ATE146189T1 - Selektive vernetzung von hemoglobin mittels oxidierten, ringgeöffneten sacchariden - Google Patents

Selektive vernetzung von hemoglobin mittels oxidierten, ringgeöffneten sacchariden

Info

Publication number: ATE146189T1
Authority: AT; Austria
Prior art keywords: hemoglobin; saccharide; tri; reaction; ring
Prior art date: 1993-03-16

Application number

AT94908913T

Other languages

English (en)

Inventor

Diana Pliura

Lawrence T Wong

Song Swee Er

Original Assignee

Hemosol Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-03-16

Filing date

1994-03-11

Publication date

1996-12-15

1994-03-11 Application filed by Hemosol Inc filed Critical Hemosol Inc

1996-12-15 Application granted granted Critical

1996-12-15 Publication of ATE146189T1 publication Critical patent/ATE146189T1/de

Links

102000001554 Hemoglobins Human genes 0.000 title abstract 5
108010054147 Hemoglobins Proteins 0.000 title abstract 5
238000004132 cross linking Methods 0.000 title abstract 2
150000001720 carbohydrates Chemical class 0.000 title 1
238000006243 chemical reaction Methods 0.000 abstract 3
150000004043 trisaccharides Chemical class 0.000 abstract 3
229920001744 Polyaldehyde Polymers 0.000 abstract 2
238000007142 ring opening reaction Methods 0.000 abstract 2
MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 abstract 1
239000002262 Schiff base Substances 0.000 abstract 1
150000004753 Schiff bases Chemical class 0.000 abstract 1
MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 abstract 1
230000009286 beneficial effect Effects 0.000 abstract 1
239000003633 blood substitute Substances 0.000 abstract 1
239000006227 byproduct Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000003647 oxidation Effects 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1
239000000047 product Substances 0.000 abstract 1
-1 raffinose Chemical class 0.000 abstract 1
MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Medicinal Preparation (AREA)
Saccharide Compounds (AREA)

AT94908913T 1993-03-16 1994-03-11 Selektive vernetzung von hemoglobin mittels oxidierten, ringgeöffneten sacchariden ATE146189T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US3183093A	1993-03-16	1993-03-16

Publications (1)

Publication Number	Publication Date
ATE146189T1 true ATE146189T1 (de)	1996-12-15

Family

ID=21861634

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94908913T ATE146189T1 (de)	1993-03-16	1994-03-11	Selektive vernetzung von hemoglobin mittels oxidierten, ringgeöffneten sacchariden

Country Status (13)

Country	Link
US (2)	US5532352A (de)
EP (1)	EP0646130B1 (de)
JP (1)	JP2594241B2 (de)
KR (1)	KR100306000B1 (de)
CN (1)	CN1046292C (de)
AT (1)	ATE146189T1 (de)
AU (1)	AU668294B2 (de)
CA (1)	CA2131455C (de)
DE (1)	DE69401109T2 (de)
DK (1)	DK0646130T3 (de)
ES (1)	ES2095751T3 (de)
NZ (1)	NZ262349A (de)
WO (1)	WO1994021682A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE503711C2 (sv) *	1994-12-14	1996-08-12	Medicarb Ab	Flerstegsförfarande för beläggning av en intraokulär lins
US5952470A (en) *	1995-06-07	1999-09-14	Biopure Corporation	Method for separating unmodified hemoglobin from cross-linked hemoglobin
US5891506A (en) *	1996-08-09	1999-04-06	Medtronic, Inc.	Oxidative method for attachment of glycoproteins or glycopeptides to surfaces of medical devices
WO1998008537A1 (en) *	1996-08-27	1998-03-05	Hemosol Inc.	Enhanced stimulation of erythropoiesis
US5917020A (en) *	1997-01-15	1999-06-29	Kluger; Ronald H.	Bis-tetrameric hemoglobin and reagents for its production
US6054427A (en) *	1997-02-28	2000-04-25	The Regents Of The University Of California	Methods and compositions for optimization of oxygen transport by cell-free systems
US5814601A (en) *	1997-02-28	1998-09-29	The Regents Of The University Of California	Methods and compositions for optimization of oxygen transport by cell-free systems
CA2233725A1 (en) *	1998-03-31	1999-09-30	Hemosol Inc.	Hemoglobin-hydroxyethyl starch complexes
CA2266174A1 (en)	1999-03-18	2000-09-18	Hemosol Inc.	Hemoglobin-antioxidant conjugates
DE19933275A1 (de) *	1999-07-14	2001-01-18	Fresenius Ag	Verwendung von Hämoglobin-Derivaten zur Bestimmung des Plasma- und/oder Blutvolumens
US6894150B1 (en)	1999-10-01	2005-05-17	Ross Walden Tye	Non-pyrogenic, endotoxin-free, stroma-free tetrameric hemoglobin
US6500809B1 (en)	1999-11-12	2002-12-31	Neuron Therapeutics, Inc.	Hyperoncotic artificial cerebrospinal fluid and method of treating neural tissue edema therewith
DE10031742A1 (de) *	2000-06-29	2002-01-17	Sanguibio Tech Ag	Verfahren zur Herstellung künstlicher Sauerstoffträger aus kovalent vernetzten Hämoglobinen mit verbesserten funktionellen Eigenschaften durch Vernetzung in Anwesenheit chemisch nicht reagierender Effektoren der Sauerstoffaffinität der Hämoglobine
DE10112825A1 (de)	2001-03-16	2002-10-02	Fresenius Kabi De Gmbh	HESylierung von Wirkstoffen in wässriger Lösung
US20050164915A1 (en) *	2002-04-01	2005-07-28	Sangart, Inc.	Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
US20030153491A1 (en) *	2002-01-11	2003-08-14	Winslow Robert M.	Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
DE10209822A1 (de)	2002-03-06	2003-09-25	Biotechnologie Ges Mittelhesse	Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid
DE10209821A1 (de)	2002-03-06	2003-09-25	Biotechnologie Ges Mittelhesse	Kopplung von Proteinen an ein modifiziertes Polysaccharid
JP3912206B2 (ja) *	2002-07-05	2007-05-09	株式会社日立製作所	筒内直接燃料噴射装置用燃料ポンプ
MXPA05002594A (es)	2002-09-11	2005-05-27	Fresenius Kabi Gmbh	Derivados de polipeptidos con hidroxialquilalmidon, especialmente derivados de eritropoyetina con hidroxialquilalmidon.
WO2004032971A1 (en)	2002-10-08	2004-04-22	Fresenius Kabi Deutschland Gmbh	Pharmaceutically active oligosaccharide conjugates
WO2005014655A2 (en)	2003-08-08	2005-02-17	Fresenius Kabi Deutschland Gmbh	Conjugates of hydroxyalkyl starch and a protein
US7135554B1 (en)	2004-01-27	2006-11-14	Biopure Corporation	Method of forming a polymerized hemoglobin solution from stabilized hemoglobin
EP2336192A1 (de)	2004-03-11	2011-06-22	Fresenius Kabi Deutschland GmbH	Hydroxyalkylstärke-Protein-Konjugate, durch reduktive Aminierung hergestellt.
WO2006108047A2 (en) *	2005-04-05	2006-10-12	Biopure Corporation	Oxygenated polymerized hemoglobin solutions and their uses for tissue visualization
US7504377B2 (en) *	2006-10-23	2009-03-17	Ikor, Inc.	Nitric oxide-blocked cross-linked tetrameric hemoglobin
US7494974B2 (en) *	2006-10-24	2009-02-24	Ikor, Inc.	Carboxymethylated cross-linked tetrameric hemoglobin
EP2070950A1 (de)	2007-12-14	2009-06-17	Fresenius Kabi Deutschland GmbH	Hydroxyalkylstärkederivate und deren Herstellungsverfahren
US20140260586A1 (en) *	2013-03-14	2014-09-18	Schlumberger Technology Corporation	Method to perform rapid formation fluid analysis

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4529719A (en) *	1983-05-04	1985-07-16	Tye Ross W	Modified crosslinked stroma-free tetrameric hemoglobin
JPH0645681B2 (ja) *	1986-02-05	1994-06-15	美浜久春	修飾ヘム
DE3636590A1 (de) *	1986-10-28	1988-05-26	Braun Melsungen Ag	Blutersatzmittel
GB8710598D0 (en) *	1987-05-05	1987-06-10	Star Medical Diagnostics Ltd	Hemoglobin based blood substitute
FR2640141B1 (fr) *	1988-12-14	1993-04-16	Merieux Inst	Conjugues macromoleculaires d'hemoglobine, leur procede de preparation et leurs applications
US5234903A (en) *	1989-11-22	1993-08-10	Enzon, Inc.	Chemically modified hemoglobin as an effective, stable non-immunogenic red blood cell substitute
ATE119917T1 (de) *	1990-11-29	1995-04-15	Upjohn Co	Mit imidoester quer-vernetzte hämoglobinzusammensetzungen.
FR2680369B1 (fr) *	1991-08-14	1993-11-05	Pasteur Merieux Serums Vaccins	Derives d'hemoglobine humaine, leur procede de preparation, produits en derivant et utilisation de ces derives et produits.
US5399671A (en) *	1992-11-18	1995-03-21	Kluger; Ronald	Specifically crosslinked hemoglobin with free functionality

1994
- 1994-03-11 KR KR1019940703254A patent/KR100306000B1/ko not_active Expired - Fee Related
- 1994-03-11 DK DK94908913.0T patent/DK0646130T3/da active
- 1994-03-11 CA CA002131455A patent/CA2131455C/en not_active Expired - Fee Related
- 1994-03-11 WO PCT/CA1994/000140 patent/WO1994021682A1/en not_active Ceased
- 1994-03-11 EP EP94908913A patent/EP0646130B1/de not_active Expired - Lifetime
- 1994-03-11 JP JP6520446A patent/JP2594241B2/ja not_active Expired - Fee Related
- 1994-03-11 AT AT94908913T patent/ATE146189T1/de not_active IP Right Cessation
- 1994-03-11 NZ NZ262349A patent/NZ262349A/en not_active IP Right Cessation
- 1994-03-11 ES ES94908913T patent/ES2095751T3/es not_active Expired - Lifetime
- 1994-03-11 AU AU61793/94A patent/AU668294B2/en not_active Ceased
- 1994-03-11 DE DE69401109T patent/DE69401109T2/de not_active Expired - Fee Related
- 1994-03-11 CN CN94190130A patent/CN1046292C/zh not_active Expired - Fee Related
- 1994-04-21 US US08/231,945 patent/US5532352A/en not_active Expired - Lifetime
1996
- 1996-06-28 US US08/672,868 patent/US5770727A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
NZ262349A (en)	1996-05-28
CN1046292C (zh)	1999-11-10
CA2131455C (en)	1998-08-18
JPH07506123A (ja)	1995-07-06
JP2594241B2 (ja)	1997-03-26
US5770727A (en)	1998-06-23
CN1105800A (zh)	1995-07-26
AU668294B2 (en)	1996-04-26
EP0646130A1 (de)	1995-04-05
CA2131455A1 (en)	1994-09-29
WO1994021682A1 (en)	1994-09-29
ES2095751T3 (es)	1997-02-16
KR100306000B1 (ko)	2001-12-01
DE69401109D1 (de)	1997-01-23
EP0646130B1 (de)	1996-12-11
DK0646130T3 (da)	1997-06-02
US5532352A (en)	1996-07-02
DE69401109T2 (de)	1997-05-28
AU6179394A (en)	1994-10-11

Legal Events

Date	Code	Title	Description
2008-12-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69401109D1 (de)	1997-01-23	Selektive vernetzung von hemoglobin mittels oxidierten, ringgeöffneten sacchariden
KR900013082A (ko)	1990-09-03	Pf1022 물질, 그 생산방법 및 그 물질을 포함한 구충제 조성물
ATE82283T1 (de)	1992-11-15	Herstellung von 2-(2-pyridylmethylsulfinyl)benzimidazol-verbindungen.
DE3775140D1 (de)	1992-01-23	Herstellung von reinen aminosaeurechelaten der pharmazeutischen qualitaet.
ES2072907T3 (es)	1995-08-01	Produccion de cultivo hidroponico.
DK0508194T3 (da)	1998-08-24	Stabiliserede faktor VIII-præparater
DE69211403D1 (de)	1996-07-18	Multifunktionelle wasserdispergierbare Verknüpfungsmittel
NO941770D0 (no)	1994-05-11	Substituert mono- og bipyridylmetylpyridon
DE69108600D1 (de)	1995-05-11	Verfahren zur Herstellung von e-Caprolacton.
ATE353324T1 (de)	2007-02-15	Herstellung von furanonen
CA2176155A1 (en)	1996-11-13	Percarboxylic acid solutions with improved stability in contact with stainless steel
HUT48231A (en)	1989-05-29	Process for producing 2-phenylbenzoxepin derivatives and pharmaceutical compositions comprising such compounds
ATE94070T1 (de)	1993-09-15	Faktor xiii zur vorbeugung von intraventrikulaeren blutungen.
DE69902114D1 (de)	2002-08-22	Verfahren zur Herstellung von olefinischen Epoxiden
AU2001279641A1 (en)	2002-01-08	Method for the production of artificial oxygen carriers from covalently cross linking haemoglobin with improved functional properties of haemoglobin by cross-linking in the presence of chemically non-reacting effectors of the oxygen affinity of the haemoglobin
AU5838498A (en)	1998-09-17	Antifungal complexes
ATE85601T1 (de)	1993-02-15	Verfahren zur herstellung von 4demethoxydaunomycinon.
CS8706614A2 (en)	1991-07-16	Self-supporting ceramic body and method of its production
KR910700271A (ko)	1991-03-14	조절된 분자량 분포를 갖는 폴리올페핀 제조용의 지지된 바나듐 촉매
WO1990007260A3 (en)	1990-11-01	2,3-methanoproline
DE59007117D1 (de)	1994-10-20	Optimierte Fermentationsverfahren zur Herstellung von Fremdproteinen in E.coli.
TW245713B (de)	1995-04-21
GR3001799T3 (en)	1992-11-23	Process for preparation of n-allyl-piperidine derivatives
ZA861729B (en)	1986-10-29	A process for producing aqueous ammonium thiocyanate solutions
SU1391030A3 (ru)	2000-07-20	СПОСОБ СОВМЕСТНОГО ПОЛУЧЕНИЯ ФЕНОЛА, АЦЕТОНА И α-МЕТИЛСТИРОЛА