DK0649650T3 - Bioadhæsiv farmaceutisk sammensætning til styret frigivelse af aktive bestanddele - Google Patents
Bioadhæsiv farmaceutisk sammensætning til styret frigivelse af aktive bestanddeleInfo
- Publication number
- DK0649650T3 DK0649650T3 DK94402060T DK94402060T DK0649650T3 DK 0649650 T3 DK0649650 T3 DK 0649650T3 DK 94402060 T DK94402060 T DK 94402060T DK 94402060 T DK94402060 T DK 94402060T DK 0649650 T3 DK0649650 T3 DK 0649650T3
- Authority
- DK
- Denmark
- Prior art keywords
- pharmaceutical composition
- controlled release
- active ingredients
- bioadhesive pharmaceutical
- bioadhesive
- Prior art date
Links
- 239000000227 bioadhesive Substances 0.000 title abstract 2
- 238000013270 controlled release Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000004480 active ingredient Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 210000004400 mucous membrane Anatomy 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Virology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9311259A FR2710265B1 (fr) | 1993-09-22 | 1993-09-22 | Composition pharmaceutique bioadhésive pour la libération contrôlée de principes actifs. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0649650T3 true DK0649650T3 (da) | 2001-02-12 |
Family
ID=9451097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94402060T DK0649650T3 (da) | 1993-09-22 | 1994-09-15 | Bioadhæsiv farmaceutisk sammensætning til styret frigivelse af aktive bestanddele |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5672356A (de) |
| EP (1) | EP0649650B1 (de) |
| JP (1) | JPH07173077A (de) |
| AT (1) | ATE197899T1 (de) |
| AU (1) | AU672526B2 (de) |
| CA (1) | CA2132512C (de) |
| DE (1) | DE69426382T2 (de) |
| DK (1) | DK0649650T3 (de) |
| ES (1) | ES2154288T3 (de) |
| FR (1) | FR2710265B1 (de) |
| GR (1) | GR3035308T3 (de) |
| NZ (1) | NZ264500A (de) |
| PT (1) | PT649650E (de) |
| ZA (1) | ZA947402B (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5688520A (en) * | 1995-03-29 | 1997-11-18 | Minnesota Mining And Manufacturing Company | Transmucosal delivery of melatonin for prevention of migraine |
| FR2742989B1 (fr) * | 1995-12-29 | 1998-01-23 | Adir | Composition pharmaceutique bioadhesive pour la liberation controlee de principes actifs |
| FR2762513B1 (fr) * | 1997-04-23 | 2003-08-22 | Permatec Pharma Ag | Comprimes bioadhesifs |
| US6423345B2 (en) | 1998-04-30 | 2002-07-23 | Acusphere, Inc. | Matrices formed of polymer and hydrophobic compounds for use in drug delivery |
| US6319513B1 (en) | 1998-08-24 | 2001-11-20 | The Procter & Gamble Company | Oral liquid mucoadhesive compounds |
| US6159491A (en) * | 1999-02-12 | 2000-12-12 | Biovector Technologies, Inc. | Prolonged release bioadhesive vaginal gel dosage form |
| US6297337B1 (en) | 1999-05-19 | 2001-10-02 | Pmd Holdings Corp. | Bioadhesive polymer compositions |
| US6887493B2 (en) * | 2000-10-25 | 2005-05-03 | Adi Shefer | Multi component controlled release system for oral care, food products, nutraceutical, and beverages |
| US20030017175A1 (en) * | 2001-07-05 | 2003-01-23 | R.T. Alamo Ventures I, Inc. | Sublingual administration of dihydroergotamine for the treatment of migraine |
| US20030198669A1 (en) * | 2001-07-05 | 2003-10-23 | R.T. Alamo Ventures I, Llc | Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine |
| US6685951B2 (en) | 2001-07-05 | 2004-02-03 | R. T. Alamo Ventures I, Inc. | Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine |
| FR2834894B1 (fr) * | 2002-01-21 | 2004-02-27 | Servier Lab | Composition pharmaceutique orodispersible de piribedil |
| FR2834890B1 (fr) * | 2002-01-23 | 2004-02-27 | Servier Lab | Composition pharmaceutique orodispersible d'agomelatine |
| FR2834896B1 (fr) * | 2002-01-23 | 2004-02-27 | Servier Lab | Composition pharmaceutique orodispersible d'ivabradine |
| ES2209649B1 (es) * | 2002-12-09 | 2005-03-16 | Carlos Arana Molina (Titular Al 25%) | Utilizacion de la melatonina para la higiene bucodental para uso humano y veterinario como producto activo. |
| JP5137286B2 (ja) * | 2003-06-10 | 2013-02-06 | 帝國製薬株式会社 | フェンタニル含有口腔粘膜貼付剤 |
| FR2857594B1 (fr) * | 2003-07-17 | 2005-09-16 | Servier Lab | Composition pharmaceutique pour l'administration par voie nasale de piribedil |
| US20060062833A1 (en) * | 2004-09-22 | 2006-03-23 | Cima Labs Inc. | Wound dressing |
| US7803778B2 (en) | 2006-05-23 | 2010-09-28 | Theracos, Inc. | Glucose transport inhibitors and methods of use |
| US8748419B2 (en) | 2006-06-16 | 2014-06-10 | Theracos, Inc. | Treating obesity with muscarinic receptor M1 antagonists |
| US7893053B2 (en) | 2006-06-16 | 2011-02-22 | Theracos, Inc. | Treating psychological conditions using muscarinic receptor M1 antagonists |
| US20080171085A1 (en) * | 2007-01-11 | 2008-07-17 | Natrol, Inc. | Novel biphasic delivery system for a pharmaceutical or nutraceutical composition and method of administration |
| JP5583003B2 (ja) | 2007-04-02 | 2014-09-03 | セラコス・インコーポレイテッド | ベンジルグルコシド誘導体およびその用途 |
| NZ583369A (en) | 2007-08-23 | 2011-08-26 | Theracos Inc | Benzylbenzene derivatives and methods of use |
| AU2009270936B2 (en) | 2008-07-15 | 2014-12-18 | Theracos, Inc. | Deuterated benzylbenzene derivatives and methods of use |
| CN103910702A (zh) | 2008-08-22 | 2014-07-09 | 泰拉科斯有限公司 | 制备sglt2抑制剂的方法 |
| WO2010068483A2 (en) | 2008-11-25 | 2010-06-17 | University Of Rochester | Mlk inhibitors and methods of use |
| WO2011027216A2 (en) * | 2009-09-04 | 2011-03-10 | Davis Robert J | Reversible oral adhesive gel |
| JP6086326B2 (ja) | 2010-05-24 | 2017-03-01 | ユニヴァーシティー オブ ロチェスター | 二環式ヘテロアリールキナーゼ阻害剤および使用方法 |
| WO2011153712A1 (en) | 2010-06-12 | 2011-12-15 | Theracos, Inc. | Crystalline form of benzylbenzene sglt2 inhibitor |
| EP3502236B1 (de) | 2011-02-18 | 2023-08-23 | The Scripps Research Institute | Gezielte differenzierung von oligodendrozyten-vorläuferzellen zu einem myelinierungszellenschicksal |
| US8524664B2 (en) | 2011-06-02 | 2013-09-03 | Colorado Seminary, Which owns and Operates The Univeristy of Denver | Methods of treating overproduction of cortisol using ACTH antagonist peptides |
| CN104884059B (zh) | 2012-11-30 | 2018-08-10 | 罗切斯特大学 | 用于hiv/aids治疗的混合谱系激酶抑制剂 |
| BR102014028009B1 (pt) | 2014-11-10 | 2023-04-18 | Universidade Federal De Pelotas | Composições filmogênicas para bioadesivos anestésicos tópicos (bats) para liberação controlada de princípios ativos e bioadesivos anestésicos tópicos |
| CN109196002A (zh) * | 2016-03-03 | 2019-01-11 | 博爱新开源医疗科技集团股份有限公司 | 精细和均匀的甲基乙烯基醚-马来酸无机盐共聚物及其在口腔护理和药物应用中的用途 |
| CN108535249B (zh) * | 2018-04-25 | 2021-02-26 | 郑州贝贝生物科技有限公司 | 农药残留快速检测点卡 |
| PE20220381A1 (es) * | 2019-04-05 | 2022-03-18 | Gedea Biotech Ab | Formulacion de tableta vaginal |
| CN116096366A (zh) * | 2021-04-21 | 2023-05-09 | 藤森顺也 | 植物化学物质组合物 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4553973A (en) * | 1982-07-12 | 1985-11-19 | Alza Corporation | Process for preparing osmotic device |
| US4740365A (en) * | 1984-04-09 | 1988-04-26 | Toyo Boseki Kabushiki Kaisha | Sustained-release preparation applicable to mucous membrane in oral cavity |
| JPS6117510A (ja) * | 1984-07-03 | 1986-01-25 | Toyobo Co Ltd | 口腔粘膜適用徐放性ニフエジピン製剤 |
| DE3686275T2 (de) * | 1985-01-11 | 1993-03-18 | Teijin Ltd | Praeparate mit verzoegerter freisetzung. |
| DE3681754D1 (de) * | 1985-04-27 | 1991-11-07 | Nitto Denko Corp | Klebepflaster und arzneimittel fuer die mundhoehle. |
| US4666705A (en) * | 1985-06-03 | 1987-05-19 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
| US4755386A (en) * | 1986-01-22 | 1988-07-05 | Schering Corporation | Buccal formulation |
| JPS63311960A (ja) * | 1987-06-16 | 1988-12-20 | Sekisui Chem Co Ltd | 医療用粘着剤組成物及びその製造方法 |
| US4948580A (en) * | 1988-12-08 | 1990-08-14 | E. R. Squibb & Sons, Inc. | Muco-bioadhesive composition |
| US5032384A (en) * | 1989-01-27 | 1991-07-16 | Block Drug Company, Inc. | Compositions and method for the treatment of disease |
| US5112620A (en) * | 1990-09-20 | 1992-05-12 | Mikkur, Inc. | Polyethylene glycol ointment for apthous ulcers |
| IT1251114B (it) * | 1991-07-26 | 1995-05-04 | Farcon Ag | Forme farmaceutiche antivirali per applicazione vaginale |
| US5385729A (en) * | 1991-08-01 | 1995-01-31 | Colgate Palmolive Company | Viscoelastic personal care composition |
| US5292517A (en) * | 1992-02-25 | 1994-03-08 | Allergan, Inc. | pH sensitive, reversible gelling, copolymeric erodible drug delivery system |
| US5330761A (en) * | 1993-01-29 | 1994-07-19 | Edward Mendell Co. Inc. | Bioadhesive tablet for non-systemic use products |
-
1993
- 1993-09-22 FR FR9311259A patent/FR2710265B1/fr not_active Expired - Fee Related
-
1994
- 1994-09-15 DK DK94402060T patent/DK0649650T3/da active
- 1994-09-15 DE DE69426382T patent/DE69426382T2/de not_active Expired - Fee Related
- 1994-09-15 EP EP94402060A patent/EP0649650B1/de not_active Expired - Lifetime
- 1994-09-15 ES ES94402060T patent/ES2154288T3/es not_active Expired - Lifetime
- 1994-09-15 AT AT94402060T patent/ATE197899T1/de not_active IP Right Cessation
- 1994-09-15 PT PT94402060T patent/PT649650E/pt unknown
- 1994-09-20 CA CA002132512A patent/CA2132512C/fr not_active Expired - Fee Related
- 1994-09-20 AU AU74110/94A patent/AU672526B2/en not_active Ceased
- 1994-09-21 US US08/309,930 patent/US5672356A/en not_active Expired - Fee Related
- 1994-09-21 JP JP6226876A patent/JPH07173077A/ja active Pending
- 1994-09-21 NZ NZ264500A patent/NZ264500A/en unknown
- 1994-09-22 ZA ZA947402A patent/ZA947402B/xx unknown
-
2001
- 2001-01-26 GR GR20010400133T patent/GR3035308T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0649650B1 (de) | 2000-12-06 |
| US5672356A (en) | 1997-09-30 |
| AU672526B2 (en) | 1996-10-03 |
| PT649650E (pt) | 2001-05-31 |
| GR3035308T3 (en) | 2001-04-30 |
| EP0649650A1 (de) | 1995-04-26 |
| DE69426382D1 (de) | 2001-01-11 |
| ZA947402B (en) | 1995-05-15 |
| CA2132512C (fr) | 2001-07-03 |
| ES2154288T3 (es) | 2001-04-01 |
| DE69426382T2 (de) | 2001-06-21 |
| CA2132512A1 (fr) | 1995-03-23 |
| AU7411094A (en) | 1995-04-06 |
| ATE197899T1 (de) | 2000-12-15 |
| FR2710265A1 (fr) | 1995-03-31 |
| FR2710265B1 (fr) | 1995-10-20 |
| NZ264500A (en) | 1996-07-26 |
| JPH07173077A (ja) | 1995-07-11 |
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