NO990351L - FremgangsmÕte for fremstilling av den venstredreiende og h°yredreiende enantiomer av et 1-[(4-klorfenyl)fenylmetyl]-piperazin - Google Patents

FremgangsmÕte for fremstilling av den venstredreiende og h°yredreiende enantiomer av et 1-[(4-klorfenyl)fenylmetyl]-piperazin

Info

Publication number: NO990351L
Authority: NO; Norway
Prior art keywords: turn; chlorophenyl; ethyl; phenylmethyl; piperazine
Prior art date: 1993-03-15

Application number

NO990351A

Other languages

English (en)

Other versions

NO306616B1 (no

NO990351D0 (no

Inventor

Eric Cossement

Guy Bodson

Jean Gobert

Original Assignee

Ucb Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-03-15

Filing date

1999-01-26

Publication date

1999-01-26

1999-01-26 Application filed by Ucb Sa filed Critical Ucb Sa

1999-01-26 Publication of NO990351D0 publication Critical patent/NO990351D0/no

1999-01-26 Publication of NO990351L publication Critical patent/NO990351L/no

1999-11-29 Publication of NO306616B1 publication Critical patent/NO306616B1/no

Links

UZKBSZSTDQSMDR-UHFFFAOYSA-N 1-[(4-chlorophenyl)-phenylmethyl]piperazine Chemical compound C1=CC(Cl)=CC=C1C(C=1C=CC=CC=1)N1CCNCC1 UZKBSZSTDQSMDR-UHFFFAOYSA-N 0.000 title 1
-1 (3-methylphenyl)methyl Chemical group 0.000 abstract 7
HIKIBGRLBOCOAZ-UHFFFAOYSA-N 1-[[1-(4-chlorophenyl)cyclohexa-2,4-dien-1-yl]methyl]piperazine Chemical class C1=CC(Cl)=CC=C1C1(CN2CCNCC2)C=CC=CC1 HIKIBGRLBOCOAZ-UHFFFAOYSA-N 0.000 abstract 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 2
206010020751 Hypersensitivity Diseases 0.000 abstract 2
230000007815 allergy Effects 0.000 abstract 2
229940079593 drug Drugs 0.000 abstract 2
239000003814 drug Substances 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Epidemiology (AREA)
Immunology (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)

NO990351A 1993-03-15 1999-01-26 Fremgangsmåte for fremstilling av den venstredreiende og höyredreiende enantiomer av et 1-[(4-klorfenyl)fenylmetyl]-piperazin NO306616B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB939305282A GB9305282D0 (en)	1993-03-15	1993-03-15	Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine

Publications (3)

Publication Number	Publication Date
NO990351D0 NO990351D0 (no)	1999-01-26
NO990351L true NO990351L (no)	1999-01-26
NO306616B1 NO306616B1 (no)	1999-11-29

Family

ID=10732080

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO940881A NO305908B1 (no)	1993-03-15	1994-03-11	Enantiomerer av 1-[(4-klorfenyl)fenylmethyl]-4-[(4-methylfenyl)sulfonyl]piperazin og fremgangsmåte for fremstilling av disse
NO990351A NO306616B1 (no)	1993-03-15	1999-01-26	Fremgangsmåte for fremstilling av den venstredreiende og höyredreiende enantiomer av et 1-[(4-klorfenyl)fenylmetyl]-piperazin

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
NO940881A NO305908B1 (no)	1993-03-15	1994-03-11	Enantiomerer av 1-[(4-klorfenyl)fenylmethyl]-4-[(4-methylfenyl)sulfonyl]piperazin og fremgangsmåte for fremstilling av disse

Country Status (23)

Country	Link
US (17)	US5478941A (no)
EP (3)	EP0955295B1 (no)
JP (3)	JP3267434B2 (no)
KR (1)	KR100322415B1 (no)
AT (2)	ATE267185T1 (no)
AU (1)	AU678426B2 (no)
CA (2)	CA2118859C (no)
DE (2)	DE69424893T2 (no)
DK (1)	DK0617028T3 (no)
ES (2)	ES2147569T3 (no)
FI (3)	FI105477B (no)
GB (1)	GB9305282D0 (no)
GR (1)	GR3034340T3 (no)
HU (1)	HU219230B (no)
NO (2)	NO305908B1 (no)
NZ (1)	NZ260062A (no)
PL (1)	PL178546B1 (no)
PT (1)	PT617028E (no)
RU (1)	RU2118320C1 (no)
SG (1)	SG43683A1 (no)
SI (2)	SI0617028T1 (no)
TW (1)	TW237452B (no)
ZA (1)	ZA941724B (no)

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HU227074B1 (en) *	2005-12-08	2010-06-28	Egis Gyogyszergyar Nyrt	An optically active carbamic acid derivative, method for producing the same and use as a pharmaceutical intermediate
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KR101427100B1 (ko)	2007-10-23	2014-08-08	주식회사 씨트리	광학활성을 갖는 1-[(4-클로로페닐)페닐메틸]-피페라진의제조방법
US7989623B2 (en) *	2007-11-21	2011-08-02	Synthon Bv	Process for making n-(diphenylmethyl)piperazines
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KR100954755B1 (ko) *	2007-12-17	2010-04-27	한미약품 주식회사	(ｒ)-(-)-1-[(4-클로로페닐)페닐메틸]피페라진의 제조방법
AU2009254959B2 (en) *	2008-06-02	2014-01-30	Cipla Limited	Processes for the synthesis of levocetirizine and intermediates for use therein
KR100998067B1 (ko)	2008-09-08	2010-12-03	주식회사 삼오제약	비스(1-[(4-클로로페닐)페닐메틸]피페라진)-2,3-디벤조일 타르타르산 신규 중간체 염 및 이를 이용한 광학 활성적으로 순수한 1-[(4-클로로페닐)페닐메틸]피페라진을 분리하는 분리방법
US20100145049A1 (en) *	2008-11-21	2010-06-10	Jie Zhu	Process for making n-(diphenylmethyl)piperazines
AR076363A1 (es) *	2009-04-22	2011-06-08	Axikin Pharmaceuticals Inc	Antagonistas de ccr3 de arilsulfonamida
CN101928223A (zh) *	2009-06-26	2010-12-29	华东理工大学	一种(r)-(-)-4-氯二苯甲胺的拆分方法
WO2012101475A1 (en)	2011-01-27	2012-08-02	Jubilant Life Sciences Limited	An improved process for the preparation of antihistaminic drugs via a novel carbamate intermediate
KR101418404B1 (ko)	2012-01-06	2014-07-10	한미약품 주식회사	레보세티리진 또는 이의 약학적으로 허용가능한 염 및 몬테루카스트 또는 이의 약학적으로 허용가능한 염을 함유하는 안정한 경구투여용 약학 제제
WO2013158318A1 (en)	2012-04-16	2013-10-24	Zemtsov Enterprises, Llc	Formulations and methods for treatment of acne and inflammatory skin conditions
CN103613567A (zh) *	2012-11-09	2014-03-05	焦作福瑞堂制药有限公司	盐酸氯环利嗪的合成工艺
KR102226833B1 (ko)	2013-06-28	2021-03-12	한미약품 주식회사	레보세티리진 및 몬테루카스트를 포함하는 안정성이 개선된 복합 과립 제형
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1993
- 1993-03-15 GB GB939305282A patent/GB9305282D0/en active Pending
1994
- 1994-03-08 US US08/207,096 patent/US5478941A/en not_active Expired - Lifetime
- 1994-03-08 TW TW083102003A patent/TW237452B/zh active
- 1994-03-09 DK DK94870043T patent/DK0617028T3/da active
- 1994-03-09 PT PT94870043T patent/PT617028E/pt unknown
- 1994-03-09 EP EP99109564A patent/EP0955295B1/fr not_active Expired - Lifetime
- 1994-03-09 DE DE69424893T patent/DE69424893T2/de not_active Expired - Fee Related
- 1994-03-09 SI SI9430329T patent/SI0617028T1/xx unknown
- 1994-03-09 AT AT99109564T patent/ATE267185T1/de not_active IP Right Cessation
- 1994-03-09 AT AT94870043T patent/ATE193889T1/de not_active IP Right Cessation
- 1994-03-09 ES ES94870043T patent/ES2147569T3/es not_active Expired - Lifetime
- 1994-03-09 EP EP04002438A patent/EP1413307A1/fr not_active Withdrawn
- 1994-03-09 EP EP94870043A patent/EP0617028B1/fr not_active Expired - Lifetime
- 1994-03-09 SG SG1995002010A patent/SG43683A1/en unknown
- 1994-03-09 ES ES99109564T patent/ES2221262T3/es not_active Expired - Lifetime
- 1994-03-09 SI SI9430468T patent/SI0955295T1/xx unknown
- 1994-03-09 DE DE69433802T patent/DE69433802T2/de not_active Expired - Fee Related
- 1994-03-10 FI FI941134A patent/FI105477B/fi active
- 1994-03-10 NZ NZ260062A patent/NZ260062A/en not_active IP Right Cessation
- 1994-03-11 PL PL94302565A patent/PL178546B1/pl not_active IP Right Cessation
- 1994-03-11 NO NO940881A patent/NO305908B1/no not_active IP Right Cessation
- 1994-03-11 HU HU9400727A patent/HU219230B/hu not_active IP Right Cessation
- 1994-03-11 AU AU57771/94A patent/AU678426B2/en not_active Ceased
- 1994-03-11 CA CA002118859A patent/CA2118859C/en not_active Expired - Fee Related
- 1994-03-11 ZA ZA941724A patent/ZA941724B/xx unknown
- 1994-03-11 CA CA002443216A patent/CA2443216C/en not_active Expired - Fee Related
- 1994-03-14 JP JP04254794A patent/JP3267434B2/ja not_active Expired - Fee Related
- 1994-03-14 RU RU94008618A patent/RU2118320C1/ru active
- 1994-03-14 KR KR1019940005172A patent/KR100322415B1/ko not_active Expired - Fee Related
1995
- 1995-06-05 US US08/460,844 patent/US5703082A/en not_active Expired - Fee Related
1997
- 1997-10-09 US US08/947,859 patent/US5792770A/en not_active Expired - Fee Related
1999
- 1999-01-26 NO NO990351A patent/NO306616B1/no not_active IP Right Cessation
- 1999-07-19 US US09/356,865 patent/US6436942B1/en not_active Expired - Fee Related
- 1999-08-16 FI FI991729A patent/FI105914B/fi active
- 1999-08-16 FI FI991730A patent/FI105915B/fi active
2000
- 2000-09-06 GR GR20000402028T patent/GR3034340T3/el not_active IP Right Cessation
2001
- 2001-11-22 JP JP2001356849A patent/JP3880842B2/ja not_active Expired - Fee Related
2002
- 2002-05-10 US US10/141,933 patent/US20030105112A1/en not_active Abandoned
- 2002-06-06 US US10/162,576 patent/US20030105113A1/en not_active Abandoned
2003
- 2003-03-12 US US10/385,522 patent/US20030204089A1/en not_active Abandoned
- 2003-10-07 US US10/679,376 patent/US20040072845A1/en not_active Abandoned
- 2003-12-02 US US10/724,640 patent/US20040122021A1/en not_active Abandoned
- 2003-12-02 US US10/724,611 patent/US20040122023A1/en not_active Abandoned
2005
- 2005-04-15 US US11/106,528 patent/US20050182069A1/en not_active Abandoned
- 2005-04-15 US US11/106,613 patent/US20050176732A1/en not_active Abandoned
- 2005-04-15 US US11/106,456 patent/US20050182070A1/en not_active Abandoned
2006
- 2006-06-16 US US11/453,987 patent/US20060229319A1/en not_active Abandoned
- 2006-06-16 US US11/453,986 patent/US20060229320A1/en not_active Abandoned
- 2006-07-17 US US11/487,331 patent/US20060252934A1/en not_active Abandoned
- 2006-09-29 JP JP2006266195A patent/JP2006342190A/ja not_active Abandoned
2007
- 2007-01-11 US US11/652,092 patent/US20070142400A1/en not_active Abandoned

Also Published As

Publication number	Publication date
ES2147569T3 (es)	2000-09-16
US20060229319A1 (en)	2006-10-12
HU9400727D0 (en)	1994-06-28
NO306616B1 (no)	1999-11-29
HK1024232A1 (en)	2000-10-05
JP2006342190A (ja)	2006-12-21
FI941134A0 (fi)	1994-03-10
FI105914B (fi)	2000-10-31
NO305908B1 (no)	1999-08-16
GR3034340T3 (en)	2000-12-29
CA2118859A1 (en)	1994-09-16
HU219230B (en)	2001-03-28
SI0617028T1 (en)	2000-10-31
US20040122023A1 (en)	2004-06-24
US20070142400A1 (en)	2007-06-21
ATE193889T1 (de)	2000-06-15
US20050176732A1 (en)	2005-08-11
US20060229320A1 (en)	2006-10-12
FI941134L (fi)	1994-09-16
RU2118320C1 (ru)	1998-08-27
US20050182069A1 (en)	2005-08-18
GB9305282D0 (en)	1993-05-05
PT617028E (pt)	2000-11-30
NO990351D0 (no)	1999-01-26
TW237452B (no)	1995-01-01
EP1413307A1 (fr)	2004-04-28
US20040122021A1 (en)	2004-06-24
HUT70959A (en)	1995-11-28
JP3880842B2 (ja)	2007-02-14
US5792770A (en)	1998-08-11
SG43683A1 (en)	1997-11-14
DE69433802T2 (de)	2005-05-12
JP3267434B2 (ja)	2002-03-18
JP2002201187A (ja)	2002-07-16
US20060252934A1 (en)	2006-11-09
NZ260062A (en)	1995-09-26
KR100322415B1 (ko)	2002-06-20
AU678426B2 (en)	1997-05-29
US20040072845A1 (en)	2004-04-15
PL178546B1 (pl)	2000-05-31
EP0617028B1 (fr)	2000-06-14
NO940881L (no)	1994-09-16
US5478941A (en)	1995-12-26
US6436942B1 (en)	2002-08-20
AU5777194A (en)	1994-09-22
FI19991730L (fi)	1999-08-16
EP0955295B1 (fr)	2004-05-19
US5703082A (en)	1997-12-30
US20030105113A1 (en)	2003-06-05
SI0955295T1 (en)	2004-10-31
US20030204089A1 (en)	2003-10-30
ATE267185T1 (de)	2004-06-15
EP0617028A1 (fr)	1994-09-28
FI105915B (fi)	2000-10-31
US20050182070A1 (en)	2005-08-18
US20030105112A1 (en)	2003-06-05
CA2443216A1 (en)	1994-09-16
FI105477B (fi)	2000-08-31
DE69424893T2 (de)	2000-10-12
ES2221262T3 (es)	2004-12-16
CA2443216C (en)	2007-05-08
EP0955295A1 (fr)	1999-11-10
FI19991729L (fi)	1999-08-16
DE69433802D1 (de)	2004-06-24
ZA941724B (en)	1994-10-13
DE69424893D1 (de)	2000-07-20
NO940881D0 (no)	1994-03-11
CA2118859C (en)	2004-07-13
JPH072816A (ja)	1995-01-06
DK0617028T3 (da)	2000-09-04

Legal Events

Date	Code	Title	Description
2010-11-01	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO990351D0 (no)	1999-01-26	FremgangsmÕte for fremstilling av den venstredreiende og h°yredreiende enantiomer av et 1-[(4-klorfenyl)fenylmetyl]-piperazin
BR9205811A (pt)	1994-06-28	Derivados heterociclicos de aminas ciclicas
NO306994B1 (no)	2000-01-24	Heteroarylpiperidiner, pyrrolidiner og piperaziner, deres anvendelse for fremstilling av antipsykotika og analgetika samt farmasoeytiske preparater inneholdende forbindelsene
YU43794A (sh)	1997-07-31	Nova farmaceutska formulacija magnezijum omeprazola i postupak za njeno dobijanje
YU44895A (sh)	1998-07-10	Višejedinični dozni oblici u tabletama koji sadrže omeprazol i jednu njegovu alkalnu so ili jedan enantiomer omeprazola ili jednu njegovu alkalnu so
MY153718A (en)	2015-03-13	Formulation of human antibodies for treating tnf-(?) associated disorders
NO20023037D0 (no)	2002-06-21	Nye piperidin- og piperazinderivater
FI913142A0 (fi)	1991-06-27	Migraenfoerhindrande alkoxipyrimidinderivat.
UA74337C2 (uk)	2005-12-15	Застосування 1-[4-(5-ціаноіндол-3-іл)бутил]-4-(2-карбамоїлбензофуран-5-іл)-піперазину для лікування біполярних розладів та манії
ATE152448T1 (de)	1997-05-15	Heterozyklische alkylamide, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
DE60220055D1 (de)	2007-06-21	4-(4-methoxybenzyl)-n'-(5-nitro-1,3-thiazol-2-yl)harnstoff und dessen verwendung bei der behandlung von mit glycogensynthasekinase-3 (gsk3) assoziierten leiden
DK591488D0 (da)	1988-10-25	1-acyl-3-oe4-(2-pyrimidinyl)-1-piperazinylaapropan-forbindelser, deres anvendelse til fremstilling af et angstdaempende laegemiddel og farmaceutiske praeparater indeholdende disse forbindelser
NZ334571A (en)	2000-10-27	Pharmaceutical composition comprising 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy-acetic acid for treating diseases induced by respiratory syncytial virus
YU67402A (sh)	2006-01-16	Nova upotreba (r)-(-)-2-/5-(4-fluorofenil)-3- piridilmetilaminometil/-hromana i njegovih fiziološki prihvatljivih soli
DE3875543D1 (de)	1992-12-03	1-(2-(phenylmethyl)phenyl)-piperazin-verbindungen, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen.
HUP0302842A2 (hu)	2003-12-29	Az 1-[6-klór-5-(trifluor-metil)-2-piridinil]-piperazin-hidroklorid kristályalakjai, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
NO881554L (no)	1988-10-17	Analogifremgangsmaate for fremstilling av terapeutisk aktive 1-((1,1-difenyl)-1-alkenyl)piperazin-derivater og farmasoeytisk aksepterbare salter av disse derivater.
EE05178B1 (et)	2009-06-15	1,3-dioksolaanid, nende saamine ja kasutamine khavastaste ravimite valmistamiseks ning neid sisaldavad farmatseutilised kompositsioonid
ATE17120T1 (de)	1986-01-15	N-((2-oxo-1-pyrrolidinyl)acetyl)piperazine, verfahren zu ihrer herstellung sowie ihre salze und ihre verwendung in pharmazeutischen zubereitungen.
ATE306276T1 (de)	2005-10-15	Verwendung von selenithältigen wässerigen lösungen zur herstellung eines medikaments zur behandlung viraler erkrankungen und pigmentflecken