DK0603650T3 - 3,5-Substituerede aminobenzoylguanidiner, fremgangsmåde til deres freemstilling, deres anvendelse som lægemiddel eller diagnostikum samt lægemiddel med indhold deraf. - Google Patents

3,5-Substituerede aminobenzoylguanidiner, fremgangsmåde til deres freemstilling, deres anvendelse som lægemiddel eller diagnostikum samt lægemiddel med indhold deraf.

Info

Publication number: DK0603650T3
Authority: DK; Denmark
Prior art keywords: drug; properties; substituents; alkyl; image
Prior art date: 1992-12-16

Application number

DK93119784.2T

Other languages

English (en)

Inventor

Heinz-Werner Dr Kleemann

Wolfgang Dr Scholz

Udo Dr Albus

Andreas Dr Weichert

Hans-Jochen Dr Lang

Heinrich Dr Englert

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-16

Filing date

1993-12-08

Publication date

1997-10-20

1993-12-08 Application filed by Hoechst Ag filed Critical Hoechst Ag

1997-10-20 Application granted granted Critical

1997-10-20 Publication of DK0603650T3 publication Critical patent/DK0603650T3/da

Links

239000003814 drug Substances 0.000 title 2
229940079593 drug Drugs 0.000 title 2
VUKXXOLBVCEOPX-UHFFFAOYSA-N 1-amino-1-benzoylguanidine Chemical class NC(=N)N(N)C(=O)C1=CC=CC=C1 VUKXXOLBVCEOPX-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
230000002401 inhibitory effect Effects 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
239000003416 antiarrhythmic agent Substances 0.000 abstract 1
230000003293 cardioprotective effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000027119 gastric acid secretion Effects 0.000 abstract 1
230000002178 gastroprotective effect Effects 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
238000000338 in vitro Methods 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
AJDQRQQNNLZLPM-UHFFFAOYSA-N n-(diaminomethylidene)benzamide Chemical class NC(N)=NC(=O)C1=CC=CC=C1 AJDQRQQNNLZLPM-UHFFFAOYSA-N 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
210000000056 organ Anatomy 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
230000035755 proliferation Effects 0.000 abstract 1
230000001681 protective effect Effects 0.000 abstract 1
230000000054 salidiuretic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK93119784.2T 1992-12-16 1993-12-08 3,5-Substituerede aminobenzoylguanidiner, fremgangsmåde til deres freemstilling, deres anvendelse som lægemiddel eller diagnostikum samt lægemiddel med indhold deraf. DK0603650T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4242554		1992-12-16

Publications (1)

Publication Number	Publication Date
DK0603650T3 true DK0603650T3 (da)	1997-10-20

Family

ID=6475499

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK93119784.2T DK0603650T3 (da)	1992-12-16	1993-12-08	3,5-Substituerede aminobenzoylguanidiner, fremgangsmåde til deres freemstilling, deres anvendelse som lægemiddel eller diagnostikum samt lægemiddel med indhold deraf.

Country Status (17)

Country	Link
US (1)	US5516805A (da)
EP (1)	EP0603650B1 (da)
JP (1)	JP3875731B2 (da)
AT (1)	ATE151071T1 (da)
AU (1)	AU664930B2 (da)
CA (1)	CA2111512C (da)
DE (1)	DE59306029D1 (da)
DK (1)	DK0603650T3 (da)
ES (1)	ES2100435T3 (da)
FI (1)	FI113860B (da)
GR (1)	GR3023634T3 (da)
HU (1)	HU215438B (da)
IL (1)	IL108027A (da)
NO (1)	NO300416B1 (da)
NZ (1)	NZ250450A (da)
TW (1)	TW384281B (da)
ZA (1)	ZA939360B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CZ284456B6 (cs) *	1992-02-15	1998-12-16	Hoechst Aktiengesellschaft	Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje
DK0612723T3 (da) *	1993-02-20	1998-03-30	Hoechst Ag	Substituerede benzoylguanidiner, fremgangsmåde til fremstilling, deres anvendelse som lægemiddel, som inhibitor af den cellulære Na+/H+-udbytning eller som diagnostikum samt lægemiddel med indhold deraf
IL109570A0 (en) *	1993-05-17	1994-08-26	Fujisawa Pharmaceutical Co	Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof
DE4325822A1 (de) *	1993-07-31	1995-02-02	Hoechst Ag	Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4328869A1 (de) *	1993-08-27	1995-03-02	Hoechst Ag	Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4337611A1 (de) *	1993-11-04	1995-05-11	Boehringer Ingelheim Kg	Neue Benzoylguanidine, ihre Herstellung und ihre Verwendung in Arzneimitteln
DE4412334A1 (de) *	1994-04-11	1995-10-19	Hoechst Ag	Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4422685A1 (de) *	1994-06-29	1996-01-04	Hoechst Ag	Ortho-amino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
IL114670A0 (en) *	1994-08-05	1995-11-27	Fujisawa Pharmaceutical Co	Guanidine derivatives pharmaceutical compositions containing the same and processes for the preparation thereof
DE4430213A1 (de) *	1994-08-28	1996-02-29	Merck Patent Gmbh	Arylbenzoylguanidine
DE4430916A1 (de) *	1994-08-31	1996-03-07	Merck Patent Gmbh	Alkyl-benzoylguanidin-Derivate
DE4432106A1 (de) *	1994-09-09	1996-03-14	Hoechst Ag	Mit Heterocyclen-N-Oxid-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum, sie enthaltendes Medikament sowie Zwischenprodukte zu ihrer Herstellung
DE19502644A1 (de) *	1995-01-28	1996-08-01	Merck Patent Gmbh	4-Amino-benzoylguanidin-Derivate
DE19502795A1 (de) *	1995-01-30	1996-08-01	Hoechst Ag	Benzolsulfonamid-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19526381A1 (de) *	1995-07-19	1997-01-23	Hoechst Ag	4-Fluoralkyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
EP0765867A1 (de) *	1995-09-27	1997-04-02	Hoechst Aktiengesellschaft	Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Antiarrhytmika oder Diagnostikum sowie sie enthaltendes Medikament
DE19540995A1 (de) *	1995-11-03	1997-05-07	Hoechst Ag	Substituierte Sulfonimidamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19542306A1 (de) *	1995-11-14	1997-05-15	Hoechst Ag	Sulfonylamino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
PL316439A1 (en) *	1995-11-20	1997-05-26	Hoechst Ag	Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such
DE19546736A1 (de) *	1995-12-14	1997-06-19	Hoechst Ag	Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate
ATE440827T1 (de) *	2002-12-04	2009-09-15	Ore Pharmaceuticals Inc	Melanocortin-rezeptormodulatoren

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3780027A (en) *	1970-04-29	1973-12-18	Merck & Co Inc	Anthranilic acid derivatives
DE3929582A1 (de) *	1989-09-06	1991-03-07	Hoechst Ag	Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
GB9016579D0 (en) *	1990-07-27	1990-09-12	Ici Plc	Fungicides

1993
- 1993-12-08 ES ES93119784T patent/ES2100435T3/es not_active Expired - Lifetime
- 1993-12-08 DK DK93119784.2T patent/DK0603650T3/da active
- 1993-12-08 DE DE59306029T patent/DE59306029D1/de not_active Expired - Lifetime
- 1993-12-08 EP EP93119784A patent/EP0603650B1/de not_active Expired - Lifetime
- 1993-12-08 AT AT93119784T patent/ATE151071T1/de active
- 1993-12-14 AU AU52405/93A patent/AU664930B2/en not_active Ceased
- 1993-12-14 FI FI935617A patent/FI113860B/fi not_active IP Right Cessation
- 1993-12-14 ZA ZA939360A patent/ZA939360B/xx unknown
- 1993-12-14 NZ NZ250450A patent/NZ250450A/en not_active IP Right Cessation
- 1993-12-15 CA CA002111512A patent/CA2111512C/en not_active Expired - Fee Related
- 1993-12-15 JP JP31459293A patent/JP3875731B2/ja not_active Expired - Fee Related
- 1993-12-15 IL IL10802793A patent/IL108027A/en not_active IP Right Cessation
- 1993-12-15 HU HU9303596A patent/HU215438B/hu not_active IP Right Cessation
- 1993-12-15 NO NO934634A patent/NO300416B1/no not_active IP Right Cessation
- 1993-12-17 TW TW082110702A patent/TW384281B/zh active
1995
- 1995-05-25 US US08/450,225 patent/US5516805A/en not_active Expired - Lifetime
1997
- 1997-05-30 GR GR970401280T patent/GR3023634T3/el unknown

Also Published As

Publication number	Publication date
FI113860B (fi)	2004-06-30
ATE151071T1 (de)	1997-04-15
IL108027A (en)	1998-12-06
NO934634L (no)	1994-06-17
CA2111512C (en)	2005-11-15
TW384281B (en)	2000-03-11
JPH06256290A (ja)	1994-09-13
AU664930B2 (en)	1995-12-07
ZA939360B (en)	1994-08-08
HU215438B (hu)	2000-12-28
NO300416B1 (no)	1997-05-26
FI935617A0 (fi)	1993-12-14
IL108027A0 (en)	1994-04-12
GR3023634T3 (en)	1997-08-29
HU9303596D0 (en)	1994-04-28
NO934634D0 (no)	1993-12-15
DE59306029D1 (de)	1997-05-07
US5516805A (en)	1996-05-14
FI935617A7 (fi)	1994-06-17
EP0603650B1 (de)	1997-04-02
CA2111512A1 (en)	1994-06-17
HUT65747A (en)	1994-07-28
ES2100435T3 (es)	1997-06-16
EP0603650A1 (de)	1994-06-29
AU5240593A (en)	1994-06-30
NZ250450A (en)	1995-08-28
JP3875731B2 (ja)	2007-01-31

Publication	Publication Date	Title
DK0603650T3 (da)	1997-10-20	3,5-Substituerede aminobenzoylguanidiner, fremgangsmåde til deres freemstilling, deres anvendelse som lægemiddel eller diagnostikum samt lægemiddel med indhold deraf.
ATE127797T1 (de)	1995-09-15	Aminocoumaranderivate, ihre herstellung und verwendung.
CA2078790A1 (en)	1992-07-22	3-benzylidene-1-carbamoyl-2-pyrrolidone analogues
NO945015D0 (no)	1994-12-23	Substituerte 1-oxo-1,2-dihydro-isochinolinoyl- og 1,1-dioxo-2H-1,2-benzotiazinoylguanidiner, fremgangsmåte for fremstilling og anvendelse som medikament eller diagnostikum
DK0526531T3 (da)	1994-08-22	Liposomer med positiv overskudsladning
DK0391799T3 (da)	1993-02-22	Sulfonamider afledt af benzocykliske eller benzoheterocykliske syrer, fremstilling deraf samt anvendelse deraf til terapi
BR9913665A (pt)	2001-06-05	Aceleradores para sistemas endurecìveis
DE69311118D1 (de)	1997-07-03	Phosphono-arylethanolamin-verbindungen mit antihyperglykämischer und/oder antiobeser wirkung
HUP9700955A2 (hu)	1998-03-02	Szubsztituált 2-naftoil-guanidin-származékok, előállításuk, valamint az e vegyületeket tartalmazó gyógyszerkészítmények
DK412782A (da)	1983-03-17	Substituerede phenylurinstofderivater, deres fremstilling og mellemprodukter hertil samt deres anvendelse som herbicider
ES2119106T3 (es)	1998-10-01	Nuevos benzo-espiro-alquenos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
NZ332575A (en)	2000-03-27	Sulfonamide-substituted benzopyran derivatives, processes for preparation, medicament use and compositions comprising them
GB935384A (en)	1963-08-28	Tetracycline derivatives and preparation thereof
DK455285A (da)	1986-04-06	2-pyridin-thiolderivater
FI870811A7 (fi)	1987-02-25	Pentapeptider med en cellvaextreglerande effekt och ett foerfarande foer framstaellning av desamma.
MY131365A (en)	2007-08-30	Carbamic acid derivatives
ES2102754T3 (es)	1997-08-01	Sales del acido piromelitico, un procedimiento para su fabricacion asi como el uso de las mismas.
ES488388A1 (es)	1980-10-01	Procedimiento de preparacion de derivados hidroxilados del tiazol
DK446081A (da)	1982-04-12	Fremgangsmaade til fremstilling af cephalosporiner eller salte deraf
ATE44741T1 (de)	1989-08-15	2-(n-substituierte guanidino)-4heteroarylthiazole als mittel gegen geschwuere.
DK460789D0 (da)	1989-09-19	2-aminoacetamidderivater
GB1348558A (en)	1974-03-20	Meta-bis-anilide derivatives and their use as herbicides
FR2603035A1 (fr)	1988-02-26	Nouveaux derives de l'indane, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
TH6029A (th)	1989-05-01	อนุพันธ์ของควิโนลิเนียม และไอโซควิโนลิเนียมที่ควบแน่น
TH13347A (th)	1993-11-15	อนุพันธ์ต่าง ๆ ของอะเซทิดิโนนที่ใช้เป็นประโยชน์ในการเตรียมสารปฏิชีวนะคาร์แบพีเนม