DK0591275T3 - Anvendelse af 2-(2-nitro-4-trifluormethylbenzoyl)-1,3-cyklohexandion til behandling af tyrosinæmi samt farmaceutiske sammen - Google Patents

Anvendelse af 2-(2-nitro-4-trifluormethylbenzoyl)-1,3-cyklohexandion til behandling af tyrosinæmi samt farmaceutiske sammen

Info

Publication number: DK0591275T3
Authority: DK; Denmark
Prior art keywords: cyclohexanedione; trifluoromethylbenzoyl; anemia; tyrosine; nitro
Prior art date: 1991-06-24

Application number

DK92912215T

Other languages

Danish (da)

English (en)

Inventor

Martin Keith Ellis

Sven Torvald Lindstedt

Edward Alan Lock

Maj Elisabeth Holme Markstedt

Linda Carol Mutter

Michael Paul Prisbylla

Original Assignee

Zeneca Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-06-24

Filing date

1992-06-18

Publication date

1999-10-11

1991-06-24 Priority claimed from GB919113622A external-priority patent/GB9113622D0/en

1992-03-24 Priority claimed from GB929206412A external-priority patent/GB9206412D0/en

1992-06-18 Application filed by Zeneca Ltd filed Critical Zeneca Ltd

1999-10-11 Application granted granted Critical

1999-10-11 Publication of DK0591275T3 publication Critical patent/DK0591275T3/da

Links

OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 title 1
208000007502 anemia Diseases 0.000 title 1
239000003814 drug Substances 0.000 title 1
OUBCNLGXQFSTLU-UHFFFAOYSA-N nitisinone Chemical compound [O-][N+](=O)C1=CC(C(F)(F)F)=CC=C1C(=O)C1C(=O)CCCC1=O OUBCNLGXQFSTLU-UHFFFAOYSA-N 0.000 title 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 title 1
108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 abstract 3
102100028626 4-hydroxyphenylpyruvate dioxygenase Human genes 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
QMNFICMPAXFAPC-UHFFFAOYSA-N 2-benzoylcyclohexane-1,3-dione Chemical compound C=1C=CC=CC=1C(=O)C1C(=O)CCCC1=O QMNFICMPAXFAPC-UHFFFAOYSA-N 0.000 abstract 1
208000032001 Tyrosinemia type 1 Diseases 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
230000002503 metabolic effect Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
201000011296 tyrosinemia Diseases 0.000 abstract 1
201000007972 tyrosinemia type I Diseases 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Inorganic Compounds Of Heavy Metals (AREA)
Hydrogenated Pyridines (AREA)

DK92912215T 1991-06-24 1992-06-18 Anvendelse af 2-(2-nitro-4-trifluormethylbenzoyl)-1,3-cyklohexandion til behandling af tyrosinæmi samt farmaceutiske sammen DK0591275T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB919113622A GB9113622D0 (en)	1991-06-24	1991-06-24	Medicinal agents
GB929206412A GB9206412D0 (en)	1992-03-24	1992-03-24	Pharmaceutical compositions
PCT/GB1992/001094 WO1993000080A1 (fr)	1991-06-24	1992-06-18	Utilisation de 2-(2-nitro-4-trifluoromethylbenzoyle)-1,3-cyclohexanedione pour le traitement de la tirosinemie et compositions pharmaceutiques

Publications (1)

Publication Number	Publication Date
DK0591275T3 true DK0591275T3 (da)	1999-10-11

Family

ID=26299120

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92912215T DK0591275T3 (da)	1991-06-24	1992-06-18	Anvendelse af 2-(2-nitro-4-trifluormethylbenzoyl)-1,3-cyklohexandion til behandling af tyrosinæmi samt farmaceutiske sammen

Country Status (16)

Country	Link
US (1)	US5550165A (fr)
EP (1)	EP0591275B1 (fr)
JP (1)	JP3130935B2 (fr)
AT (1)	ATE178207T1 (fr)
AU (1)	AU672361B2 (fr)
CA (1)	CA2072047C (fr)
DE (2)	DE69228813T2 (fr)
DK (1)	DK0591275T3 (fr)
ES (1)	ES2129448T3 (fr)
GR (1)	GR3029841T3 (fr)
IE (1)	IE922024A1 (fr)
LU (1)	LU91180I2 (fr)
NL (1)	NL300198I2 (fr)
NO (3)	NO304923B1 (fr)
PT (1)	PT100619B (fr)
WO (1)	WO1993000080A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4305696A1 (de) *	1993-02-25	1994-09-01	Hoechst Ag	Nachweisverfahren zur Identifizierung von Inhibitoren
AU5116099A (en) *	1998-07-21	2000-02-14	Sui Xiong Cai	Novel fluorescence dyes and their applications for whole cell fluorescence screening assays for caspases, peptidases, proteases and other enzymes and the use thereof
GB0504103D0 (en) *	2005-02-28	2005-04-06	Syngenta Ltd	Novel method
CA2659424A1 (fr) *	2006-08-18	2008-02-21	Syngenta Limited	Utilisation d'inhibiteurs de l'hppd dans le traitement de la depression et/ou des symptomes de sevrage associes aux drogues engendrant la dependance
JP5867081B2 (ja) *	2010-01-29	2016-02-24	東レ株式会社	胆道疾患の治療又は予防剤
RS54632B1 (sr) *	2011-06-23	2016-08-31	Swedish Orphan Biovitrum International Ab	Tečna farmaceutska kompozicija koja sadrži nitizinon
WO2013181292A1 (fr) *	2012-05-29	2013-12-05	Biotie Therapies, Inc.	Formulations de nitisinone
CN102976948B (zh) *	2012-11-28	2014-07-09	郑州大明药物科技有限公司	尼替西农的制备方法
GB201400117D0 (en)	2014-01-03	2014-02-19	Cycle Pharmaceuticals Ltd	Pharmaceutical composition
ITUB20160650A1 (it) *	2016-02-11	2017-08-11	Dipharma S A	Formulazioni farmaceutiche solide stabili contenenti 2-(2-nitro-4-trifluorometilbenzoil)-1,3-cicloesandione
US9783485B1 (en)	2016-11-30	2017-10-10	Dipharma S.A.	Crystalline inhibitor of 4-hydroxyphenylpyruvate dioxygenase, and a process of synthesis and crystallization thereof
EP3888684A1 (fr) *	2020-03-31	2021-10-06	Bayer Animal Health GmbH	Composition ayant une acceptation volontaire améliorée
CN112460914A (zh) *	2020-11-01	2021-03-09	江苏珠合新能源科技有限公司	一种干冰机尾气冷量回收调节工艺装置
WO2024047657A1 (fr) *	2022-08-28	2024-03-07	Brawn Laboratories Ltd	Procédé de préeparation de nitisinone

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4780127A (en) *	1982-03-25	1988-10-25	Stauffer Chemical Company	Certain 2-(substituted benzoyl)-1,3-cyclohexanediones and their use as herbicides
IL77349A (en) *	1984-12-20	1990-07-12	Stauffer Chemical Co	2-(2'-nitrobenzoyl)-1,3-cyclohexanediones,their preparation and their use as herbicides
US4774360A (en)	1987-06-29	1988-09-27	Stauffer Chemical Company	Converting enol ester precursor of a benzoyl-1,3-cycloalkyldione to a benzoyl-1,3-cycloalkyldione
US4859234A (en)	1987-09-14	1989-08-22	Ici Americas Inc.	Herbicidal compositions of acylated 1,3-dicarbonyl herbicides and phenoxyalkanoic acids, salts, amides and esters therof as antidotes

1992
- 1992-06-18 AU AU19860/92A patent/AU672361B2/en not_active Expired
- 1992-06-18 DE DE69228813T patent/DE69228813T2/de not_active Expired - Lifetime
- 1992-06-18 WO PCT/GB1992/001094 patent/WO1993000080A1/fr not_active Ceased
- 1992-06-18 JP JP05501383A patent/JP3130935B2/ja not_active Expired - Lifetime
- 1992-06-18 EP EP92912215A patent/EP0591275B1/fr not_active Expired - Lifetime
- 1992-06-18 ES ES92912215T patent/ES2129448T3/es not_active Expired - Lifetime
- 1992-06-18 DE DE1992628813 patent/DE122005000032I2/de active Active
- 1992-06-18 AT AT92912215T patent/ATE178207T1/de active
- 1992-06-18 DK DK92912215T patent/DK0591275T3/da active
- 1992-06-23 CA CA002072047A patent/CA2072047C/fr not_active Expired - Lifetime
- 1992-06-24 PT PT100619A patent/PT100619B/pt not_active IP Right Cessation
- 1992-07-01 IE IE202492A patent/IE922024A1/en not_active IP Right Cessation
1993
- 1993-12-23 NO NO934798A patent/NO304923B1/no active Protection Beyond IP Right Term
1994
- 1994-12-19 US US08/359,361 patent/US5550165A/en not_active Expired - Lifetime
1999
- 1999-04-01 GR GR990400803T patent/GR3029841T3/el unknown
2005
- 2005-06-09 NL NL300198C patent/NL300198I2/nl unknown
- 2005-07-06 LU LU91180C patent/LU91180I2/fr unknown
- 2005-08-31 NO NO2005018C patent/NO2005018I2/no unknown
2017
- 2017-08-23 NO NO2017045C patent/NO2017045I1/no unknown

Also Published As

Publication number	Publication date
NL300198I2 (nl)	2005-09-01
DE69228813T2 (de)	1999-08-05
NO304923B1 (no)	1999-03-08
US5550165A (en)	1996-08-27
EP0591275B1 (fr)	1999-03-31
CA2072047A1 (fr)	1992-12-25
DE122005000032I2 (de)	2006-06-08
AU1986092A (en)	1993-01-25
NL300198I1 (nl)	2005-08-01
NO2017045I1 (no)	2017-08-23
JP3130935B2 (ja)	2001-01-31
AU672361B2 (en)	1996-10-03
NO2005018I1 (no)	2005-09-26
NO934798D0 (no)	1993-12-23
NO2005018I2 (no)	2008-02-11
ATE178207T1 (de)	1999-04-15
DE69228813D1 (de)	1999-05-06
PT100619B (pt)	1999-07-30
JPH06508628A (ja)	1994-09-29
IE922024A1 (en)	1992-12-30
LU91180I2 (fr)	2005-09-06
HK1008662A1 (en)	1999-05-14
WO1993000080A1 (fr)	1993-01-07
PT100619A (pt)	1994-01-31
EP0591275A1 (fr)	1994-04-13
ES2129448T3 (es)	1999-06-16
GR3029841T3 (en)	1999-07-30
DE122005000032I1 (de)	2005-09-29
NO934798L (no)	1993-12-23
CA2072047C (fr)	2003-06-10

Publication	Publication Date	Title
NO2017045I1 (no)	2017-08-23	Farmasøøytisk preparat inneholdende 2-(2-nitro-4-ifluormetylbenzoyl)-1,3-cykloheksandion eller et farmasøytisk godtagbart salt derav
IS4695A (is)	1998-03-20	(Metýlsúlfónýl)fenýl-2-(5H)-fúranón sem sýklóoxýgenasa-2 tálmar
DE69410092D1 (en)	1998-06-10	Phenyl heterocyclen als cyclooxygenase-2 inhibitoren
ATE443043T1 (de)	2009-10-15	Phenylcarboxamide als beta-sekretase-hemmer zur behandlung von alzheimer
DE69427704D1 (de)	2001-08-16	Neue (r)-5-carbamoyl-8-fluor-3-n,n-disubstituierte-amino-3,4-dihydro-2h-1-benzopyrane
TNSN98017A1 (fr)	2005-03-15	Derives de sulfonyluree, procede pour leur preparation et compositions pharmaceutiques les contenant.
MA26723A1 (fr)	2004-12-20	Acides oxamiques nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant
TNSN97198A1 (fr)	2005-03-15	Derives de 6-phenylpyridyl-2- amine et compositions pharmaceutiques les contenant
MA27937A1 (fr)	2006-06-01	Dérivés d'indazole 3, 5-disubstitués, compositions pharmaceutiques, et méthodes de médiation ou d'inhibition de la prolifération cellulaire
BR9713186A (pt)	1999-11-03	Inibidores de metaloprotease 1,3-diheterocìclicos
CA2224528A1 (fr)	1998-06-30	Composes stilbeniques a groupement adamantyl, compositions les contenant et utilisations
ATE212343T1 (de)	2002-02-15	3,4-diaryl-2-hydroxy-2,5-dihydrofurane als wirkstoffvorstufen von cox-2 inhibitoren
DE69816047D1 (en)	2003-08-07	(methylsulfonyl)phenyl-2-(5h)-furanone mit sauerstoff-bindung als cox-2-hemmer
HN1997000070A (es)	1997-09-08	Inhibición de las metaloproteinasas de matriz por acidos 2-((1)-aroilalquil) -4-biaril-4-oxoburiticos
CA2291650A1 (fr)	1999-10-07	Nouveaux composes heteroethynylenes et compositions pharmaceutiques et cosmetiques les contenant
DE59101267D1 (de)	1994-05-05	N-Alkyl-N-(meth)acryloyloxyalkylcarboxamide aromatischer Carbonsäuren und aromatischer Carbonsäureanhydride sowie Adhäsive enthaltend diese Verbindungen.
ATE190484T1 (de)	2000-04-15	Arzneimittel zur behandlung von durch babesia verursachten protozoeninfektionen
ATE308984T1 (de)	2005-11-15	Arzneiformen zur behandlung von krankheiten, die auf aktivierung des ppar-gamma-rezeptors ansprechen
TH45444A (th)	2001-05-31	(เมทิลซัลโฟนิล) ฟีนิล-2-(5h)-ฟูราโนน ที่เป็นตัวขัดขวาง cox-2
GEP20033130B (en)	2003-12-25	Inhibitors of IMPDH Enzyme
GEP20022764B (en)	2002-08-26	HIV Protease Inhibitors, Pharmaceutical Compositions and Methods for Inhibiting HIV Protease