DK0626385T3 - Tetrahydropyranderivater - Google Patents

Tetrahydropyranderivater

Info

Publication number: DK0626385T3
Authority: DK; Denmark
Prior art keywords: hydroxy groups; antiinflammatory; free; various; antiproliferative
Prior art date: 1993-05-27

Application number

DK94810297T

Other languages

English (en)

Inventor

A R C Murty Bulusu

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-05-27

Filing date

1994-05-24

Publication date

2004-02-16

1993-05-27 Priority claimed from GB939310969A external-priority patent/GB9310969D0/en

1993-05-27 Priority claimed from GB939310975A external-priority patent/GB9310975D0/en

1993-06-18 Priority claimed from GB939312590A external-priority patent/GB9312590D0/en

1993-07-01 Priority claimed from GB939313553A external-priority patent/GB9313553D0/en

1993-09-23 Priority claimed from GB939319618A external-priority patent/GB9319618D0/en

1993-09-23 Priority claimed from GB939319617A external-priority patent/GB9319617D0/en

1993-12-21 Priority claimed from GB939326045A external-priority patent/GB9326045D0/en

1994-05-24 Application filed by Novartis Ag filed Critical Novartis Ag

2004-02-16 Application granted granted Critical

2004-02-16 Publication of DK0626385T3 publication Critical patent/DK0626385T3/da

Links

DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical compound C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 title 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
230000010933 acylation Effects 0.000 abstract 1
238000005917 acylation reaction Methods 0.000 abstract 1
239000002260 anti-inflammatory agent Substances 0.000 abstract 1
229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
230000001028 anti-proliverative effect Effects 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000010511 deprotection reaction Methods 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000008030 elimination Effects 0.000 abstract 1
238000003379 elimination reaction Methods 0.000 abstract 1
230000026030 halogenation Effects 0.000 abstract 1
238000005658 halogenation reaction Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000003647 oxidation Effects 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1
150000003839 salts Chemical group 0.000 abstract 1
238000000926 separation method Methods 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Steroid Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Color Printing (AREA)

DK94810297T 1993-05-27 1994-05-24 Tetrahydropyranderivater DK0626385T3 (da)

Applications Claiming Priority (7)

Application Number	Priority Date	Filing Date	Title
GB939310969A GB9310969D0 (en)	1993-05-27	1993-05-27	Organic compounds
GB939310975A GB9310975D0 (en)	1993-05-27	1993-05-27	Organic compounds
GB939312590A GB9312590D0 (en)	1993-06-18	1993-06-18	Organic compounds
GB939313553A GB9313553D0 (en)	1993-07-01	1993-07-01	Organic compounds
GB939319618A GB9319618D0 (en)	1993-09-23	1993-09-23	Organic compounds
GB939319617A GB9319617D0 (en)	1993-09-23	1993-09-23	Organic compounds
GB939326045A GB9326045D0 (en)	1993-12-21	1993-12-21	Organic compounds

Publications (1)

Publication Number	Publication Date
DK0626385T3 true DK0626385T3 (da)	2004-02-16

Family

ID=27562893

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94810297T DK0626385T3 (da)	1993-05-27	1994-05-24	Tetrahydropyranderivater

Country Status (23)

Country	Link
US (1)	US5493019A (da)
EP (1)	EP0626385B1 (da)
JP (1)	JP3076724B2 (da)
CN (1)	CN1048495C (da)
AT (1)	ATE252105T1 (da)
AU (1)	AU682499B2 (da)
CA (1)	CA2124260C (da)
CY (1)	CY2523B1 (da)
CZ (1)	CZ286157B6 (da)
DE (1)	DE69433234T2 (da)
DK (1)	DK0626385T3 (da)
ES (1)	ES2208651T3 (da)
FI (1)	FI107159B (da)
HU (1)	HU218919B (da)
IL (1)	IL109775A (da)
MY (1)	MY110603A (da)
NO (1)	NO308302B1 (da)
NZ (1)	NZ260596A (da)
PH (1)	PH30420A (da)
PT (1)	PT626385E (da)
RU (1)	RU2130460C1 (da)
SI (1)	SI0626385T1 (da)
SK (1)	SK281541B6 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0786986T3 (da)	1994-10-26	2002-04-29	Novartis Ag	Anvendelse af en umættet fedtalkohol
CA2306448A1 (en)	1997-10-16	1999-04-22	Board Of Regents, The University Of Texas System	Models and treatments for cardiac hypertrophy in relation with nf-at3 function
AU749623B2 (en)	1998-03-26	2002-06-27	Astellas Pharma Inc.	Sustained release preparations
US6307049B1 (en)	1998-09-30	2001-10-23	The Procter & Gamble Co.	Heterocyclic 2-substituted ketoamides
US6300341B1 (en)	1998-09-30	2001-10-09	The Procter & Gamble Co.	2-substituted heterocyclic sulfonamides
GB9826656D0 (en)	1998-12-03	1999-01-27	Novartis Ag	Organic compounds
US6121257A (en) *	1999-03-31	2000-09-19	Abbott Laboratories	Sulfamate containing macrocyclic immunomodulators
US7063857B1 (en)	1999-04-30	2006-06-20	Sucampo Ag	Use of macrolide compounds for the treatment of dry eye
CN101897662B (zh)	2002-07-23	2013-05-22	诺瓦提斯公司	包含药物、软膏基质和增溶剂/分散剂的眼用软膏剂组合物
EP1699456A1 (en) *	2003-12-30	2006-09-13	Astellas Pharma Inc.	Use of macrolides for treating or preventing airflow obstruction
GT200500282A (es)	2004-10-12	2006-05-04		Heteroatomos conteniendo compuestos triciclicos.
EP1688161A1 (en) *	2004-11-02	2006-08-09	Switch Biotech Aktiengesellschaft	Use of pirlindole for the treatment of diseases which are characterized by proliferation of t-lymphocytes and/or hyperproliferation of keratinocytes in particular atopic dermatitis and psoriasis
BR112012000750B1 (pt) *	2009-07-15	2021-05-25	Cti Biopharma Corp.	sal citrato cristalino, composição farmacêutica compreendendo o referido sal e uso do mesmo
US10143682B2 (en)	2014-10-28	2018-12-04	Koushi Yamaguchi	Medicine for improving state of pregnancy, and use thereof
AU2019318035A1 (en)	2018-08-10	2021-03-04	Koushi Yamaguchi	Therapeutic agent for humoral immunity-related diseases in materno-fetal relationship
CN113226331A (zh)	2018-12-18	2021-08-06	山口晃史	用于改善不孕不育症或妊娠状态的药物
CN119751235A (zh) *	2019-01-23	2025-04-04	约翰霍普金斯大学	非免疫抑制性fk506类似物及其用途
WO2021256894A1 (ko) *	2020-06-19	2021-12-23	서울대학교 산학협력단	신경 돌기 생장 및 시냅스 형성 활성을 갖는 신규 prolylfk506 유도체 및 그의 용도
US20230094227A1 (en) *	2020-12-24	2023-03-30	Seoul National University R&Db Foundation	Novel fk506 derivative and composition comprising same for promoting hair growth

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0078235A3 (de) *	1981-10-23	1983-06-29	Ciba-Geigy Ag	Dihalogenierte Steroide
US4894366A (en) *	1984-12-03	1990-01-16	Fujisawa Pharmaceutical Company, Ltd.	Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
PH26083A (en) *	1987-11-09	1992-02-06	Sandoz Ltd	11, 28-dioxa-4-azatricyclo [22.3.1.04.9) octacos-18-ene derivatives and pharmaceutical compositions containing them and method of use thereof
EP0356399A3 (en) *	1988-08-26	1991-03-20	Sandoz Ag	Substituted 4-azatricyclo (22.3.1.04.9) octacos-18-ene derivatives, their preparation and pharmaceutical compositions containing them
US4980466A (en) *	1988-10-12	1990-12-25	Merck & Co., Inc.	Hydroxide mediated FK-506 rearrangement product
EP0385936A1 (de) *	1989-02-27	1990-09-05	Ciba-Geigy Ag	Peptidlacton und derivate davon, Verfahren zu ihrer Herstellung und Mittel zur Ausführung des Verfahrens
US5057608A (en) *	1989-04-21	1991-10-15	Merck & Co., Inc.	Immunoregulants, immunosuppressants, process to make ring expanded macrolide related to FK-506/FK-520
WO1991013889A1 (en) *	1990-03-13	1991-09-19	Fisons Plc	Immunosuppressive macrocyclic compounds
CA2051872A1 (en) *	1990-09-24	1992-03-25	Kevin M. Byrne	Directed biosynthesis process for prolyl-immunomycin
GB2249787A (en) *	1990-11-19	1992-05-20	Fujisawa Pharmaceutical Co	Lactone compounds
WO1992013862A1 (en) *	1991-02-05	1992-08-20	Fujisawa Pharmaceutical Co., Ltd.	Lactone compounds
JP3036923B2 (ja) *	1991-10-28	2000-04-24	理化学研究所	デプシペプチドａ、ｂその製造方法、並びに抗ウイルス剤及び抗菌剤
HUT66531A (en) *	1992-05-07	1994-12-28	Sandoz Ag	Heteroatoms-containing tricyclic compounds, pharmaceutical prepns contg. them and process for producing them

1994
- 1994-05-23 MY MYPI94001314A patent/MY110603A/en unknown
- 1994-05-24 SI SI9430457T patent/SI0626385T1/xx unknown
- 1994-05-24 AT AT94810297T patent/ATE252105T1/de not_active IP Right Cessation
- 1994-05-24 DE DE69433234T patent/DE69433234T2/de not_active Expired - Lifetime
- 1994-05-24 ES ES94810297T patent/ES2208651T3/es not_active Expired - Lifetime
- 1994-05-24 EP EP94810297A patent/EP0626385B1/en not_active Expired - Lifetime
- 1994-05-24 PH PH48331A patent/PH30420A/en unknown
- 1994-05-24 DK DK94810297T patent/DK0626385T3/da active
- 1994-05-24 PT PT94810297T patent/PT626385E/pt unknown
- 1994-05-25 IL IL10977594A patent/IL109775A/xx not_active IP Right Cessation
- 1994-05-25 NO NO941936A patent/NO308302B1/no not_active IP Right Cessation
- 1994-05-25 HU HU9401582A patent/HU218919B/hu not_active IP Right Cessation
- 1994-05-25 SK SK611-94A patent/SK281541B6/sk not_active IP Right Cessation
- 1994-05-25 AU AU63317/94A patent/AU682499B2/en not_active Ceased
- 1994-05-25 CA CA002124260A patent/CA2124260C/en not_active Expired - Fee Related
- 1994-05-25 NZ NZ260596A patent/NZ260596A/en not_active IP Right Cessation
- 1994-05-25 FI FI942444A patent/FI107159B/fi not_active IP Right Cessation
- 1994-05-26 US US08/249,911 patent/US5493019A/en not_active Expired - Lifetime
- 1994-05-26 RU RU94018524A patent/RU2130460C1/ru not_active IP Right Cessation
- 1994-05-26 JP JP06112552A patent/JP3076724B2/ja not_active Expired - Fee Related
- 1994-05-26 CN CN94105935A patent/CN1048495C/zh not_active Expired - Fee Related
- 1994-05-26 CZ CZ19941295A patent/CZ286157B6/cs not_active IP Right Cessation
2005
- 2005-04-14 CY CY0500023A patent/CY2523B1/xx unknown

Also Published As

Publication number	Publication date
MY110603A (en)	1998-08-29
IL109775A (en)	1999-07-14
DE69433234D1 (de)	2003-11-20
CN1048495C (zh)	2000-01-19
FI942444A7 (fi)	1994-11-28
NO308302B1 (no)	2000-08-28
NZ260596A (en)	1995-10-26
US5493019A (en)	1996-02-20
FI942444A0 (fi)	1994-05-25
CZ129594A3 (en)	1995-01-18
CA2124260C (en)	2007-04-17
ATE252105T1 (de)	2003-11-15
ES2208651T3 (es)	2004-06-16
CZ286157B6 (cs)	2000-01-12
NO941936L (no)	1994-11-28
DE69433234T2 (de)	2004-08-05
JPH06340672A (ja)	1994-12-13
CN1099756A (zh)	1995-03-08
EP0626385B1 (en)	2003-10-15
HUT71396A (en)	1995-11-28
HU9401582D0 (en)	1994-08-29
FI107159B (fi)	2001-06-15
PT626385E (pt)	2004-03-31
CA2124260A1 (en)	1994-11-28
CY2523B1 (en)	2006-02-08
NO941936D0 (no)	1994-05-25
SI0626385T1 (en)	2004-02-29
HU218919B (hu)	2000-12-28
SK61194A3 (en)	1995-02-08
HK1011684A1 (en)	1999-07-16
EP0626385A1 (en)	1994-11-30
RU2130460C1 (ru)	1999-05-20
JP3076724B2 (ja)	2000-08-14
PH30420A (en)	1997-05-09
IL109775A0 (en)	1994-08-26
AU6331794A (en)	1994-12-01
AU682499B2 (en)	1997-10-09
SK281541B6 (sk)	2001-04-09

Publication	Publication Date	Title
DE69433234D1 (de)	2003-11-20	Tetrahydropyran-Derivate
DE69316921D1 (de)	1998-03-12	Neue verwendungen für il-10
DE60228761D1 (de)	2008-10-16	Pharmazeutische zusammensetzung (kit) enthaltend dihydropyridinonverbindungen und eine verbindung mit immunmodulatorischer (oder antiinflammatorischer) wirkung und ihre verwendung
PL300068A1 (en)	1994-02-21	9-(substituted glycil) amido-6-demethyl-6-deoxytetracyclines, methods of obtaining such compounds as well as their organic and inorganic salts or metal complexes, pharmaceutical agent and veterinari agent
DE69608993D1 (de)	2000-08-03	UV Schutzmittel
RU94018524A (ru)	1996-01-10	Производные тетрагидропирана, способ их получения и фармацевтическая композиция на их основе
AU3839393A (en)	1993-11-11	Improvements in or relating to organic compounds
NO308607B1 (no)	2000-10-02	Kjemisk forbindelse, et farmasøytisk preparat inneholdende denne, samt anvendelse av forbindelsen til fremstilling av en blodplateaggregeringsinhibiotor og fremstilling av et farmasøytisk preparat til behandling eller forebygging av trombotiske
GB9409882D0 (en)	1994-07-06	Organic compounds
AU2704492A (en)	1993-04-22	Improvements in or relating to organic compounds
TW235294B (da)	1994-12-01
NO305556B1 (no)	1999-06-21	Tiokarbamoylforbindelser og anvendelse derav samt middel for beskyttelse av tekniske materialer
TW232007B (da)	1994-10-11
ITBG930012A0 (it)	1993-03-04	Depuratore mono-blocco multi-stadio particolarmente per acque contenenti particelle sabbiose o simili
ATE44144T1 (de)	1989-07-15	6h-dibenzo(b,e)(1,4)oxathiepin-verbindungen.