DK0627002T3 - Kloning og ekspression af humaniserede monoklonale antistoffer mod human interleukin-4 - Google Patents

Kloning og ekspression af humaniserede monoklonale antistoffer mod human interleukin-4

Info

Publication number
DK0627002T3
DK0627002T3 DK93905927T DK93905927T DK0627002T3 DK 0627002 T3 DK0627002 T3 DK 0627002T3 DK 93905927 T DK93905927 T DK 93905927T DK 93905927 T DK93905927 T DK 93905927T DK 0627002 T3 DK0627002 T3 DK 0627002T3
Authority
DK
Denmark
Prior art keywords
human interleukin
pct
monoclonal antibodies
cloning
expression
Prior art date
Application number
DK93905927T
Other languages
English (en)
Inventor
John S Abrams
Barbara Dalie
Hung V Le
Kenneth Miller
Nicholas J Murgolo
Hanh Nguyen
Michael Pearce
Stephen Tindall
Paul J Zavodny
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DK0627002T3 publication Critical patent/DK0627002T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • C07K16/465—Igs containing CDR-residues from one specie grafted between FR-residues from another with additional modified FR-residues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/247—IL-4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK93905927T 1992-02-19 1993-02-18 Kloning og ekspression af humaniserede monoklonale antistoffer mod human interleukin-4 DK0627002T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84165992A 1992-02-19 1992-02-19
PCT/US1993/001301 WO1993017106A1 (en) 1992-02-19 1993-02-18 Cloning and expression of humanized monoclonal antibodies against human interleukin-4

Publications (1)

Publication Number Publication Date
DK0627002T3 true DK0627002T3 (da) 1999-06-14

Family

ID=25285411

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93905927T DK0627002T3 (da) 1992-02-19 1993-02-18 Kloning og ekspression af humaniserede monoklonale antistoffer mod human interleukin-4

Country Status (17)

Country Link
US (2) US5863537A (da)
EP (1) EP0627002B1 (da)
JP (1) JPH07502901A (da)
KR (1) KR0158240B1 (da)
CN (1) CN1076966A (da)
AT (1) ATE171472T1 (da)
AU (1) AU684041B2 (da)
CA (1) CA2130436C (da)
DE (1) DE69321218T2 (da)
DK (1) DK0627002T3 (da)
ES (1) ES2121078T3 (da)
IL (1) IL104782A0 (da)
MX (1) MX9300913A (da)
NZ (1) NZ249677A (da)
SG (1) SG52215A1 (da)
WO (1) WO1993017106A1 (da)
ZA (1) ZA931148B (da)

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US5597710A (en) * 1994-03-10 1997-01-28 Schering Corporation Humanized monoclonal antibodies against human interleukin-4
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US7572442B2 (en) 2002-07-15 2009-08-11 Board Of Regents, The University Of Texas System Selected antibody compositions for binding to aminophospholipids
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US5041381A (en) * 1986-07-03 1991-08-20 Schering Corporation Monoclonal antibodies against human interleukin-4 and hybridomas producing the same
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DE69321218T2 (de) * 1992-02-19 1999-02-18 Schering Corp., Kenilworth, N.J. Klonierung und expression von humanisierten monoklonalen antikörpern gegen menschliches interleukin-4

Also Published As

Publication number Publication date
US5863537A (en) 1999-01-26
JPH07502901A (ja) 1995-03-30
WO1993017106A1 (en) 1993-09-02
AU3666293A (en) 1993-09-13
DE69321218D1 (de) 1998-10-29
ES2121078T3 (es) 1998-11-16
MX9300913A (es) 1994-08-31
EP0627002A1 (en) 1994-12-07
CA2130436C (en) 2001-04-10
NZ249677A (en) 1996-08-27
EP0627002B1 (en) 1998-09-23
CA2130436A1 (en) 1993-09-02
CN1076966A (zh) 1993-10-06
KR950700414A (ko) 1995-01-16
US5770403A (en) 1998-06-23
AU684041B2 (en) 1997-12-04
DE69321218T2 (de) 1999-02-18
ATE171472T1 (de) 1998-10-15
SG52215A1 (en) 1998-09-28
IL104782A0 (en) 1993-06-10
KR0158240B1 (ko) 1998-11-16
HK1008831A1 (en) 1999-05-21
ZA931148B (en) 1993-08-18

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