DK0643701T3 - Benzimidazolderivater, fremgangsmåde til deres fremstilling og deres anvendelse inden for det terapeutiske og kosmetiske område - Google Patents

Benzimidazolderivater, fremgangsmåde til deres fremstilling og deres anvendelse inden for det terapeutiske og kosmetiske område

Info

Publication number: DK0643701T3
Authority: DK; Denmark
Prior art keywords: radical; lower alkyl; hydrogen atom; pct; carbon atoms
Prior art date: 1991-05-31

Application number

DK92911098T

Other languages

English (en)

Inventor

Jean-Philippe Rocher

Daniel Cavey

Original Assignee

Galderma Rech Dermatologique

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-31

Filing date

1992-05-29

Publication date

2002-04-15

1992-05-29 Application filed by Galderma Rech Dermatologique filed Critical Galderma Rech Dermatologique

2002-04-15 Application granted granted Critical

2002-04-15 Publication of DK0643701T3 publication Critical patent/DK0643701T3/da

Links

229940058303 antinematodal benzimidazole derivative Drugs 0.000 title abstract 2
125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 title abstract 2
239000002537 cosmetic Substances 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
-1 alkyl radical Chemical class 0.000 abstract 12
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
125000004432 carbon atom Chemical group C* 0.000 abstract 4
150000003254 radicals Chemical class 0.000 abstract 4
SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical compound [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
229910018830 PO3H Inorganic materials 0.000 abstract 1
229910006069 SO3H Inorganic materials 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000000539 amino acid group Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000002757 inflammatory effect Effects 0.000 abstract 1
125000002950 monocyclic group Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
LEVJVKGPFAQPOI-UHFFFAOYSA-N phenylmethanone Chemical compound O=[C]C1=CC=CC=C1 LEVJVKGPFAQPOI-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
- C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Dermatology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Birds (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cosmetics (AREA)
Plural Heterocyclic Compounds (AREA)

DK92911098T 1991-05-31 1992-05-29 Benzimidazolderivater, fremgangsmåde til deres fremstilling og deres anvendelse inden for det terapeutiske og kosmetiske område DK0643701T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9106583A FR2677020B1 (fr)	1991-05-31	1991-05-31	Composes derives de benzimidazole, leur procede de preparation et leur utilisation dans les domaines therapeutique et cosmetique.
PCT/FR1992/000482 WO1992021663A1 (fr)	1991-05-31	1992-05-29	Composes derives de benzimidazole, leur procede de preparation et leur utilisation dans les domaines therapeutique et cosmetique

Publications (1)

Publication Number	Publication Date
DK0643701T3 true DK0643701T3 (da)	2002-04-15

Family

ID=9413334

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92911098T DK0643701T3 (da)	1991-05-31	1992-05-29	Benzimidazolderivater, fremgangsmåde til deres fremstilling og deres anvendelse inden for det terapeutiske og kosmetiske område

Country Status (11)

Country	Link
US (1)	US5446059A (da)
EP (1)	EP0643701B1 (da)
JP (1)	JP3282630B2 (da)
AT (1)	ATE210122T1 (da)
AU (1)	AU661487B2 (da)
CA (1)	CA2110273C (da)
DE (1)	DE69232270T2 (da)
DK (1)	DK0643701T3 (da)
ES (1)	ES2168259T3 (da)
FR (1)	FR2677020B1 (da)
WO (1)	WO1992021663A1 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3637055B2 (ja) *	1992-02-13	2005-04-06	メルクパテントゲゼルシャフトミットベシュレンクテルハフトング	光保護フィルターとしてのベンズイミダゾール誘導体の使用
FR2731706B1 (fr) *	1995-03-14	1997-04-11	Cird Galderma	Composes heterocycliques aromatiques, compositions pharmaceutiques et cosmetiques les contenant et utilisations
US5861142A (en) *	1996-03-25	1999-01-19	Schick; Mary Pichler	Method for promoting hair, nail, and skin keratinization
US6630496B1 (en)	1996-08-26	2003-10-07	Genetics Institute Llc	Inhibitors of phospholipase enzymes
US6828344B1 (en)	1998-02-25	2004-12-07	Genetics Institute, Llc	Inhibitors of phospholipase enzymes
US6916841B2 (en) *	1998-02-25	2005-07-12	Genetics Institute, Llc	Inhibitors of phospholipase enzymes
US6500853B1 (en)	1998-02-28	2002-12-31	Genetics Institute, Llc	Inhibitors of phospholipase enzymes
WO2000007446A1 (de) *	1998-08-04	2000-02-17	Ciba Specialty Chemicals Holding Inc.	Mikrobizide wirksubstanzen
US20070004713A1 (en) *	2000-12-07	2007-01-04	Bernard Barlaam	Therapeutic benimidazole compounds
TW200804345A (en) *	2005-08-30	2008-01-16	Novartis Ag	Substituted benzimidazoles and methods of preparation
CL2007003443A1 (es) *	2006-11-30	2008-07-11	Wyeth6 3	Compuestos derivados de benzoxazoles sustituidos; procedimiento de preparacion, utiles como agentes estrogenicos.
CA2737495A1 (en) *	2008-10-08	2010-04-15	Cephalon, Inc.	Processes for the preparation of bendamustine
US20240423959A1 (en)	2022-06-21	2024-12-26	Jjr&D, Llc	Topical benzimidazole formulations and methods for use in treating inflammatory dermatoses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3224512A1 (de) *	1982-07-01	1984-01-05	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE3346575A1 (de) *	1983-12-23	1985-07-04	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue benzimidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel
LU85544A1 (fr) *	1984-09-19	1986-04-03	Cird	Derives heterocycliques aromatiques,leur procede de preparation et leur application dans les domaines therapeutique et cosmetique
LU85849A1 (fr) *	1985-04-11	1986-11-05	Cird	Derives benzonaphtaleniques,leur procede de preparation et leur application dans les domaines pharmaceutiques et cosmetiques

1991
- 1991-05-31 FR FR9106583A patent/FR2677020B1/fr not_active Expired - Fee Related
1992
- 1992-05-29 CA CA002110273A patent/CA2110273C/fr not_active Expired - Fee Related
- 1992-05-29 JP JP51047792A patent/JP3282630B2/ja not_active Expired - Fee Related
- 1992-05-29 US US08/142,464 patent/US5446059A/en not_active Expired - Lifetime
- 1992-05-29 EP EP92911098A patent/EP0643701B1/fr not_active Expired - Lifetime
- 1992-05-29 DK DK92911098T patent/DK0643701T3/da active
- 1992-05-29 AU AU18832/92A patent/AU661487B2/en not_active Ceased
- 1992-05-29 AT AT92911098T patent/ATE210122T1/de not_active IP Right Cessation
- 1992-05-29 WO PCT/FR1992/000482 patent/WO1992021663A1/fr not_active Ceased
- 1992-05-29 DE DE69232270T patent/DE69232270T2/de not_active Expired - Fee Related
- 1992-05-29 ES ES92911098T patent/ES2168259T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2110273C (fr)	2002-02-12
ES2168259T3 (es)	2002-06-16
ATE210122T1 (de)	2001-12-15
EP0643701A1 (fr)	1995-03-22
CA2110273A1 (fr)	1992-12-10
FR2677020A1 (fr)	1992-12-04
FR2677020B1 (fr)	1993-08-27
JP3282630B2 (ja)	2002-05-20
DE69232270T2 (de)	2002-08-08
AU1883292A (en)	1993-01-08
US5446059A (en)	1995-08-29
EP0643701B1 (fr)	2001-12-05
AU661487B2 (en)	1995-07-27
WO1992021663A1 (fr)	1992-12-10
DE69232270D1 (de)	2002-01-17
JPH06510743A (ja)	1994-12-01

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