DK0619735T3 - Lyofiliseret præparat, der indeholder S(+)-4,4'-(1-methyl-1,2ethandijyl)-bis(2,6-piperazindion) - Google Patents
Lyofiliseret præparat, der indeholder S(+)-4,4'-(1-methyl-1,2ethandijyl)-bis(2,6-piperazindion)Info
- Publication number
- DK0619735T3 DK0619735T3 DK92921457T DK92921457T DK0619735T3 DK 0619735 T3 DK0619735 T3 DK 0619735T3 DK 92921457 T DK92921457 T DK 92921457T DK 92921457 T DK92921457 T DK 92921457T DK 0619735 T3 DK0619735 T3 DK 0619735T3
- Authority
- DK
- Denmark
- Prior art keywords
- ethanedijyl
- bis
- methyl
- preparation containing
- icrf
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- CYJAWBVQRMVFEO-UHFFFAOYSA-N piperazine-2,6-dione Chemical compound O=C1CNCC(=O)N1 CYJAWBVQRMVFEO-UHFFFAOYSA-N 0.000 title 1
- BMKDZUISNHGIBY-ZETCQYMHSA-N (+)-dexrazoxane Chemical compound C([C@H](C)N1CC(=O)NC(=O)C1)N1CC(=O)NC(=O)C1 BMKDZUISNHGIBY-ZETCQYMHSA-N 0.000 abstract 3
- 238000001035 drying Methods 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 230000002939 deleterious effect Effects 0.000 abstract 1
- 238000012792 lyophilization process Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919122720A GB9122720D0 (en) | 1991-10-25 | 1991-10-25 | (s)(+)-4,4'-(1-methyl-1,2-ethanediyl)-bis(2,6-piperazinedione)formulations and their preparation |
| PCT/EP1992/002400 WO1993007873A1 (en) | 1991-10-25 | 1992-10-22 | Lyophilized composition containing s(+)-4,4'-(1-methyl-1,2-ethanediyl)-bis(2,6-piperazinedione) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0619735T3 true DK0619735T3 (da) | 2000-12-04 |
Family
ID=10703550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK92921457T DK0619735T3 (da) | 1991-10-25 | 1992-10-22 | Lyofiliseret præparat, der indeholder S(+)-4,4'-(1-methyl-1,2ethandijyl)-bis(2,6-piperazindion) |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0619735B1 (da) |
| AT (1) | ATE193205T1 (da) |
| AU (1) | AU2791292A (da) |
| DE (1) | DE69231098T2 (da) |
| DK (1) | DK0619735T3 (da) |
| ES (1) | ES2145748T3 (da) |
| GB (1) | GB9122720D0 (da) |
| GR (1) | GR3034135T3 (da) |
| MX (1) | MX9206139A (da) |
| PT (1) | PT101007B (da) |
| WO (1) | WO1993007873A1 (da) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6265385B1 (en) * | 1996-01-11 | 2001-07-24 | Topo Target Aps | Topoisomerase II poison and bis-dioxopiperazine derivative combination therapy |
| ATE265215T1 (de) | 1999-03-12 | 2004-05-15 | Antianthra Aps | Dexrazoxan zur behandlung von unerwünschter extravasation von anthrazyklinen |
| WO2007062076A2 (en) * | 2005-11-23 | 2007-05-31 | Novartis Ag | Dexrazoxane formulations and methods |
| CN114306251B (zh) * | 2021-12-22 | 2023-08-11 | 乐普药业股份有限公司 | 一种含有右雷佐生的冻干制剂及其制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1234935A (en) * | 1967-07-03 | 1971-06-09 | Nat Res Dev | Piperazine derivatives |
| US4963551A (en) * | 1987-12-21 | 1990-10-16 | Erbamont Inc. | Stable lyophilized form of (S)-(+)-bis-4,4'-(1-methyl-1,2-ethanediyl)2,6-piperazinedione and solutions thereof |
-
1991
- 1991-10-25 GB GB919122720A patent/GB9122720D0/en active Pending
-
1992
- 1992-10-22 WO PCT/EP1992/002400 patent/WO1993007873A1/en not_active Ceased
- 1992-10-22 ES ES92921457T patent/ES2145748T3/es not_active Expired - Lifetime
- 1992-10-22 DE DE69231098T patent/DE69231098T2/de not_active Expired - Lifetime
- 1992-10-22 EP EP92921457A patent/EP0619735B1/en not_active Expired - Lifetime
- 1992-10-22 AT AT92921457T patent/ATE193205T1/de active
- 1992-10-22 AU AU27912/92A patent/AU2791292A/en not_active Abandoned
- 1992-10-22 DK DK92921457T patent/DK0619735T3/da active
- 1992-10-23 PT PT101007A patent/PT101007B/pt not_active IP Right Cessation
- 1992-10-23 MX MX9206139A patent/MX9206139A/es unknown
-
2000
- 2000-08-07 GR GR20000401830T patent/GR3034135T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1993007873A1 (en) | 1993-04-29 |
| GR3034135T3 (en) | 2000-11-30 |
| MX9206139A (es) | 1993-07-01 |
| EP0619735A1 (en) | 1994-10-19 |
| DE69231098D1 (de) | 2000-06-29 |
| ATE193205T1 (de) | 2000-06-15 |
| PT101007B (pt) | 1999-07-30 |
| GB9122720D0 (en) | 1991-12-11 |
| DE69231098T2 (de) | 2000-09-14 |
| AU2791292A (en) | 1993-05-21 |
| PT101007A (pt) | 1994-01-31 |
| ES2145748T3 (es) | 2000-07-16 |
| EP0619735B1 (en) | 2000-05-24 |
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