DK0615445T3 - Farmaceutisk administrerbar nanosol og fremgangsmåde til fremstilling deraf - Google Patents

Farmaceutisk administrerbar nanosol og fremgangsmåde til fremstilling deraf

Info

Publication number: DK0615445T3
Authority: DK; Denmark
Prior art keywords: gelatin; charge; pct; particles; active substance
Prior art date: 1991-12-05

Application number

DK92924547.0T

Other languages

English (en)

Inventor

Jens-Christian Wunderlich

Ursula Schick

Juergen Freidenreich

Juergen Werry

Original Assignee

Alfatec Pharma Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-12-05

Filing date

1992-12-04

Publication date

1996-06-03

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27203166&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0615445(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1991-12-05 Priority claimed from DE19914140195 external-priority patent/DE4140195C2/de

1991-12-05 Priority claimed from DE19914140177 external-priority patent/DE4140177C2/de

1991-12-05 Priority claimed from DE19914140178 external-priority patent/DE4140178C2/de

1992-12-04 Application filed by Alfatec Pharma Gmbh filed Critical Alfatec Pharma Gmbh

1996-06-03 Application granted granted Critical

1996-06-03 Publication of DK0615445T3 publication Critical patent/DK0615445T3/da

Links

108010010803 Gelatin Proteins 0.000 abstract 5
229920000159 gelatin Polymers 0.000 abstract 5
239000008273 gelatin Substances 0.000 abstract 5
235000019322 gelatine Nutrition 0.000 abstract 5
235000011852 gelatine desserts Nutrition 0.000 abstract 5
239000013543 active substance Substances 0.000 abstract 4
239000002245 particle Substances 0.000 abstract 4
239000003814 drug Substances 0.000 abstract 2
CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 abstract 2
229960004892 acemetacin Drugs 0.000 abstract 1
FSQKKOOTNAMONP-UHFFFAOYSA-N acemetacin Chemical compound CC1=C(CC(=O)OCC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 FSQKKOOTNAMONP-UHFFFAOYSA-N 0.000 abstract 1
229960004580 glibenclamide Drugs 0.000 abstract 1
ZNNLBTZKUZBEKO-UHFFFAOYSA-N glyburide Chemical compound COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZNNLBTZKUZBEKO-UHFFFAOYSA-N 0.000 abstract 1
SEOVTRFCIGRIMH-UHFFFAOYSA-N indole-3-acetic acid Chemical class C1=CC=C2C(CC(=O)O)=CNC2=C1 SEOVTRFCIGRIMH-UHFFFAOYSA-N 0.000 abstract 1
229960000905 indomethacin Drugs 0.000 abstract 1
150000002484 inorganic compounds Chemical class 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
230000035800 maturation Effects 0.000 abstract 1
230000007935 neutral effect Effects 0.000 abstract 1
150000002894 organic compounds Chemical class 0.000 abstract 1
230000000087 stabilizing effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5169—Proteins, e.g. albumin, gelatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2063—Proteins, e.g. gelatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03C—PHOTOSENSITIVE MATERIALS FOR PHOTOGRAPHIC PURPOSES; PHOTOGRAPHIC PROCESSES, e.g. CINE, X-RAY, COLOUR, STEREO-PHOTOGRAPHIC PROCESSES; AUXILIARY PROCESSES IN PHOTOGRAPHY
- G03C1/00—Photosensitive materials
- G03C1/005—Silver halide emulsions; Preparation thereof; Physical treatment thereof; Incorporation of additives therein
- G03C1/04—Silver halide emulsions; Preparation thereof; Physical treatment thereof; Incorporation of additives therein with macromolecular additives; with layer-forming substances
- G03C1/047—Proteins, e.g. gelatine derivatives; Hydrolysis or extraction products of proteins
- G03C2001/0471—Isoelectric point of gelatine
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
- Y10S977/775—Nanosized powder or flake, e.g. nanosized catalyst
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/788—Of specified organic or carbon-based composition
- Y10S977/797—Lipid particle
- Y10S977/798—Lipid particle having internalized material
- Y10S977/799—Containing biological material
- Y10S977/801—Drug
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
- Y10S977/907—Liposome
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/915—Therapeutic or pharmaceutical composition

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Zoology (AREA)
Optics & Photonics (AREA)
Diabetes (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Physics & Mathematics (AREA)
Biomedical Technology (AREA)
Nanotechnology (AREA)
Endocrinology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Cephalosporin Compounds (AREA)
Manufacturing Of Micro-Capsules (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK92924547.0T 1991-12-05 1992-12-04 Farmaceutisk administrerbar nanosol og fremgangsmåde til fremstilling deraf DK0615445T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE19914140195 DE4140195C2 (de)	1991-12-05	1991-12-05	Pharmazeutisch applizierbares Nanosol und Verfahren zu seiner Herstellung
DE19914140177 DE4140177C2 (de)	1991-12-05	1991-12-05	Nanosol-Akutform für Glibenclamid
DE19914140178 DE4140178C2 (de)	1991-12-05	1991-12-05	Akutform für ein Indolylessigsäurederivat enthaltendes Arzneimittel und seine Herstellung

Publications (1)

Publication Number	Publication Date
DK0615445T3 true DK0615445T3 (da)	1996-06-03

Family

ID=27203166

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92924547.0T DK0615445T3 (da)	1991-12-05	1992-12-04	Farmaceutisk administrerbar nanosol og fremgangsmåde til fremstilling deraf

Country Status (10)

Country	Link
US (1)	US5932245A (da)
EP (1)	EP0615445B1 (da)
AT (1)	ATE137962T1 (da)
AU (1)	AU671965B2 (da)
CA (1)	CA2125282C (da)
DE (1)	DE59206324D1 (da)
DK (1)	DK0615445T3 (da)
ES (1)	ES2087565T3 (da)
GR (1)	GR3020248T3 (da)
WO (1)	WO1993010768A1 (da)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3010160B1 (ja) *	1998-10-28	2000-02-14	株式会社ニッピ	コラーゲン配合化粧品
US7708989B2 (en) *	1999-10-29	2010-05-04	Nitromed, Inc.	Methods of treating vascular diseases characterized by nitric oxide insufficiency
US20010036479A1 (en) *	2000-01-14	2001-11-01	Gillian Cave	Glyburide composition
ATE358469T1 (de) *	2000-11-29	2007-04-15	Basf Ag	Verfahren zur herstellung fester zubereitungen wasserlöslicher, schwer wasserlöslicher oder wasserunlöslicher wirkstoffe
US7105176B2 (en)	2000-11-29	2006-09-12	Basf Aktiengesellschaft	Production of solid preparations of water-soluble, sparingly water-soluble or water-insoluble active compounds
DE10114178A1 (de)	2001-03-23	2002-10-10	Aventis Pharma Gmbh	Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
CN1254233C (zh) *	2001-08-06	2006-05-03	阿斯特拉曾尼卡有限公司	含有水不溶性的稳定纳米颗粒和赋形剂如中链甘油三酯(mct)的水性分散体
DE10205362A1 (de) *	2002-02-08	2003-08-21	Abbott Gmbh & Co Kg	Verfahren zur Herstellung wasserdispergierbarer Trockenpulver von in Wasser schwer löslichen Verbindungen
US7923029B2 (en) *	2002-04-11	2011-04-12	Medimmune Llc	Spray freeze dry of compositions for pulmonary administration
GB0216700D0 (en) *	2002-07-18	2002-08-28	Astrazeneca Ab	Process
SI1553927T1 (sl)	2002-09-11	2010-12-31	Elan Pharma Int Ltd	Z gelom stabilizirani nanodeläśni sestavki uäśinkovine
US6841179B2 (en) *	2002-11-14	2005-01-11	The Meow Mix Company	Pet food compositions comprising electrostatically charged gelatin
GB0230088D0 (en) *	2002-12-24	2003-01-29	Astrazeneca Ab	Therapeutic agents
GB0230087D0 (en) *	2002-12-24	2003-01-29	Astrazeneca Ab	Therapeutic agents
GB0302673D0 (en) *	2003-02-06	2003-03-12	Astrazeneca Ab	Pharmaceutical formulations
GB0302672D0 (en) *	2003-02-06	2003-03-12	Astrazeneca Ab	Pharmaceutical formulations
GB0302671D0 (en) *	2003-02-06	2003-03-12	Astrazeneca Ab	Pharmaceutical formulations
US20060183680A1 (en) *	2003-04-01	2006-08-17	Yasuhiko Tabata	Remedy for ischemia
EP1641779A1 (en) *	2003-06-18	2006-04-05	AstraZeneca AB	2-substitued 5, 6-diaryl-pyrazine derivatives as cb1 modulator.
GB0314057D0 (en) *	2003-06-18	2003-07-23	Astrazeneca Ab	Therapeutic agents
GB0314261D0 (en) *	2003-06-19	2003-07-23	Astrazeneca Ab	Therapeutic agents
DE102004041340A1 (de) *	2004-08-20	2006-02-23	Deutsche Gelatine-Fabriken Stoess Ag	Nanopartikel und Verfahren zu deren Herstellung
KR101409302B1 (ko) *	2005-08-02	2014-06-20	드로싸팜 아게	인도메타신 및／또는 아세메타신을 포함하는 약학적 조성물
JP5558712B2 (ja) *	2005-08-02	2014-07-23	ドロサファームアクチェンゲゼルシャフト	インドメタシン及び／又はアセメタシンを含む医薬組成物
CN102014973A (zh)	2008-02-29	2011-04-13	弗罗桑医疗设备公司	用于促进止血和/或伤口愈合的装置
US9775819B2 (en) *	2009-09-16	2017-10-03	R.P. Scherer Technologies, Llc	Oral solid dosage form containing nanoparticles and process of formulating the same using fish gelatin
GB201006218D0 (en) *	2010-04-14	2010-06-02	Ayanda As	Composition
EP2540287A1 (en)	2011-07-01	2013-01-02	FutureChemistry	Continuous flow production of gelatin nanoparticles
DE102011052396A1 (de) *	2011-08-04	2013-02-07	Gelita Ag	Verfahren zur Herstellung einer stabilen Dispersion von Nanopartikeln, hergestellte Dispersion und deren Verwendung
BR112014012444B1 (pt)	2011-11-23	2021-12-14	Therapeuticsmd, Inc	Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher
US9301920B2 (en)	2012-06-18	2016-04-05	Therapeuticsmd, Inc.	Natural combination hormone replacement formulations and therapies
RU2657955C2 (ru)	2012-03-06	2018-06-18	Ферросан Медикал Дивайсиз А/С	Контейнер под давлением, содержащий гемостатическую пасту
EP2977066A3 (en)	2012-06-12	2016-07-27	Ferrosan Medical Devices A/S	Dry haemostatic composition
US8313774B1 (en)	2012-06-26	2012-11-20	Magnifica Inc.	Oral solid composition
US9180091B2 (en) *	2012-12-21	2015-11-10	Therapeuticsmd, Inc.	Soluble estradiol capsule for vaginal insertion
AU2014283170B2 (en)	2013-06-21	2017-11-02	Ferrosan Medical Devices A/S	Vacuum expanded dry composition and syringe for retaining same
JP6489485B2 (ja)	2013-12-11	2019-03-27	フェロサンメディカルデバイシーズエイ／エス	押し出し増強因子を含んでいる乾燥組成物
AU2015333206B2 (en)	2014-10-13	2019-07-11	Ferrosan Medical Devices A/S.	Dry composition for use in haemostasis and wound healing
RU2705905C2 (ru)	2014-12-24	2019-11-12	Ферросан Медикал Дивайсиз А/С	Шприц для удерживания и смешивания первого и второго веществ
CN107771093B (zh)	2015-07-03	2021-06-15	弗罗桑医疗设备公司	用于混合两种组分和用于在存储条件下保持真空的注射器
CN110944641A (zh) *	2017-06-20	2020-03-31	西雅图咖米公司	明胶胶粘组合物及其制造和使用方法
US11801324B2 (en)	2018-05-09	2023-10-31	Ferrosan Medical Devices A/S	Method for preparing a haemostatic composition

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB887901A (da) *	1960-04-13	1900-01-01
WO1985005029A1 (en) *	1984-05-09	1985-11-21	Medaphore Inc.	Oral insulin and a method of making the same
HU205861B (en) *	1986-12-19	1992-07-28	Sandoz Ag	Process for producing hydrosole of pharmaceutically effective material
FR2634397B2 (fr) *	1986-12-31	1991-04-19	Centre Nat Rech Scient	Procede de preparation de systemes colloidaux dispersibles d'une proteine sous forme de nanoparticules
FR2608988B1 (fr) *	1986-12-31	1991-01-11	Centre Nat Rech Scient	Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanoparticules
CA1324083C (en) *	1987-03-09	1993-11-09	Tetsu Miyoshi	Pharmaceutical preparations containing non-steroidal anti-inflammatory agents
ATE84710T1 (de) *	1988-06-30	1993-02-15	Centre Nat Rech Scient	Verfahren zur herstellung von kolloidalen dispergierbaren proteinsystemen, wie nanopartikeln.

1992
- 1992-12-04 CA CA002125282A patent/CA2125282C/en not_active Expired - Fee Related
- 1992-12-04 US US08/244,615 patent/US5932245A/en not_active Expired - Fee Related
- 1992-12-04 DE DE59206324T patent/DE59206324D1/de not_active Ceased
- 1992-12-04 DK DK92924547.0T patent/DK0615445T3/da active
- 1992-12-04 AU AU30802/92A patent/AU671965B2/en not_active Ceased
- 1992-12-04 AT AT92924547T patent/ATE137962T1/de not_active IP Right Cessation
- 1992-12-04 EP EP92924547A patent/EP0615445B1/de not_active Expired - Lifetime
- 1992-12-04 WO PCT/DE1992/001010 patent/WO1993010768A1/de not_active Ceased
- 1992-12-04 ES ES92924547T patent/ES2087565T3/es not_active Expired - Lifetime
1996
- 1996-06-18 GR GR960401627T patent/GR3020248T3/el unknown

Also Published As

Publication number	Publication date
WO1993010768A1 (de)	1993-06-10
ATE137962T1 (de)	1996-06-15
AU671965B2 (en)	1996-09-19
GR3020248T3 (en)	1996-09-30
EP0615445B1 (de)	1996-05-15
US5932245A (en)	1999-08-03
CA2125282C (en)	1999-08-31
CA2125282A1 (en)	1993-06-10
DE59206324D1 (de)	1996-06-20
EP0615445A1 (de)	1994-09-21
ES2087565T3 (es)	1996-07-16
AU3080292A (en)	1993-06-28

Publication	Publication Date	Title
DK0615445T3 (da)	1996-06-03	Farmaceutisk administrerbar nanosol og fremgangsmåde til fremstilling deraf
Ohnishi et al.	1974	Calcium-induced phase separations in phosphatidylserine-phosphatidylcholine membranes
KR830005850A (ko)	1983-09-14	경구 투여용, 특히 소아경구 투여용 마이크로 캡슐화 바캄피실린산 부가염의 현탁액
ATE181087T1 (de)	1999-06-15	Superporöse polysaccharidgele
NO982364L (no)	1998-05-25	FremgangsmÕte for fremstilling av morfologisk anhetlige mikrokapsler, samt mikrokapsler fremstilt ved fremgangsmÕten
ES8600931A1 (es)	1985-10-16	Un procedimiento para preparar una solucion acuosa que contiene una sustancia farmaceutica soluble en lipidos
DK0477333T3 (da)	1994-03-14	Farmaceutiske præparater
IE43809L (en)	1977-05-07	Low fat spread
DK3891A (da)	1991-02-05	Stabiliseret enzymdispersion
NO971986L (no)	1997-04-29	Fremgangsmåte for fremstilling av små partikler
DK0615440T3 (da)	1996-02-05	Lægemiddel indeholdende et 2-arylpropionsyrederivat i nanosolform og dets fremstilling
AR240874A2 (es)	1991-03-27	Un metodo para preparacion de una composicion que contiene un agente biologicamente activo de leberacion prolongada
GR3018064T3 (en)	1996-02-29	Aqueous phospholipid vesicle dispersion, process for its manufacture and use thereof.
EP0343775A3 (en)	1990-02-21	Chewing gum containing delayed release protein sweetener and method
KR860003249A (ko)	1986-05-21	피록시캄 1수화물의 제조 방법
Brierley et al.	1967	Ion Transport by Heart Mitochondria: IX. INDUCTION OF THE ENERGY-LINKED UPTAKE OF K+ BY ZINC ION
EP0374796A3 (en)	1992-03-04	Stable emulsion formulations of water-insoluble organic pesticides, their use and preparation
AU6431398A (en)	1998-10-12	Stimulation, culture and preservation of pancreatic and other cells
JP2758297B2 (ja)	1998-05-28	リポソーム調製物
GB1521691A (en)	1978-08-16	Oleoresin emulsions
TR199901044T2 (en)	1999-07-21	Endos�lfan-mikrokaps�l da��l�m�.
Pearce et al.	1983	Histamine secretion from mast cells treated with chlortetracycline (aureomycin): a novel calcium ionophore
Azhar et al.	1978	Role of gangliosides in gonadotropin and cholera enterotoxin stimulated steroidogenesis in isolated rat ovarian cells
Habib et al.	1989	Influence of Certain Additives on the Photostability of Colch Icine Solutions
US3361627A (en)	1968-01-02	Phenothiazine compositions