DK0626385T3 - Tetrahydropyranderivater - Google Patents

Tetrahydropyranderivater

Info

Publication number: DK0626385T3
Authority: DK; Denmark
Prior art keywords: hydroxy groups; antiinflammatory; free; various; antiproliferative
Prior art date: 1993-05-27

Application number

DK94810297T

Other languages

English (en)

Inventor

A R C Murty Bulusu

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-05-27

Filing date

1994-05-24

Publication date

2004-02-16

1993-05-27 Priority claimed from GB939310969A external-priority patent/GB9310969D0/en

1993-05-27 Priority claimed from GB939310975A external-priority patent/GB9310975D0/en

1993-06-18 Priority claimed from GB939312590A external-priority patent/GB9312590D0/en

1993-07-01 Priority claimed from GB939313553A external-priority patent/GB9313553D0/en

1993-09-23 Priority claimed from GB939319618A external-priority patent/GB9319618D0/en

1993-09-23 Priority claimed from GB939319617A external-priority patent/GB9319617D0/en

1993-12-21 Priority claimed from GB939326045A external-priority patent/GB9326045D0/en

1994-05-24 Application filed by Novartis Ag filed Critical Novartis Ag

2004-02-16 Application granted granted Critical

2004-02-16 Publication of DK0626385T3 publication Critical patent/DK0626385T3/da

Links

DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical compound C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 title 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
230000010933 acylation Effects 0.000 abstract 1
238000005917 acylation reaction Methods 0.000 abstract 1
239000002260 anti-inflammatory agent Substances 0.000 abstract 1
229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
230000001028 anti-proliverative effect Effects 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000010511 deprotection reaction Methods 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000008030 elimination Effects 0.000 abstract 1
238000003379 elimination reaction Methods 0.000 abstract 1
230000026030 halogenation Effects 0.000 abstract 1
238000005658 halogenation reaction Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000003647 oxidation Effects 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1
150000003839 salts Chemical group 0.000 abstract 1
238000000926 separation method Methods 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Immunology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Steroid Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Color Printing (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK94810297T 1993-05-27 1994-05-24 Tetrahydropyranderivater DK0626385T3 (da)

Applications Claiming Priority (7)

Application Number	Priority Date	Filing Date	Title
GB939310969A GB9310969D0 (en)	1993-05-27	1993-05-27	Organic compounds
GB939310975A GB9310975D0 (en)	1993-05-27	1993-05-27	Organic compounds
GB939312590A GB9312590D0 (en)	1993-06-18	1993-06-18	Organic compounds
GB939313553A GB9313553D0 (en)	1993-07-01	1993-07-01	Organic compounds
GB939319618A GB9319618D0 (en)	1993-09-23	1993-09-23	Organic compounds
GB939319617A GB9319617D0 (en)	1993-09-23	1993-09-23	Organic compounds
GB939326045A GB9326045D0 (en)	1993-12-21	1993-12-21	Organic compounds

Publications (1)

Publication Number	Publication Date
DK0626385T3 true DK0626385T3 (da)	2004-02-16

Family

ID=27562893

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94810297T DK0626385T3 (da)	1993-05-27	1994-05-24	Tetrahydropyranderivater

Country Status (23)

Country	Link
US (1)	US5493019A (da)
EP (1)	EP0626385B1 (da)
JP (1)	JP3076724B2 (da)
CN (1)	CN1048495C (da)
AT (1)	ATE252105T1 (da)
AU (1)	AU682499B2 (da)
CA (1)	CA2124260C (da)
CY (1)	CY2523B1 (da)
CZ (1)	CZ286157B6 (da)
DE (1)	DE69433234T2 (da)
DK (1)	DK0626385T3 (da)
ES (1)	ES2208651T3 (da)
FI (1)	FI107159B (da)
HU (1)	HU218919B (da)
IL (1)	IL109775A (da)
MY (1)	MY110603A (da)
NO (1)	NO308302B1 (da)
NZ (1)	NZ260596A (da)
PH (1)	PH30420A (da)
PT (1)	PT626385E (da)
RU (1)	RU2130460C1 (da)
SI (1)	SI0626385T1 (da)
SK (1)	SK281541B6 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN100335063C (zh)	1994-10-26	2007-09-05	诺瓦蒂斯有限公司	药物组合物
US6673768B1 (en)	1997-10-16	2004-01-06	Board Of Regents, The University Of Texas System	Transgenic animal models for cardiac hypertrophy and methods of use thereof (treating)
ME00189B (me)	1998-03-26	2011-02-10	Astellas Pharma Inc	Preparati sa neprekidnim oslobađanjem
US6300341B1 (en)	1998-09-30	2001-10-09	The Procter & Gamble Co.	2-substituted heterocyclic sulfonamides
US6307049B1 (en)	1998-09-30	2001-10-23	The Procter & Gamble Co.	Heterocyclic 2-substituted ketoamides
GB9826656D0 (en)	1998-12-03	1999-01-27	Novartis Ag	Organic compounds
US6121257A (en) *	1999-03-31	2000-09-19	Abbott Laboratories	Sulfamate containing macrocyclic immunomodulators
US7063857B1 (en)	1999-04-30	2006-06-20	Sucampo Ag	Use of macrolide compounds for the treatment of dry eye
EP1531793A1 (en)	2002-07-23	2005-05-25	Novartis AG	Ophtalmic ointment composition comprising a drug, an ointment base and a solubiling/dispersing agent
JP2007516951A (ja) *	2003-12-30	2007-06-28	アステラス製薬株式会社	気道閉塞症の治療または予防のためのマクロライドの使用
GT200500282A (es)	2004-10-12	2006-05-04		Heteroatomos conteniendo compuestos triciclicos.
EP1688161A1 (en) *	2004-11-02	2006-08-09	Switch Biotech Aktiengesellschaft	Use of pirlindole for the treatment of diseases which are characterized by proliferation of t-lymphocytes and/or hyperproliferation of keratinocytes in particular atopic dermatitis and psoriasis
ES2429525T3 (es) *	2009-07-15	2013-11-15	Cell Therapeutics, Inc.	Sal de citrato de 9E-15-(2-pirrolidin-1-il-etoxi)-7,12,25-trioxa-19,21,24-triaza-tetraciclo[18.3.1.1(2,5).1(14)18)]-hexacosa-1(24),2,4,9,14,16,18(26),20,22-nonaeno
US10143682B2 (en)	2014-10-28	2018-12-04	Koushi Yamaguchi	Medicine for improving state of pregnancy, and use thereof
US20210228551A1 (en)	2018-08-10	2021-07-29	Koushi Yamaguchi	Therapeutic agent for humoral immunity-related diseases in maternofetal relationship
CN120053439A (zh)	2018-12-18	2025-05-30	山口晃史	用于改善不孕不育症或妊娠状态的药物
MX2021008824A (es) *	2019-01-23	2021-10-13	Univ Johns Hopkins	Análogos no inmunosupresores de tacrolimus (fk506) y uso de los mismos.
WO2021256894A1 (ko) *	2020-06-19	2021-12-23	서울대학교 산학협력단	신경 돌기 생장 및 시냅스 형성 활성을 갖는 신규 prolylfk506 유도체 및 그의 용도
US20230094227A1 (en) *	2020-12-24	2023-03-30	Seoul National University R&Db Foundation	Novel fk506 derivative and composition comprising same for promoting hair growth

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0078235A3 (de) *	1981-10-23	1983-06-29	Ciba-Geigy Ag	Dihalogenierte Steroide
US4894366A (en) *	1984-12-03	1990-01-16	Fujisawa Pharmaceutical Company, Ltd.	Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
DK175235B1 (da) *	1987-11-09	2004-07-19	Novartis Ag	Ny anvendelse af azatricycloderivater og farmaceutiske præparater med indhold deraf
EP0356399A3 (en) *	1988-08-26	1991-03-20	Sandoz Ag	Substituted 4-azatricyclo (22.3.1.04.9) octacos-18-ene derivatives, their preparation and pharmaceutical compositions containing them
US4980466A (en) *	1988-10-12	1990-12-25	Merck & Co., Inc.	Hydroxide mediated FK-506 rearrangement product
EP0385936A1 (de) *	1989-02-27	1990-09-05	Ciba-Geigy Ag	Peptidlacton und derivate davon, Verfahren zu ihrer Herstellung und Mittel zur Ausführung des Verfahrens
US5057608A (en) *	1989-04-21	1991-10-15	Merck & Co., Inc.	Immunoregulants, immunosuppressants, process to make ring expanded macrolide related to FK-506/FK-520
EP0594600A1 (en) *	1990-03-13	1994-05-04	FISONS plc	Immunosuppressive macrocyclic compounds
CA2051872A1 (en) *	1990-09-24	1992-03-25	Kevin M. Byrne	Directed biosynthesis process for prolyl-immunomycin
GB2249787A (en) *	1990-11-19	1992-05-20	Fujisawa Pharmaceutical Co	Lactone compounds
WO1992013862A1 (en) *	1991-02-05	1992-08-20	Fujisawa Pharmaceutical Co., Ltd.	Lactone compounds
JP3036923B2 (ja) *	1991-10-28	2000-04-24	理化学研究所	デプシペプチドａ、ｂその製造方法、並びに抗ウイルス剤及び抗菌剤
HUT66531A (en) *	1992-05-07	1994-12-28	Sandoz Ag	Heteroatoms-containing tricyclic compounds, pharmaceutical prepns contg. them and process for producing them

1994
- 1994-05-23 MY MYPI94001314A patent/MY110603A/en unknown
- 1994-05-24 PH PH48331A patent/PH30420A/en unknown
- 1994-05-24 PT PT94810297T patent/PT626385E/pt unknown
- 1994-05-24 SI SI9430457T patent/SI0626385T1/xx unknown
- 1994-05-24 ES ES94810297T patent/ES2208651T3/es not_active Expired - Lifetime
- 1994-05-24 DK DK94810297T patent/DK0626385T3/da active
- 1994-05-24 DE DE69433234T patent/DE69433234T2/de not_active Expired - Lifetime
- 1994-05-24 EP EP94810297A patent/EP0626385B1/en not_active Expired - Lifetime
- 1994-05-24 AT AT94810297T patent/ATE252105T1/de not_active IP Right Cessation
- 1994-05-25 AU AU63317/94A patent/AU682499B2/en not_active Ceased
- 1994-05-25 CA CA002124260A patent/CA2124260C/en not_active Expired - Fee Related
- 1994-05-25 SK SK611-94A patent/SK281541B6/sk not_active IP Right Cessation
- 1994-05-25 HU HU9401582A patent/HU218919B/hu not_active IP Right Cessation
- 1994-05-25 FI FI942444A patent/FI107159B/fi not_active IP Right Cessation
- 1994-05-25 IL IL10977594A patent/IL109775A/xx not_active IP Right Cessation
- 1994-05-25 NZ NZ260596A patent/NZ260596A/en not_active IP Right Cessation
- 1994-05-25 NO NO941936A patent/NO308302B1/no not_active IP Right Cessation
- 1994-05-26 CN CN94105935A patent/CN1048495C/zh not_active Expired - Fee Related
- 1994-05-26 US US08/249,911 patent/US5493019A/en not_active Expired - Lifetime
- 1994-05-26 JP JP06112552A patent/JP3076724B2/ja not_active Expired - Fee Related
- 1994-05-26 RU RU94018524A patent/RU2130460C1/ru not_active IP Right Cessation
- 1994-05-26 CZ CZ19941295A patent/CZ286157B6/cs not_active IP Right Cessation
2005
- 2005-04-14 CY CY0500023A patent/CY2523B1/xx unknown

Also Published As

Publication number	Publication date
JP3076724B2 (ja)	2000-08-14
AU682499B2 (en)	1997-10-09
FI107159B (fi)	2001-06-15
IL109775A (en)	1999-07-14
CZ129594A3 (en)	1995-01-18
HU218919B (hu)	2000-12-28
SK61194A3 (en)	1995-02-08
AU6331794A (en)	1994-12-01
ES2208651T3 (es)	2004-06-16
EP0626385A1 (en)	1994-11-30
EP0626385B1 (en)	2003-10-15
ATE252105T1 (de)	2003-11-15
CY2523B1 (en)	2006-02-08
JPH06340672A (ja)	1994-12-13
HU9401582D0 (en)	1994-08-29
DE69433234D1 (de)	2003-11-20
DE69433234T2 (de)	2004-08-05
FI942444A7 (fi)	1994-11-28
CN1048495C (zh)	2000-01-19
HUT71396A (en)	1995-11-28
CA2124260C (en)	2007-04-17
RU2130460C1 (ru)	1999-05-20
CN1099756A (zh)	1995-03-08
CA2124260A1 (en)	1994-11-28
PT626385E (pt)	2004-03-31
US5493019A (en)	1996-02-20
NO941936D0 (no)	1994-05-25
FI942444A0 (fi)	1994-05-25
IL109775A0 (en)	1994-08-26
PH30420A (en)	1997-05-09
SK281541B6 (sk)	2001-04-09
HK1011684A1 (en)	1999-07-16
SI0626385T1 (en)	2004-02-29
CZ286157B6 (cs)	2000-01-12
NO941936L (no)	1994-11-28
NZ260596A (en)	1995-10-26
NO308302B1 (no)	2000-08-28
MY110603A (en)	1998-08-29

Publication	Publication Date	Title
DK0626385T3 (da)	2004-02-16	Tetrahydropyranderivater
DE69316921D1 (de)	1998-03-12	Neue verwendungen für il-10
DE60228761D1 (de)	2008-10-16	Pharmazeutische zusammensetzung (kit) enthaltend dihydropyridinonverbindungen und eine verbindung mit immunmodulatorischer (oder antiinflammatorischer) wirkung und ihre verwendung
DE69608993D1 (de)	2000-08-03	UV Schutzmittel
RU94018524A (ru)	1996-01-10	Производные тетрагидропирана, способ их получения и фармацевтическая композиция на их основе
AU3839393A (en)	1993-11-11	Improvements in or relating to organic compounds
NO308607B1 (no)	2000-10-02	Kjemisk forbindelse, et farmasøytisk preparat inneholdende denne, samt anvendelse av forbindelsen til fremstilling av en blodplateaggregeringsinhibiotor og fremstilling av et farmasøytisk preparat til behandling eller forebygging av trombotiske
GB9409882D0 (en)	1994-07-06	Organic compounds
AU2704492A (en)	1993-04-22	Improvements in or relating to organic compounds
TW235294B (da)	1994-12-01
NO305556B1 (no)	1999-06-21	Tiokarbamoylforbindelser og anvendelse derav samt middel for beskyttelse av tekniske materialer
TW232007B (da)	1994-10-11
ITBG930012A0 (it)	1993-03-04	Depuratore mono-blocco multi-stadio particolarmente per acque contenenti particelle sabbiose o simili