DK0655058T3 - Pyridinyl/quinolinyl-terminerede alkylamino-ethynyl-alanin-aminodiol-forbindelser til behandling af hypertension - Google Patents

Pyridinyl/quinolinyl-terminerede alkylamino-ethynyl-alanin-aminodiol-forbindelser til behandling af hypertension

Info

Publication number: DK0655058T3
Authority: DK; Denmark
Prior art keywords: quinolinyl; hypertension; treatment; ethynyl; pyridinyl
Prior art date: 1992-08-14

Application number

DK93919921T

Other languages

English (en)

Inventor

Gunnar J Hanson

Robert E Manning

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-08-14

Filing date

1993-08-10

Publication date

1999-09-27

1993-08-10 Application filed by Searle & Co filed Critical Searle & Co

1999-09-27 Application granted granted Critical

1999-09-27 Publication of DK0655058T3 publication Critical patent/DK0655058T3/da

Links

206010020772 Hypertension Diseases 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 title abstract 2
125000004076 pyridyl group Chemical group 0.000 title 1
-1 alkylamino ethynyl alanine amino diol Chemical class 0.000 abstract 2
125000001145 hydrido group Chemical group *[H] 0.000 abstract 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
239000002461 renin inhibitor Substances 0.000 abstract 1
229940086526 renin-inhibitors Drugs 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Ophthalmology & Optometry (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyridine Compounds (AREA)
Quinoline Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)

DK93919921T 1992-08-14 1993-08-10 Pyridinyl/quinolinyl-terminerede alkylamino-ethynyl-alanin-aminodiol-forbindelser til behandling af hypertension DK0655058T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/930,068 US5252591A (en)	1992-08-14	1992-08-14	Pyridinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension
PCT/US1993/007428 WO1994004503A1 (en)	1992-08-14	1993-08-10	Pyridinyl/quinolinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension

Publications (1)

Publication Number	Publication Date
DK0655058T3 true DK0655058T3 (da)	1999-09-27

Family

ID=25458881

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK93919921T DK0655058T3 (da)	1992-08-14	1993-08-10	Pyridinyl/quinolinyl-terminerede alkylamino-ethynyl-alanin-aminodiol-forbindelser til behandling af hypertension

Country Status (11)

Country	Link
US (3)	US5252591A (da)
EP (1)	EP0655058B1 (da)
JP (1)	JPH08500116A (da)
AT (1)	ATE177736T1 (da)
AU (1)	AU4999493A (da)
CA (1)	CA2138518A1 (da)
DE (1)	DE69324019T2 (da)
DK (1)	DK0655058T3 (da)
ES (1)	ES2128434T3 (da)
GR (1)	GR3030225T3 (da)
WO (1)	WO1994004503A1 (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5508466A (en) *	1994-04-13	1996-04-16	G.D. Searle & Co.	Synthesis of N-protected-α-substituted-glycine racemic esters by zinc-mediated addition of organic halide to glycine cation equivalent
WO1999031061A1 (en) *	1997-12-17	1999-06-24	Merck & Co., Inc.	Integrin receptor antagonists
CA2467476A1 (en) *	2001-11-19	2003-05-30	Pharmacia & Upjohn Company	Amino diols useful in the treatment of alzheimer's disease

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS59227851A (ja) *	1983-06-09	1984-12-21	Sankyo Co Ltd	レニン阻害作用を有するペプチド類
EP0181110A3 (en) *	1984-10-22	1988-05-11	Kissei Pharmaceutical Co. Ltd.	Histidine derivatives as renin inhibitors
SU1676454A3 (ru) *	1984-11-30	1991-09-07	Санкио Компани Лимитед (Фирма)	Способ получени пептидов или их фармацевтически приемлемых солей
DK34086A (da) *	1985-01-23	1986-07-24	Abbott Lab	Peptidylaminodioler
JPS61236770A (ja) *	1985-04-15	1986-10-22	Kissei Pharmaceut Co Ltd	新規なアミノ酸誘導体
JPS6256458A (ja) *	1985-09-04	1987-03-12	Kissei Pharmaceut Co Ltd	新規なアミノ酸誘導体
IL81234A (en) *	1986-01-16	1992-09-06	Abbott Lab	Peptidylaminodiols,process for their preparation and pharmaceutical compositions comprising them
JPS63503380A (ja) *	1986-01-16	1988-12-08	アボット・ラボラトリーズ	ペプチド類似体
US5032577A (en) *	1986-12-31	1991-07-16	Abbott Laboratories	Peptidylaminodiols
US4921855A (en) *	1987-06-22	1990-05-01	Fujisawa Pharmaceutical Co., Ltd.	New Histidyl amino acid derivatives, and pharmaceutical composition comprising the same
US5036053A (en)	1988-05-27	1991-07-30	Warner-Lambert Company	Diol-containing renin inhibitors
US4902706A (en) *	1988-07-01	1990-02-20	G. D. Searle & Co.	Aminoalkylaminocarbonyl aminodiol amino acid derivatives as antihypertensive agents
IE902446A1 (en) *	1989-07-26	1991-02-13	Abbott Lab	Peptidyl aminodiol renin inhibitors
IE68045B1 (en) *	1990-05-11	1996-05-15	Abbott Lab	Renin inhibitors

1992
- 1992-08-14 US US07/930,068 patent/US5252591A/en not_active Expired - Fee Related
1993
- 1993-08-10 AT AT93919921T patent/ATE177736T1/de not_active IP Right Cessation
- 1993-08-10 CA CA002138518A patent/CA2138518A1/en not_active Abandoned
- 1993-08-10 DE DE69324019T patent/DE69324019T2/de not_active Expired - Fee Related
- 1993-08-10 WO PCT/US1993/007428 patent/WO1994004503A1/en not_active Ceased
- 1993-08-10 AU AU49994/93A patent/AU4999493A/en not_active Abandoned
- 1993-08-10 DK DK93919921T patent/DK0655058T3/da active
- 1993-08-10 ES ES93919921T patent/ES2128434T3/es not_active Expired - Lifetime
- 1993-08-10 EP EP93919921A patent/EP0655058B1/en not_active Expired - Lifetime
- 1993-08-10 JP JP6506332A patent/JPH08500116A/ja active Pending
- 1993-09-13 US US08/120,882 patent/US5434162A/en not_active Expired - Fee Related
1995
- 1995-06-01 US US08/456,364 patent/US5563154A/en not_active Expired - Fee Related
1999
- 1999-05-14 GR GR990401312T patent/GR3030225T3/el unknown

Also Published As

Publication number	Publication date
US5563154A (en)	1996-10-08
CA2138518A1 (en)	1994-03-03
ATE177736T1 (de)	1999-04-15
WO1994004503A1 (en)	1994-03-03
EP0655058B1 (en)	1999-03-17
US5434162A (en)	1995-07-18
JPH08500116A (ja)	1996-01-09
US5252591A (en)	1993-10-12
EP0655058A1 (en)	1995-05-31
DE69324019T2 (de)	1999-08-05
AU4999493A (en)	1994-03-15
GR3030225T3 (en)	1999-08-31
ES2128434T3 (es)	1999-05-16
DE69324019D1 (de)	1999-04-22

Publication	Publication Date	Title
AU529854B2 (en)	1983-06-23	Dihydropyridine anti-ischaemic and antihypertensive agents
FI935471A0 (fi)	1993-12-07	Preparat med utdragen frigoering
CA2055670A1 (en)	1992-05-21	Retroviral protease inhibiting compounds
DK1021456T3 (da)	2003-08-18	Makrocykliske derivater af erythromysin A og B med 13-leddet ring
ES8600312A1 (es)	1985-10-01	Un procedimiento para preparacion de nuevos derivados de cefalosporina.
DK0655056T3 (da)	2000-04-17	N-(Dihydroxyalkyl) -ethynylalanin-amider med azacyclyl-endegruppe til behandling af hypertension
DK0655062T3 (da)	1998-05-18	Morpholino/thiomorpholino-terminerede alkylaminoethynylalaninaminodiolforbindelser som renininhibitorer
GR3030225T3 (en)	1999-08-31	Pyridinyl/quinolinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension.
DK0655059T3 (da)	1997-01-06	Imidazolyl/benzimidazolyl-terminerede alkylaminoethynylalaninaminodiol-forbindelser til behandling af hypertension
GR3031861T3 (en)	2000-02-29	Ethynyl alanine amino diol compounds having a piperazinyl-terminated group or a piperazinyl-alkylamino-terminated group for treatment of hypertension.
IE42154L (en)	1976-02-20	Substituted phenyl ketones
NO983527L (no)	1998-09-28	Dihydrobenzofuran og relaterte forbindelser anvendelig som anti-inflammatoriske midler
ES2163765T3 (es)	2002-02-01	Mezclas fungicidas.
NO874374L (no)	1988-04-22	Fremstilling av peptid-aminoalkylamider og peptid-hydrazider ved hjelp av fastfasemetoden.
HK77191A (en)	1991-10-11	Aminoacylates of glycerol acetal
JPS5285156A (en)	1977-07-15	2-(omega-aminoalkoxy)diphenylmethylmethanes