DK0592433T3 - Sertindole Prodrugs - Google Patents

Sertindole Prodrugs

Info

Publication number: DK0592433T3
Authority: DK; Denmark
Prior art keywords: sertindole; group; prodrugs; iii; optionally substituted
Prior art date: 1990-10-03

Application number

DK91919394T

Other languages

English (en)

Inventor

Jens Kristian Perregaard

Henrik Perdersen

Original Assignee

Lundbeck & Co As H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-10-03

Filing date

1991-09-27

Publication date

1999-09-13

1991-09-27 Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H

1999-09-13 Application granted granted Critical

1999-09-13 Publication of DK0592433T3 publication Critical patent/DK0592433T3/da

Links

GZKLJWGUPQBVJQ-UHFFFAOYSA-N sertindole Chemical compound C1=CC(F)=CC=C1N1C2=CC=C(Cl)C=C2C(C2CCN(CCN3C(NCC3)=O)CC2)=C1 GZKLJWGUPQBVJQ-UHFFFAOYSA-N 0.000 title abstract 4
229960000652 sertindole Drugs 0.000 title abstract 4
229940002612 prodrug Drugs 0.000 title abstract 2
239000000651 prodrug Substances 0.000 title abstract 2
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 6
239000002253 acid Substances 0.000 abstract 2
201000000980 schizophrenia Diseases 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
208000019901 Anxiety disease Diseases 0.000 abstract 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
239000007795 chemical reaction product Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
150000004820 halides Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
208000020016 psychiatric disease Diseases 0.000 abstract 1
238000013268 sustained release Methods 0.000 abstract 1
239000012730 sustained-release form Substances 0.000 abstract 1
208000024891 symptom Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Veterinary Medicine (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Inorganic Compounds Of Heavy Metals (AREA)
Pyrane Compounds (AREA)
Saccharide Compounds (AREA)
Indole Compounds (AREA)
Curing Cements, Concrete, And Artificial Stone (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK91919394T 1990-10-03 1991-09-27 Sertindole Prodrugs DK0592433T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK238190A DK238190D0 (da)	1990-10-03	1990-10-03	Depotderivater
PCT/DK1991/000291 WO1992006089A1 (en)	1990-10-03	1991-09-27	Sertindole prodrugs

Publications (1)

Publication Number	Publication Date
DK0592433T3 true DK0592433T3 (da)	1999-09-13

Family

ID=8111993

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK238190A DK238190D0 (da)	1990-10-03	1990-10-03	Depotderivater
DK91919394T DK0592433T3 (da)	1990-10-03	1991-09-27	Sertindole Prodrugs

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK238190A DK238190D0 (da)	1990-10-03	1990-10-03	Depotderivater

Country Status (20)

Country	Link
US (1)	US5428036A (da)
EP (1)	EP0592433B1 (da)
JP (1)	JP3100980B2 (da)
KR (1)	KR100212430B1 (da)
AT (1)	ATE175964T1 (da)
AU (1)	AU652783B2 (da)
CA (1)	CA2093433C (da)
DE (1)	DE69130803T2 (da)
DK (2)	DK238190D0 (da)
ES (1)	ES2125870T3 (da)
FI (1)	FI102679B (da)
GR (1)	GR3029399T3 (da)
IE (1)	IE913384A1 (da)
IL (1)	IL99652A (da)
NO (1)	NO301475B1 (da)
NZ (1)	NZ240051A (da)
PH (1)	PH30129A (da)
PT (1)	PT99142B (da)
WO (1)	WO1992006089A1 (da)
ZA (1)	ZA917881B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5776963A (en)	1989-05-19	1998-07-07	Hoechst Marion Roussel, Inc.	3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
US5643784A (en) *	1990-12-04	1997-07-01	H, Lundbeck A/S	Indan derivatives
NZ243065A (en) *	1991-06-13	1995-07-26	Lundbeck & Co As H	Piperidine derivatives and pharmaceutical compositions
DK206591D0 (da) *	1991-12-23	1991-12-23	Lundbeck & Co As H	Behandling af psykoser
JPH0625964U (ja) *	1992-05-25	1994-04-08	ミクロン機器株式会社	通信機能付きコインカウンタ及び有料装置
US6489341B1 (en)	1999-06-02	2002-12-03	Sepracor Inc.	Methods for the treatment of neuroleptic and related disorders using sertindole derivatives
EP1423107B1 (en)	2001-03-23	2012-05-09	Luitpold Pharmaceuticals, Inc.	Fatty alcohol drug conjugates
AU2002303164A1 (en) *	2001-03-23	2002-10-08	Protarga, Inc.	Fatty amine drug conjugates
US20100168197A1 (en) *	2007-02-28	2010-07-01	Naresh Kumar	Muscarinic receptor antagonists
US8686009B2 (en)	2009-06-25	2014-04-01	Alkermes Pharma Ireland Limited	Prodrugs of NH-acidic compounds
AU2010266018B2 (en)	2009-06-25	2014-01-09	Alkermes Pharma Ireland Limited	Heterocyclic compounds for the treatment of neurological and psychological disorders
CA2802733C (en) *	2010-06-24	2017-11-21	Alkermes Pharma Ireland Limited	Prodrugs of nh-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives
WO2019173230A1 (en)	2018-03-05	2019-09-12	Alkermes Pharma Ireland Limited	Aripiprazole dosing strategy

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3408356A (en) *	1965-08-31	1968-10-29	Squibb & Sons Inc	Long chain esters of 4'-fluoro-4-[4-hydroxy-4-(alpha, alpha, alpha-trifluorotolyl)piperi-dino]butyrophenone and the like
US4038305A (en) *	1972-03-20	1977-07-26	Aktieselskabet Grindstedvaerket	Cyclopentenone derivatives
GB1469108A (en) *	1973-06-25	1977-03-30	Kefalas As	Thiaxanthene derivative
JPS568318A (en) *	1979-06-28	1981-01-28	Janssen Pharmaceutica Nv	Non oral long acting composition of haloperidol and bromperidol derivative
IT1199116B (it) *	1984-07-03	1988-12-30	Fidia Farmaceutici	Derivati di gangliosidi
IE58370B1 (en) *	1985-04-10	1993-09-08	Lundbeck & Co As H	Indole derivatives
GB8621892D0 (en) *	1986-09-11	1986-10-15	Lundbeck & Co As H	Organic compound
GB8908085D0 (en) *	1989-04-11	1989-05-24	Lundbeck & Co As H	New therapeutic use
DE3921886A1 (de) *	1989-07-04	1991-01-17	Wolfgang Mohr	Vorrichtung zum schneiden von gestapeltem, blattfoermigen gut

1990
- 1990-10-03 DK DK238190A patent/DK238190D0/da not_active Application Discontinuation
1991
- 1991-09-26 IE IE338491A patent/IE913384A1/en not_active IP Right Cessation
- 1991-09-27 EP EP91919394A patent/EP0592433B1/en not_active Expired - Lifetime
- 1991-09-27 AU AU87104/91A patent/AU652783B2/en not_active Ceased
- 1991-09-27 WO PCT/DK1991/000291 patent/WO1992006089A1/en not_active Ceased
- 1991-09-27 DK DK91919394T patent/DK0592433T3/da active
- 1991-09-27 JP JP03516372A patent/JP3100980B2/ja not_active Expired - Fee Related
- 1991-09-27 DE DE69130803T patent/DE69130803T2/de not_active Expired - Fee Related
- 1991-09-27 CA CA002093433A patent/CA2093433C/en not_active Expired - Fee Related
- 1991-09-27 KR KR1019930701041A patent/KR100212430B1/ko not_active Expired - Fee Related
- 1991-09-27 AT AT91919394T patent/ATE175964T1/de not_active IP Right Cessation
- 1991-09-27 ES ES91919394T patent/ES2125870T3/es not_active Expired - Lifetime
- 1991-10-01 NZ NZ240051A patent/NZ240051A/xx not_active IP Right Cessation
- 1991-10-01 PH PH43225A patent/PH30129A/en unknown
- 1991-10-02 PT PT99142A patent/PT99142B/pt not_active IP Right Cessation
- 1991-10-02 ZA ZA917881A patent/ZA917881B/xx unknown
- 1991-10-04 IL IL99652A patent/IL99652A/xx not_active IP Right Cessation
1993
- 1993-03-30 US US08/039,228 patent/US5428036A/en not_active Expired - Lifetime
- 1993-03-31 NO NO931219A patent/NO301475B1/no unknown
- 1993-04-01 FI FI931472A patent/FI102679B/fi not_active IP Right Cessation
1999
- 1999-02-12 GR GR990400483T patent/GR3029399T3/el unknown

Also Published As

Publication number	Publication date
FI102679B1 (fi)	1999-01-29
GR3029399T3 (en)	1999-05-28
NZ240051A (en)	1993-05-26
NO301475B1 (no)	1997-11-03
NO931219D0 (no)	1993-03-31
ES2125870T3 (es)	1999-03-16
FI931472A7 (fi)	1993-04-01
CA2093433C (en)	2000-11-21
FI931472A0 (fi)	1993-04-01
NO931219L (no)	1993-04-01
PT99142B (pt)	1999-04-30
AU8710491A (en)	1992-04-28
DE69130803D1 (de)	1999-03-04
IL99652A0 (en)	1992-08-18
ATE175964T1 (de)	1999-02-15
AU652783B2 (en)	1994-09-08
EP0592433B1 (en)	1999-01-20
PH30129A (en)	1997-01-21
EP0592433A1 (en)	1994-04-20
DE69130803T2 (de)	1999-08-19
WO1992006089A1 (en)	1992-04-16
KR100212430B1 (ko)	1999-08-02
HK1009273A1 (en)	1999-05-28
KR930702335A (ko)	1993-09-08
CA2093433A1 (en)	1992-04-04
JPH06501939A (ja)	1994-03-03
IE913384A1 (en)	1992-04-08
FI102679B (fi)	1999-01-29
PT99142A (pt)	1994-02-28
US5428036A (en)	1995-06-27
ZA917881B (en)	1992-07-29
JP3100980B2 (ja)	2000-10-23
DK238190D0 (da)	1990-10-03
IL99652A (en)	1997-04-15

Publication	Publication Date	Title
DK0592433T3 (da)	1999-09-13	Sertindole Prodrugs
IL104305A0 (en)	1993-05-13	Piperazine derivatives,their preparation and pharmaceutical compositions containing them
ATE19513T1 (de)	1986-05-15	Neue verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel.
ATE25251T1 (de)	1987-02-15	Anti srs-a carbonsaeure-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische formulierungen.
ES8301962A1 (es)	1982-11-01	Un procedimiento para la produccion de un derivado de carboslivilo.
ATE14579T1 (de)	1985-08-15	Pharmazeutische heterocyclische verbindungen, verfahren zu ihrer herstellung und sie enthaltende zusammensetzungen.
AT397654B (de)	1994-06-27	Neue pleuromutilinderivate, ihre verwendung und verfahren zu ihrer herstellung
ES8200323A1 (es)	1981-10-16	Procedimiento de preparacion de esteres de derivados de la aletrolona y de acidos ciclopropeno-carboxilicos
ES8200648A2 (es)	1981-12-01	Procedimiento de preparacion de compuestos opacificantes para radiografia y similares
ES466682A1 (es)	1979-06-01	Procedimiento para la obtencion de derivados del acido inde-no - 2.1-b-tiopen-2-oxamico
ATE19879T1 (de)	1986-06-15	Furyloxazolylessigsaeure-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
ATE70531T1 (de)	1992-01-15	Carbacyclinester, verfahren zu ihrer herstellung und ihre verwendung in der medizin.
ATE36520T1 (de)	1988-09-15	Polyprenylverbindung, ihre herstellung und pharmazeutische verwendung.
ES8707204A1 (es)	1987-07-16	Procedimiento para preparar diazepinoindoles
DE69102309D1 (de)	1994-07-14	N-cycloalkyl-Alkylamine, Verfahren zu ihrer Herstellung, ihre Verwendung als Arzneimittel und Zwischenprodukte zu ihrer Synthese.
ES272324A1 (es)	1962-06-16	Procedimiento para la preparaciën de nuevos derivados de piperidina
ATE186907T1 (de)	1999-12-15	Optisch aktives 1-phenylpyrrolidonderivat und dessen herstellung
ATE22683T1 (de)	1986-10-15	Substituiertes heterocyclylphenylsulphonyl und phosphonylamidine, verfahren zu deren herstellung und deren pharmazeutische anwendung.
HUT53638A (en)	1990-11-28	Process for producing 15-amino-substituted 20,21-dinoreburnamenie derivatives and pharmaceutical compositions containing them
TH13395A (th)	1993-11-15	อนุพันธ์ของสเทรอยด์สำหรับใช้รักษาอาการต่อมลูกหมากโตเกินไป การเตรียมและการใช้สารนั้น
ES8301482A1 (es)	1982-05-01	Un procedimiento para la preparacion de un derivado del aci-do clavulanico