ATE143941T1 - Salpetersäureester von 2-(2,6- dihalophenylamino)phenylessigsäurederivaten und verfahren zu ihrer herstellung - Google Patents

Salpetersäureester von 2-(2,6- dihalophenylamino)phenylessigsäurederivaten und verfahren zu ihrer herstellung

Info

Publication number: ATE143941T1
Authority: AT; Austria
Prior art keywords: pct; dihalophenylamino; production; phenylacetic acid; date mar
Prior art date: 1992-08-20

Application number

AT93917596T

Other languages

English (en)

Inventor

Jose Antonio Matji

Antonio Alcaide

Original Assignee

Corlay Sl

Metgrove Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-08-20

Filing date

1993-07-20

Publication date

1996-10-15

1993-07-20 Application filed by Corlay Sl, Metgrove Ltd filed Critical Corlay Sl

1996-10-15 Application granted granted Critical

1996-10-15 Publication of ATE143941T1 publication Critical patent/ATE143941T1/de

Links

GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical class O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 title 1
WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical class OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 title 1
WLJVXDMOQOGPHL-PPJXEINESA-N 2-phenylacetic acid Chemical compound O[14C](=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-PPJXEINESA-N 0.000 abstract 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
125000000547 substituted alkyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT93917596T 1992-08-20 1993-07-20 Salpetersäureester von 2-(2,6- dihalophenylamino)phenylessigsäurederivaten und verfahren zu ihrer herstellung ATE143941T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITMI922006A IT1256345B (it)	1992-08-20	1992-08-20	Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione

Publications (1)

Publication Number	Publication Date
ATE143941T1 true ATE143941T1 (de)	1996-10-15

Family

ID=11363881

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93917596T ATE143941T1 (de)	1992-08-20	1993-07-20	Salpetersäureester von 2-(2,6- dihalophenylamino)phenylessigsäurederivaten und verfahren zu ihrer herstellung

Country Status (14)

Country	Link
US (1)	US5597847A (de)
EP (1)	EP0609415B1 (de)
JP (1)	JP3231042B2 (de)
KR (1)	KR100269727B1 (de)
AT (1)	ATE143941T1 (de)
CA (1)	CA2120942C (de)
DE (1)	DE69305322T2 (de)
DK (1)	DK0609415T3 (de)
ES (1)	ES2093979T3 (de)
GR (1)	GR3021404T3 (de)
IT (1)	IT1256345B (de)
RU (1)	RU2109009C1 (de)
UA (1)	UA39172C2 (de)
WO (1)	WO1994004484A1 (de)

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HU218923B (hu) *	1993-10-06	2000-12-28	Nicox S.A.	Gyulladásgátló és/vagy fájdalomcsillapító hatású nitrát-észterek, ezeket tartalmazó gyógyszerkészítmények és eljárás a vegyületek előállítására
WO1995030641A1 (en) *	1994-05-10	1995-11-16	Nicox S.A.	Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities
US6043232A (en) *	1997-07-23	2000-03-28	Nitromed, Inc.	Nitroso esters of beta-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs
US5703073A (en)	1995-04-19	1997-12-30	Nitromed, Inc.	Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
ES2092962B1 (es) *	1995-04-19	1997-07-16	Prodes Sa	Esteres nitricos de derivados del acido 2-(2,6-dihalofenilamino) fenilacetoxiacetico y sus procedimientos de preparacion.
US5792758A (en) *	1995-12-08	1998-08-11	G. D. Searle & Co.	Steroid nitrite ester derivatives useful as anti-inflammatory drugs
SE9600070D0 (sv)	1996-01-08	1996-01-08	Astra Ab	New oral pharmaceutical dosage forms
US6355680B1 (en) *	1996-02-20	2002-03-12	Exocell, Inc.	Albumin-binding compounds that prevent nonenzymatic glycation and that may be used for treatment of glycation-related pathologies
IT1282686B1 (it)	1996-02-26	1998-03-31	Nicox Sa	Composti in grado di ridurre la tossicita' da farmaci
WO1998007701A1 (en) *	1996-08-16	1998-02-26	Handforth Investments Ltd.	Non-ulcerogenic analgesic/anti-inflammatory clonixin derivative
IT1288123B1 (it) *	1996-09-04	1998-09-10	Nicox Sa	Uso di nitroderivati per l'incontinenza urinaria
IT1285770B1 (it)	1996-10-04	1998-06-18	Nicox Sa	Composti corticoidei
IT1295694B1 (it)	1996-11-14	1999-05-27	Nicox Sa	Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica
FR2757159B1 (fr) *	1996-12-12	1999-12-17	Hoechst Marion Roussel Inc	Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments
ID24062A (id) *	1997-07-25	2000-07-06	Kissei Pharmaceutical	Turunan-turunan asam aminoetilfenoksiasetat dan obat untuk mengurangi nyeri dan membantu penyingkiran dalam litiasis saluran air kencing
CO4960662A1 (es)	1997-08-28	2000-09-25	Novartis Ag	Ciertos acidos 5-alquil-2-arilaminofenilaceticos y sus derivados
JP2002528495A (ja)	1998-10-30	2002-09-03	ニトロメドインコーポレーテッド	ニトロソ化およびニトロシル化された非ステロイド抗炎症性化合物、組成物および使用方法
IT1308633B1 (it)	1999-03-02	2002-01-09	Nicox Sa	Nitrossiderivati.
IT1311924B1 (it) *	1999-04-13	2002-03-20	Nicox Sa	Composti farmaceutici.
IT1311923B1 (it) *	1999-04-13	2002-03-20	Nicox Sa	Composti farmaceutici.
TWI243672B (en) *	1999-06-01	2005-11-21	Astrazeneca Ab	New use of compounds as antibacterial agents
IT1312115B1 (it)	1999-06-24	2002-04-04	Nicox Sa	Composti amorfi e relative composizioni farmaceutiche
IT1314184B1 (it)	1999-08-12	2002-12-06	Nicox Sa	Composizioni farmaceutiche per la terapia di condizioni di stressossidativo
US6713454B1 (en)	1999-09-13	2004-03-30	Nobex Corporation	Prodrugs of etoposide and etoposide analogs
GB9922830D0 (en) *	1999-09-27	1999-11-24	Novartis Ag	Processes
RU2172309C2 (ru) *	1999-10-06	2001-08-20	Государственный научный центр Российской Федерации "НИОПИК"	Способ получения производных 2-(фениламино)фенилуксусной кислоты
US6552078B2 (en)	1999-10-27	2003-04-22	Nobex Corp	6-methoxy-2-naphthylacetic acid prodrugs
US6436990B1 (en)	1999-10-27	2002-08-20	Nobex Corporation	6-methoxy-2-naphthylacetic acid prodrugs
TWI262791B (en)	1999-10-27	2006-10-01	Nobex Corp	6-methoxy-2-naphthylacetic acid prodrugs
IL150368A0 (en)	1999-12-23	2002-12-01	Nitromed Inc	Nitrosated and nitrosylated cyclooxygenase-2-inhibitors, compositions and methods of use
SE0000773D0 (sv) *	2000-03-08	2000-03-08	Astrazeneca Ab	New formulation
SE0000774D0 (sv)	2000-03-08	2000-03-08	Astrazeneca Ab	New formulation
IT1319202B1 (it)	2000-10-12	2003-09-26	Nicox Sa	Farmaci per le malattie a base infiammatoria.
IT1319201B1 (it) *	2000-10-12	2003-09-26	Nicox Sa	Farmaci per il diabete.
JP4092203B2 (ja)	2000-12-21	2008-05-28	ニトロメッド，インク．	新規のシクロオキシゲナーゼ２選択的阻害剤としての置換アリール化合物、組成物、および使用方法
ITMI20010985A1 (it) *	2001-05-15	2002-11-15	Nicox Sa	Farmaci per il morbo di alzheimer
ITMI20011744A1 (it) *	2001-08-09	2003-02-09	Nicox Sa	Farmaci per le vasculopatie
SE0102993D0 (sv) *	2001-09-07	2001-09-07	Astrazeneca Ab	New self emulsifying drug delivery system
CA2487414A1 (en)	2002-06-11	2003-12-18	Nitromed, Inc.	Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
WO2004002420A2 (en)	2002-06-28	2004-01-08	Nitromed, Inc.	Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxigenase-2 selective inhibitors, compositions and methods of use
CA2491127A1 (en)	2002-07-03	2004-01-15	Nitromed, Inc.	Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
JP2005538110A (ja)	2002-07-29	2005-12-15	ニトロメッドインコーポレーティッド	シクロオキシゲナーゼ−２選択的阻害剤、組成物、および使用方法
SE0203093D0 (en) *	2002-10-18	2002-10-18	Astrazeneca Uk Ltd	New use
AR042206A1 (es)	2002-11-26	2005-06-15	Novartis Ag	Acidos fenilaceticos y derivados
US8067464B2 (en)	2004-10-04	2011-11-29	Nitromed, Inc.	Compositions and methods using apocynin compounds and nitric oxide donors
AR061623A1 (es)	2006-06-26	2008-09-10	Novartis Ag	Derivados de acido fenilacetico

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US3558690A (en) *	1965-04-08	1971-01-26	Gelgy Chemical Corp	Substituted derivatives of 2-anilinophenylacetic acids and a process of preparation
NL133740C (de) *	1965-04-08
US3552690A (en) *	1968-05-31	1971-01-05	Lloyd S Turner	Kite control device
DE3407507A1 (de) *	1984-03-01	1985-09-05	A. Nattermann & Cie GmbH, 5000 Köln	Neue o-(2,6-dichloranilino)-phenylessigsaeureester, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
US5021576A (en) *	1989-10-27	1991-06-04	American Home Products Corporation	2-Anilino phenylacetic acid derivatives

1992
- 1992-08-20 IT ITMI922006A patent/IT1256345B/it active IP Right Grant
1993
- 1993-07-20 US US08/211,447 patent/US5597847A/en not_active Expired - Lifetime
- 1993-07-20 EP EP93917596A patent/EP0609415B1/de not_active Expired - Lifetime
- 1993-07-20 RU RU94046148A patent/RU2109009C1/ru not_active IP Right Cessation
- 1993-07-20 AT AT93917596T patent/ATE143941T1/de not_active IP Right Cessation
- 1993-07-20 CA CA002120942A patent/CA2120942C/en not_active Expired - Fee Related
- 1993-07-20 WO PCT/EP1993/001906 patent/WO1994004484A1/en not_active Ceased
- 1993-07-20 DE DE69305322T patent/DE69305322T2/de not_active Expired - Lifetime
- 1993-07-20 ES ES93917596T patent/ES2093979T3/es not_active Expired - Lifetime
- 1993-07-20 DK DK93917596.4T patent/DK0609415T3/da active
- 1993-07-20 JP JP50582694A patent/JP3231042B2/ja not_active Expired - Fee Related
- 1993-07-20 KR KR1019940701286A patent/KR100269727B1/ko not_active Expired - Fee Related
- 1993-07-20 UA UA94005348A patent/UA39172C2/uk unknown
1996
- 1996-10-21 GR GR960402711T patent/GR3021404T3/el unknown

Also Published As

Publication number	Publication date
UA39172C2 (uk)	2001-06-15
WO1994004484A1 (en)	1994-03-03
EP0609415A1 (de)	1994-08-10
ES2093979T3 (es)	1997-01-01
DK0609415T3 (da)	1996-11-18
CA2120942C (en)	2005-09-27
EP0609415B1 (de)	1996-10-09
US5597847A (en)	1997-01-28
DE69305322T2 (de)	1997-02-20
RU2109009C1 (ru)	1998-04-20
ITMI922006A0 (it)	1992-08-20
HK1006967A1 (en)	1999-03-26
JPH07500355A (ja)	1995-01-12
KR100269727B1 (ko)	2000-10-16
JP3231042B2 (ja)	2001-11-19
GR3021404T3 (en)	1997-01-31
IT1256345B (it)	1995-12-01
DE69305322D1 (de)	1996-11-14
ITMI922006A1 (it)	1994-02-20
CA2120942A1 (en)	1994-03-03

Legal Events

Date	Code	Title
1997-05-15	UEP	Publication of translation of european patent specification
2002-08-15	EEIH	Change in the person of patent owner
2012-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE143941T1 (de)	1996-10-15	Salpetersäureester von 2-(2,6- dihalophenylamino)phenylessigsäurederivaten und verfahren zu ihrer herstellung
DE69310204D1 (de)	1997-05-28	Salpetersäureester mit pharmazeutischer wirkung und verfahren zu deren herstellung
DE69515390D1 (de)	2000-04-13	Ureido-derivate von naphtalenphosphonsäure und verfahren zu ihrer herstellung
DE59409880D1 (de)	2001-10-31	Methylphosphonsäureester, verfahren zu deren herstellung und deren verwendung
DE69325262D1 (de)	1999-07-15	Vinylen-azaindolderivate und verfahren zu ihrer herstellung
DE69113155D1 (de)	1995-10-26	17-beta-substituierte-4-aza-5-alpha-androstan-3-one-derivate und verfahren zu ihrer herstellung.
DE3876813D1 (de)	1993-02-04	3(2h)pyridazinon, verfahren zu dessen herstellung und dieses enthaltendes mittel gegen srs-a.
IS4133A (is)	1994-08-27	Aðferð við framleiðslu á nýjum afleiðum af 3-hýdroxýantraniliksýru og milliefni við framleiðslu þeirra
ATE151401T1 (de)	1997-04-15	Thermisch stabile fullerenderivate und verfahren zu ihrer herstellung
ATE73798T1 (de)	1992-04-15	Neue harnstoffderivate, verfahren zu ihrer herstellung und herbizide.
DK0689534T3 (da)	2003-02-03	Amidderivater som 5-HT1A-ligander
HUP0001058A2 (hu)	2001-06-28	5-Hidroxi-metil-2-amino-tetralinok mint szív-érrendszerre ható szerek, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények
DE59008494D1 (de)	1995-03-23	Beschichtungsmasse, verfahren zu ihrer herstellung sowie deren verwendung.
ATE288899T1 (de)	2005-02-15	Substituierte alkylaminopyridazinonderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
ATE140693T1 (de)	1996-08-15	Phenylalkylaminoalkyl-verbindungen sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
ATE28858T1 (de)	1987-08-15	Derivate von n-(methoxyphenacyl)aminen, ihre therapeutische verwendung und verfahren zu ihrer herstellung.
GB9806358D0 (en)	1998-05-20	Synthesis of carboxylic acid derivatives
ATE153996T1 (de)	1997-06-15	Salze der pyromellitsäure, ein verfahren zu ihrer herstellung sowie deren verwendung
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ATE178322T1 (de)	1999-04-15	Isoxazolcarbonsäureamide, verfahren zu ihrer herstellung und ihre verwendung
ATE32069T1 (de)	1988-02-15	Analgetische dibenz(b,f>oxepine, ein verfahren zu ihrer herstellung und ihre verwendung als heilmittel.
ATE206127T1 (de)	2001-10-15	Inhibitoren retroviraler proteasen
ES2105312T3 (es)	1997-10-16	Procedimiento quimico de preparacion de un aminodiol opticamente activo.