DK0646130T3 - Selektiv tværbinding af hæmoglobiner ved hjælp af oxiderede, ringåbnede saccharider - Google Patents

Selektiv tværbinding af hæmoglobiner ved hjælp af oxiderede, ringåbnede saccharider

Info

Publication number: DK0646130T3
Authority: DK; Denmark
Prior art keywords: saccharide; hemoglobin; tri; reaction; ring
Prior art date: 1993-03-16

Application number

DK94908913.0T

Other languages

Danish (da)

English (en)

Inventor

Diana Pliura

Lawrence T Wong

Song Swee Er

Original Assignee

Hemosol Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-03-16

Filing date

1994-03-11

Publication date

1997-06-02

1994-03-11 Application filed by Hemosol Inc filed Critical Hemosol Inc

1997-06-02 Application granted granted Critical

1997-06-02 Publication of DK0646130T3 publication Critical patent/DK0646130T3/da

Links

102000001554 Hemoglobins Human genes 0.000 title abstract 5
108010054147 Hemoglobins Proteins 0.000 title abstract 5
238000004132 cross linking Methods 0.000 title abstract 2
INGWEZCOABYORO-UHFFFAOYSA-N 2-(furan-2-yl)-7-methyl-1h-1,8-naphthyridin-4-one Chemical compound N=1C2=NC(C)=CC=C2C(O)=CC=1C1=CC=CO1 INGWEZCOABYORO-UHFFFAOYSA-N 0.000 title 1
150000001720 carbohydrates Chemical class 0.000 title 1
238000006243 chemical reaction Methods 0.000 abstract 3
150000004043 trisaccharides Chemical class 0.000 abstract 3
229920001744 Polyaldehyde Polymers 0.000 abstract 2
238000007142 ring opening reaction Methods 0.000 abstract 2
MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 abstract 1
239000002262 Schiff base Substances 0.000 abstract 1
150000004753 Schiff bases Chemical class 0.000 abstract 1
MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 abstract 1
230000009286 beneficial effect Effects 0.000 abstract 1
239000003633 blood substitute Substances 0.000 abstract 1
239000006227 byproduct Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000003647 oxidation Effects 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1
239000000047 product Substances 0.000 abstract 1
-1 raffinose Chemical class 0.000 abstract 1
MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Saccharide Compounds (AREA)
Medicinal Preparation (AREA)

DK94908913.0T 1993-03-16 1994-03-11 Selektiv tværbinding af hæmoglobiner ved hjælp af oxiderede, ringåbnede saccharider DK0646130T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US3183093A	1993-03-16	1993-03-16

Publications (1)

Publication Number	Publication Date
DK0646130T3 true DK0646130T3 (da)	1997-06-02

Family

ID=21861634

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94908913.0T DK0646130T3 (da)	1993-03-16	1994-03-11	Selektiv tværbinding af hæmoglobiner ved hjælp af oxiderede, ringåbnede saccharider

Country Status (13)

Country	Link
US (2)	US5532352A (de)
EP (1)	EP0646130B1 (de)
JP (1)	JP2594241B2 (de)
KR (1)	KR100306000B1 (de)
CN (1)	CN1046292C (de)
AT (1)	ATE146189T1 (de)
AU (1)	AU668294B2 (de)
CA (1)	CA2131455C (de)
DE (1)	DE69401109T2 (de)
DK (1)	DK0646130T3 (de)
ES (1)	ES2095751T3 (de)
NZ (1)	NZ262349A (de)
WO (1)	WO1994021682A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE503711C2 (sv) *	1994-12-14	1996-08-12	Medicarb Ab	Flerstegsförfarande för beläggning av en intraokulär lins
US5952470A (en) *	1995-06-07	1999-09-14	Biopure Corporation	Method for separating unmodified hemoglobin from cross-linked hemoglobin
US5891506A (en) *	1996-08-09	1999-04-06	Medtronic, Inc.	Oxidative method for attachment of glycoproteins or glycopeptides to surfaces of medical devices
EP0939644B1 (de) *	1996-08-27	2004-01-14	Hemosol Inc.	Gesteigerte stimulation der erythropoesis
US5917020A (en) *	1997-01-15	1999-06-29	Kluger; Ronald H.	Bis-tetrameric hemoglobin and reagents for its production
US5814601A (en) *	1997-02-28	1998-09-29	The Regents Of The University Of California	Methods and compositions for optimization of oxygen transport by cell-free systems
AU735799C (en) *	1997-02-28	2005-04-28	Regents Of The University Of California, The	Methods and compositions for optimisation of oxygen transport by cell-free systems
CA2233725A1 (en) *	1998-03-31	1999-09-30	Hemosol Inc.	Hemoglobin-hydroxyethyl starch complexes
CA2266174A1 (en) *	1999-03-18	2000-09-18	Hemosol Inc.	Hemoglobin-antioxidant conjugates
DE19933275A1 (de) *	1999-07-14	2001-01-18	Fresenius Ag	Verwendung von Hämoglobin-Derivaten zur Bestimmung des Plasma- und/oder Blutvolumens
US6894150B1 (en)	1999-10-01	2005-05-17	Ross Walden Tye	Non-pyrogenic, endotoxin-free, stroma-free tetrameric hemoglobin
US6500809B1 (en)	1999-11-12	2002-12-31	Neuron Therapeutics, Inc.	Hyperoncotic artificial cerebrospinal fluid and method of treating neural tissue edema therewith
DE10031742A1 (de) *	2000-06-29	2002-01-17	Sanguibio Tech Ag	Verfahren zur Herstellung künstlicher Sauerstoffträger aus kovalent vernetzten Hämoglobinen mit verbesserten funktionellen Eigenschaften durch Vernetzung in Anwesenheit chemisch nicht reagierender Effektoren der Sauerstoffaffinität der Hämoglobine
DE10112825A1 (de)	2001-03-16	2002-10-02	Fresenius Kabi De Gmbh	HESylierung von Wirkstoffen in wässriger Lösung
US20030153491A1 (en) *	2002-01-11	2003-08-14	Winslow Robert M.	Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
US20050164915A1 (en)	2002-04-01	2005-07-28	Sangart, Inc.	Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
DE10209822A1 (de)	2002-03-06	2003-09-25	Biotechnologie Ges Mittelhesse	Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid
DE10209821A1 (de)	2002-03-06	2003-09-25	Biotechnologie Ges Mittelhesse	Kopplung von Proteinen an ein modifiziertes Polysaccharid
JP3912206B2 (ja) *	2002-07-05	2007-05-09	株式会社日立製作所	筒内直接燃料噴射装置用燃料ポンプ
BR0314106A (pt)	2002-09-11	2005-07-19	Fresenius Kabi De Gmbh	Polipeptìdeos hasilados, especialmente eritropoietina hasilada
ATE409048T1 (de)	2002-10-08	2008-10-15	Fresenius Kabi De Gmbh	Pharmazeutisch aktive oligosaccharid-conjugate
WO2005014655A2 (en)	2003-08-08	2005-02-17	Fresenius Kabi Deutschland Gmbh	Conjugates of hydroxyalkyl starch and a protein
US7135554B1 (en)	2004-01-27	2006-11-14	Biopure Corporation	Method of forming a polymerized hemoglobin solution from stabilized hemoglobin
TWI417303B (zh)	2004-03-11	2013-12-01	Fresenius Kabi De Gmbh	經由還原胺化作用製得之羥烷基澱粉及蛋白質的接合物
EP1865993A2 (de) *	2005-04-05	2007-12-19	Biopure Corporation	Sauerstoffangereicherte, polymerisierte hämoglobinlösungen und ihre verwendung zur sichtbarmachung von gewebe
US7494974B2 (en) *	2006-10-24	2009-02-24	Ikor, Inc.	Carboxymethylated cross-linked tetrameric hemoglobin
US7504377B2 (en) *	2006-10-23	2009-03-17	Ikor, Inc.	Nitric oxide-blocked cross-linked tetrameric hemoglobin
EP2070950A1 (de)	2007-12-14	2009-06-17	Fresenius Kabi Deutschland GmbH	Hydroxyalkylstärkederivate und deren Herstellungsverfahren
US20140260586A1 (en) *	2013-03-14	2014-09-18	Schlumberger Technology Corporation	Method to perform rapid formation fluid analysis

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4529719A (en) *	1983-05-04	1985-07-16	Tye Ross W	Modified crosslinked stroma-free tetrameric hemoglobin
JPH0645681B2 (ja) *	1986-02-05	1994-06-15	美浜久春	修飾ヘム
DE3636590A1 (de) *	1986-10-28	1988-05-26	Braun Melsungen Ag	Blutersatzmittel
GB8710598D0 (en) *	1987-05-05	1987-06-10	Star Medical Diagnostics Ltd	Hemoglobin based blood substitute
FR2640141B1 (fr) *	1988-12-14	1993-04-16	Merieux Inst	Conjugues macromoleculaires d'hemoglobine, leur procede de preparation et leurs applications
US5234903A (en) *	1989-11-22	1993-08-10	Enzon, Inc.	Chemically modified hemoglobin as an effective, stable non-immunogenic red blood cell substitute
SK54993A3 (en) *	1990-11-29	1993-10-06	Upjohn Co	Imidoester cross-linked hemoglobin compositions
FR2680369B1 (fr) *	1991-08-14	1993-11-05	Pasteur Merieux Serums Vaccins	Derives d'hemoglobine humaine, leur procede de preparation, produits en derivant et utilisation de ces derives et produits.
US5399671A (en) *	1992-11-18	1995-03-21	Kluger; Ronald	Specifically crosslinked hemoglobin with free functionality

1994
- 1994-03-11 ES ES94908913T patent/ES2095751T3/es not_active Expired - Lifetime
- 1994-03-11 WO PCT/CA1994/000140 patent/WO1994021682A1/en not_active Ceased
- 1994-03-11 NZ NZ262349A patent/NZ262349A/en not_active IP Right Cessation
- 1994-03-11 DK DK94908913.0T patent/DK0646130T3/da active
- 1994-03-11 JP JP6520446A patent/JP2594241B2/ja not_active Expired - Fee Related
- 1994-03-11 CN CN94190130A patent/CN1046292C/zh not_active Expired - Fee Related
- 1994-03-11 DE DE69401109T patent/DE69401109T2/de not_active Expired - Fee Related
- 1994-03-11 EP EP94908913A patent/EP0646130B1/de not_active Expired - Lifetime
- 1994-03-11 AU AU61793/94A patent/AU668294B2/en not_active Ceased
- 1994-03-11 KR KR1019940703254A patent/KR100306000B1/ko not_active Expired - Fee Related
- 1994-03-11 AT AT94908913T patent/ATE146189T1/de not_active IP Right Cessation
- 1994-03-11 CA CA002131455A patent/CA2131455C/en not_active Expired - Fee Related
- 1994-04-21 US US08/231,945 patent/US5532352A/en not_active Expired - Lifetime
1996
- 1996-06-28 US US08/672,868 patent/US5770727A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
KR100306000B1 (ko)	2001-12-01
US5532352A (en)	1996-07-02
JPH07506123A (ja)	1995-07-06
WO1994021682A1 (en)	1994-09-29
CA2131455A1 (en)	1994-09-29
AU6179394A (en)	1994-10-11
CN1105800A (zh)	1995-07-26
EP0646130A1 (de)	1995-04-05
NZ262349A (en)	1996-05-28
US5770727A (en)	1998-06-23
ES2095751T3 (es)	1997-02-16
AU668294B2 (en)	1996-04-26
CN1046292C (zh)	1999-11-10
ATE146189T1 (de)	1996-12-15
CA2131455C (en)	1998-08-18
DE69401109D1 (de)	1997-01-23
EP0646130B1 (de)	1996-12-11
DE69401109T2 (de)	1997-05-28
JP2594241B2 (ja)	1997-03-26

Publication	Publication Date	Title
DK0646130T3 (da)	1997-06-02	Selektiv tværbinding af hæmoglobiner ved hjælp af oxiderede, ringåbnede saccharider
DE3775140D1 (de)	1992-01-23	Herstellung von reinen aminosaeurechelaten der pharmazeutischen qualitaet.
EP0755944A3 (de)	1997-10-01	Zusammensetzung aus Polyhydroxycarbonsäure auf Basis von Maltodextrinen durch Oxidation mit einem sauerstoffhaltigen Oxidationsmittel
DE69211403D1 (de)	1996-07-18	Multifunktionelle wasserdispergierbare Verknüpfungsmittel
NO941770D0 (no)	1994-05-11	Substituert mono- og bipyridylmetylpyridon
DK389287D0 (da)	1987-07-27	Fremgangsmaade til fremstilling af keramisk artikel
CA2106863A1 (en)	1992-09-26	Process for preparing an alkanone and/or alkanol
DE69822117D1 (de)	2004-04-08	Verfahren zur Herstellung von olefinischen Epoxiden
HUT48231A (en)	1989-05-29	Process for producing 2-phenylbenzoxepin derivatives and pharmaceutical compositions comprising such compounds
RU94044355A (ru)	1996-10-27	Способ получения алканона и/или алканола
AU7818287A (en)	1988-03-24	Modified ceramic structures and methods of making the same
EP0330049A3 (de)	1991-01-30	Faktor XIII zur Vorbeugung von intraventrikulären Blutungen
EP0537160A4 (en)	1993-09-01	Expression of recombinant hemoglobin in yeast
ATE141919T1 (de)	1996-09-15	Methode um methylol-hydantoine mit niedriger konzentration an freiem formaldehyd, herstellung und deren zusammensetzungen
CS8706614A2 (en)	1991-07-16	Self-supporting ceramic body and method of its production
AU626470B2 (en)	1992-07-30	Benzocycloalkylaminopyridinamines and related compounds, a process and intermediates for their preparation and their use as medicaments
GR3019932T3 (en)	1996-08-31	Process for preparing sulfonated paraffins with a larger content of polysulfonated species.
ZA934583B (en)	1994-02-02	Imidazolyl-substituted cyclohexane derivatives
KR890012953A (ko)	1989-09-20	1,2-디설폰 화합물의 제조방법
JPS53111054A (en)	1978-09-28	Preparation of lactones
ZA861729B (en)	1986-10-29	A process for producing aqueous ammonium thiocyanate solutions
MD380C2 (ro)	1996-06-30	Procedeu de obţinere a hidroperoxidului de ciclohexil în amestec cu ciclohexanonă şi ciclohexanol
HUT38323A (en)	1986-05-28	Microbicide compositions containing organic complex compounds as active substances and process for preparing the active substances
JPS51125208A (en)	1976-11-01	Carbon chain lengthening
SU1391030A3 (ru)	2000-07-20	СПОСОБ СОВМЕСТНОГО ПОЛУЧЕНИЯ ФЕНОЛА, АЦЕТОНА И α-МЕТИЛСТИРОЛА