DK0625137T3 - Fremgangsmåde til racematadskillelse af verapamil - Google Patents

Fremgangsmåde til racematadskillelse af verapamil

Info

Publication number: DK0625137T3
Authority: DK; Denmark
Prior art keywords: pct; ratio; verapamil; sec; date
Prior art date: 1992-02-07

Application number

DK93903886.5T

Other languages

English (en)

Inventor

Oskar Ehrmann

Herbert Nagel

Original Assignee

Knoll Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-02-07

Filing date

1993-01-28

Publication date

1997-05-05

1993-01-28 Application filed by Knoll Ag filed Critical Knoll Ag

1997-05-05 Application granted granted Critical

1997-05-05 Publication of DK0625137T3 publication Critical patent/DK0625137T3/da

Links

SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
229960001722 verapamil Drugs 0.000 title abstract 2
238000000926 separation method Methods 0.000 title 1
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
239000000203 mixture Substances 0.000 abstract 3
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
KMGUEILFFWDGFV-UHFFFAOYSA-N 2-benzoyl-2-benzoyloxy-3-hydroxybutanedioic acid Chemical compound C=1C=CC=CC=1C(=O)C(C(C(O)=O)O)(C(O)=O)OC(=O)C1=CC=CC=C1 KMGUEILFFWDGFV-UHFFFAOYSA-N 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
239000002585 base Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000002425 crystallisation Methods 0.000 abstract 1
230000008025 crystallization Effects 0.000 abstract 1
239000012458 free base Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/32—Separation; Purification; Stabilisation; Use of additives
- C07C253/34—Separation; Purification
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Compounds Of Unknown Constitution (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Electrotherapy Devices (AREA)
Steroid Compounds (AREA)

DK93903886.5T 1992-02-07 1993-01-28 Fremgangsmåde til racematadskillelse af verapamil DK0625137T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4203547A DE4203547A1 (de)	1992-02-07	1992-02-07	Verfahren zur racemattrennung von verapamil

Publications (1)

Publication Number	Publication Date
DK0625137T3 true DK0625137T3 (da)	1997-05-05

Family

ID=6451183

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK93903886.5T DK0625137T3 (da)	1992-02-07	1993-01-28	Fremgangsmåde til racematadskillelse af verapamil

Country Status (10)

Country	Link
US (1)	US5457224A (da)
EP (1)	EP0625137B1 (da)
JP (1)	JP3307641B2 (da)
AT (1)	ATE151413T1 (da)
CA (1)	CA2122254C (da)
DE (2)	DE4203547A1 (da)
DK (1)	DK0625137T3 (da)
ES (1)	ES2099421T3 (da)
MX (1)	MX9300473A (da)
WO (1)	WO1993016035A1 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9319918D0 (en) *	1993-09-27	1993-11-10	Chiros Ltd	Chiral compounds and their preparation
US5910601A (en) *	1994-09-26	1999-06-08	Darwin Discovery Limited	Chiral nitriles, their preparation and their use for the manufacture of verapamil and analogues
DE19502967A1 (de) *	1995-01-31	1996-08-01	Basf Ag	Verfahren zur Racemattrennung von 2-Aryl-2-omega-alkylaminoalkannitrilen
WO1997044025A1 (en) *	1996-05-23	1997-11-27	G.D. Searle & Co.	Pharmaceutical compositions containing non-racemic verapamil and process for optimizing the pharmaceutical activity of r- and s-verapamil
GB9616549D0 (en) *	1996-08-06	1996-09-25	Chiroscience Ltd	Therapeutic product and its use
KR100341256B1 (ko) *	1999-09-11	2002-06-21	박호군	리파제를 이용한 베라파밀 중간체의 분할 및 (ｒ)- 및 (ｓ)-베라파밀의 제조 방법
JP4814228B2 (ja) *	2004-05-18	2011-11-16	エフ．ホフマン−ラロシュアーゲー	新規ｃｉｓ−イミダゾリン
US7893278B2 (en)	2004-06-17	2011-02-22	Hoffman-La Roche Inc.	CIS-imidazolines
CA2637542A1 (en) *	2006-01-17	2007-07-26	Glenmark Pharmaceuticals Limited	Improved process for the preparation of an optically active 5h-pyrrolo [3,4-b] pyrazine derivative
CA2656064C (en) *	2006-06-19	2013-11-05	Merck Patent Gesellschaft Mit Beschraenkter Haftung	Polymorphic forms and process
ITMI20071160A1 (it)	2007-06-07	2008-12-08	Cosma S P A	Procedimento di risoluzione del verapamil
US9793080B2 (en)	2013-08-23	2017-10-17	Inoso, Llc	Electromechanical power switch integrated circuits and devices and methods thereof
CA2964177A1 (en) *	2014-10-29	2016-05-06	Center Laboratories, Inc.	Crystal forms of verapamil hydrochloride

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1154810B (de) *	1961-04-01	1963-09-26	Knoll Ag	Verfahren zur Herstellung basisch substituierter Phenylacetonitrile
DE2059923C3 (de) *	1970-12-05	1979-01-25	Knoll Ag, 6700 Ludwigshafen	l-a-Isopropyl-o-[(N-methyl-N-homoveratryl)v-aminopropyl] -3,4-dimethoxyphenylacetonitril, Verfahren zu dessen Herstellung und dieses enthaltende Arzneimittel
DE2946545A1 (de) *	1979-11-17	1981-05-27	Basf Ag, 6700 Ludwigshafen	Verfahren zur gewinnung der enantiomeren formen von 4-cyan-1-(n-methyl-n-(2'-((3'',4'',-dimethoxyphenyl))-aethyl)-amino)-5-methyl-4-(3',4',5'-trimethoxyphenyl)-hexan und dessen salzen
DE3723684A1 (de) *	1987-07-17	1989-01-26	Basf Ag	Verfahren zur herstellung der enantiomeren von verapamil

1992
- 1992-02-07 DE DE4203547A patent/DE4203547A1/de not_active Withdrawn
1993
- 1993-01-09 US US08/244,681 patent/US5457224A/en not_active Expired - Lifetime
- 1993-01-28 DE DE59306121T patent/DE59306121D1/de not_active Expired - Lifetime
- 1993-01-28 WO PCT/EP1993/000196 patent/WO1993016035A1/de not_active Ceased
- 1993-01-28 ES ES93903886T patent/ES2099421T3/es not_active Expired - Lifetime
- 1993-01-28 CA CA002122254A patent/CA2122254C/en not_active Expired - Lifetime
- 1993-01-28 MX MX9300473A patent/MX9300473A/es unknown
- 1993-01-28 AT AT93903886T patent/ATE151413T1/de active
- 1993-01-28 DK DK93903886.5T patent/DK0625137T3/da active
- 1993-01-28 JP JP51371693A patent/JP3307641B2/ja not_active Expired - Lifetime
- 1993-01-28 EP EP93903886A patent/EP0625137B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2122254C (en)	2004-05-18
US5457224A (en)	1995-10-10
ATE151413T1 (de)	1997-04-15
JP3307641B2 (ja)	2002-07-24
EP0625137A1 (de)	1994-11-23
EP0625137B1 (de)	1997-04-09
JPH07503475A (ja)	1995-04-13
WO1993016035A1 (de)	1993-08-19
DE59306121D1 (de)	1997-05-15
DE4203547A1 (de)	1993-08-12
ES2099421T3 (es)	1997-05-16
MX9300473A (es)	1993-09-01
CA2122254A1 (en)	1993-08-19

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