bicyclic anxiolytic agents.

Country Status (23)

Country	Link
US (1)	US5185449A (de)
EP (1)	EP0586376B1 (de)
JP (1)	JPH0784467B2 (de)
KR (1)	KR100189044B1 (de)
AT (1)	ATE153662T1 (de)
AU (1)	AU647562B2 (de)
CA (1)	CA2101433C (de)
DE (1)	DE69126326T2 (de)
DK (1)	DK0586376T3 (de)
ES (1)	ES2101831T3 (de)
FI (1)	FI107153B (de)
GR (1)	GR3024125T3 (de)
HU (2)	HUT67440A (de)
IE (1)	IE920600A1 (de)
IL (1)	IL101022A (de)
MX (1)	MX9200802A (de)
MY (1)	MY110167A (de)
NO (1)	NO302947B1 (de)
NZ (1)	NZ241738A (de)
PT (1)	PT100161B (de)
TW (1)	TW268949B (de)
WO (1)	WO1992015575A1 (de)
ZA (1)	ZA921406B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69218414T2 (de) *	1991-02-27	1998-01-22	Pfizer	Verfahren zur herstellung von trans-piperidin-2,5-dicarboxylaten
WO1996010570A1 (en) *	1994-09-30	1996-04-11	Pfizer Inc.	NEUROLEPTIC 2,7-DISUBSTITUTED PERHYDRO-1H-PYRIDO[1,2-a]PYRAZINES
DK0783503T3 (da) *	1994-09-30	2002-02-11	Pfizer	2,7-substituerede octahydro-1H-pyrido(1,2-a)pyrazinderivater
US6670476B2 (en)	2000-11-29	2003-12-30	Pfizer Inc.	Resolution of trans-7-(hydroxy-methyl)octa-hydro-2H-pyrido[1,2-a]pyrazine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3388128A (en) *	1965-09-03	1968-06-11	Allan R. Day	Substituted 1, 4-diazabicyclo [4. 4. 9] decanes
WO1990008148A1 (en) *	1989-01-23	1990-07-26	Pfizer Inc.	Bis-aza-bicyclic anxiolytic agents
DE69218414T2 (de) *	1991-02-27	1998-01-22	Pfizer	Verfahren zur herstellung von trans-piperidin-2,5-dicarboxylaten

1991
- 1991-02-27 US US07/661,730 patent/US5185449A/en not_active Expired - Lifetime
- 1991-11-19 WO PCT/US1991/008400 patent/WO1992015575A1/en not_active Ceased
- 1991-11-19 HU HU9302428A patent/HUT67440A/hu unknown
- 1991-11-19 AU AU90666/91A patent/AU647562B2/en not_active Ceased
- 1991-11-19 CA CA002101433A patent/CA2101433C/en not_active Expired - Fee Related
- 1991-11-19 EP EP92900722A patent/EP0586376B1/de not_active Expired - Lifetime
- 1991-11-19 AT AT92900722T patent/ATE153662T1/de not_active IP Right Cessation
- 1991-11-19 HU HU9302428A patent/HU223138B1/hu not_active IP Right Cessation
- 1991-11-19 ES ES92900722T patent/ES2101831T3/es not_active Expired - Lifetime
- 1991-11-19 DE DE69126326T patent/DE69126326T2/de not_active Expired - Fee Related
- 1991-11-19 JP JP4501915A patent/JPH0784467B2/ja not_active Expired - Fee Related
- 1991-11-19 KR KR1019930702557A patent/KR100189044B1/ko not_active Expired - Fee Related
- 1991-11-19 DK DK92900722.7T patent/DK0586376T3/da active
1992
- 1992-02-20 IL IL10102292A patent/IL101022A/en not_active IP Right Cessation
- 1992-02-25 PT PT100161A patent/PT100161B/pt not_active IP Right Cessation
- 1992-02-25 MX MX9200802A patent/MX9200802A/es not_active IP Right Cessation
- 1992-02-26 NZ NZ241738A patent/NZ241738A/xx not_active IP Right Cessation
- 1992-02-26 ZA ZA921406A patent/ZA921406B/xx unknown
- 1992-02-26 MY MYPI92000314A patent/MY110167A/en unknown
- 1992-02-26 IE IE060092A patent/IE920600A1/en not_active IP Right Cessation
- 1992-03-14 TW TW081101935A patent/TW268949B/zh active
1993
- 1993-08-26 FI FI933754A patent/FI107153B/fi not_active IP Right Cessation
- 1993-08-26 NO NO933048A patent/NO302947B1/no unknown
1997
- 1997-07-16 GR GR970401775T patent/GR3024125T3/el unknown

Also Published As

Publication number	Publication date
CA2101433C (en)	1999-07-27
HU223138B1 (hu)	2004-03-29
FI933754L (fi)	1993-08-26
IE920600A1 (en)	1992-09-09
WO1992015575A1 (en)	1992-09-17
FI107153B (fi)	2001-06-15
US5185449A (en)	1993-02-09
DE69126326T2 (de)	1997-09-04
GR3024125T3 (en)	1997-10-31
TW268949B (de)	1996-01-21
IL101022A (en)	1996-06-18
JPH0784467B2 (ja)	1995-09-13
JPH06501021A (ja)	1994-01-27
PT100161B (pt)	1999-09-30
MY110167A (en)	1998-02-28
FI933754A0 (fi)	1993-08-26
NO933048D0 (no)	1993-08-26
NO933048L (no)	1993-08-26
DK0586376T3 (da)	1997-10-27
ES2101831T3 (es)	1997-07-16
NO302947B1 (no)	1998-05-11
KR100189044B1 (ko)	1999-06-01
HUT67440A (en)	1995-04-28
NZ241738A (en)	1993-05-26
AU647562B2 (en)	1994-03-24
DE69126326D1 (de)	1997-07-03
ATE153662T1 (de)	1997-06-15
IL101022A0 (en)	1992-11-15
PT100161A (pt)	1993-05-31
EP0586376B1 (de)	1997-05-28
AU9066691A (en)	1992-10-06
HU9302428D0 (en)	1993-11-29
MX9200802A (es)	1992-08-01
CA2101433A1 (en)	1992-08-28
EP0586376A1 (de)	1994-03-16

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