DK0613499T4 - Humane IT-4-mutantproteiner - Google Patents

Humane IT-4-mutantproteiner

Info

Publication number: DK0613499T4
Authority: DK; Denmark
Prior art keywords: pct; date; human; mutant proteins; antagonists
Prior art date: 1991-11-13

Application number

DK92923502T

Other languages

English (en)

Other versions

DK0613499T3 (da

Inventor

Walter Prof Dr Sebald

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-11-13

Filing date

1992-11-13

Publication date

2005-04-18

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6444719&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0613499(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-11-13 Application filed by Bayer Ag filed Critical Bayer Ag

1998-09-23 Publication of DK0613499T3 publication Critical patent/DK0613499T3/da

2005-04-18 Application granted granted Critical

2005-04-18 Publication of DK0613499T4 publication Critical patent/DK0613499T4/da

Links

102000008300 Mutant Proteins Human genes 0.000 title 1
108010021466 Mutant Proteins Proteins 0.000 title 1
239000005557 antagonist Substances 0.000 abstract 2
239000004031 partial agonist Substances 0.000 abstract 2
101100069857 Caenorhabditis elegans hil-4 gene Proteins 0.000 abstract 1
101001002709 Homo sapiens Interleukin-4 Proteins 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
102000055229 human IL4 Human genes 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5406—IL-4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Toxicology (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Immunology (AREA)
Pulmonology (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

DK92923502T 1991-11-13 1992-11-13 Humane IT-4-mutantproteiner DK0613499T4 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE4137333A DE4137333A1 (de)	1991-11-13	1991-11-13	Therapeutische mittel, die antagonisten oder partielle agonisten des humanen interleukin 4 sind oder diese enthalten, hil-4-mutantenproteine sowie vefahren zu deren herstellung
PCT/EP1992/002614 WO1993010235A1 (de)	1991-11-13	1992-11-13	Menschliche il-4 mutantenproteine

Publications (2)

Publication Number	Publication Date
DK0613499T3 DK0613499T3 (da)	1998-09-23
DK0613499T4 true DK0613499T4 (da)	2005-04-18

Family

ID=6444719

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92923502T DK0613499T4 (da)	1991-11-13	1992-11-13	Humane IT-4-mutantproteiner

Country Status (16)

Country	Link
US (1)	US5723118A (da)
EP (1)	EP0613499B2 (da)
JP (2)	JP3470970B2 (da)
KR (1)	KR100276410B1 (da)
AT (1)	ATE163196T1 (da)
AU (1)	AU671960B2 (da)
CA (1)	CA2123315C (da)
CZ (1)	CZ283467B6 (da)
DE (2)	DE4137333A1 (da)
DK (1)	DK0613499T4 (da)
ES (1)	ES2112340T5 (da)
GR (1)	GR3026600T3 (da)
HU (1)	HU217326B (da)
NO (1)	NO312707B1 (da)
SK (1)	SK280114B6 (da)
WO (1)	WO1993010235A1 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4423131A1 (de) *	1994-07-01	1996-01-04	Bayer Ag	Neue hIL-4-Mutantenproteine als Antagonisten oder partielle Agonisten des humanen Interleukin 4
GB9415379D0 (en) *	1994-07-29	1994-09-21	Smithkline Beecham Plc	Novel compounds
HUT76369A (en) *	1994-07-29	1997-08-28	Smithkline Beecham Corp	Novel soluble protein compounds
US6335426B1 (en)	1996-06-14	2002-01-01	Bayer Corporation	T-cell selective interleukin-4 agonists
JP2000515007A (ja) *	1996-06-14	2000-11-14	バイエル・コーポレーシヨン	Ｔ細胞選択的インターロイキン―４アゴニスト
US5986059A (en) *	1996-06-14	1999-11-16	Bayer Corporation	T-cell selective interleukin-4 agonists
MY124565A (en) *	1996-07-19	2006-06-30	Bayer Corp	High-affinity interleukin-4-muteins
US6180108B1 (en) *	1998-12-10	2001-01-30	Bayer Corporation	Vectors having terminal repeat sequence of Epstein-Barr virus
DE10022258A1 (de)	2000-05-08	2001-11-15	Bayer Ag	Reinigung von Proteineinschlusskörpern durch Querstrom-Mikrofiltration
DK2990420T3 (da)	2000-05-26	2017-04-03	Immunex Corp	Anvendelse af interleukin-4-receptor-antistoffer samt sammensætninger deraf
GB0105360D0 (en) *	2001-03-03	2001-04-18	Glaxo Group Ltd	Chimaeric immunogens
EP1314739A1 (en) *	2001-11-22	2003-05-28	Bayer Ag	Process for renaturation of recombinant, disulfide containing proteins at high protein concentrations in the presence of amines
EP1382614A1 (en) *	2002-07-15	2004-01-21	Bayer HealthCare AG	Process for the purification of interleukin-4 and its muteins
US7635754B2 (en) *	2004-09-22	2009-12-22	Aerovance, Inc.	Interleukin-9 and interleukin-4 chimeric antagonist muteins and methods of using same
US20070009479A1 (en) *	2005-06-17	2007-01-11	Aerovance, Inc.	Methods for treating dermatitis using mutant human IL-4 compositions
WO2007147600A2 (en) *	2006-06-21	2007-12-27	Apogenix Gmbh	Differential il-4 and/or il-10 cytokine expression in human cancer
US20100086515A1 (en) *	2006-07-06	2010-04-08	Apogenix Gmbh	Human il-4 muteins in cancer therapy
EP2596802A1 (en)	2011-11-23	2013-05-29	PLS-Design GmbH	Pharmaceutical composition for treatment of allergic reactions
EP2674168A1 (en)	2012-06-14	2013-12-18	PLS-Design GmbH	Modulation of effector T cell responses by local depletion of complement component C3

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5017691A (en) *	1986-07-03	1991-05-21	Schering Corporation	Mammalian interleukin-4
US5041381A (en) *	1986-07-03	1991-08-20	Schering Corporation	Monoclonal antibodies against human interleukin-4 and hybridomas producing the same
DE68908431T2 (de) *	1988-02-02	1993-12-23	Schering Biotech Corp	Methode zur Verminderung der Immunglobulin-E-Reaktion.
US5188827A (en) *	1989-12-18	1993-02-23	Schering Corporation	Use of interleukin-4- for lowering blood-cholesterol levels

1991
- 1991-11-13 DE DE4137333A patent/DE4137333A1/de not_active Withdrawn
1992
- 1992-11-13 EP EP92923502A patent/EP0613499B2/de not_active Expired - Lifetime
- 1992-11-13 AT AT92923502T patent/ATE163196T1/de active
- 1992-11-13 US US08/232,289 patent/US5723118A/en not_active Expired - Lifetime
- 1992-11-13 ES ES92923502T patent/ES2112340T5/es not_active Expired - Lifetime
- 1992-11-13 JP JP50897393A patent/JP3470970B2/ja not_active Expired - Fee Related
- 1992-11-13 AU AU29282/92A patent/AU671960B2/en not_active Expired
- 1992-11-13 HU HU9401369A patent/HU217326B/hu unknown
- 1992-11-13 KR KR1019940701592A patent/KR100276410B1/ko not_active Expired - Fee Related
- 1992-11-13 DE DE59209196T patent/DE59209196D1/de not_active Expired - Lifetime
- 1992-11-13 DK DK92923502T patent/DK0613499T4/da active
- 1992-11-13 CA CA002123315A patent/CA2123315C/en not_active Expired - Lifetime
- 1992-11-13 SK SK554-94A patent/SK280114B6/sk not_active IP Right Cessation
- 1992-11-13 WO PCT/EP1992/002614 patent/WO1993010235A1/de not_active Ceased
- 1992-11-13 CZ CZ941185A patent/CZ283467B6/cs not_active IP Right Cessation
1994
- 1994-05-06 NO NO19941681A patent/NO312707B1/no not_active IP Right Cessation
1998
- 1998-04-10 GR GR980400796T patent/GR3026600T3/el unknown
2002
- 2002-09-30 JP JP2002287074A patent/JP2003174894A/ja active Pending

Also Published As

Publication number	Publication date
US5723118A (en)	1998-03-03
AU671960B2 (en)	1996-09-19
EP0613499A1 (de)	1994-09-07
JP3470970B2 (ja)	2003-11-25
NO941681L (no)	1994-05-06
DE4137333A1 (de)	1993-05-19
ATE163196T1 (de)	1998-02-15
DK0613499T3 (da)	1998-09-23
NO312707B1 (no)	2002-06-24
CA2123315C (en)	2003-06-17
JP2003174894A (ja)	2003-06-24
HU217326B (hu)	1999-12-28
HU9401369D0 (en)	1994-08-29
JPH07501522A (ja)	1995-02-16
SK280114B6 (sk)	1999-08-06
CA2123315A1 (en)	1993-05-27
WO1993010235A1 (de)	1993-05-27
CZ118594A3 (en)	1994-12-15
AU2928292A (en)	1993-06-15
ES2112340T3 (es)	1998-04-01
HUT66826A (en)	1995-01-30
DE59209196D1 (de)	1998-03-19
KR100276410B1 (ko)	2000-12-15
NO941681D0 (no)	1994-05-06
EP0613499B1 (de)	1998-02-11
EP0613499B2 (de)	2005-03-30
GR3026600T3 (en)	1998-07-31
CZ283467B6 (cs)	1998-04-15
SK55494A3 (en)	1994-12-07
ES2112340T5 (es)	2005-10-16

Publication	Publication Date	Title
DK0613499T4 (da)	2005-04-18	Humane IT-4-mutantproteiner
NO965621L (no)	1996-12-30	Nye hIL-4-mutantproteiner som antagonister eller partielle agonister for det humane interleukin 4
KR950700333A (ko)	1995-01-16	개량된 알파 인터페론 조성물 및 인간 말초혈 백혈구로부터의 제조 방법(improved alpha interferon composition and method for its production from human peripheral blood leukocytes)
BG103575A (en)	2000-06-30	SUBSTITUTED NITROGENCONTAINING HETEROCYCLES AS p38 PROTEINKINASE INHIBIRORS
ATE136026T1 (de)	1996-04-15	Substituierte bizyklische arylderivate mit selektiver leukotrien b4 antagonistischer wirkung
PT815087E (pt)	2002-04-29	Derivados de fenilo trissubstituidos
DE69226649D1 (de)	1998-09-17	Analoge des menschlichen Interleukin-8.
DK0609280T3 (da)	1999-10-25	Humane IL-3 varianter
ES2084149T3 (es)	1996-05-01	Conjugados de hirudinpolialquilenglicol.
ATE204021T1 (de)	2001-08-15	Klonierung, expression und charakterisierung einer neuen form der phosphatidylinositol-3- kinase
DK0649433T3 (da)	1998-07-27	Antigeniske regioner fra komplekser af tumorfrigivne partikler (TLP) og antistoffer mod sådanne.
NO961423D0 (no)	1996-04-11	Oligopeptider avledet fra C-reaktive proteinfragmenter
NO995692D0 (no)	1999-11-19	Nye BPC-peptidsalter med organbeskyttende aktivitet, metoden for deres fremstilling og deres anvendelse
DE69816808D1 (de)	2003-09-04	Somatostatin agoniste zur reduzierung von körpergewicht
YU61096A (sh)	1999-03-04	Novi intermedijari, njihova primena u sintezi n,n'-premoštenih bisindolilmaleimida i farmaceutske formulacije
MX9206339A (es)	1993-05-01	Nueva proteina inhibidora de trombina a partir de chinches de monte
DK0673377T3 (da)	1997-03-17	Nye triazoloquinazoliner, fremstilling og anvendelse deraf
GB9723630D0 (en)	1998-01-07	M.vaccae preparation and its use