ES2119106T3 - Nuevos benzo-espiro-alquenos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen. - Google Patents
Nuevos benzo-espiro-alquenos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.Info
- Publication number
- ES2119106T3 ES2119106T3 ES94401549T ES94401549T ES2119106T3 ES 2119106 T3 ES2119106 T3 ES 2119106T3 ES 94401549 T ES94401549 T ES 94401549T ES 94401549 T ES94401549 T ES 94401549T ES 2119106 T3 ES2119106 T3 ES 2119106T3
- Authority
- ES
- Spain
- Prior art keywords
- branched
- linear
- group
- unsubstituted
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Abstract
COMPUESTOS DE FORMULA (I): EN LA QUE: RE O UN GRUPO UN GRUPO DE ALQUILO (C1 ENTA UN ATOMO DE HIDROGENO, DE HALOGENO, UN GRUPO DE ALQUILO (C1 XI, UN GRUPO ALCOXI (C1 LQUILTIO (C1 MO DE HIDROGENO, DE HALOGENO, UN GRUPO ALQUILO (C1 EAL O RAMIFICADO O UN GRUPO ALQUILTIO (C1 C6) LINEAL O RAMIFICADO, QUE EN ESTE CASO R1 REPRESENTE UN ATOMO DE HIDROGENO), UN ATOMO DE HALOGENO, UN GRUPO ALQUILO (C1 (SUSTITUIDO O NO) O UN GRUPO HIDROXI, O BIEN 3, R3 Y R4 O R4 Y X FORMAN JUNTO CON LOS ATOMOS DE CARBONO QUE LOS LLEVAN, UN CICLO BENZENICO CON LA CONDICION DE QUE EN CASO DE QUE R1 Y R2 FORMEN UN CICLO BENZENICO, X TIENE QUE SER DIFERENTE DE ROGENO O UN GRUPO AMINO (SUSTITUIDO O NO), SIGNIFICADO QUE R1, SUS ISOMEROS ASI COMO SUS SALES DE ADICION A UN ACIDO FARMACEUTICAMENTE ACEPTABLE. MEDICAMENTOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9308861A FR2709306B1 (fr) | 1993-07-20 | 1993-07-20 | Nouveaux dérivés de benzospiroalcène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2119106T3 true ES2119106T3 (es) | 1998-10-01 |
Family
ID=9449388
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94401549T Expired - Lifetime ES2119106T3 (es) | 1993-07-20 | 1994-07-06 | Nuevos benzo-espiro-alquenos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5436261A (es) |
| EP (1) | EP0635497B1 (es) |
| JP (1) | JP3105138B2 (es) |
| AT (1) | ATE166345T1 (es) |
| AU (1) | AU674080B2 (es) |
| CA (1) | CA2128359C (es) |
| CY (1) | CY2158B1 (es) |
| DE (1) | DE69410359T2 (es) |
| DK (1) | DK0635497T3 (es) |
| ES (1) | ES2119106T3 (es) |
| FR (1) | FR2709306B1 (es) |
| NZ (1) | NZ264050A (es) |
| ZA (1) | ZA945337B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2707981B1 (fr) * | 1993-07-20 | 1995-09-01 | Adir | Nouveaux dérivés de benzospiroalcène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
| US6156783A (en) * | 1996-04-30 | 2000-12-05 | Smithkline Beecham P.L.C. | Spiroazabicyclic compounds, processes for their preparation, and their pharmaceutical use |
| FR2787450B1 (fr) * | 1998-12-18 | 2001-01-26 | Adir | Nouveaux derives spiroimidazoliniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CA2518830A1 (en) * | 2003-03-14 | 2004-09-30 | Merck & Co., Inc. | Carboxamide spirohydantoin cgrp receptor antagonists |
| US7115767B2 (en) * | 2003-07-18 | 2006-10-03 | Abbott Laboratories | Tetraline derivatives as ghrelin receptor modulators |
| JP2009515976A (ja) * | 2005-11-18 | 2009-04-16 | メルク エンド カムパニー インコーポレーテッド | スピロラクタム二環式ｃｇｒｐ受容体アンタゴニスト |
| WO2007061677A2 (en) * | 2005-11-18 | 2007-05-31 | Merck & Co., Inc. | Spirolactam aryl cgrp receptor antagonists |
| ATE493412T1 (de) | 2005-11-18 | 2011-01-15 | Merck Sharp & Dohme | Spirohydantoin-aryl-cgrp-rezeptorantagonisten |
| WO2007061692A2 (en) * | 2005-11-18 | 2007-05-31 | Merck & Co., Inc. | Spirolactam tricyclic cgrp receptor antagonists |
| WO2007061694A2 (en) | 2005-11-18 | 2007-05-31 | Merck & Co., Inc. | Spirohydantoin tricyclic cgrp receptor antagonists |
| WO2007061695A2 (en) | 2005-11-18 | 2007-05-31 | Merck & Co., Inc. | Bicyclic spirohydantoin cgrp receptor antagonists |
| EP2356106A1 (en) | 2008-10-07 | 2011-08-17 | Schering Corporation | Biaryl spiroaminooxazoline analogues as alpha2c adrenergic receptor modulators |
| WO2011041181A1 (en) * | 2009-10-01 | 2011-04-07 | Schering Corporation | Reversed biaryl spiroaminooxazoline analogues as alpha2c adrenergic receptor modulators |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2716648A (en) * | 1955-08-30 | Hydantoin derivatives | ||
| US3532744A (en) * | 1967-07-28 | 1970-10-06 | American Home Prod | 1- and 2-amino substituted indane and tetralene carboxylic acids |
-
1993
- 1993-07-20 FR FR9308861A patent/FR2709306B1/fr not_active Expired - Fee Related
-
1994
- 1994-07-06 DE DE69410359T patent/DE69410359T2/de not_active Expired - Fee Related
- 1994-07-06 EP EP94401549A patent/EP0635497B1/fr not_active Expired - Lifetime
- 1994-07-06 ES ES94401549T patent/ES2119106T3/es not_active Expired - Lifetime
- 1994-07-06 AT AT94401549T patent/ATE166345T1/de not_active IP Right Cessation
- 1994-07-06 DK DK94401549T patent/DK0635497T3/da active
- 1994-07-18 AU AU67550/94A patent/AU674080B2/en not_active Ceased
- 1994-07-19 US US08/276,918 patent/US5436261A/en not_active Expired - Fee Related
- 1994-07-19 CA CA002128359A patent/CA2128359C/fr not_active Expired - Fee Related
- 1994-07-20 NZ NZ264050A patent/NZ264050A/en unknown
- 1994-07-20 JP JP06198901A patent/JP3105138B2/ja not_active Expired - Fee Related
- 1994-07-20 ZA ZA945337A patent/ZA945337B/xx unknown
-
1999
- 1999-11-19 CY CY9900039A patent/CY2158B1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0635497A2 (fr) | 1995-01-25 |
| CA2128359C (fr) | 2002-03-19 |
| AU674080B2 (en) | 1996-12-05 |
| ZA945337B (en) | 1995-03-01 |
| JP3105138B2 (ja) | 2000-10-30 |
| DK0635497T3 (da) | 1999-03-08 |
| NZ264050A (en) | 1995-07-26 |
| FR2709306B1 (fr) | 1995-10-20 |
| EP0635497B1 (fr) | 1998-05-20 |
| CY2158B1 (en) | 2002-08-23 |
| HK1009648A1 (en) | 1999-06-04 |
| EP0635497A3 (fr) | 1995-02-22 |
| ATE166345T1 (de) | 1998-06-15 |
| US5436261A (en) | 1995-07-25 |
| DE69410359D1 (de) | 1998-06-25 |
| DE69410359T2 (de) | 1999-01-07 |
| AU6755094A (en) | 1995-02-02 |
| FR2709306A1 (fr) | 1995-03-03 |
| JPH07304753A (ja) | 1995-11-21 |
| CA2128359A1 (fr) | 1995-01-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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