NO982364L - FremgangsmÕte for fremstilling av morfologisk anhetlige mikrokapsler, samt mikrokapsler fremstilt ved fremgangsmÕten - Google Patents
FremgangsmÕte for fremstilling av morfologisk anhetlige mikrokapsler, samt mikrokapsler fremstilt ved fremgangsmÕtenInfo
- Publication number
- NO982364L NO982364L NO982364A NO982364A NO982364L NO 982364 L NO982364 L NO 982364L NO 982364 A NO982364 A NO 982364A NO 982364 A NO982364 A NO 982364A NO 982364 L NO982364 L NO 982364L
- Authority
- NO
- Norway
- Prior art keywords
- microcapsules
- well
- preparation
- solvent
- morphologically uniform
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 6
- 239000003094 microcapsule Substances 0.000 title abstract 5
- 239000004480 active ingredient Substances 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- 238000005054 agglomeration Methods 0.000 abstract 1
- 230000002776 aggregation Effects 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 229920002988 biodegradable polymer Polymers 0.000 abstract 1
- 239000004621 biodegradable polymer Substances 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 238000005538 encapsulation Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000011877 solvent mixture Substances 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 239000008307 w/o/w-emulsion Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/38—Albumins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Dispersion Chemistry (AREA)
- Reproductive Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Peptides Or Proteins (AREA)
- Biological Depolymerization Polymers (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19545257A DE19545257A1 (de) | 1995-11-24 | 1995-11-24 | Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln |
| PCT/EP1996/004701 WO1997019676A1 (de) | 1995-11-24 | 1996-10-30 | Verfahren zur herstellung von morphologisch einheitlichen mikrokapseln sowie nach diesem verfahren hergestellte mikrokapseln |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO982364L true NO982364L (no) | 1998-05-25 |
| NO982364D0 NO982364D0 (no) | 1998-05-25 |
| NO320493B1 NO320493B1 (no) | 2005-12-12 |
Family
ID=7779181
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19982364A NO320493B1 (no) | 1995-11-24 | 1998-05-25 | Fremgangsmate for fremstilling av morfologisk enhetlige mikrokapsler, samt mikrokapsler fremstilt ved fremgangsmaten |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US6294204B1 (no) |
| EP (1) | EP0862418B1 (no) |
| JP (2) | JP2000501084A (no) |
| KR (1) | KR100479895B1 (no) |
| CN (1) | CN1193742C (no) |
| AT (1) | ATE204469T1 (no) |
| AU (1) | AU712351B2 (no) |
| DE (2) | DE19545257A1 (no) |
| DK (1) | DK0862418T3 (no) |
| ES (1) | ES2161379T3 (no) |
| HU (1) | HU223975B1 (no) |
| IL (1) | IL124373A (no) |
| NO (1) | NO320493B1 (no) |
| NZ (1) | NZ321592A (no) |
| PT (1) | PT862418E (no) |
| WO (1) | WO1997019676A1 (no) |
Families Citing this family (149)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6428771B1 (en) * | 1995-05-15 | 2002-08-06 | Pharmaceutical Discovery Corporation | Method for drug delivery to the pulmonary system |
| US6143211A (en) * | 1995-07-21 | 2000-11-07 | Brown University Foundation | Process for preparing microparticles through phase inversion phenomena |
| DE19545257A1 (de) | 1995-11-24 | 1997-06-19 | Schering Ag | Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln |
| FR2766368B1 (fr) * | 1997-07-24 | 2000-03-31 | Univ Claude Bernard Lyon | Procede de preparation de nanocapsules de type vesiculaire, utilisables notamment comme vecteurs colloidaux de principes actifs pharmaceutiques ou autres |
| US7128927B1 (en) * | 1998-04-14 | 2006-10-31 | Qlt Usa, Inc. | Emulsions for in-situ delivery systems |
| US6234167B1 (en) | 1998-10-14 | 2001-05-22 | Chrysalis Technologies, Incorporated | Aerosol generator and methods of making and using an aerosol generator |
| DE19925184A1 (de) * | 1999-05-26 | 2000-11-30 | Schering Ag | Kontinuierliches Verfahren zur Herstellung von morphologisch einheitlichen Mikro- und Nanopartikeln mittels Mikromischer sowie nach diesem Verfahren hergestellte Partikel |
| US9006175B2 (en) * | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| EP2280004B1 (en) * | 1999-06-29 | 2016-04-20 | MannKind Corporation | Pharmaceutical formulations comprising insulin complexed with a diketopiperazine |
| ES2169980B1 (es) | 1999-12-17 | 2003-11-01 | Lipotec Sa | Microcapsulas para la liberacion prolongada de farmacos. |
| US6883516B2 (en) | 2000-04-27 | 2005-04-26 | Chrysalis Technologies Incorporated | Method for generating an aerosol with a predetermined and/or substantially monodispersed particle size distribution |
| MY136453A (en) | 2000-04-27 | 2008-10-31 | Philip Morris Usa Inc | "improved method and apparatus for generating an aerosol" |
| KR100381382B1 (ko) * | 2000-06-28 | 2003-04-23 | 한국과학기술원 | 지속적 약물조절방출이 가능한 생분해성 미립담체 및 그의제조방법 |
| KR100392501B1 (ko) * | 2000-06-28 | 2003-07-22 | 동국제약 주식회사 | 다중 에멀젼법에 의한 서방출성 미립구의 제조방법 |
| US7252842B2 (en) * | 2000-12-21 | 2007-08-07 | Alrise Biosystems Gmbh | Induced phase transition method for the production of microparticles containing hydrophilic active agents |
| US6607784B2 (en) * | 2000-12-22 | 2003-08-19 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
| US6884436B2 (en) | 2000-12-22 | 2005-04-26 | Baxter International Inc. | Method for preparing submicron particle suspensions |
| US6977085B2 (en) | 2000-12-22 | 2005-12-20 | Baxter International Inc. | Method for preparing submicron suspensions with polymorph control |
| US6501052B2 (en) | 2000-12-22 | 2002-12-31 | Chrysalis Technologies Incorporated | Aerosol generator having multiple heating zones and methods of use thereof |
| US20050048126A1 (en) | 2000-12-22 | 2005-03-03 | Barrett Rabinow | Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug |
| US6701921B2 (en) | 2000-12-22 | 2004-03-09 | Chrysalis Technologies Incorporated | Aerosol generator having heater in multilayered composite and method of use thereof |
| US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
| US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
| US6799572B2 (en) | 2000-12-22 | 2004-10-05 | Chrysalis Technologies Incorporated | Disposable aerosol generator system and methods for administering the aerosol |
| US6681998B2 (en) | 2000-12-22 | 2004-01-27 | Chrysalis Technologies Incorporated | Aerosol generator having inductive heater and method of use thereof |
| US6491233B2 (en) | 2000-12-22 | 2002-12-10 | Chrysalis Technologies Incorporated | Vapor driven aerosol generator and method of use thereof |
| US7077130B2 (en) | 2000-12-22 | 2006-07-18 | Chrysalis Technologies Incorporated | Disposable inhaler system |
| US20030096013A1 (en) * | 2000-12-22 | 2003-05-22 | Jane Werling | Preparation of submicron sized particles with polymorph control |
| US7193084B2 (en) * | 2000-12-22 | 2007-03-20 | Baxter International Inc. | Polymorphic form of itraconazole |
| DE10114178A1 (de) * | 2001-03-23 | 2002-10-10 | Aventis Pharma Gmbh | Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität |
| JP2004537401A (ja) * | 2001-08-08 | 2004-12-16 | ブラウン ユニバーシティ リサーチ ファウンデーション | 疎水性薬物の微粉砕方法 |
| US7498045B2 (en) * | 2001-08-31 | 2009-03-03 | Thomas M. S. Chang | Biodegradable polymeric nanocapsules and uses thereof |
| US6640050B2 (en) | 2001-09-21 | 2003-10-28 | Chrysalis Technologies Incorporated | Fluid vaporizing device having controlled temperature profile heater/capillary tube |
| US6568390B2 (en) | 2001-09-21 | 2003-05-27 | Chrysalis Technologies Incorporated | Dual capillary fluid vaporizing device |
| US20060003012A9 (en) | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
| AU2002337692B2 (en) | 2001-09-26 | 2007-09-13 | Baxter International Inc. | Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal |
| US7112340B2 (en) * | 2001-10-19 | 2006-09-26 | Baxter International Inc. | Compositions of and method for preparing stable particles in a frozen aqueous matrix |
| ATE381963T1 (de) * | 2001-10-26 | 2008-01-15 | Octoplus Technologies B V | Verfahren zur herstellung von gereinigten partikeln |
| US6681769B2 (en) | 2001-12-06 | 2004-01-27 | Crysalis Technologies Incorporated | Aerosol generator having a multiple path heater arrangement and method of use thereof |
| US6804458B2 (en) | 2001-12-06 | 2004-10-12 | Chrysalis Technologies Incorporated | Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate |
| WO2003049701A2 (en) * | 2001-12-10 | 2003-06-19 | Spherics, Inc. | Methods and products useful in the formation and isolation of microparticles |
| US6701922B2 (en) | 2001-12-20 | 2004-03-09 | Chrysalis Technologies Incorporated | Mouthpiece entrainment airflow control for aerosol generators |
| DE10205362A1 (de) * | 2002-02-08 | 2003-08-21 | Abbott Gmbh & Co Kg | Verfahren zur Herstellung wasserdispergierbarer Trockenpulver von in Wasser schwer löslichen Verbindungen |
| WO2003075892A1 (en) * | 2002-03-13 | 2003-09-18 | Novartis Ag | Pharmaceutical microparticles |
| GB0206048D0 (en) * | 2002-03-14 | 2002-04-24 | Croda Int Plc | Use |
| EP1344520B1 (en) * | 2002-03-15 | 2007-10-03 | Alrise Biosystems GmbH | Microparticles and method for their production |
| EP1494732B1 (en) | 2002-03-20 | 2008-01-30 | MannKind Corporation | Inhalation apparatus |
| AU2003230908A1 (en) * | 2002-04-11 | 2003-10-27 | Medimmune Vaccines, Inc. | Spray freeze dry of compositions for intranasal administration |
| US20030228365A1 (en) * | 2002-06-07 | 2003-12-11 | Fortuna Haviv | Pharmaceutical formulation |
| DE10227232A1 (de) * | 2002-06-18 | 2004-01-15 | Aventis Pharma Deutschland Gmbh | Saure Insulinzubereitungen mit verbesserter Stabilität |
| US8506617B1 (en) * | 2002-06-21 | 2013-08-13 | Advanced Cardiovascular Systems, Inc. | Micronized peptide coated stent |
| WO2004022000A2 (en) * | 2002-09-05 | 2004-03-18 | Ambrose Catherine G | Antibiotic microspheres for treatment of infections and osteomyelitis |
| AU2003262048A1 (en) * | 2002-09-11 | 2004-04-30 | Tanabe Seiyaku Co., Ltd. | Process for the production of microspheres and unit therefor |
| US20040191215A1 (en) * | 2003-03-25 | 2004-09-30 | Michael Froix | Compositions for induction of a therapeutic response |
| US7367334B2 (en) | 2003-08-27 | 2008-05-06 | Philip Morris Usa Inc. | Fluid vaporizing device having controlled temperature profile heater/capillary tube |
| US7338171B2 (en) * | 2003-10-27 | 2008-03-04 | Jen-Chuen Hsieh | Method and apparatus for visual drive control |
| AU2005204378B2 (en) * | 2004-01-12 | 2009-01-22 | Mannkind Corporation | A method of reducing serum proinsulin levels in type 2 diabetics |
| EP1711163A2 (en) * | 2004-02-05 | 2006-10-18 | Baxter International Inc. | Dispersions prepared by use of self-stabilizing agents |
| US7592431B2 (en) * | 2004-02-26 | 2009-09-22 | Immunovative Therapies, Ltd. | Biodegradable T-cell Activation device |
| SI2573166T1 (sl) * | 2004-02-26 | 2016-09-30 | Immunovative Therapies, Ltd. | Metode za pripravo T-celic za celično terapijo |
| US20080248999A1 (en) * | 2007-04-04 | 2008-10-09 | Biodel Inc. | Amylin formulations |
| US20080090753A1 (en) | 2004-03-12 | 2008-04-17 | Biodel, Inc. | Rapid Acting Injectable Insulin Compositions |
| CN103223160B (zh) | 2004-07-19 | 2015-02-18 | 比奥孔有限公司 | 胰岛素-低聚物共轭物,制剂及其用途 |
| DK1786784T3 (da) | 2004-08-20 | 2011-02-14 | Mannkind Corp | Katalyse af diketopiperazinsyntese |
| CN104436170B (zh) | 2004-08-23 | 2018-02-23 | 曼金德公司 | 用于药物输送的二酮哌嗪盐 |
| WO2006066595A2 (en) * | 2004-12-22 | 2006-06-29 | Novozymes A/S | Recombinant production of serum albumin |
| EP1679065A1 (en) * | 2005-01-07 | 2006-07-12 | OctoPlus Sciences B.V. | Controlled release compositions for interferon based on PEGT/PBT block copolymers |
| WO2006078841A1 (en) * | 2005-01-21 | 2006-07-27 | President And Fellows Of Harvard College | Systems and methods for forming fluidic droplets encapsulated in particles such as colloidal particles |
| CN100362075C (zh) * | 2005-05-18 | 2008-01-16 | 东华大学 | 动物蛋白外包覆的相变储能微胶囊、制备方法及其用途 |
| CN100382792C (zh) * | 2005-09-12 | 2008-04-23 | 大连三仪动物药品有限公司 | 药用水溶性微胶囊及生产方法 |
| AU2006290227B2 (en) | 2005-09-14 | 2012-08-02 | Mannkind Corporation | Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents |
| US20070086952A1 (en) * | 2005-09-29 | 2007-04-19 | Biodel, Inc. | Rapid Acting and Prolonged Acting Inhalable Insulin Preparations |
| US7713929B2 (en) | 2006-04-12 | 2010-05-11 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
| US8084420B2 (en) * | 2005-09-29 | 2011-12-27 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
| KR20080096809A (ko) | 2006-02-22 | 2008-11-03 | 맨카인드 코포레이션 | 디케토피페라진 및 활성제를 포함하는 마이크로입자의 약학특성의 개선 방법 |
| JP2009533471A (ja) * | 2006-04-12 | 2009-09-17 | バイオデル, インコーポレイテッド | 即効型および長時間作用型組合せインスリン製剤 |
| EP3061791B1 (en) | 2006-07-20 | 2019-01-16 | OrbusNeich Medical, Inc. | Bioabsorbable polymeric composition for a medical device |
| US8202524B2 (en) * | 2006-08-31 | 2012-06-19 | Sk Chemicals Co., Ltd. | Method for producing microspheres loaded with drugs and microspheres loaded with drugs produced thereby |
| US7959942B2 (en) | 2006-10-20 | 2011-06-14 | Orbusneich Medical, Inc. | Bioabsorbable medical device with coating |
| EP2073754A4 (en) | 2006-10-20 | 2012-09-26 | Orbusneich Medical Inc | BIOABSORBABLE POLYMER COMPOSITION AND MEDICAL DEVICE BACKGROUND |
| US8628701B2 (en) * | 2006-10-31 | 2014-01-14 | Xavier University Of Louisiana | Method of micro-encapsulation |
| US7887984B2 (en) * | 2007-01-18 | 2011-02-15 | Eastman Kodak Company | Toner porous particles containing hydrocolloids |
| US8747872B2 (en) * | 2007-05-02 | 2014-06-10 | The Regents Of The University Of Michigan | Nanoemulsion therapeutic compositions and methods of using the same |
| US8426467B2 (en) | 2007-05-22 | 2013-04-23 | Baxter International Inc. | Colored esmolol concentrate |
| US8722736B2 (en) | 2007-05-22 | 2014-05-13 | Baxter International Inc. | Multi-dose concentrate esmolol with benzyl alcohol |
| CA2709712C (en) * | 2007-12-20 | 2016-05-10 | Surmodics Pharmaceuticals, Inc. | Process for preparing microparticles having a low residual solvent volume |
| US20090175840A1 (en) * | 2008-01-04 | 2009-07-09 | Biodel, Inc. | Insulin formulations for insulin release as a function of tissue glucose levels |
| US20110020466A1 (en) | 2008-01-11 | 2011-01-27 | United Paragon Associates Inc. | Fertilized egg isolate and use thereof |
| CN101932311B (zh) | 2008-02-22 | 2014-07-16 | 东丽株式会社 | 微粒及其药物组合物 |
| US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
| SG10201507036TA (en) | 2008-06-13 | 2015-10-29 | Mannkind Corp | A dry powder inhaler and system for drug delivery |
| EP2609954B1 (en) | 2008-06-20 | 2021-12-29 | MannKind Corporation | An interactive apparatus for real-time profiling of inhalation efforts |
| TWI614024B (zh) | 2008-08-11 | 2018-02-11 | 曼凱公司 | 超快起作用胰島素之用途 |
| JP2010064956A (ja) * | 2008-09-08 | 2010-03-25 | Tokyo Univ Of Agriculture & Technology | 粒子およびその製造方法、ならびにゲル |
| EP2349209A2 (en) * | 2008-09-26 | 2011-08-03 | Nanobio Corporation | Nanoemulsion therapeutic compositions and methods of using the same |
| PT3228320T (pt) | 2008-10-17 | 2020-03-26 | Sanofi Aventis Deutschland | Combinação de uma insulina e de um agonista do glp-1 |
| KR101181563B1 (ko) | 2008-11-14 | 2012-09-10 | 에스케이케미칼주식회사 | 고분자 미립구의 제조방법 및 그 방법에 의해 제조된 고분자 미립구 |
| EP2376089B1 (en) | 2008-11-17 | 2018-03-14 | The Regents of the University of Michigan | Cancer vaccine compositions and methods of using the same |
| US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| US9060927B2 (en) * | 2009-03-03 | 2015-06-23 | Biodel Inc. | Insulin formulations for rapid uptake |
| MX2011009512A (es) | 2009-03-11 | 2011-11-29 | Mannkind Corp | Aparato, sistema y metodo para medir la resistencia de un inhalador. |
| MY157166A (en) | 2009-06-12 | 2016-05-13 | Mankind Corp | Diketopiperazine microparticles with defined specific surface areas |
| KR101853606B1 (ko) | 2009-07-06 | 2018-05-03 | 사노피-아벤티스 도이칠란트 게엠베하 | 메티오닌을 함유하는 수성 인슐린 제제 |
| CA2778698A1 (en) | 2009-11-03 | 2011-05-12 | Mannkind Corporation | An apparatus and method for simulating inhalation efforts |
| DK2498802T3 (en) | 2009-11-13 | 2015-04-13 | Sanofi Aventis Deutschland | Pharmaceutical composition comprising a GLP-1 agonist, insulin and a methionine |
| KR101337322B1 (ko) | 2009-11-13 | 2013-12-06 | 사노피-아벤티스 도이칠란트 게엠베하 | Glp-1 효능제 및 메티오닌을 포함하는 약제학적 조성물 |
| IL223742A (en) | 2010-06-21 | 2016-06-30 | Mannkind Corp | A dry powder inhaler and preparation for it |
| ES2606554T3 (es) | 2010-08-30 | 2017-03-24 | Sanofi-Aventis Deutschland Gmbh | Uso de AVE0010 para la fabricación de un medicamento para el tratamiento de la diabetes mellitus de tipo 2 |
| US9125835B2 (en) * | 2010-11-12 | 2015-09-08 | Rutgers, The State University Of New Jersey | Synergistic combinations to reduce particle dose for targeted treatment of cancer and its metastases |
| EP2653482B1 (en) | 2010-12-16 | 2015-09-30 | Sumitomo Seika Chemicals Co. Ltd. | Method for producing pseudopolyrotaxane |
| KR101817379B1 (ko) | 2010-12-16 | 2018-01-11 | 스미또모 세이까 가부시키가이샤 | 유사 폴리로탁산의 제조 방법 |
| CN103261234B (zh) * | 2010-12-16 | 2016-12-14 | 住友精化株式会社 | 纯化聚轮烷的制造方法 |
| WO2012081431A1 (ja) | 2010-12-16 | 2012-06-21 | 住友精化株式会社 | 擬ポリロタキサン水性分散体の製造方法 |
| MX347090B (es) | 2010-12-29 | 2017-04-11 | Medincell | Composiciones de suministro de farmacos biodegradables. |
| US9409999B2 (en) * | 2011-03-14 | 2016-08-09 | Sumitomo Seika Chemicals Co., Ltd. | Production method for hydrophilic modified polyrotaxane |
| WO2012124219A1 (ja) * | 2011-03-14 | 2012-09-20 | 住友精化株式会社 | ポリロタキサン組成物 |
| ES2552468T3 (es) * | 2011-03-14 | 2015-11-30 | Sumitomo Seika Chemicals Co. Ltd. | Método de producción de un polirrotaxano hidrófilo modificado pulverizado |
| EP2694402B1 (en) | 2011-04-01 | 2017-03-22 | MannKind Corporation | Blister package for pharmaceutical cartridges |
| PH12013502252B1 (en) | 2011-05-03 | 2018-09-21 | Immunovative Therapies Ltd | Induction of il-12 using immunotherapy |
| KR102202460B1 (ko) | 2011-05-03 | 2021-01-14 | 이뮤노베이티브 테라피스, 엘티디. | 생세포를 포함하는 생물학적 약물을 처리하기 위한 방법 |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
| PL2750699T3 (pl) | 2011-08-29 | 2015-12-31 | Sanofi Aventis Deutschland | Kombinacja farmaceutyczna do stosowania w kontroli glikemii u pacjentów z cukrzycą typu 2 |
| AR087744A1 (es) | 2011-09-01 | 2014-04-16 | Sanofi Aventis Deutschland | Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa |
| HK1200318A1 (en) | 2011-10-24 | 2015-08-07 | 曼金德公司 | Methods and compositions for treating pain |
| US20150094463A1 (en) * | 2012-03-30 | 2015-04-02 | Ube Industries, Ltd. | Hydroxyalkylated polyrotaxane production method |
| WO2013166487A1 (en) * | 2012-05-04 | 2013-11-07 | Yale University | Highly penetrative nanocarriers for treatment of cns disease |
| EP2872205B1 (en) | 2012-07-12 | 2017-02-08 | MannKind Corporation | Dry powder drug delivery systems |
| US10159644B2 (en) | 2012-10-26 | 2018-12-25 | Mannkind Corporation | Inhalable vaccine compositions and methods |
| DE102012221460A1 (de) * | 2012-11-23 | 2014-06-12 | Beiersdorf Ag | Verwendung von Triethylcitrat als Vergällungsmittel für Ethanol |
| WO2014144895A1 (en) | 2013-03-15 | 2014-09-18 | Mannkind Corporation | Microcrystalline diketopiperazine compositions and methods |
| CN103211281B (zh) * | 2013-04-10 | 2015-01-28 | 陕西科技大学 | 一种抗氧化油包水微乳液的制备方法 |
| BR112015027291A8 (pt) | 2013-05-03 | 2019-12-24 | Selecta Biosciences Inc | uso de um imunossupressor que têm uma vida eficaz farmacodinâmica especificada e composição compreendendo o referido imunossupressor |
| KR102465025B1 (ko) | 2013-07-18 | 2022-11-09 | 맨카인드 코포레이션 | 열-안정성 건조 분말 약제학적 조성물 및 방법 |
| EP3030294B1 (en) | 2013-08-05 | 2020-10-07 | MannKind Corporation | Insufflation apparatus |
| US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
| JP6300926B2 (ja) * | 2014-07-08 | 2018-03-28 | 国立大学法人大阪大学 | 自己修復性を有する高分子材料及びその製造方法 |
| US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
| EP4112076A1 (en) | 2014-10-10 | 2023-01-04 | The Regents of The University of Michigan | Nanoemulsion compositions for preventing, suppressing or eliminating allergic and inflammatory disease |
| AU2015359376B2 (en) | 2014-12-12 | 2021-09-09 | Sanofi-Aventis Deutschland Gmbh | Insulin glargine/lixisenatide fixed ratio formulation |
| TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患治療 |
| TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患之治療 |
| WO2016198113A1 (en) * | 2015-06-11 | 2016-12-15 | Alrise Biosystems Gmbh | Process for the preparation of drug loaded microparticles |
| EP4374861A3 (en) | 2015-11-16 | 2024-08-07 | MedinCell S.A. | A method for morselizing and/or targeting pharmaceutically active principles to synovial tissue |
| JP7299625B2 (ja) * | 2017-04-05 | 2023-06-28 | カーネギー-メロン ユニバーシティ | 付加製造用サポート材 |
| EP3980784A1 (en) | 2019-06-04 | 2022-04-13 | Selecta Biosciences, Inc. | Formulations and doses of pegylated uricase |
| AU2021236234A1 (en) * | 2020-03-11 | 2022-10-06 | Selecta Biosciences, Inc. | Methods and compositions related to synthetic nanocarriers |
| KR20240167410A (ko) | 2023-05-19 | 2024-11-26 | 주식회사 아울바이오 | 티르제파타이드를 포함하는 미립구, 이의 제조방법, 및 이를 포함하는 약학적 조성물 |
| EP4721726A1 (en) | 2023-06-02 | 2026-04-08 | Aulbio Co., Ltd. | Pharmaceutical composition comprising glp-1 receptor agonist, gip/glp-1 receptor agonist and/or glp-1/gip/gcg receptor triple agonist |
Family Cites Families (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL280825A (no) | 1962-07-11 | |||
| BE744162A (fr) | 1969-01-16 | 1970-06-15 | Fuji Photo Film Co Ltd | Procede d'encapsulage |
| DE2010115A1 (de) | 1970-03-04 | 1971-09-16 | Farbenfabriken Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von Mikrogranulaten |
| BE792550A (nl) | 1971-12-23 | 1973-06-12 | Agfa Gevaert Nv | Procede voor het vervaardigen van microcapsules |
| JPS528795B2 (no) | 1971-12-30 | 1977-03-11 | ||
| JPS523342B2 (no) | 1972-01-26 | 1977-01-27 | ||
| GB1413186A (en) | 1973-06-27 | 1975-11-12 | Toyo Jozo Kk | Process for encapsulation of medicaments |
| US4166800A (en) | 1977-08-25 | 1979-09-04 | Sandoz, Inc. | Processes for preparation of microspheres |
| US4732763A (en) | 1978-10-17 | 1988-03-22 | Stolle Research And Development Corporation | Active/passive immunization of the internal female reproductive organs |
| US4384975A (en) | 1980-06-13 | 1983-05-24 | Sandoz, Inc. | Process for preparation of microspheres |
| US4389330A (en) | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
| US4675189A (en) | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
| US5366734A (en) | 1981-02-16 | 1994-11-22 | Zeneca Limited | Continuous release pharmaceutical compositions |
| CH661206A5 (fr) | 1983-09-23 | 1987-07-15 | Debiopharm Sa | Procede pour la preparation d'un medicament destine au traitement de maladies hormonodependantes. |
| JPS60100516A (ja) | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
| US4568559A (en) | 1984-02-06 | 1986-02-04 | Biotek, Inc. | Composite core coated microparticles and process of preparing same |
| EP0190833B1 (en) | 1985-02-07 | 1991-03-27 | Takeda Chemical Industries, Ltd. | Method for producing microcapsule |
| JP2551756B2 (ja) | 1985-05-07 | 1996-11-06 | 武田薬品工業株式会社 | ポリオキシカルボン酸エステルおよびその製造法 |
| US4962091A (en) | 1986-05-23 | 1990-10-09 | Syntex (U.S.A.) Inc. | Controlled release of macromolecular polypeptides |
| PT85521B (pt) | 1986-08-11 | 1990-06-29 | Innovata Biomed Ltd | Processo para a preparacao de composicoes farmaceuticas que consistem em microcapsulas |
| IL84167A (en) * | 1986-10-24 | 1991-04-15 | Southern Res Inst | Oral delivery of bioactive agents to and through the peyer's patch by use of microencapsulation |
| JPS63122620A (ja) | 1986-11-12 | 1988-05-26 | Sanraku Inc | ポリ乳酸マイクロスフエア及びその製造方法 |
| US5690954A (en) | 1987-05-22 | 1997-11-25 | Danbiosyst Uk Limited | Enhanced uptake drug delivery system having microspheres containing an active drug and a bioavailability improving material |
| US4897268A (en) | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
| DE3738228A1 (de) | 1987-11-11 | 1989-05-24 | Hoechst Ag | Verfahren zur herstellung von bioabbaubaren mikrokapseln wasserloeslicher peptide und proteine sowie nach diesem verfahren erhaltene mikrokapseln |
| JP2670680B2 (ja) | 1988-02-24 | 1997-10-29 | 株式会社ビーエムジー | 生理活性物質含有ポリ乳酸系微小球およびその製造法 |
| US4902515A (en) | 1988-04-28 | 1990-02-20 | E. I. Dupont De Nemours And Company | Polylactide compositions |
| ATE102134T1 (de) | 1989-02-16 | 1994-03-15 | Sig Schweiz Industrieges | Vorrichtung fuer reisezugwagen mit uic-zug- und stossvorrichtungen und reisezugwagen. |
| US5019400A (en) | 1989-05-01 | 1991-05-28 | Enzytech, Inc. | Very low temperature casting of controlled release microspheres |
| HU221294B1 (en) | 1989-07-07 | 2002-09-28 | Novartis Ag | Process for producing retarde compositions containing the active ingredient in a polymeric carrier |
| US5271961A (en) | 1989-11-06 | 1993-12-21 | Alkermes Controlled Therapeutics, Inc. | Method for producing protein microspheres |
| MY107937A (en) | 1990-02-13 | 1996-06-29 | Takeda Chemical Industries Ltd | Prolonged release microcapsules. |
| JP2653255B2 (ja) | 1990-02-13 | 1997-09-17 | 武田薬品工業株式会社 | 長期徐放型マイクロカプセル |
| US5478564A (en) | 1990-02-22 | 1995-12-26 | Teva Pharmaceutical Industries, Ltd. | Preparation of microparticles for controlled release of water-soluble substances |
| US6120805A (en) | 1990-04-06 | 2000-09-19 | Rhone-Poulenc Rorer Sa | Microspheres, process for their preparation and their use |
| JP3116311B2 (ja) | 1990-06-13 | 2000-12-11 | エーザイ株式会社 | マイクロスフィアの製法 |
| ZA918168B (en) | 1990-10-16 | 1993-04-14 | Takeda Chemical Industries Ltd | Prolonged release preparation and polymers thereof. |
| IT1243390B (it) | 1990-11-22 | 1994-06-10 | Vectorpharma Int | Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione. |
| CH683149A5 (fr) | 1991-07-22 | 1994-01-31 | Debio Rech Pharma Sa | Procédé pour la préparation de microsphères en matériau polymère biodégradable. |
| GB9116610D0 (en) | 1991-08-01 | 1991-09-18 | Danbiosyst Uk | Preparation of microparticles |
| DE69220317T2 (de) | 1991-10-01 | 1997-10-16 | Takeda Chemical Industries Ltd | Mikropartikeln-Zusammenfassung zur verlängerten Freigabe und Herstellung derselbe |
| US5676968A (en) | 1991-10-31 | 1997-10-14 | Schering Aktiengesellschaft | Transdermal therapeutic systems with crystallization inhibitors |
| DE4223169C1 (de) | 1992-07-10 | 1993-11-25 | Ferring Arzneimittel Gmbh | Verfahren zur Mikroverkapselung wasserlöslicher Wirkstoffe |
| JP2651320B2 (ja) | 1992-07-16 | 1997-09-10 | 田辺製薬株式会社 | 徐放性マイクロスフェア製剤の製造方法 |
| AU4198793A (en) | 1992-07-24 | 1994-01-27 | Takeda Chemical Industries Ltd. | Microparticle preparation and production thereof |
| FR2693905B1 (fr) | 1992-07-27 | 1994-09-02 | Rhone Merieux | Procédé de préparation de microsphères pour la libération prolongée de l'hormone LHRH et ses analogues, microsphères et formulations obtenues. |
| US5661125A (en) | 1992-08-06 | 1997-08-26 | Amgen, Inc. | Stable and preserved erythropoietin compositions |
| DE69316101T2 (de) | 1992-08-07 | 1998-10-22 | Takeda Chemical Industries Ltd | Herstellung von Mikrokapseln, die wasserlösliche Arzneimittel enthalten |
| AU5171293A (en) | 1992-10-14 | 1994-05-09 | Regents Of The University Of Colorado, The | Ion-pairing of drugs for improved efficacy and delivery |
| KR100225983B1 (ko) | 1992-10-26 | 1999-10-15 | 클라우스-디터 홈메리히, 디트리히 빌헬름 샤흐트 | 마이크로캡슐의 제조 방법 |
| US5603960A (en) | 1993-05-25 | 1997-02-18 | O'hagan; Derek T. | Preparation of microparticles and method of immunization |
| US5635216A (en) | 1993-12-16 | 1997-06-03 | Eli Lilly And Company | Microparticle compositions containing peptides, and methods for the preparation thereof |
| DE4330958A1 (de) * | 1993-09-09 | 1995-03-16 | Schering Ag | Neue wirkstoffhaltige Mikropartikel, diese enthaltende Mittel, deren Verwendung zur ultraschallgesteuerten Freisetzung von Wirkstoffen sowie Verfahren zu deren Herstellung |
| US5500161A (en) | 1993-09-21 | 1996-03-19 | Massachusetts Institute Of Technology And Virus Research Institute | Method for making hydrophobic polymeric microparticles |
| DE69415684T2 (de) * | 1993-10-22 | 1999-06-10 | Genentech Inc., San Francisco, Calif. | Verfahren zur herstellung von mikrospharen mit einer wirbelschichtstufe |
| US6080429A (en) | 1993-10-25 | 2000-06-27 | Genentech, Inc. | Method for drying microspheres |
| US5643605A (en) | 1993-10-25 | 1997-07-01 | Genentech, Inc. | Methods and compositions for microencapsulation of adjuvants |
| EP2283821A1 (en) * | 1993-11-19 | 2011-02-16 | Alkermes, Inc. | Preparation of biodegradable microparticles containing a biologically active agent |
| US5650173A (en) | 1993-11-19 | 1997-07-22 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of biodegradable microparticles containing a biologically active agent |
| US5902565A (en) | 1993-12-24 | 1999-05-11 | Csl Limited | Spray dried vaccine preparation comprising aluminium adsorbed immunogens |
| US5594091A (en) | 1994-02-21 | 1997-01-14 | Takeda Chemical Industries, Ltd. | Matrix for sustained-release preparation |
| DE4406172C2 (de) | 1994-02-25 | 2003-10-02 | Sanol Arznei Schwarz Gmbh | Polyester |
| GB9406094D0 (en) | 1994-03-28 | 1994-05-18 | Univ Nottingham And University | Polymer microspheres and a method of production thereof |
| FR2718642B1 (fr) | 1994-04-15 | 1996-07-12 | Pf Medicament | Microsphères biodégradables à libération contrôlée et leur procédé de préparation. |
| US5902834A (en) | 1994-05-15 | 1999-05-11 | Pharmacia Biotech Ab | Method of manufacturing particles, and particles that can be produced in accordance with the method |
| US6007845A (en) | 1994-07-22 | 1999-12-28 | Massachusetts Institute Of Technology | Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers |
| US6143211A (en) | 1995-07-21 | 2000-11-07 | Brown University Foundation | Process for preparing microparticles through phase inversion phenomena |
| JP2909418B2 (ja) | 1995-09-18 | 1999-06-23 | 株式会社資生堂 | 薬物の遅延放出型マイクロスフイア |
| DE19545257A1 (de) | 1995-11-24 | 1997-06-19 | Schering Ag | Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln |
| CA2192782C (en) | 1995-12-15 | 2008-10-14 | Nobuyuki Takechi | Production of microspheres |
| US5955143A (en) | 1995-12-21 | 1999-09-21 | Drexel University | Hollow polymer microcapsules and method of producing the same |
| US5985312A (en) | 1996-01-26 | 1999-11-16 | Brown University Research Foundation | Methods and compositions for enhancing the bioadhesive properties of polymers |
| US5611344A (en) | 1996-03-05 | 1997-03-18 | Acusphere, Inc. | Microencapsulated fluorinated gases for use as imaging agents |
| US5792477A (en) | 1996-05-07 | 1998-08-11 | Alkermes Controlled Therapeutics, Inc. Ii | Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent |
| GB2316316A (en) | 1996-08-23 | 1998-02-25 | Int Centre Genetic Eng & Bio | Sustained release of erythropoietin from microspheres |
| US5766637A (en) | 1996-10-08 | 1998-06-16 | University Of Delaware | Microencapsulation process using supercritical fluids |
| ES2221019T3 (es) | 1996-10-31 | 2004-12-16 | Takeda Chemical Industries, Ltd. | Preparacion de liberacion mantenida. |
| JP2002512597A (ja) | 1996-12-20 | 2002-04-23 | アルザ コーポレイション | 注射可能な貯留槽ゲル組成物およびこの組成物の製造方法 |
| US5783567A (en) | 1997-01-22 | 1998-07-21 | Pangaea Pharmaceuticals, Inc. | Microparticles for delivery of nucleic acid |
| US6048551A (en) | 1997-03-27 | 2000-04-11 | Hilfinger; John M. | Microsphere encapsulation of gene transfer vectors |
| US6020004A (en) | 1997-04-17 | 2000-02-01 | Amgen Inc. | Biodegradable microparticles for the sustained delivery of therapeutic drugs |
| SE512663C2 (sv) | 1997-10-23 | 2000-04-17 | Biogram Ab | Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer |
| US6197229B1 (en) | 1997-12-12 | 2001-03-06 | Massachusetts Institute Of Technology | Method for high supercoiled DNA content microspheres |
| GB9810236D0 (en) | 1998-05-13 | 1998-07-08 | Microbiological Res Authority | Improvements relating to encapsulation of bioactive agents |
| KR19990085365A (ko) | 1998-05-16 | 1999-12-06 | 허영섭 | 지속적으로 약물 조절방출이 가능한 생분해성 고분자 미립구 및그 제조방법 |
| WO2000004916A1 (en) | 1998-07-23 | 2000-02-03 | Societe De Conseils De Recherches Et D'applications Scientifiques Sas | Encapsulation of water soluble peptides |
| US6291013B1 (en) | 1999-05-03 | 2001-09-18 | Southern Biosystems, Inc. | Emulsion-based processes for making microparticles |
| US7582311B1 (en) | 1999-10-15 | 2009-09-01 | Genentech, Inc. | Injection vehicle for polymer-based formulations |
-
1995
- 1995-11-24 DE DE19545257A patent/DE19545257A1/de not_active Ceased
-
1996
- 1996-10-30 KR KR10-1998-0703871A patent/KR100479895B1/ko not_active Expired - Lifetime
- 1996-10-30 DE DE59607548T patent/DE59607548D1/de not_active Expired - Lifetime
- 1996-10-30 AU AU74955/96A patent/AU712351B2/en not_active Expired
- 1996-10-30 ES ES96937286T patent/ES2161379T3/es not_active Expired - Lifetime
- 1996-10-30 DK DK96937286T patent/DK0862418T3/da active
- 1996-10-30 WO PCT/EP1996/004701 patent/WO1997019676A1/de not_active Ceased
- 1996-10-30 NZ NZ321592A patent/NZ321592A/en not_active IP Right Cessation
- 1996-10-30 US US09/068,471 patent/US6294204B1/en not_active Expired - Lifetime
- 1996-10-30 AT AT96937286T patent/ATE204469T1/de active
- 1996-10-30 PT PT96937286T patent/PT862418E/pt unknown
- 1996-10-30 IL IL12437396A patent/IL124373A/xx not_active IP Right Cessation
- 1996-10-30 EP EP96937286A patent/EP0862418B1/de not_active Expired - Lifetime
- 1996-10-30 CN CNB961985461A patent/CN1193742C/zh not_active Expired - Lifetime
- 1996-10-30 JP JP9520098A patent/JP2000501084A/ja not_active Withdrawn
- 1996-10-30 HU HU9903334A patent/HU223975B1/hu active IP Right Grant
-
1998
- 1998-05-25 NO NO19982364A patent/NO320493B1/no not_active IP Right Cessation
-
2001
- 2001-06-21 US US09/886,504 patent/US6572894B2/en not_active Expired - Lifetime
-
2008
- 2008-04-16 JP JP2008107032A patent/JP5021552B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2161379T3 (es) | 2001-12-01 |
| HK1018689A1 (en) | 1999-12-30 |
| NZ321592A (en) | 1999-10-28 |
| HUP9903334A2 (hu) | 2000-03-28 |
| US6294204B1 (en) | 2001-09-25 |
| NO320493B1 (no) | 2005-12-12 |
| WO1997019676A1 (de) | 1997-06-05 |
| PT862418E (pt) | 2001-12-28 |
| KR19990071595A (ko) | 1999-09-27 |
| EP0862418A1 (de) | 1998-09-09 |
| AU712351B2 (en) | 1999-11-04 |
| AU7495596A (en) | 1997-06-19 |
| IL124373A0 (en) | 1998-12-06 |
| ATE204469T1 (de) | 2001-09-15 |
| DK0862418T3 (da) | 2001-11-05 |
| IL124373A (en) | 2003-01-12 |
| EP0862418B1 (de) | 2001-08-22 |
| DE19545257A1 (de) | 1997-06-19 |
| HU223975B1 (hu) | 2005-03-29 |
| JP2000501084A (ja) | 2000-02-02 |
| CN1193742C (zh) | 2005-03-23 |
| JP5021552B2 (ja) | 2012-09-12 |
| US20010033868A1 (en) | 2001-10-25 |
| DE59607548D1 (de) | 2001-09-27 |
| KR100479895B1 (ko) | 2005-08-04 |
| NO982364D0 (no) | 1998-05-25 |
| CN1213963A (zh) | 1999-04-14 |
| HUP9903334A3 (en) | 2000-04-28 |
| US6572894B2 (en) | 2003-06-03 |
| JP2008273964A (ja) | 2008-11-13 |
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