DK0609210T3 - Optisk aktivt 5H-pyrrolo(3,4-b)pyrazinderivat, dets fremstilling og farmaceutiske præparater deraf - Google Patents

Optisk aktivt 5H-pyrrolo(3,4-b)pyrazinderivat, dets fremstilling og farmaceutiske præparater deraf

Info

Publication number: DK0609210T3
Authority: DK; Denmark
Prior art keywords: pyrrolo; preparation; optically active; pharmaceutical preparations; pyrazine derivative
Prior art date: 1991-01-17

Application number

DK92903994.9T

Other languages

Danish (da)

English (en)

Inventor

Gerard Roussel

Claude Cotrel

Original Assignee

Rhone Poulenc Rorer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-01-17

Filing date

1992-01-16

Publication date

1995-07-03

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9408772&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0609210(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-01-16 Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa

1995-07-03 Application granted granted Critical

1995-07-03 Publication of DK0609210T3 publication Critical patent/DK0609210T3/da

Links

ZMJIPNACONXBCG-UHFFFAOYSA-N 7h-pyrrolo[3,4-b]pyrazine Chemical class C1=CN=C2CN=CC2=N1 ZMJIPNACONXBCG-UHFFFAOYSA-N 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
238000002360 preparation method Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK92903994.9T 1991-01-17 1992-01-16 Optisk aktivt 5H-pyrrolo(3,4-b)pyrazinderivat, dets fremstilling og farmaceutiske præparater deraf DK0609210T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9100490A FR2671800B1 (fr)	1991-01-17	1991-01-17	Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent.

Publications (1)

Publication Number	Publication Date
DK0609210T3 true DK0609210T3 (da)	1995-07-03

Family

ID=9408772

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92903994.9T DK0609210T3 (da)	1991-01-17	1992-01-16	Optisk aktivt 5H-pyrrolo(3,4-b)pyrazinderivat, dets fremstilling og farmaceutiske præparater deraf

Country Status (29)

Country	Link
US (5)	US6319926B1 (de)
EP (2)	EP0609210B1 (de)
JP (1)	JPH06504548A (de)
AR (1)	AR248024A1 (de)
AT (1)	ATE121089T1 (de)
AU (2)	AU671797B2 (de)
CA (1)	CA2099782C (de)
CZ (1)	CZ281011B6 (de)
DE (1)	DE69202060T2 (de)
DK (1)	DK0609210T3 (de)
ES (1)	ES2071486T3 (de)
FI (1)	FI100331B (de)
FR (1)	FR2671800B1 (de)
HU (1)	HU218928B (de)
IE (1)	IE66110B1 (de)
IL (1)	IL100677A (de)
MA (1)	MA22392A1 (de)
MX (1)	MX9200180A (de)
NO (1)	NO179911C (de)
NZ (1)	NZ241313A (de)
OA (1)	OA09807A (de)
PH (1)	PH30982A (de)
PL (1)	PL166976B1 (de)
RU (1)	RU2110519C1 (de)
SK (1)	SK279060B6 (de)
TN (1)	TNSN92004A1 (de)
WO (1)	WO1992012980A1 (de)
YU (1)	YU48878B (de)
ZA (1)	ZA92302B (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
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FR2671800B1 (fr)	1991-01-17	1993-03-12	Rhone Poulenc Rorer Sa	Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent.
US5786357A (en) *	1991-12-02	1998-07-28	Sepracor Inc.	Methods and compositions for treating sleep disorders, convulsive seizures and other disorders using optically pure (+) zopiclone
ES2101653B1 (es) *	1995-07-10	1998-04-01	Asturpharma S A	(+)-6-(5-cloropirid-2-il)-7-oxo-viniloxicarboniloxi-5,6-dihidropirrolo(3,4b)pirazina y su uso para un procedimiento de preparacion de (+)-6-(5-cloropirid-2-il)-5-(4-metilpiperazin-1-il)-carboniloxi-7-oxo-5,6-dihidropirrolo(3,4b)pirazina.
US6339086B1 (en) *	1999-05-14	2002-01-15	Swpracor, Inc.	Methods of making and using N-desmethylzopiclone
TW200734460A (en)	1999-10-04	2007-09-16	Ajinomoto Kk	Genes for heat resistant enzymes of amino acid biosynthetic pathway derived from thermophilic coryneform bacteria
PL1691811T3 (pl)	2003-12-11	2014-12-31	Sunovion Pharmaceuticals Inc	Skojarzenie leku uspokajającego i modulatora neuroprzekaźnikowego oraz sposoby poprawy jakości snu i leczenia depresji
US20050215521A1 (en) *	2003-12-22	2005-09-29	Karim Lalji	Modafinil combination therapy for improving sleep quality
EP1696959A2 (de) *	2003-12-24	2006-09-06	Sepracor, Inc.	Melatonin-kombinationstherapie zur verbesserung der schlafqualität
DK1742624T3 (da) *	2004-02-18	2010-03-08	Sepracor Inc	Dopamin-agonist-kombinationsterapi med sedativer til forbedring af søvnkvalitet
US7776858B2 (en)	2004-04-05	2010-08-17	Sepracor Inc.	Methods of treatment of chronic pain using eszopiclone
CA2612763A1 (en) *	2005-06-21	2006-12-28	Generics (Uk) Limited	Process for enantiomeric separation of zopiclone
WO2007005961A2 (en) *	2005-07-06	2007-01-11	Sepracor Inc.	Combinations of eszopiclone and o-desmethylvenlafaxine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders
JP2009500425A (ja)	2005-07-06	2009-01-08	セプラコアインコーポレーテッド	エスゾピクロン及びトランス４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロ−ｎ−メチル−１−ナフタレンアミン又はトランス４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロ−１−ナフタレンアミンの組み合わせ、並びに閉経期並びに気分、不安、及び認知障害の治療方法
US7476737B2 (en) *	2005-09-05	2009-01-13	Dr. Reddy's Laboratories Limited	Eszopiclone process
US20070098788A1 (en) *	2005-10-28	2007-05-03	Gore Subhash P	Non-benzodiazepine hypnotic compositions
AU2006308889A1 (en)	2005-10-31	2007-05-10	Braincells, Inc.	GABA receptor mediated modulation of neurogenesis
CA2637542A1 (en) *	2006-01-17	2007-07-26	Glenmark Pharmaceuticals Limited	Improved process for the preparation of an optically active 5h-pyrrolo [3,4-b] pyrazine derivative
WO2007088073A1 (en) *	2006-02-03	2007-08-09	Synthon B.V.	Zopiclone resolution using l-tartaric acid
WO2007109799A2 (en) *	2006-03-23	2007-09-27	Teva Pharmaceutical Industries Ltd.	Polymorphs of eszopiclone malate
JP2008543953A (ja) *	2006-04-20	2008-12-04	テバファーマシューティカルインダストリーズリミティド	エスゾピクロン結晶形態ａ、実質的に純粋なエスゾピクロン及び光学的に豊富なエスゾピクロンを調製するための方法
WO2008002629A1 (en) *	2006-06-26	2008-01-03	Teva Pharmaceutical Industries Ltd.	Process for the preparation of zopiclone
US7786304B2 (en) *	2006-11-06	2010-08-31	Centaur Pharmaceutical Pvt. Ltd.	Process for the preparation of eszopiclone
WO2008094690A2 (en) *	2007-01-31	2008-08-07	Teva Pharmaceutical Industries Ltd.	Methods for preparing eszopiclone
EP1997482B1 (de) *	2007-05-29	2011-07-06	LEK Pharmaceuticals d.d.	Pharmazeutische Zusammensetzung mit Eszopiclon
US20080305171A1 (en) *	2007-06-07	2008-12-11	Kristin Anne Arnold	Pyrrolopyrazine, formulations, methods of manufacture, and methods of use there
WO2009002552A1 (en) *	2007-06-25	2008-12-31	Teva Pharmaceutical Industries Ltd.	Racemization process of r-zopiclone
EP2020403A1 (de)	2007-08-02	2009-02-04	Esteve Quimica, S.A.	Verfahren zur Auflösung von Zopiclon und Zwischenprodukten
US20090198058A1 (en) *	2007-08-06	2009-08-06	Dhananjay Govind Sathe	Process for Preparation of Dextrorotatory Isomer of 6-(5- chloro-pyrid-2-yl)-5-[(4-methyl -1-piperazinyl) carbonyloxy] -7-oxo-6,7-dihydro-5H-pyrrolo [3,4-b] pyrazine (Eszopiclone)
WO2009085988A1 (en) *	2007-12-19	2009-07-09	Sepracor Inc.	Salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7- dihydro-5h-pyrrolo[3,4-b]pyrazine
US8268832B2 (en) *	2007-12-19	2012-09-18	Sunovion Pharmaceuticals Inc.	Maleate salts of 6-(5-chloro-2-Pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US8212036B2 (en) *	2007-12-19	2012-07-03	Sunovion Pharmaceuticals Inc.	Maleate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US8198277B2 (en)	2007-12-19	2012-06-12	Sunovion Pharmaceuticals Inc.	L-malate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US8198278B2 (en)	2007-12-19	2012-06-12	Sunovion Pharmaceuticals Inc.	Besylate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US8269005B2 (en) *	2007-12-19	2012-09-18	Sunovion Pharmaceuticals Inc.	L-malate salts of 6-(5-chloro-2-Pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-Oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
WO2009085972A1 (en) *	2007-12-19	2009-07-09	Sepracor Inc.	Maleate, besylate, and l-malate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo[3,4-b]pyrazine
WO2009101634A2 (en) *	2008-02-13	2009-08-20	Lupin Limited	A novel process for the preparation of eszopiclone
WO2009114740A2 (en)	2008-03-12	2009-09-17	Emory University	USE OF GABAa RECEPTOR ANTAGONISTS FOR THE TREATMENT OF EXCESSIVE SLEEPINESS AND DISORDERS ASSOCIATED WITH EXCESSIVE SLEEPINESS
US20090269409A1 (en) *	2008-04-24	2009-10-29	Mukesh Kumar Garg	Pharmaceutical compositions comprising eszopiclone
CN101607961B (zh) *	2008-06-18	2011-08-10	天津天士力集团有限公司	一种右佐匹克隆结晶及其组合物
KR20110086723A (ko)	2008-11-07	2011-07-29	시플라 리미티드	조피클론을 광학분할하는 방법
US20100196286A1 (en) *	2008-12-01	2010-08-05	Armer Thomas A	Inhalation delivery methods and devices
US8555875B2 (en)	2008-12-23	2013-10-15	Map Pharmaceuticals, Inc.	Inhalation devices and related methods for administration of sedative hypnotic compounds
CN104316631A (zh)	2009-01-30	2015-01-28	桑诺维恩药品公司	一种检测包衣的固体口服剂型中外露核芯物质的存在的方法
WO2010116385A2 (en)	2009-04-08	2010-10-14	Rubicon Research Private Limited	Pharmaceutical compositions for alleviating unpleasant taste
EP2345654A1 (de)	2010-01-05	2011-07-20	LEK Pharmaceuticals d.d.	Eszopiclon-Teilchen und Verfahren zu deren Herstellung
EP2345655A1 (de)	2010-01-05	2011-07-20	LEK Pharmaceuticals d.d.	Verfahren zur Racemisierung von 6-(5-Chlorpyridin-2-yl)-7-(4-methyl-1-piperazinyl)carbonyloxy-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin
CN103193779B (zh) *	2012-01-05	2016-04-20	成都弘达药业有限公司	一种右佐匹克隆的制备方法
EP2934486A2 (de) *	2012-12-20	2015-10-28	Kashiv Pharma, LLC	Schmelztablettenformulierung zur erhöhten bioverfügbarkeit
US9636340B2 (en)	2013-11-12	2017-05-02	Ayyappan K. Rajasekaran	Kinase inhibitors
JP2020007252A (ja) *	2018-07-05	2020-01-16	アクティブファーマ株式会社	エスゾピクロンジベンゾイル−ｄ−酒石酸塩の製造方法、エスゾピクロンの製造方法、及びエスゾピクロンジベンゾイル−ｄ−酒石酸塩の結晶

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OA04285A (fr) *	1972-01-07	1979-12-31	Rhone Poulenc Sa	Nouveaux dérivés de la pyrrolo (3,4-b) pyrazine et leur préparation.
FR2166314A1 (en) *	1972-01-07	1973-08-17	Rhone Poulenc Sa	6-substd 5-(4-methyl 1-piperazinyl)carbonyloxy 7-oxo - 5,6-dihydro-pyrrolo (3,4-b)pyrazines - tranquillizers and anticonvuls
AR208414A1 (es) *	1974-11-07	1976-12-27	Rhone Poulenc Ind	Procedimiento para obtener nuevos derivados de la((acil-4piperazinil-1)carboniloxi-5 pirrolinona-2)
US4868214A (en)	1987-11-17	1989-09-19	Analgesic Associates	Onset-hastened/enhanced analgesia
US4962124A (en)	1987-11-17	1990-10-09	Analgesic Associates	Onset-hastened/enhanced antipyretic response
US5102890A (en)	1989-09-05	1992-04-07	Rhone-Poulenc Sante	Pyrrole derivatives, their preparation and pharmaceutical compositions which contain them
FR2671800B1 (fr) *	1991-01-17	1993-03-12	Rhone Poulenc Rorer Sa	Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent.
US5786357A (en)	1991-12-02	1998-07-28	Sepracor Inc.	Methods and compositions for treating sleep disorders, convulsive seizures and other disorders using optically pure (+) zopiclone
AU3275993A (en)	1991-12-02	1993-06-28	Sepracor, Inc.	Methods and compositions for treating sleep disorders, convulsive seizures, and other disorders using optically pure (-) zopiclone
US5331000A (en)	1992-03-09	1994-07-19	Sepracor Inc.	Antipyretic and analgesic methods and compositions containing optically pure R(-) ketoprofen
US6436926B1 (en) *	1999-05-10	2002-08-20	Medpointe, Inc.	Compositions and methods for treating superficial fungal infections
US7476737B2 (en) *	2005-09-05	2009-01-13	Dr. Reddy's Laboratories Limited	Eszopiclone process
WO2007088073A1 (en) *	2006-02-03	2007-08-09	Synthon B.V.	Zopiclone resolution using l-tartaric acid

1991
- 1991-01-17 FR FR9100490A patent/FR2671800B1/fr not_active Expired - Fee Related
1992
- 1992-01-15 NZ NZ241313A patent/NZ241313A/xx not_active IP Right Cessation
- 1992-01-15 MA MA22677A patent/MA22392A1/fr unknown
- 1992-01-15 ZA ZA92302A patent/ZA92302B/xx unknown
- 1992-01-16 IL IL10067792A patent/IL100677A/en not_active IP Right Cessation
- 1992-01-16 IE IE920126A patent/IE66110B1/en not_active IP Right Cessation
- 1992-01-16 SK SK719-93A patent/SK279060B6/sk not_active IP Right Cessation
- 1992-01-16 MX MX9200180A patent/MX9200180A/es unknown
- 1992-01-16 DK DK92903994.9T patent/DK0609210T3/da active
- 1992-01-16 EP EP92903994A patent/EP0609210B1/de not_active Expired - Lifetime
- 1992-01-16 AU AU12264/92A patent/AU671797B2/en not_active Expired
- 1992-01-16 EP EP92400111A patent/EP0495717A1/de active Pending
- 1992-01-16 CZ CS931380A patent/CZ281011B6/cs not_active IP Right Cessation
- 1992-01-16 CA CA002099782A patent/CA2099782C/fr not_active Expired - Fee Related
- 1992-01-16 PH PH43784A patent/PH30982A/en unknown
- 1992-01-16 WO PCT/FR1992/000031 patent/WO1992012980A1/fr not_active Ceased
- 1992-01-16 AR AR92321649A patent/AR248024A1/es active
- 1992-01-16 HU HU9302063A patent/HU218928B/hu unknown
- 1992-01-16 RU RU93051787A patent/RU2110519C1/ru active
- 1992-01-16 AT AT92903994T patent/ATE121089T1/de not_active IP Right Cessation
- 1992-01-16 JP JP4504006A patent/JPH06504548A/ja active Pending
- 1992-01-16 DE DE69202060T patent/DE69202060T2/de not_active Expired - Lifetime
- 1992-01-16 PL PL92299834A patent/PL166976B1/pl unknown
- 1992-01-16 ES ES92903994T patent/ES2071486T3/es not_active Expired - Lifetime
- 1992-01-17 YU YU5592A patent/YU48878B/sh unknown
- 1992-01-17 TN TNTNSN92004A patent/TNSN92004A1/fr unknown
1993
- 1993-05-26 NO NO931919A patent/NO179911C/no not_active IP Right Cessation
- 1993-06-17 OA OA60387A patent/OA09807A/fr unknown
- 1993-07-16 FI FI933248A patent/FI100331B/fi active
1995
- 1995-08-30 AU AU30321/95A patent/AU3032195A/en not_active Abandoned
1998
- 1998-07-29 US US09/124,651 patent/US6319926B1/en not_active Expired - Fee Related
2000
- 2000-11-28 US US09/722,438 patent/US6444673B1/en not_active Expired - Lifetime
2002
- 2002-07-23 US US10/200,510 patent/US6864257B2/en not_active Expired - Fee Related
2004
- 2004-09-28 US US10/951,844 patent/US7125874B2/en not_active Expired - Fee Related
2006
- 2006-05-03 US US11/416,570 patent/US7381724B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
NO179911B (no)	1996-09-30
JPH06504548A (ja)	1994-05-26
EP0495717A1 (de)	1992-07-22
AU1226492A (en)	1992-08-27
OA09807A (fr)	1994-04-15
PL166976B1 (pl)	1995-07-31
RU2110519C1 (ru)	1998-05-10
IE66110B1 (en)	1995-12-13
FI933248A0 (fi)	1993-07-16
IL100677A (en)	1995-11-27
CA2099782C (fr)	2002-12-03
DE69202060T2 (de)	1995-10-26
EP0609210B1 (de)	1995-04-12
YU48878B (sh)	2002-09-19
AR248024A1 (es)	1995-05-31
AU671797B2 (en)	1996-09-12
ZA92302B (en)	1992-10-28
FR2671800A1 (fr)	1992-07-24
ATE121089T1 (de)	1995-04-15
FR2671800B1 (fr)	1993-03-12
SK279060B6 (sk)	1998-06-03
EP0609210A1 (de)	1994-08-10
US6444673B1 (en)	2002-09-03
US6864257B2 (en)	2005-03-08
FI933248L (fi)	1993-07-16
US20060194806A1 (en)	2006-08-31
HU218928B (hu)	2000-12-28
NO179911C (no)	1997-01-08
ES2071486T3 (es)	1995-06-16
NO931919D0 (no)	1993-05-26
CZ281011B6 (cs)	1996-05-15
SK71993A3 (en)	1993-12-08
TNSN92004A1 (fr)	1993-06-08
MX9200180A (es)	1992-07-01
HUT68915A (en)	1995-08-28
AU3032195A (en)	1995-11-09
IE920126A1 (en)	1992-07-29
HU9302063D0 (en)	1993-10-28
IL100677A0 (en)	1992-09-06
FI100331B (fi)	1997-11-14
EP0609210A4 (de)	1993-09-17
NO931919L (no)	1993-05-26
PH30982A (en)	1997-12-23
NZ241313A (en)	1993-03-26
US20020193378A1 (en)	2002-12-19
WO1992012980A1 (fr)	1992-08-06
US6319926B1 (en)	2001-11-20
US20050043311A1 (en)	2005-02-24
US7125874B2 (en)	2006-10-24
DE69202060D1 (de)	1995-05-18
CA2099782A1 (fr)	1992-07-18
YU5592A (sh)	1994-11-15
CZ138093A3 (en)	1994-02-16
US7381724B2 (en)	2008-06-03
MA22392A1 (fr)	1992-10-01

Publication	Publication Date	Title
DK0609210T3 (da)	1995-07-03	Optisk aktivt 5H-pyrrolo(3,4-b)pyrazinderivat, dets fremstilling og farmaceutiske præparater deraf
FI924340L (fi)	1992-09-28	Farmaceutiska beredningar
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