ATE148165T1 - Stabilisierung von hochgereinigten proteinen - Google Patents

Stabilisierung von hochgereinigten proteinen

Info

Publication number
ATE148165T1
ATE148165T1 AT90113210T AT90113210T ATE148165T1 AT E148165 T1 ATE148165 T1 AT E148165T1 AT 90113210 T AT90113210 T AT 90113210T AT 90113210 T AT90113210 T AT 90113210T AT E148165 T1 ATE148165 T1 AT E148165T1
Authority
AT
Austria
Prior art keywords
protein
stabilization
highly purified
purified proteins
carbohydrate
Prior art date
Application number
AT90113210T
Other languages
English (en)
Inventor
Michael H Coan
Vivian W Lee
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23517903&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE148165(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ag filed Critical Bayer Ag
Application granted granted Critical
Publication of ATE148165T1 publication Critical patent/ATE148165T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT90113210T 1989-07-24 1990-07-11 Stabilisierung von hochgereinigten proteinen ATE148165T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38458489A 1989-07-24 1989-07-24

Publications (1)

Publication Number Publication Date
ATE148165T1 true ATE148165T1 (de) 1997-02-15

Family

ID=23517903

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90113210T ATE148165T1 (de) 1989-07-24 1990-07-11 Stabilisierung von hochgereinigten proteinen

Country Status (8)

Country Link
EP (1) EP0410207B1 (de)
JP (1) JPH0358998A (de)
AT (1) ATE148165T1 (de)
CA (1) CA2021452A1 (de)
DE (1) DE69029765T2 (de)
DK (1) DK0410207T3 (de)
ES (1) ES2097120T3 (de)
GR (1) GR3022614T3 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2966592B2 (ja) * 1991-07-20 1999-10-25 萩原 義秀 安定化されたヒトモノクローナル抗体製剤
US6165467A (en) * 1991-07-20 2000-12-26 Yoshihide Hagiwara Stabilized human monoclonal antibody preparation
US6270723B1 (en) * 1998-06-15 2001-08-07 Bbi Bioseq, Inc. Rapid cryobaric sterilization and vaccine preparation
PT2193809E (pt) 1999-02-22 2015-08-24 Baxter Int Formulações de fator viii livres de albumina
CA2378742C (en) 1999-07-14 2010-06-01 Spectral Diagnostics, Inc. Preparation of spheres for diagnostic tests
WO2002038170A2 (en) 2000-11-07 2002-05-16 Chiron Corporation Stabilized inteferon compositions
US6887462B2 (en) 2001-04-09 2005-05-03 Chiron Corporation HSA-free formulations of interferon-beta
CN100494362C (zh) * 2001-08-07 2009-06-03 诺维信公司 碳水化合物和多元醇用于溶解蛋白晶体
KR20030060660A (ko) * 2002-01-10 2003-07-16 손정일 앞/뒷면 구별 없는 양면 양말
US20050276823A1 (en) * 2002-07-12 2005-12-15 Cini John K Methods and compositions for preventing oxidative degradation of proteins
CA2563877A1 (en) * 2004-04-23 2005-11-03 Novexin Limited Methods and kits for stabilising, protecting and solubilising proteins
JP2008501639A (ja) * 2004-04-23 2008-01-24 ノベシン リミテッド タンパク質を安定化、保護及び可溶化させるための方法及びキット
EP2124889A2 (de) * 2007-02-16 2009-12-02 Wyeth a Corporation of the State of Delaware Proteinformulierungen mit sorbitol
JP2011520889A (ja) 2008-05-15 2011-07-21 バクスター・インターナショナル・インコーポレイテッド 安定な医薬製剤
BRPI0921429B1 (pt) 2008-11-07 2022-07-12 Takeda Pharmaceutical Company Limited Formulação farmacêutica liofilizada estável, e, método para preparar um fator liofilizado estável
CA2819246C (en) 2010-12-02 2023-04-25 Oncolytics Biotech Inc. Liquid viral formulations
US9044498B2 (en) 2010-12-02 2015-06-02 Oncolytics Biotech Inc. Lyophilized viral formulations
ES2822199T3 (es) * 2011-04-29 2021-04-29 Oncolytics Biotech Inc Métodos de purificación de virus usando cromatografía por permeación en gel
NZ729629A (en) 2014-08-04 2021-12-24 Csl Ltd Factor viii formulation
KR20220029733A (ko) 2019-07-04 2022-03-08 체에스엘 베링 렝나우 아게 응고 인자 viii의 시험관내 안정성을 증가시키기 위한 절단된 폰 빌레브란트 인자 (vwf)
US20220380439A1 (en) 2020-11-09 2022-12-01 Takeda Pharmaceutical Company Limited Purification of fviii from plasma using silicon oxide adsorption

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4743680A (en) * 1985-02-01 1988-05-10 New York University Method for purifying antihemophilic factor
JPH0387173A (ja) * 1987-09-10 1991-04-11 Teijin Ltd ヒト活性化天然型ファクター８ｃの製造方法及びそれに用いる形質転換体
CA1329760C (en) * 1987-10-29 1994-05-24 Ted C. K. Lee Plasma and recombinant protein formulations in high ionic strength media

Also Published As

Publication number Publication date
DE69029765D1 (de) 1997-03-06
EP0410207A2 (de) 1991-01-30
JPH0358998A (ja) 1991-03-14
GR3022614T3 (en) 1997-05-31
EP0410207B1 (de) 1997-01-22
CA2021452A1 (en) 1991-01-25
ES2097120T3 (es) 1997-04-01
EP0410207A3 (en) 1992-01-15
DK0410207T3 (da) 1997-07-14
DE69029765T2 (de) 1997-05-15

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UEP Publication of translation of european patent specification