DK0622076T3 - Inhibitor for restenose efter perkutan coronar arterioplasti - Google Patents

Inhibitor for restenose efter perkutan coronar arterioplasti

Info

Publication number: DK0622076T3
Authority: DK; Denmark
Prior art keywords: restenosis; percutaneous coronary; inhibitor; substituted; alkyl
Prior art date: 1992-01-17

Application number

DK93901553.3T

Other languages

English (en)

Inventor

Kazuhisa Kodama

Atsushi Hirayama

Hiroyuki Masayasu

Original Assignee

Daiichi Seiyaku Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-01-17

Filing date

1993-01-14

Publication date

1997-06-02

1993-01-14 Application filed by Daiichi Seiyaku Co filed Critical Daiichi Seiyaku Co

1997-06-02 Application granted granted Critical

1997-06-02 Publication of DK0622076T3 publication Critical patent/DK0622076T3/da

Links

239000003112 inhibitor Substances 0.000 title abstract 2
208000037803 restenosis Diseases 0.000 title abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical group [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
-1 methylenedioxy Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052711 selenium Inorganic materials 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1
231100000331 toxic Toxicity 0.000 abstract 1
230000002588 toxic effect Effects 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
- A61K38/063—Glutathione
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

DK93901553.3T 1992-01-17 1993-01-14 Inhibitor for restenose efter perkutan coronar arterioplasti DK0622076T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP655292		1992-01-17

Publications (1)

Publication Number	Publication Date
DK0622076T3 true DK0622076T3 (da)	1997-06-02

Family

ID=11641498

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK93901553.3T DK0622076T3 (da)	1992-01-17	1993-01-14	Inhibitor for restenose efter perkutan coronar arterioplasti

Country Status (11)

Country	Link
US (1)	US5480888A (da)
EP (1)	EP0622076B1 (da)
JP (1)	JPH05255084A (da)
KR (1)	KR100214453B1 (da)
AT (1)	ATE150964T1 (da)
CA (1)	CA2126465C (da)
DE (1)	DE69309435T2 (da)
DK (1)	DK0622076T3 (da)
ES (1)	ES2100520T3 (da)
GR (1)	GR3023308T3 (da)
WO (1)	WO1993013762A1 (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6515009B1 (en)	1991-09-27	2003-02-04	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en)	1993-01-28	1998-09-22	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US6395494B1 (en)	1993-05-13	2002-05-28	Neorx Corporation	Method to determine TGF-β
US5770609A (en)	1993-01-28	1998-06-23	Neorx Corporation	Prevention and treatment of cardiovascular pathologies
US6306421B1 (en)	1992-09-25	2001-10-23	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US6251920B1 (en)	1993-05-13	2001-06-26	Neorx Corporation	Prevention and treatment of cardiovascular pathologies
US6663881B2 (en)	1993-01-28	2003-12-16	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US6491938B2 (en)	1993-05-13	2002-12-10	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US5981568A (en)	1993-01-28	1999-11-09	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
DE69435137D1 (de)	1993-05-13	2008-10-16	Poniard Pharmaceuticals Inc	Prävention und behandlung von pathologien, die mit einer abnormalen proliferationglatter muskelzellen verbunden sind
WO1996040098A2 (en)	1995-06-07	1996-12-19	Neorx Corporation	Prevention and treatment of cardiovascular pathologies with tamoxifen analogues
US5824644A (en) *	1994-07-07	1998-10-20	G. D. Searle & Co.	Method of attenuating arterial stenosis
US20030083733A1 (en) *	1997-10-10	2003-05-01	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US6099562A (en) *	1996-06-13	2000-08-08	Schneider (Usa) Inc.	Drug coating with topcoat
US20020091433A1 (en) *	1995-04-19	2002-07-11	Ni Ding	Drug release coated stent
US5837313A (en) *	1995-04-19	1998-11-17	Schneider (Usa) Inc	Drug release stent coating process
WO1996033712A1 (en) *	1995-04-25	1996-10-31	Daiichi Pharmaceutical Co., Ltd.	Remedy for acquired immunodeficiency syndrome
US7611533B2 (en)	1995-06-07	2009-11-03	Cook Incorporated	Coated implantable medical device
TW565558B (en)	1995-11-09	2003-12-11	Chugai Pharmaceutical Co Ltd	Intimal thickening inhibitory agent
WO1998046588A2 (en) *	1997-04-11	1998-10-22	Neorx Corporation	Compounds and therapies for the prevention of vascular and non-vascular pathologies
HK1042082A1 (en)	1999-03-31	2002-08-02	Holmgren Arne	Substrates for thioredoxin reductase
US6613083B2 (en)	2001-05-02	2003-09-02	Eckhard Alt	Stent device and method
US7776925B2 (en) *	2002-03-06	2010-08-17	Duke University	Reversing, postponing or preventing the occurrence of GTN tolerance and/or generation of reactive oxygen species from mitochondria
US10058542B1 (en)	2014-09-12	2018-08-28	Thioredoxin Systems Ab	Composition comprising selenazol or thiazolone derivatives and silver and method of treatment therewith

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3407511A1 (de) *	1984-03-01	1985-09-05	A. Nattermann & Cie GmbH, 5000 Köln	Benzisoselenazolthione, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE3568775D1 (en) *	1984-06-22	1989-04-20	Nattermann A & Cie	S-(carbamoyl-phenylselenyl) derivatives of glutathion and of amino mercaptocarboxylic acids, process for their preparation and pharmaceutical preparations containing them
DE3422962A1 (de) *	1984-06-22	1986-01-02	A. Nattermann & Cie GmbH, 5000 Köln	Glutathion-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE3443467A1 (de) *	1984-11-29	1986-05-28	A. Nattermann & Cie GmbH, 5000 Köln	Mercaptanderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
EP0198277B1 (de) *	1985-04-12	1989-05-03	A. Nattermann & Cie. GmbH	Diselenobis-benzoesäureamide primärer und sekundärer Amine, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
DE3626554A1 (de) *	1986-08-06	1988-02-18	Nattermann A & Cie	Diselenobis-benzoesaeureamide primaerer heterocyclischer amine, verfahren zur ihrer herstellung und diese enthaltende pharmazeutische praeparate
JP2710633B2 (ja) *	1987-08-28	1998-02-10	第一製薬株式会社	心臓疾患治療剤
JP2596970B2 (ja) *	1988-05-23	1997-04-02	第一製薬株式会社	白血球の粘着又は凝集抑制剤
US5187105A (en) *	1988-07-01	1993-02-16	Miles Inc.	Process for determining thiols using chromogenic benzoisothiazolone derivatives
DE3937169A1 (de) *	1989-11-08	1991-05-16	Nattermann A & Cie	Benzylselenobenzamide von anilinen und benzylaminen

1993
- 1993-01-14 DK DK93901553.3T patent/DK0622076T3/da active
- 1993-01-14 EP EP93901553A patent/EP0622076B1/en not_active Expired - Lifetime
- 1993-01-14 WO PCT/JP1993/000045 patent/WO1993013762A1/ja not_active Ceased
- 1993-01-14 ES ES93901553T patent/ES2100520T3/es not_active Expired - Lifetime
- 1993-01-14 JP JP5005063A patent/JPH05255084A/ja active Pending
- 1993-01-14 KR KR1019940702270A patent/KR100214453B1/ko not_active Expired - Fee Related
- 1993-01-14 CA CA002126465A patent/CA2126465C/en not_active Expired - Fee Related
- 1993-01-14 US US08/256,268 patent/US5480888A/en not_active Expired - Fee Related
- 1993-01-14 DE DE69309435T patent/DE69309435T2/de not_active Expired - Fee Related
- 1993-01-14 AT AT93901553T patent/ATE150964T1/de not_active IP Right Cessation
1997
- 1997-05-02 GR GR970400964T patent/GR3023308T3/el unknown

Also Published As

Publication number	Publication date
DE69309435D1 (de)	1997-05-07
EP0622076A1 (en)	1994-11-02
JPH05255084A (ja)	1993-10-05
DE69309435T2 (de)	1997-07-10
CA2126465C (en)	2002-03-05
EP0622076A4 (en)	1994-12-21
ATE150964T1 (de)	1997-04-15
CA2126465A1 (en)	1993-07-22
US5480888A (en)	1996-01-02
GR3023308T3 (en)	1997-08-29
ES2100520T3 (es)	1997-06-16
EP0622076B1 (en)	1997-04-02
WO1993013762A1 (fr)	1993-07-22
KR100214453B1 (ko)	1999-08-02

Publication	Publication Date	Title
DE69309435D1 (de)	1997-05-07	Restenosehemmer nach perkutaner koronarer arterioplastie
FI953968A0 (fi)	1995-08-23	Antraniiliset happojohdannaiset
LU91210I2 (fr)	2006-11-06	Emodepside & Praziquantel ainsi que leurs dérivés pharmaceutiqement acceptables (PROFENDER)
DE60006216D1 (de)	2003-12-04	Chinolinderivate und chinazolinderivate
ATE338754T1 (de)	2006-09-15	Heterocyclische verbindungen, ihre herstellung und verwendung
IL161559A0 (en)	2004-09-27	Dibenzylamine derivatives and pharmaceutical compositions containing the same
DK1258484T3 (da)	2009-04-20	Nye isoxazol- og thiazolforbindelser og anvendelse deraf som lægemidler
BRPI0213243B8 (pt)	2021-05-25	composto heterocíclico aromático contendo um anel oxazol, tiazol ou imidazol, ou um sal farmaceuticamente aceitável do mesmo, e, composição farmacêutica
FI943561A0 (fi)	1994-07-29	Uudet ainekoostumukset
ATE105711T1 (de)	1994-06-15	5-lipoxygenasehemmende 4-(4-phenyl-1- piperazinyl)phenole.
DE68906183D1 (de)	1993-06-03	2'-desoxy-5-fluoruridinderivate.
DE69935718D1 (de)	2007-05-16	Antidiabetische medikamente
DE69323090D1 (de)	1999-02-25	4-ALKOXY-2,6-DI-t-BUTYLPHENOLDERIVATE
DE69229637D1 (de)	1999-08-26	Oxazolidone Derivative als Monoamine-Oxidaseinhibitoren
NZ221699A (en)	1990-03-27	Pyridazinone derivatives; pharmaceutical compositions and intermediates
DE69525763D1 (de)	2002-04-11	4,6-DI-t-BUTYL-2,3-DIHYDROBENZOTHIOPHENE, DIE LDL OXIDATION HEMMEN
ATE283840T1 (de)	2004-12-15	Chondrogonese promotoren und indolin-2-on derivate
DE69629838D1 (de)	2003-10-09	Inhibitoren der kainsäure-neurotoxizität sowie pyridothiazinderivate
DE60045821D1 (de)	2011-05-19	Derivate von aromatische heterocyclen enthaltende integraseinhibitoren
ATE205209T1 (de)	2001-09-15	Chinolincarbonsäurederivate und ihre salze
EP1375489A4 (en)	2005-03-02	MEDICINAL PREPARATION CONTAINING A 1,3-THIAZINE DERIVATIVE
ES2155655T3 (es)	2001-05-16	Compuestos de benzotiofeno, usos y formulaciones de los mismos.
HU9600597D0 (en)	1996-05-28	4-alkylthio-pyrimidin-5-yl acetic acid derivates and fungicidal compositions containing them as an active ingredient