DK0647275T3 - Kloning og ekspression af receptoren for gonatotropin-frigörende hormon - Google Patents

Kloning og ekspression af receptoren for gonatotropin-frigörende hormon

Info

Publication number: DK0647275T3
Authority: DK; Denmark
Prior art keywords: gnrh; expression; cell lines; products; gonatotropin
Prior art date: 1992-06-23

Application number

DK93915447T

Other languages

English (en)

Inventor

Stuart C Sealfon

Original Assignee

Sinai School Medicine

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-23

Filing date

1993-06-22

Publication date

2005-01-24

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25418494&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0647275(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1993-06-21 Priority claimed from US08/080,386 external-priority patent/US5750366A/en

1993-06-22 Application filed by Sinai School Medicine filed Critical Sinai School Medicine

2005-01-24 Application granted granted Critical

2005-01-24 Publication of DK0647275T3 publication Critical patent/DK0647275T3/da

Links

230000014509 gene expression Effects 0.000 title abstract 6
102000016983 Releasing hormones receptors Human genes 0.000 title 1
108070000025 Releasing hormones receptors Proteins 0.000 title 1
238000010367 cloning Methods 0.000 title 1
NMJREATYWWNIKX-UHFFFAOYSA-N GnRH Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CC(C)C)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 NMJREATYWWNIKX-UHFFFAOYSA-N 0.000 abstract 5
101710082444 Gonadotropin-releasing hormone receptor Proteins 0.000 abstract 4
101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 abstract 4
102100033851 Gonadotropin-releasing hormone receptor Human genes 0.000 abstract 3
108020004414 DNA Proteins 0.000 abstract 1
101150110792 GNRHR gene Proteins 0.000 abstract 1
241001465754 Metazoa Species 0.000 abstract 1
108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
108091034117 Oligonucleotide Proteins 0.000 abstract 1
108700019146 Transgenes Proteins 0.000 abstract 1
230000002159 abnormal effect Effects 0.000 abstract 1
239000000556 agonist Substances 0.000 abstract 1
238000010171 animal model Methods 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
239000000074 antisense oligonucleotide Substances 0.000 abstract 1
238000012230 antisense oligonucleotides Methods 0.000 abstract 1
238000003745 diagnosis Methods 0.000 abstract 1
238000011156 evaluation Methods 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
230000002018 overexpression Effects 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108020003175 receptors Proteins 0.000 abstract 1
102000005962 receptors Human genes 0.000 abstract 1
230000001850 reproductive effect Effects 0.000 abstract 1
238000012216 screening Methods 0.000 abstract 1
230000019491 signal transduction Effects 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1
230000009261 transgenic effect Effects 0.000 abstract 1
230000009452 underexpressoin Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/76—Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Endocrinology (AREA)
Immunology (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Cell Biology (AREA)
Biophysics (AREA)
Medicinal Chemistry (AREA)
General Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Microbiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Gastroenterology & Hepatology (AREA)
Urology & Nephrology (AREA)
Toxicology (AREA)
Physics & Mathematics (AREA)
General Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Pathology (AREA)
Food Science & Technology (AREA)
Plant Pathology (AREA)
Reproductive Health (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

DK93915447T 1992-06-23 1993-06-22 Kloning og ekspression af receptoren for gonatotropin-frigörende hormon DK0647275T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US90407292A	1992-06-23	1992-06-23
US08/080,386 US5750366A (en)	1992-06-23	1993-06-21	Cloning and expression of gonadotropin-releasing hormone receptor
PCT/US1993/005965 WO1994000590A1 (en)	1992-06-23	1993-06-22	Cloning and expression of gonadotropin-releasing hormone receptor

Publications (1)

Publication Number	Publication Date
DK0647275T3 true DK0647275T3 (da)	2005-01-24

Family

ID=25418494

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK93915447T DK0647275T3 (da)	1992-06-23	1993-06-22	Kloning og ekspression af receptoren for gonatotropin-frigörende hormon

Country Status (9)

Country	Link
EP (1)	EP0647275B2 (da)
JP (1)	JP3719712B2 (da)
AT (1)	ATE276362T1 (da)
AU (1)	AU4542793A (da)
CA (1)	CA2138999C (da)
DE (1)	DE69333623T3 (da)
DK (1)	DK0647275T3 (da)
ES (1)	ES2229208T5 (da)
WO (1)	WO1994000590A1 (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5985583A (en) *	1992-06-23	1999-11-16	Mount Sinai School Of Medicine Of The City University Of New York	Cloning and expression of gonadotropin-releasing hormone receptor
US5688506A (en)	1994-01-27	1997-11-18	Aphton Corp.	Immunogens against gonadotropin releasing hormone
FR2716205B1 (fr)	1994-02-17	1996-04-12	Rhone Poulenc Rorer Sa	Récepteur galanine, acides nucléiques, cellules transformées et utilisations.
US5677184A (en) *	1994-04-19	1997-10-14	Takeda Chemical Industries, Ltd.	CHO cells that express human LH-RH receptor
DK0830600T3 (da) *	1995-06-07	2003-12-22	Praecis Pharm Inc	Funktionelt bioassay for G-proteinkoblede receptoragonister og -antagonister
WO1997047743A1 (en) *	1996-06-13	1997-12-18	Zymogenetics, Inc.	Human type ii gonadotropin-releasing hormone receptor
CA2287872C (en)	1997-05-12	2010-07-27	Aphton Corporation	Immunogenic compositions to the cck-b/gastrin receptor and methods for the treatment of tumors
WO1999057270A2 (en) *	1998-05-01	1999-11-11	Incyte Pharmaceuticals, Inc.	Human receptor molecules
GB9813279D0 (en) *	1998-06-20	1998-08-19	Medical Res Council	Modified receptor
WO2000077047A1 (en) *	1999-06-10	2000-12-21	Merck & Co., Inc.	Dog gonadotropin releasing hormone receptor
GB9927215D0 (en) *	1999-11-17	2000-01-12	Univ Bristol	Hormone receptor expression
PL357684A1 (en) *	2000-04-15	2004-07-26	Medical Research Council	Type ii gonadotropin-releasing hormone receptor and polynucleotides encoding therefor
WO2002070701A2 (fr) *	2001-03-01	2002-09-12	Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.)	Nouveau recepteur gnrh humain
FR2825094A1 (fr) *	2001-05-22	2002-11-29	Sod Conseils Rech Applic	Nouveau recepteur gnrh humain et ses applications
KR102772810B1 (ko)	2017-06-15	2025-02-28	캔서 어드밴시스 아이엔씨	종양 및 암에 대한 체액성 및 세포 면역을 유도하기 위한 조성물 및 방법
US12150978B2 (en)	2017-06-15	2024-11-26	Cancer Advances Inc.	Compositions and methods for preventing tumors and cancer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5190931A (en) *	1983-10-20	1993-03-02	The Research Foundation Of State University Of New York	Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA

1993
- 1993-06-22 CA CA2138999A patent/CA2138999C/en not_active Expired - Lifetime
- 1993-06-22 ES ES93915447.2T patent/ES2229208T5/es not_active Expired - Lifetime
- 1993-06-22 DK DK93915447T patent/DK0647275T3/da active
- 1993-06-22 EP EP93915447.2A patent/EP0647275B2/en not_active Expired - Lifetime
- 1993-06-22 WO PCT/US1993/005965 patent/WO1994000590A1/en not_active Ceased
- 1993-06-22 AT AT93915447T patent/ATE276362T1/de not_active IP Right Cessation
- 1993-06-22 JP JP50253594A patent/JP3719712B2/ja not_active Expired - Lifetime
- 1993-06-22 DE DE69333623.4T patent/DE69333623T3/de not_active Expired - Lifetime
- 1993-06-22 AU AU45427/93A patent/AU4542793A/en not_active Abandoned

Also Published As

Publication number	Publication date
EP0647275B2 (en)	2013-12-18
WO1994000590A1 (en)	1994-01-06
EP0647275A4 (en)	1997-03-12
DE69333623T3 (de)	2014-05-15
DE69333623D1 (de)	2004-10-21
DE69333623T2 (de)	2005-09-22
AU4542793A (en)	1994-01-24
JPH07509601A (ja)	1995-10-26
EP0647275A1 (en)	1995-04-12
ES2229208T3 (es)	2005-04-16
JP3719712B2 (ja)	2005-11-24
ATE276362T1 (de)	2004-10-15
ES2229208T5 (es)	2014-03-25
CA2138999C (en)	2010-02-23
CA2138999A1 (en)	1994-01-06
EP0647275B1 (en)	2004-09-15

Publication	Publication Date	Title
ATE276362T1 (de)	2004-10-15	Klonierung und expression von gonadotropinreleasing hormon
PT1075493E (pt)	2008-12-03	Adn que codifica receptor snorf25
Moffatt et al.	2007	Osteocrin is a specific ligand of the natriuretic Peptide clearance receptor that modulates bone growth
Chatterjee et al.	1997	A truncated form of RGS3 negatively regulates G protein-coupled receptor stimulation of adenylyl cyclase and phosphoinositide phospholipase C
ES2083344T1 (es)	1996-04-16	Dna que codifica un receptor 5-ht1f humano y utilizacion del mismo.
GR950300067T1 (en)	1996-01-31	Dna encoding human alpha 1 adrenergic receptors and uses thereof.
DE69423007D1 (de)	2000-03-16	Dna codierend für einen menschlichen neuropeptid y/peptid yy/pankreaspolypeptid-rezeptor (y4) und seine verwendung
DK0530265T3 (da)	1999-06-14	DNA kodende for humane 5-HT1D-receptorer og anvendelser deraf
Jones et al.	2007	An intron control region differentially regulates expression of thyroid hormone receptor β2 in the cochlea, pituitary, and cone photoreceptors
DE69233496D1 (de)	2005-05-04	Dna kodierend für den menschlichen 5-ht 1e-rezeptor und seine verwendungen
EP1496364A3 (en)	2008-08-06	Cloning and expression of gonadotropin-releasing hormone receptor
Lamba et al.	2008	Novel forms of Paired-like homeodomain transcription factor 2 (PITX2): generation by alternative translation initiation and mRNA splicing
Homma et al.	2001	Adenosine deaminase activity of insect-derived growth factor is essential for its growth factor activity
CN114316026A (zh)	2022-04-12	一种il17ra和/或il17rc基因人源化非人动物及其构建方法和应用
Hashemolhosseini et al.	2004	Conservation and variation of structure and function in a newly identified GCM homolog from chicken
Müller et al.	2011	Molecular cloning and functional characterization of endogenous recombinant common marmoset monkey (Callithrix jacchus) follicle‐stimulating hormone
JP2003265166A (ja)	2003-09-24	Ｅｃａｔ５ノックアウト細胞
Gangioside et al.	1994	Molecular analysis of cell surface 3-1, 4-galactosyltransferase function
de Juan Romero	2008	Functional Characterization of Satb1 and Satb2 Genes in Developing Neocortex
SE9701344D0 (sv)	1997-04-09	Transgenic, non-human animal with protein deficiency, cells derived therefrom, use of said animal and cells, and method of producing said transgenic animal
WO2002000689A3 (en)	2002-08-22	HUMAN G PROTEIN-COUPLED RECEPTOR IGPcR11, AND USES THEREOF
Song et al.	2002	Targeted, regulatable expression of activated heterotrimeric G protein α subunits in transgenic mice
Romero	0	Functional characterization of Satb 1 and Satb2 genes in developing neocortex
WO2003070916A3 (en)	2005-02-17	Dna encoding snorf44 receptor