DK0606366T3 - Substituerede phenseriner og phenylcarbamater af (-)-eserolin, (-)-N1-noreserolin og (-)-N1-benzylnoreserolin som specifikke inhibitorer af acetylcholinesterase - Google Patents

Substituerede phenseriner og phenylcarbamater af (-)-eserolin, (-)-N1-noreserolin og (-)-N1-benzylnoreserolin som specifikke inhibitorer af acetylcholinesterase

Info

Publication number: DK0606366T3
Authority: DK; Denmark
Prior art keywords: benzylnoreseroline; noreseroline; eseroline; phenserines; phenylcarbamates
Prior art date: 1991-09-26

Application number

DK92921255T

Other languages

Danish (da)

English (en)

Inventor

Xiao-Shu He

Arnold Brossi

Malgarzota Brzostowska

S Rapoport

Nigel Greig

Original Assignee

Us Gov Health & Human Serv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-09-26

Filing date

1992-09-28

Publication date

2003-10-06

1991-09-26 Priority claimed from US07/765,746 external-priority patent/US5171750A/en

1992-09-28 Application filed by Us Gov Health & Human Serv filed Critical Us Gov Health & Human Serv

2003-10-06 Application granted granted Critical

2003-10-06 Publication of DK0606366T3 publication Critical patent/DK0606366T3/da

Links

108010022752 Acetylcholinesterase Proteins 0.000 title abstract 2
229940022698 acetylcholinesterase Drugs 0.000 title abstract 2
HKGWQUVGHPDEBZ-OLZOCXBDSA-N eseroline Chemical compound C1=C(O)C=C2[C@]3(C)CCN(C)[C@@H]3N(C)C2=C1 HKGWQUVGHPDEBZ-OLZOCXBDSA-N 0.000 title abstract 2
102000012440 Acetylcholinesterase Human genes 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
PWXJULSLLONQHY-UHFFFAOYSA-N phenylcarbamic acid Chemical class OC(=O)NC1=CC=CC=C1 PWXJULSLLONQHY-UHFFFAOYSA-N 0.000 title 1
238000002560 therapeutic procedure Methods 0.000 abstract 2
102100033639 Acetylcholinesterase Human genes 0.000 abstract 1
208000024827 Alzheimer disease Diseases 0.000 abstract 1
108010053652 Butyrylcholinesterase Proteins 0.000 abstract 1
102100032404 Cholinesterase Human genes 0.000 abstract 1
108090000371 Esterases Proteins 0.000 abstract 1
208000010412 Glaucoma Diseases 0.000 abstract 1
208000007964 Organophosphate Poisoning Diseases 0.000 abstract 1
230000000903 blocking effect Effects 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
239000000064 cholinergic agonist Substances 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
206010028417 myasthenia gravis Diseases 0.000 abstract 1
239000008177 pharmaceutical agent Substances 0.000 abstract 1
BSCCSDNZEIHXOK-UHFFFAOYSA-N phenyl carbamate Chemical class NC(=O)OC1=CC=CC=C1 BSCCSDNZEIHXOK-UHFFFAOYSA-N 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Ophthalmology & Optometry (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Hospice & Palliative Care (AREA)
Toxicology (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK92921255T 1991-09-26 1992-09-28 Substituerede phenseriner og phenylcarbamater af (-)-eserolin, (-)-N1-noreserolin og (-)-N1-benzylnoreserolin som specifikke inhibitorer af acetylcholinesterase DK0606366T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US07/765,746 US5171750A (en)	1991-09-26	1991-09-26	Substituted phenserines as specific inhibitors of acetylcholinesterase
US86132992A	1992-03-31	1992-03-31
PCT/US1992/008228 WO1993006105A1 (fr)	1991-09-26	1992-09-28	Phenserines et phenylcarbamates substitues de (-)-eseroline, (-)-n1-noreseroline, et (-)-n1-benzylnoreseroline utilises comme inhibiteurs specifiques de l'acetylcholinesterase

Publications (1)

Publication Number	Publication Date
DK0606366T3 true DK0606366T3 (da)	2003-10-06

Family

ID=27117645

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92921255T DK0606366T3 (da)	1991-09-26	1992-09-28	Substituerede phenseriner og phenylcarbamater af (-)-eserolin, (-)-N1-noreserolin og (-)-N1-benzylnoreserolin som specifikke inhibitorer af acetylcholinesterase

Country Status (10)

Country	Link
US (1)	US5998460A (fr)
EP (1)	EP0606366B1 (fr)
JP (1)	JP3708957B2 (fr)
AT (1)	ATE242244T1 (fr)
AU (1)	AU674130B2 (fr)
CA (1)	CA2119783C (fr)
DE (1)	DE69233093T2 (fr)
DK (1)	DK0606366T3 (fr)
ES (1)	ES2201050T3 (fr)
WO (1)	WO1993006105A1 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5932780A (en) *	1994-02-28	1999-08-03	Yissum Research Development Company Of Hebrew University Of Jerusalem	Transgenic non-human animal assay system for anti-cholinesterase substances
US5338739A (en) *	1994-03-10	1994-08-16	Hoechst-Roussel Pharmaceuticals Inc.	(Pyrrolidinyl)phenyl carbamates, compositions and use
WO1999002154A1 (fr) *	1997-07-09	1999-01-21	Axonyx	Inhibiteurs de butyrylcholinesterase hautement selectifs pour le traitement et le diagnostic de demences et de la maladie d'alzheimer
US6534541B1 (en)	1999-10-19	2003-03-18	Novartis Ag	Treatment of ocular disorders
US6495700B1 (en)	2002-01-09	2002-12-17	Axonyx, Inc.	Process for producing phenserine and its analog
DE10301851A1 (de) *	2003-01-17	2004-07-29	Lts Lohmann Therapie-Systeme Ag	Verfahren zur medikamentösen Prophylaxe gegen Vergiftungen durch Cholinesterase-Hemmer, sowie hierfür geeignete Wirkstoffe und Arzneimittel
DE602004030931D1 (fr) *	2003-11-04	2011-02-17	Supernus Pharmaceuticals Inc
WO2005074917A1 (fr) *	2004-01-30	2005-08-18	Axonyx, Inc.	Methodes de traitement de complications du diabete
US20050182044A1 (en) *	2004-02-17	2005-08-18	Bruinsma Gosse B.	Combinatorial therapy with an acetylcholinesterase inhibitor and (3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3,-b]indol-5-yl phenylcarbamate
CA2508585A1 (fr) *	2004-06-01	2005-12-01	Axonyx, Inc.	Dispositif d'administration transdermique pour le traitement des troubles cognitifs
EP1604686A1 (fr) *	2004-06-08	2005-12-14	Axonyx, Inc.	Utilisation de la phenserine et d'un inhibiteur de la HMG CoA reductase pour retarder la progression de la maladie d'Alzheimer
US20070167509A1 (en) *	2005-06-14	2007-07-19	Joseph Araujo	Use of phenserine and analogs to treat behavioral problems and improve trainability
AU2007338878A1 (en) *	2006-11-13	2008-07-03	Ateris Technologies, Llc	Pesticide biomarker
KR20100109899A (ko) *	2007-11-14	2010-10-11	아테리스 테크놀로지스, 엘엘씨	생물마커 탐지
US8772345B2 (en) *	2011-08-03	2014-07-08	Southwest Research Institute	Oximes for treatment of peripheral and central nervous system exposure to acetyl cholinesterase inhibitors
US8653108B1 (en) *	2011-08-03	2014-02-18	Southwest Research Institute	Oximes for treatment of peripheral and central nervous system exposure to acetyl cholinesterase inhibitors
WO2014113495A1 (fr)	2013-01-15	2014-07-24	The Trustees Of Columbia University In The City Of New York	Activation ou réactivation de l'acétylcholinestérase
US9162983B2 (en)	2013-05-22	2015-10-20	Southwest Research Institute	Reactivators of organophosphorous inhibited acetylcholinesterase
US10864192B2 (en)	2016-01-15	2020-12-15	Aristea Translational Medicine Corporation	Compositions and methods for inhibiting brain trauma-induced neurodegeneration and related conditions
US10111860B1 (en)	2016-01-15	2018-10-30	Aristea Translational Medicine Corporation	Compositions and methods for treating concussion
WO2021142221A1 (fr) *	2020-01-10	2021-07-15	The Regents Of The University Of California	Compositions et méthodes de traitement de maladies neurodégénératives
US11590209B2 (en)	2020-01-21	2023-02-28	Palatin Technologies, Inc.	Use of bremelanotide in patients with controlled hypertension

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1199076B (it) *	1984-03-01	1988-12-30	Consiglio Nazionale Ricerche	Derivati della fisostigmina con proprieta'di inibizione della aceticolinesterasi e relativo procedimento di produzione
US4791107A (en) *	1986-07-16	1988-12-13	Hoechst-Roussel Pharmaceuticals, Inc.	Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
US4900748A (en) *	1988-03-04	1990-02-13	The United States Of America As Represented By The Department Of Health And Human Services	Carbamates related to (-)-physostigmine as cholinergic agents
US4914102A (en) *	1989-09-28	1990-04-03	Hoechst Roussel Pharmaceuticals, Inc.	N-aminocarbamates related to physostigmine, pharmacentical compositions and use

1992
- 1992-09-28 AT AT92921255T patent/ATE242244T1/de not_active IP Right Cessation
- 1992-09-28 AU AU27544/92A patent/AU674130B2/en not_active Ceased
- 1992-09-28 DK DK92921255T patent/DK0606366T3/da active
- 1992-09-28 EP EP92921255A patent/EP0606366B1/fr not_active Expired - Lifetime
- 1992-09-28 JP JP50640593A patent/JP3708957B2/ja not_active Expired - Fee Related
- 1992-09-28 DE DE69233093T patent/DE69233093T2/de not_active Expired - Fee Related
- 1992-09-28 ES ES92921255T patent/ES2201050T3/es not_active Expired - Lifetime
- 1992-09-28 CA CA002119783A patent/CA2119783C/fr not_active Expired - Fee Related
- 1992-09-28 WO PCT/US1992/008228 patent/WO1993006105A1/fr not_active Ceased
1993
- 1993-07-26 US US08/096,207 patent/US5998460A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2119783A1 (fr)	1993-04-01
ATE242244T1 (de)	2003-06-15
EP0606366B1 (fr)	2003-06-04
JPH07503703A (ja)	1995-04-20
DE69233093D1 (de)	2003-07-10
AU2754492A (en)	1993-04-27
DE69233093T2 (de)	2003-12-18
JP3708957B2 (ja)	2005-10-19
ES2201050T3 (es)	2004-03-16
AU674130B2 (en)	1996-12-12
WO1993006105A1 (fr)	1993-04-01
US5998460A (en)	1999-12-07
CA2119783C (fr)	2006-02-07
EP0606366A1 (fr)	1994-07-20

Publication	Publication Date	Title
ATE242244T1 (de)	2003-06-15	Substituierte phenserine und phenylcarbamate von (-)-eserolin, (-)-n1-noreserolin und (-)-n1- benzylnoresorolin als spezifische acetylcholinesterase-inhibitoren
DE69629591D1 (de)	2003-09-25	Formulierung zur intranasalen verabreichung
NO992705D0 (no)	1999-06-03	3-pyridylenantiomere og deres anvendelse som analgetika
AR013746A1 (es)	2001-01-10	Sustitucion bioisosterica de catecol por indazol en compuesto terapeuticos activos
NO980592L (no)	1998-02-11	Nye opioidpeptider
DK0841928T3 (da)	2003-01-27	Sustained release-formulering af d-threo-methylphenidat
ATE334668T1 (de)	2006-08-15	Pharmazeutische zusammensetzung zur behandlung von neurologischen und neuropsychiatrischen erkrankungen
LV12291A (lv)	1999-06-20	Savienojums un farmaceitiskas kompozicijas ar triptazes aktivitates izmainam saistitu slimibu arstesanai
DE69434121D1 (de)	2004-12-09	Pharmazeutische zusammensetzung zur immunstimulierenden therapie
ATA903796A (de)	2005-08-15	Elektrotransporteinrichtung zur verabreichung eines als fentanylsalz oder als sufentanilsalz vorliegenden analgetischen medikaments
DK0659427T3 (da)	2002-09-02	2-Phenyl-3-azoylbenzothiophener til forøgelse af thrombomodulinekspression
AU5499701A (en)	2001-10-30	A pyridine-1-oxide derivative, and process for its transformation into pharmaceutically effective compounds
NO993275D0 (no)	1999-07-01	FremgangsmÕte ved terapeutisk administrering av anti-CD40L-forbindelser
DE69824313D1 (de)	2004-07-08	Sibutramin und orlistat enthaltende pharmazeutische zusammensetzungen
MX9301527A (es)	1994-02-28	Composiciones de acido n-(fosfonoacetil)-l-aspartico y metodo para sus usos como agentes antivirales de amplio espectro.
ATE319715T1 (de)	2006-03-15	Antikonvulsive pseudofructopyranose sulfamate
UA42719C2 (uk)	2001-11-15	Сполуки, композиції та способи, які інгібують протеази, для лікування та профілактики імуномедіаторних запальних хвороб
DK675389D0 (da)	1989-12-29	Terapeutiske praeparater til forebyggelse af fibrinaflejringer
DK0758312T3 (da)	2000-05-01	Substituerede fusionerede og broforbundne bicykliske forbindelser som terapeutiske midler
HUP0000110A2 (hu)	2000-06-28	Azaciklusos, azabiciklusos vagy tetrahidropiridinszármazékokat tartalmazó, fájdalom kezelésére alkalmas gyógyászati készítmények
ES2149193T3 (es)	2000-11-01	Compuestos heterociclicos sustituidos con alquilo.
SE9900190D0 (sv)	1999-01-22	New compounds
NO20000423L (no)	2000-03-22	Tiazolobenzoheterocykler, deres fremstilling samt medikamenter inneholdende forbindelsene
DE60221104D1 (de)	2007-08-23	Substituierte diarylharnstoffe als stimulatoren der fas-vermittelten apoptose
DK0863752T3 (da)	2003-04-22	Anvendelse af alkylaminderivater såsom terbinafin ved fremstillingen af et lægemiddel til behandling af ledsagende sygdomme af en helicobacter pylori-infektion.