DK0622376T3 - Amorfe monosfæriske former af insulinderivater - Google Patents

Amorfe monosfæriske former af insulinderivater

Info

Publication number: DK0622376T3
Authority: DK; Denmark
Prior art keywords: monospheric; amorphous; forms; insulin derivatives; water
Prior art date: 1993-04-27

Application number

DK94106196T

Other languages

English (en)

Inventor

Walter Sabel

Rainer Dr Obermeier

Peter Deil

Karl Dr Geisen

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-04-27

Filing date

1994-04-21

Publication date

2001-11-12

1994-04-21 Application filed by Hoechst Ag filed Critical Hoechst Ag

2001-11-12 Application granted granted Critical

2001-11-12 Publication of DK0622376T3 publication Critical patent/DK0622376T3/da

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 3
BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 abstract 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
238000007865 diluting Methods 0.000 abstract 1
239000004026 insulin derivative Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Diabetes (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Toxicology (AREA)
Chemical Kinetics & Catalysis (AREA)
Obesity (AREA)
Hematology (AREA)
Biochemistry (AREA)
Emergency Medicine (AREA)
Biophysics (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK94106196T 1993-04-27 1994-04-21 Amorfe monosfæriske former af insulinderivater DK0622376T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4313702		1993-04-27

Publications (1)

Publication Number	Publication Date
DK0622376T3 true DK0622376T3 (da)	2001-11-12

Family

ID=6486458

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94106196T DK0622376T3 (da)	1993-04-27	1994-04-21	Amorfe monosfæriske former af insulinderivater

Country Status (8)

Country	Link
US (1)	US5466666A (da)
EP (1)	EP0622376B1 (da)
JP (1)	JP3532956B2 (da)
AT (1)	ATE203998T1 (da)
DE (1)	DE59409816D1 (da)
DK (1)	DK0622376T3 (da)
ES (1)	ES2161726T3 (da)
GR (1)	GR3036840T3 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19903125B4 (de) *	1999-01-27	2006-01-05	Sanofi-Aventis Deutschland Gmbh	Verfahren zur Trocknung von Kristallen von Insulin oder Insulinanaloga
AU2002346490A1 (en) *	2001-12-20	2003-07-09	Eli Lilly And Company	Insulin molecule having protracted time action
WO2004096854A2 (en) *	2003-04-29	2004-11-11	Eli Lilly And Company	Insulin analogs having protracted time action
JP5781308B2 (ja) *	2008-02-19	2015-09-16	バイオコン・リミテッドＢｉｏｃｏｎＬｉｍｉｔｅｄ	異種タンパク質を得る方法およびインスリン類似体
PL239062B1 (pl) *	2016-01-22	2021-11-02	Inst Biotechnologii I Antybiotykow	Sposób wytwarzania insuliny i jej pochodnych

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3333640A1 (de) *	1983-09-17	1985-04-25	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
DE4012818A1 (de) *	1990-04-21	1991-10-24	Hoechst Ag	Verfahren zur herstellung von fremdproteinen in streptomyceten
EP0347781B1 (de) *	1988-06-23	1994-02-16	Hoechst Aktiengesellschaft	Mini-Proinsulin, seine Herstellung und Verwendung
DE3837825A1 (de) *	1988-11-08	1990-05-10	Hoechst Ag	Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
IL95495A (en) *	1989-08-29	1996-10-16	Hoechst Ag	Fusion proteins their preparation and use

1994
- 1994-04-21 DE DE59409816T patent/DE59409816D1/de not_active Expired - Lifetime
- 1994-04-21 ES ES94106196T patent/ES2161726T3/es not_active Expired - Lifetime
- 1994-04-21 DK DK94106196T patent/DK0622376T3/da active
- 1994-04-21 AT AT94106196T patent/ATE203998T1/de active
- 1994-04-21 EP EP94106196A patent/EP0622376B1/de not_active Expired - Lifetime
- 1994-04-25 US US08/233,617 patent/US5466666A/en not_active Expired - Lifetime
- 1994-04-26 JP JP08811194A patent/JP3532956B2/ja not_active Expired - Lifetime
2001
- 2001-10-09 GR GR20010401702T patent/GR3036840T3/el unknown

Also Published As

Publication number	Publication date
JPH06321990A (ja)	1994-11-22
DE59409816D1 (de)	2001-09-13
JP3532956B2 (ja)	2004-05-31
ES2161726T3 (es)	2001-12-16
US5466666A (en)	1995-11-14
EP0622376A1 (de)	1994-11-02
EP0622376B1 (de)	2001-08-08
GR3036840T3 (en)	2002-01-31
ATE203998T1 (de)	2001-08-15

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