DK0617028T3 - Enantiomerer af 1-[(4-chlorphenyl)phenylmethyl]-4(4-methylphenyl)sulfonyl]piperazin - Google Patents

Enantiomerer af 1-[(4-chlorphenyl)phenylmethyl]-4(4-methylphenyl)sulfonyl]piperazin

Info

Publication number: DK0617028T3
Authority: DK; Denmark
Prior art keywords: chlorophenyl; ethyl; methylphenyl; enantiomers; phenylmethyl
Prior art date: 1993-03-15

Application number

DK94870043T

Other languages

English (en)

Inventor

Eric Cossement

Jean Gobert

Guy Bodson

Original Assignee

Ucb Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-03-15

Filing date

1994-03-09

Publication date

2000-09-04

1994-03-09 Application filed by Ucb Sa filed Critical Ucb Sa

2000-09-04 Application granted granted Critical

2000-09-04 Publication of DK0617028T3 publication Critical patent/DK0617028T3/da

Links

HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title abstract 3
GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 title 1
125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 title 1
125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 title 1
-1 (3-methylphenyl)methyl Chemical group 0.000 abstract 7
HIKIBGRLBOCOAZ-UHFFFAOYSA-N 1-[[1-(4-chlorophenyl)cyclohexa-2,4-dien-1-yl]methyl]piperazine Chemical class C1=CC(Cl)=CC=C1C1(CN2CCNCC2)C=CC=CC1 HIKIBGRLBOCOAZ-UHFFFAOYSA-N 0.000 abstract 2
206010020751 Hypersensitivity Diseases 0.000 abstract 2
230000007815 allergy Effects 0.000 abstract 2
229940079593 drug Drugs 0.000 abstract 2
239000003814 drug Substances 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Anesthesiology (AREA)
Immunology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)

DK94870043T 1993-03-15 1994-03-09 Enantiomerer af 1-[(4-chlorphenyl)phenylmethyl]-4(4-methylphenyl)sulfonyl]piperazin DK0617028T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB939305282A GB9305282D0 (en)	1993-03-15	1993-03-15	Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine

Publications (1)

Publication Number	Publication Date
DK0617028T3 true DK0617028T3 (da)	2000-09-04

Family

ID=10732080

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94870043T DK0617028T3 (da)	1993-03-15	1994-03-09	Enantiomerer af 1-[(4-chlorphenyl)phenylmethyl]-4(4-methylphenyl)sulfonyl]piperazin

Country Status (23)

Country	Link
US (17)	US5478941A (da)
EP (3)	EP1413307A1 (da)
JP (3)	JP3267434B2 (da)
KR (1)	KR100322415B1 (da)
AT (2)	ATE193889T1 (da)
AU (1)	AU678426B2 (da)
CA (2)	CA2443216C (da)
DE (2)	DE69433802T2 (da)
DK (1)	DK0617028T3 (da)
ES (2)	ES2221262T3 (da)
FI (3)	FI105477B (da)
GB (1)	GB9305282D0 (da)
GR (1)	GR3034340T3 (da)
HU (1)	HU219230B (da)
NO (2)	NO305908B1 (da)
NZ (1)	NZ260062A (da)
PL (1)	PL178546B1 (da)
PT (1)	PT617028E (da)
RU (1)	RU2118320C1 (da)
SG (1)	SG43683A1 (da)
SI (2)	SI0955295T1 (da)
TW (1)	TW237452B (da)
ZA (1)	ZA941724B (da)

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ES2326689T3 (es) *	2005-03-03	2009-10-16	Ucb Farchim, S.A.	Sales de piroglutamato y su uso en la resolucion optica de intermedios para la sintesis de dextrocetirizana y levocetirizana.
HU227074B1 (en) *	2005-12-08	2010-06-28	Egis Gyogyszergyar Nyrt	An optically active carbamic acid derivative, method for producing the same and use as a pharmaceutical intermediate
WO2008110586A2 (en)	2007-03-12	2008-09-18	Krka, Tovarna Zdravil, D.D., Novo Mesto	New process for the preparation of levocetirizine and intermediates thereof
EP2167479B1 (en)	2007-06-15	2013-09-11	Symed Labs Limited	Process for preparation of substantially optically pure levorotatory and dextrorotatory enantiomers of cetirizine using novel intermediates
US20090062305A1 (en) *	2007-08-29	2009-03-05	Protia, Llc	Deuterium-enriched cetirizine
US20090082364A1 (en) *	2007-09-26	2009-03-26	Protia, Llc	Deuterium-enriched levocedtirizine
KR101427100B1 (ko)	2007-10-23	2014-08-08	주식회사 씨트리	광학활성을 갖는 1-[(4-클로로페닐)페닐메틸]-피페라진의제조방법
US7989623B2 (en) *	2007-11-21	2011-08-02	Synthon Bv	Process for making n-(diphenylmethyl)piperazines
ES2361343T3 (es)	2007-11-21	2011-06-16	Synthon B.V.	Procedimiento para obtener n-(difenilmetil)piperazinas.
KR100954755B1 (ko) *	2007-12-17	2010-04-27	한미약품 주식회사	(ｒ)-(-)-1-[(4-클로로페닐)페닐메틸]피페라진의 제조방법
KR20110022635A (ko) *	2008-06-02	2011-03-07	시플라 리미티드	레보세티리진의 합성방법 및 이에 사용하기 위한 중간체
KR100998067B1 (ko)	2008-09-08	2010-12-03	주식회사 삼오제약	비스(1-[(4-클로로페닐)페닐메틸]피페라진)-2,3-디벤조일 타르타르산 신규 중간체 염 및 이를 이용한 광학 활성적으로 순수한 1-[(4-클로로페닐)페닐메틸]피페라진을 분리하는 분리방법
US20100145049A1 (en) *	2008-11-21	2010-06-10	Jie Zhu	Process for making n-(diphenylmethyl)piperazines
RU2539591C2 (ru) *	2009-04-22	2015-01-20	Аксикин Фармасьютикалз, Инк.	Антагонисты арилсульфонамида ccr3
CN101928223A (zh) *	2009-06-26	2010-12-29	华东理工大学	一种(r)-(-)-4-氯二苯甲胺的拆分方法
WO2012101475A1 (en)	2011-01-27	2012-08-02	Jubilant Life Sciences Limited	An improved process for the preparation of antihistaminic drugs via a novel carbamate intermediate
KR101418404B1 (ko)	2012-01-06	2014-07-10	한미약품 주식회사	레보세티리진 또는 이의 약학적으로 허용가능한 염 및 몬테루카스트 또는 이의 약학적으로 허용가능한 염을 함유하는 안정한 경구투여용 약학 제제
WO2013158318A1 (en)	2012-04-16	2013-10-24	Zemtsov Enterprises, Llc	Formulations and methods for treatment of acne and inflammatory skin conditions
CN103613567A (zh) *	2012-11-09	2014-03-05	焦作福瑞堂制药有限公司	盐酸氯环利嗪的合成工艺
KR102226833B1 (ko)	2013-06-28	2021-03-12	한미약품 주식회사	레보세티리진 및 몬테루카스트를 포함하는 안정성이 개선된 복합 과립 제형
CN104045607B (zh) *	2014-05-21	2016-04-13	丽珠医药集团股份有限公司	一种盐酸西替利嗪的纯化方法
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1993
- 1993-03-15 GB GB939305282A patent/GB9305282D0/en active Pending
1994
- 1994-03-08 US US08/207,096 patent/US5478941A/en not_active Expired - Lifetime
- 1994-03-08 TW TW083102003A patent/TW237452B/zh active
- 1994-03-09 EP EP04002438A patent/EP1413307A1/fr not_active Withdrawn
- 1994-03-09 EP EP99109564A patent/EP0955295B1/fr not_active Expired - Lifetime
- 1994-03-09 DE DE69433802T patent/DE69433802T2/de not_active Expired - Fee Related
- 1994-03-09 SI SI9430468T patent/SI0955295T1/xx unknown
- 1994-03-09 AT AT94870043T patent/ATE193889T1/de not_active IP Right Cessation
- 1994-03-09 PT PT94870043T patent/PT617028E/pt unknown
- 1994-03-09 DK DK94870043T patent/DK0617028T3/da active
- 1994-03-09 SG SG1995002010A patent/SG43683A1/en unknown
- 1994-03-09 DE DE69424893T patent/DE69424893T2/de not_active Expired - Fee Related
- 1994-03-09 ES ES99109564T patent/ES2221262T3/es not_active Expired - Lifetime
- 1994-03-09 ES ES94870043T patent/ES2147569T3/es not_active Expired - Lifetime
- 1994-03-09 SI SI9430329T patent/SI0617028T1/xx unknown
- 1994-03-09 EP EP94870043A patent/EP0617028B1/fr not_active Expired - Lifetime
- 1994-03-09 AT AT99109564T patent/ATE267185T1/de not_active IP Right Cessation
- 1994-03-10 FI FI941134A patent/FI105477B/fi active
- 1994-03-10 NZ NZ260062A patent/NZ260062A/en not_active IP Right Cessation
- 1994-03-11 PL PL94302565A patent/PL178546B1/pl not_active IP Right Cessation
- 1994-03-11 HU HU9400727A patent/HU219230B/hu not_active IP Right Cessation
- 1994-03-11 NO NO940881A patent/NO305908B1/no not_active IP Right Cessation
- 1994-03-11 AU AU57771/94A patent/AU678426B2/en not_active Ceased
- 1994-03-11 CA CA002443216A patent/CA2443216C/en not_active Expired - Fee Related
- 1994-03-11 CA CA002118859A patent/CA2118859C/en not_active Expired - Fee Related
- 1994-03-11 ZA ZA941724A patent/ZA941724B/xx unknown
- 1994-03-14 KR KR1019940005172A patent/KR100322415B1/ko not_active Expired - Fee Related
- 1994-03-14 JP JP04254794A patent/JP3267434B2/ja not_active Expired - Fee Related
- 1994-03-14 RU RU94008618A patent/RU2118320C1/ru active
1995
- 1995-06-05 US US08/460,844 patent/US5703082A/en not_active Expired - Fee Related
1997
- 1997-10-09 US US08/947,859 patent/US5792770A/en not_active Expired - Fee Related
1999
- 1999-01-26 NO NO990351A patent/NO306616B1/no not_active IP Right Cessation
- 1999-07-19 US US09/356,865 patent/US6436942B1/en not_active Expired - Fee Related
- 1999-08-16 FI FI991729A patent/FI105914B/fi active
- 1999-08-16 FI FI991730A patent/FI105915B/fi active
2000
- 2000-09-06 GR GR20000402028T patent/GR3034340T3/el not_active IP Right Cessation
2001
- 2001-11-22 JP JP2001356849A patent/JP3880842B2/ja not_active Expired - Fee Related
2002
- 2002-05-10 US US10/141,933 patent/US20030105112A1/en not_active Abandoned
- 2002-06-06 US US10/162,576 patent/US20030105113A1/en not_active Abandoned
2003
- 2003-03-12 US US10/385,522 patent/US20030204089A1/en not_active Abandoned
- 2003-10-07 US US10/679,376 patent/US20040072845A1/en not_active Abandoned
- 2003-12-02 US US10/724,640 patent/US20040122021A1/en not_active Abandoned
- 2003-12-02 US US10/724,611 patent/US20040122023A1/en not_active Abandoned
2005
- 2005-04-15 US US11/106,456 patent/US20050182070A1/en not_active Abandoned
- 2005-04-15 US US11/106,613 patent/US20050176732A1/en not_active Abandoned
- 2005-04-15 US US11/106,528 patent/US20050182069A1/en not_active Abandoned
2006
- 2006-06-16 US US11/453,987 patent/US20060229319A1/en not_active Abandoned
- 2006-06-16 US US11/453,986 patent/US20060229320A1/en not_active Abandoned
- 2006-07-17 US US11/487,331 patent/US20060252934A1/en not_active Abandoned
- 2006-09-29 JP JP2006266195A patent/JP2006342190A/ja not_active Abandoned
2007
- 2007-01-11 US US11/652,092 patent/US20070142400A1/en not_active Abandoned

Also Published As

Publication number	Publication date
GB9305282D0 (en)	1993-05-05
NO306616B1 (no)	1999-11-29
EP0955295A1 (fr)	1999-11-10
HU219230B (en)	2001-03-28
US5703082A (en)	1997-12-30
RU2118320C1 (ru)	1998-08-27
FI941134L (fi)	1994-09-16
US20060229320A1 (en)	2006-10-12
US20050176732A1 (en)	2005-08-11
CA2443216A1 (en)	1994-09-16
FI19991729L (fi)	1999-08-16
US20030105112A1 (en)	2003-06-05
US5792770A (en)	1998-08-11
TW237452B (da)	1995-01-01
SI0617028T1 (en)	2000-10-31
HUT70959A (en)	1995-11-28
NO940881L (no)	1994-09-16
US20040122023A1 (en)	2004-06-24
JP2006342190A (ja)	2006-12-21
ES2221262T3 (es)	2004-12-16
GR3034340T3 (en)	2000-12-29
SG43683A1 (en)	1997-11-14
HU9400727D0 (en)	1994-06-28
FI941134A0 (fi)	1994-03-10
ZA941724B (en)	1994-10-13
JP3267434B2 (ja)	2002-03-18
ATE267185T1 (de)	2004-06-15
PL178546B1 (pl)	2000-05-31
DE69424893D1 (de)	2000-07-20
FI105915B (fi)	2000-10-31
FI105477B (fi)	2000-08-31
KR100322415B1 (ko)	2002-06-20
SI0955295T1 (en)	2004-10-31
NO940881D0 (no)	1994-03-11
US20070142400A1 (en)	2007-06-21
EP0617028A1 (fr)	1994-09-28
US20060229319A1 (en)	2006-10-12
US20040122021A1 (en)	2004-06-24
US20030204089A1 (en)	2003-10-30
NZ260062A (en)	1995-09-26
EP0955295B1 (fr)	2004-05-19
CA2443216C (en)	2007-05-08
US20050182069A1 (en)	2005-08-18
US6436942B1 (en)	2002-08-20
US5478941A (en)	1995-12-26
CA2118859A1 (en)	1994-09-16
EP1413307A1 (fr)	2004-04-28
FI19991730L (fi)	1999-08-16
ES2147569T3 (es)	2000-09-16
AU5777194A (en)	1994-09-22
NO990351L (no)	1999-01-26
FI105914B (fi)	2000-10-31
JPH072816A (ja)	1995-01-06
US20040072845A1 (en)	2004-04-15
NO305908B1 (no)	1999-08-16
DE69433802D1 (de)	2004-06-24
HK1024232A1 (en)	2000-10-05
JP3880842B2 (ja)	2007-02-14
NO990351D0 (no)	1999-01-26
US20060252934A1 (en)	2006-11-09
US20030105113A1 (en)	2003-06-05
CA2118859C (en)	2004-07-13
EP0617028B1 (fr)	2000-06-14
JP2002201187A (ja)	2002-07-16
AU678426B2 (en)	1997-05-29
ATE193889T1 (de)	2000-06-15
DE69433802T2 (de)	2005-05-12
DE69424893T2 (de)	2000-10-12
US20050182070A1 (en)	2005-08-18
PT617028E (pt)	2000-11-30

Publication	Publication Date	Title
DK0617028T3 (da)	2000-09-04	Enantiomerer af 1-[(4-chlorphenyl)phenylmethyl]-4(4-methylphenyl)sulfonyl]piperazin
FI913142A0 (fi)	1991-06-27	Migraenfoerhindrande alkoxipyrimidinderivat.
GR1000553B (el)	1992-08-26	Μεθοδος παρασκευης του 2-(2-(4-((4-χλωριοφαινυλ)φαινυλμεθυλ)-1-πιπεραζινυλ)αιθοξυ) οξικου οξεος και του διυδροχλωρικου αλατιου του.
DE69317537D1 (de)	1998-04-23	Antiallergische Zusammensetzung zur ophthalmischen oder nasalen Anwendung
NO933093D0 (no)	1993-08-31	Monohydrat av 5-(2-(4-(1,2-benzisotiazol-3-yl)-1-piperazinyl)-etyl)-6-klor-1,3-dihydro-2h-indol-2-on hydroklorid
FR2613720B1 (fr)	1990-01-19	Derives d'aryl-heteroaryl carbinols avec activite analgesique
ATE337008T1 (de)	2006-09-15	Verwendung von 1- 4-(5-cyanoindol-3-yl)butyl -4- (2-carbamoylbenzofuran-5-yl)piperazin und deren physiologisch akzeptablen salzen
NZ237309A (en)	1993-02-25	1-(2-(4-morpholino)ethyl)-3-(arylcarbonyl)-indole derivatives and pharmaceutical compositions
DK586589A (da)	1990-05-24	Fremgangsmaade til fremstilling af 2-(2-(4-((4-chlorphenyl)phenylmethyl)-1-piperazinyl)ethoxy)eddikesyre og dens dihydrochlorid
ATE87919T1 (de)	1993-04-15	Mittel gegen angst.
BE902847A (fr)	1986-01-10	Nouvelles isoindolinylalcoylpiperazines
MX9205186A (es)	1993-03-01	Derivados de 4-[4-[4-(4-hidroxifenil)-1-piperazinil]-fenil]-5-metil-3h-1,2,4-triazo l-3-ona
SE8601883L (sv)	1986-10-25	Bensisotiazol-s-oxid med antipsykotisk verkan
ATE341329T1 (de)	2006-10-15	Arzneimittel zur behandlung von neuropathien
FI870925A7 (fi)	1987-09-06	4-(2-pyrimidinyyli)-1-piperatsinyyli-heterosyklisiä karbonyylijohdannaisia
ATE92063T1 (de)	1993-08-15	Verbrueckte bicyclische 4-(4-(3-benzisothiazolyl)1-piperazinyl)-butylimide mit antipsychotischer wirkung.
DE60111044D1 (de)	2005-06-30	Verwendung von aminen