DK0626862T3 - Lægemiddelsystem omfattende en gelmatriks indeholdende et immobiliseret lægemiddel - Google Patents
Lægemiddelsystem omfattende en gelmatriks indeholdende et immobiliseret lægemiddelInfo
- Publication number
- DK0626862T3 DK0626862T3 DK93901816T DK93901816T DK0626862T3 DK 0626862 T3 DK0626862 T3 DK 0626862T3 DK 93901816 T DK93901816 T DK 93901816T DK 93901816 T DK93901816 T DK 93901816T DK 0626862 T3 DK0626862 T3 DK 0626862T3
- Authority
- DK
- Denmark
- Prior art keywords
- drug
- polysaccharide
- gel matrix
- matrix containing
- immobilized
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6903—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being semi-solid, e.g. an ointment, a gel, a hydrogel or a solidifying gel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929200638A GB9200638D0 (en) | 1992-01-10 | 1992-01-10 | Drug system |
| PCT/GB1993/000034 WO1993013803A1 (en) | 1992-01-10 | 1993-01-08 | Drug system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0626862T3 true DK0626862T3 (da) | 1999-12-13 |
Family
ID=10708507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93901816T DK0626862T3 (da) | 1992-01-10 | 1993-01-08 | Lægemiddelsystem omfattende en gelmatriks indeholdende et immobiliseret lægemiddel |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5830506A (da) |
| EP (1) | EP0626862B1 (da) |
| JP (1) | JP4025363B2 (da) |
| AT (1) | ATE183927T1 (da) |
| AU (1) | AU3263093A (da) |
| DE (1) | DE69326234T2 (da) |
| DK (1) | DK0626862T3 (da) |
| ES (1) | ES2135458T3 (da) |
| GB (1) | GB9200638D0 (da) |
| GR (1) | GR3031479T3 (da) |
| WO (1) | WO1993013803A1 (da) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9200638D0 (en) * | 1992-01-10 | 1992-03-11 | Leicester Polytechnic | Drug system |
| GB9313484D0 (en) | 1993-06-30 | 1993-08-11 | Univ Montfort | Drug system ii |
| GB9805896D0 (en) | 1998-03-20 | 1998-05-13 | Eglise David | Remote analysis system |
| AU6931500A (en) * | 1999-08-27 | 2001-03-26 | M-Biotech, Inc. | Glucose biosensor |
| AU2001278840A1 (en) * | 2000-04-22 | 2001-11-07 | M-Biotech, Inc. | Hydrogel biosensor and biosensor-based health alarm system |
| GB0116860D0 (en) * | 2001-07-10 | 2001-09-05 | Univ Montfort | Gel compositions |
| JP2005501096A (ja) | 2001-08-17 | 2005-01-13 | ユニヴァーシティ オブ ピッツバーグ | 肥満、代謝症候群、糖尿病、血管障害及び腎臓疾患を治療又は予防するエストラジオールメタボライトの投与 |
| US6943267B1 (en) | 2001-08-24 | 2005-09-13 | Utah State University | Thiophosphonate inhibitors of phosphatase enzymes and metallophosphatases |
| US20080279936A1 (en) * | 2001-10-10 | 2008-11-13 | The University Of Pittsburgh | Estradiol metabolites for reduction of endothelin production |
| US20090118605A1 (en) * | 2002-08-30 | 2009-05-07 | Northwestern University | Surface-enhanced raman nanobiosensor |
| CA2509382A1 (en) | 2002-12-17 | 2004-07-08 | Todd C. Zion | Stimuli-responsive systems for controlled drug delivery |
| US20060194775A1 (en) * | 2003-02-20 | 2006-08-31 | University Of Pittsburgh | Estradiol metabolites for the treatment of pulmonary hypertension |
| KR20050104383A (ko) * | 2003-02-20 | 2005-11-02 | 유니버시티 오브 피츠버그 | 폐 고혈압의 치료를 위한 에스트라디올 대사물 |
| US7806856B2 (en) * | 2005-04-22 | 2010-10-05 | Accessclosure, Inc. | Apparatus and method for temporary hemostasis |
| WO2007047997A2 (en) * | 2005-10-19 | 2007-04-26 | Smartcells, Inc. | Methods for reducing the mitogenicity of lectin compositions |
| WO2010088286A1 (en) | 2009-01-28 | 2010-08-05 | Smartcells, Inc. | Synthetic conjugates and uses thereof |
| WO2010088294A1 (en) | 2009-01-28 | 2010-08-05 | Smartcells, Inc. | Conjugate based systems for controlled drug delivery |
| JP2012516339A (ja) | 2009-01-28 | 2012-07-19 | スマートセルズ・インコーポレイテツド | 外因的刺激型制御放出物質体およびその使用 |
| RU2011135730A (ru) | 2009-01-28 | 2013-03-10 | Смартселлз, Инк. | Кристаллические инсулин-коньюгаты |
| WO2010107520A1 (en) | 2009-03-20 | 2010-09-23 | Smartcells, Inc. | Soluble non-depot insulin conjugates and uses thereof |
| JP2012520879A (ja) | 2009-03-20 | 2012-09-10 | スマートセルズ・インコーポレイテツド | 末端官能基化コンジュゲートおよびその用途 |
| JP2013535467A (ja) | 2010-07-28 | 2013-09-12 | スマートセルズ・インコーポレイテツド | 組換えにより発現されたインスリンポリペプチドおよびその使用 |
| WO2012015681A2 (en) | 2010-07-28 | 2012-02-02 | Smartcells, Inc. | Drug-ligand conjugates, synthesis thereof, and intermediates thereto |
| WO2012015691A2 (en) | 2010-07-28 | 2012-02-02 | Smartcells, Inc. | Recombinant lectins, binding-site modified lectins and uses thereof |
| GB201314640D0 (en) | 2013-08-15 | 2013-10-02 | Univ Montfort | Matrix gel |
| US9884125B2 (en) | 2013-10-04 | 2018-02-06 | Merck Sharp & Dohme Corp. | Glucose-responsive insulin conjugates |
| US11041009B2 (en) | 2017-03-23 | 2021-06-22 | Merck Sharp & Dohme Corp. | Glucose responsive insulin comprising a tri-valent sugar cluster for treatment of diabetes |
| US11820805B2 (en) | 2017-12-18 | 2023-11-21 | Merck Sharp & Dohme Llc | Conjugate based systems for controlled insulin delivery |
| WO2019125879A2 (en) | 2017-12-18 | 2019-06-27 | Merck Sharp & Dohme Corp. | Conjugate based systems for controlled insulin delivery |
| CN114432243B (zh) * | 2022-01-20 | 2023-08-29 | 华南师范大学 | 一种响应pH和葡萄糖的纳米载体及其应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4348387A (en) * | 1979-07-31 | 1982-09-07 | The Rockefeller University | Method and system for the controlled release of biologically active substances to a body fluid |
| DK0531497T3 (da) * | 1991-04-02 | 1998-03-23 | Biotech Australia Pty Ltd | Orale indgivelsessystemer til mikropartikler |
| GB9200638D0 (en) * | 1992-01-10 | 1992-03-11 | Leicester Polytechnic | Drug system |
| GB9313484D0 (en) * | 1993-06-30 | 1993-08-11 | Univ Montfort | Drug system ii |
-
1992
- 1992-01-10 GB GB929200638A patent/GB9200638D0/en active Pending
-
1993
- 1993-01-08 DK DK93901816T patent/DK0626862T3/da active
- 1993-01-08 WO PCT/GB1993/000034 patent/WO1993013803A1/en not_active Ceased
- 1993-01-08 ES ES93901816T patent/ES2135458T3/es not_active Expired - Lifetime
- 1993-01-08 AU AU32630/93A patent/AU3263093A/en not_active Abandoned
- 1993-01-08 DE DE69326234T patent/DE69326234T2/de not_active Expired - Lifetime
- 1993-01-08 US US08/256,283 patent/US5830506A/en not_active Expired - Lifetime
- 1993-01-08 AT AT93901816T patent/ATE183927T1/de not_active IP Right Cessation
- 1993-01-08 EP EP93901816A patent/EP0626862B1/en not_active Expired - Lifetime
- 1993-01-08 JP JP51224793A patent/JP4025363B2/ja not_active Expired - Fee Related
-
1998
- 1998-07-29 US US09/124,694 patent/US7063863B2/en not_active Expired - Fee Related
-
1999
- 1999-10-08 GR GR990402571T patent/GR3031479T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2135458T3 (es) | 1999-11-01 |
| DE69326234T2 (de) | 1999-12-30 |
| GR3031479T3 (en) | 2000-01-31 |
| JP4025363B2 (ja) | 2007-12-19 |
| ATE183927T1 (de) | 1999-09-15 |
| EP0626862B1 (en) | 1999-09-01 |
| WO1993013803A1 (en) | 1993-07-22 |
| US5830506A (en) | 1998-11-03 |
| EP0626862A1 (en) | 1994-12-07 |
| JPH07507268A (ja) | 1995-08-10 |
| US7063863B2 (en) | 2006-06-20 |
| US20020168409A1 (en) | 2002-11-14 |
| DE69326234D1 (de) | 1999-10-07 |
| GB9200638D0 (en) | 1992-03-11 |
| AU3263093A (en) | 1993-08-03 |
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