DK0655247T3 - Anvendelse af vinkristin til bestemmelse af substanser på neuralt niveau - Google Patents

Anvendelse af vinkristin til bestemmelse af substanser på neuralt niveau

Info

Publication number: DK0655247T3
Authority: DK; Denmark
Prior art keywords: substances; vincristine; determination; level; neural level
Prior art date: 1990-05-22

Application number

DK94403014T

Other languages

English (en)

Inventor

Francois-Xavier Coude

Umberto Guzzi

Jacqueline Fournier

Original Assignee

Sanofi Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-22

Filing date

1991-05-21

Publication date

2002-02-18

1991-05-21 Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo

2002-02-18 Application granted granted Critical

2002-02-18 Publication of DK0655247T3 publication Critical patent/DK0655247T3/da

Links

230000001537 neural effect Effects 0.000 title abstract 3
239000000126 substance Substances 0.000 title abstract 3
OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 title abstract 2
229960004528 vincristine Drugs 0.000 title abstract 2
OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 title abstract 2
238000010171 animal model Methods 0.000 abstract 1
238000010876 biochemical test Methods 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
238000011156 evaluation Methods 0.000 abstract 1
230000003902 lesion Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000000877 morphologic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Immunology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
Cell Biology (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Neurology (AREA)
Toxicology (AREA)
Pathology (AREA)
Tropical Medicine & Parasitology (AREA)
Biotechnology (AREA)
General Physics & Mathematics (AREA)
Biochemistry (AREA)
Neurosurgery (AREA)
Analytical Chemistry (AREA)
Food Science & Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Investigating Or Analysing Biological Materials (AREA)

DK94403014T 1990-05-22 1991-05-21 Anvendelse af vinkristin til bestemmelse af substanser på neuralt niveau DK0655247T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9006399A FR2662355B1 (fr)	1990-05-22	1990-05-22	Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux.

Publications (1)

Publication Number	Publication Date
DK0655247T3 true DK0655247T3 (da)	2002-02-18

Family

ID=9396855

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK91401311.5T DK0458696T3 (da)	1990-05-22	1991-05-21	Anvendelse af 1-(2-naphtylethyl)-4-(3-trifluormethylphenyl)-1,2,3,6-tetrahydropyridin til fremstilling af et lægemiddel til behandling af cerebrale og neuronale sygdomme
DK94403014T DK0655247T3 (da)	1990-05-22	1991-05-21	Anvendelse af vinkristin til bestemmelse af substanser på neuralt niveau

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK91401311.5T DK0458696T3 (da)	1990-05-22	1991-05-21	Anvendelse af 1-(2-naphtylethyl)-4-(3-trifluormethylphenyl)-1,2,3,6-tetrahydropyridin til fremstilling af et lægemiddel til behandling af cerebrale og neuronale sygdomme

Country Status (16)

Country	Link
US (3)	US5229389A (da)
EP (2)	EP0458696B1 (da)
JP (2)	JP2618115B2 (da)
KR (1)	KR0181330B1 (da)
AT (2)	ATE132369T1 (da)
BR (1)	BR9105015A (da)
CA (2)	CA2042974C (da)
CY (1)	CY2283B1 (da)
DE (2)	DE69115989T2 (da)
DK (2)	DK0458696T3 (da)
FR (1)	FR2662355B1 (da)
HU (1)	HU208922B (da)
IE (1)	IE911707A1 (da)
IL (3)	IL112167A (da)
TW (1)	TW216771B (da)
ZA (1)	ZA913865B (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0192386A (ja) *	1987-10-05	1989-04-11	Hitachi Ltd	密閉循環型吸収式冷凍機及び吸収式冷凍機用吸収液
FR2662355B1 (fr) *	1990-05-22	1994-11-10	Sanofi Sa	Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux.
FR2662442A1 (fr) *	1990-05-23	1991-11-29	Midy Spa	Trifluoromethylphenyltetrahydropyridines n-substituees procede pour leur preparation, intermediaires du procede et compositions pharmaceutiques les contenant.
US5618822A (en) *	1990-05-23	1997-04-08	Sanofi	N-substituted trifluoromethylphenyltetrahydropyridines, process for the preparation thereof, intermediates in said process and pharmaceutical compositions containing them
US5557209A (en) *	1990-12-20	1996-09-17	Hewlett-Packard Company	Identification of pin-open faults by capacitive coupling through the integrated circuit package
FR2672213B1 (fr)	1991-02-05	1995-03-10	Sanofi Sa	Utilisation de derives 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridiniques comme capteurs de radicaux libres.
FR2690158B1 (fr) *	1992-04-17	1994-07-22	Sanofi Elf	Nouveau derive arylpiperidinique, procede pour sa preparation et compositions pharmaceutiques le contenant.
FR2702656B1 (fr) *	1993-03-18	1995-06-16	Sanofi Elf	Utilisation de derives de la tetrahydropyridine pour la preparation de medicaments cardioprotecteurs.
US5698565A (en) *	1995-06-09	1997-12-16	Hoffmann-La Roche Inc.	Use of phenoxy-pyridine derivatives
FR2736053B1 (fr) *	1995-06-28	1997-09-19	Sanofi Sa	Nouvelles 1-phenylalkyl-1,2,3,6-tetrahydropyridines
FR2740343B1 (fr) *	1995-10-26	1999-01-22	Sanofi Sa	Utilisation de la 1-(2-napht-2-yl-ethyl)-4- (3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de la sclerose laterale amyotrophique
ES2159362T3 (es) *	1995-10-26	2001-10-01	Sanofi Synthelabo	Utilizacion de la 1-(2-naft-2-iletil)-4-(3-trifluorometilfenil)-1,2,3,6-tetrahidropiridina para la preparacion de medicamentos destinados para el tratamiento de la esclerosis lateral amiotrofica.
WO1997037228A1 (en) *	1996-03-29	1997-10-09	The Trustees Of Boston University	Methods for diagnosing and treating alzheimer's disease
US5891465A (en) *	1996-05-14	1999-04-06	Biozone Laboratories, Inc.	Delivery of biologically active material in a liposomal formulation for administration into the mouth
FR2757160B1 (fr) *	1996-12-13	1999-03-12	Sanofi Sa	1-phenylalkyl-1,2,3,6-tetrahydropyridines
FR2757161B1 (fr) *	1996-12-13	1999-03-12	Sanofi Sa	Diphenylalkyl-tetrahydropyridines
FR2757510B1 (fr) *	1996-12-23	2000-01-07	Sanofi Sa	Forme microparticulaire d'un derive de tetrahydropyridine
FR2757512B1 (fr) *	1996-12-24	1999-03-12	Sanofi Sa	Utilisation de benzoylalkyl-1-1,2,3,6-tetrahydropyridines
AU1607397A (en) *	1997-02-03	1998-08-25	Sanofi-Synthelabo	Use of 1-(4-(3-trifluoromethylphenyl)-1,2,3, 6-tetrahydropyrid-1YL)-2-(6,7-dimethoxynapht-2-YL) ethane for preparing medicines for the treatment of cerebral and neuronal disorders
FR2762514B1 (fr)	1997-04-29	1999-10-22	Sanofi Sa	Utilisation de derives de la tetrahydropyridine pour la preparation de medicaments pour le traitement des maladies entrainant une demyelinisation
FR2763847B1 (fr) *	1997-05-28	2003-06-06	Sanofi Sa	Utilisation de tetrahydropyridines 4-substituees pour fabriquer des medicaments agissant sur le tgf-beta-1
CO4980891A1 (es) *	1997-11-14	2000-11-27	Sanofi Sa	Asociacion de principios activos para el tratamiento de la demencia senil de tipo azheimer
FR2771007B1 (fr) *	1997-11-14	2000-12-01	Sanofi Sa	Association de principes actifs pour le traitement de la demence senile du type alzheimer
DE19751949A1 (de)	1997-11-24	1999-05-27	Bayer Ag	Verwendung von substituierten Aminomethyl-Chromanen zur Verhinderung der neuronalen Degeneration und zur Förderung der neuronalen Regeneration
TWI237035B (en) *	1998-07-24	2005-08-01	Polyplastics Co	Polyacetal copolymer
CN102727501A (zh) *	2002-03-27	2012-10-17	菲特法姆股份有限公司	皂角苷配基及其衍生物的用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2531707A1 (fr) *	1982-08-16	1984-02-17	Midy Spa	Trifluoromethylphenyltetrahydropyridines substituees a activite anorexigene, un procede de preparation et compositions pharmaceutiques
FR2639226B1 (fr) *	1988-11-18	1993-11-05	Sanofi	Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles anxio-depressifs
FR2662355B1 (fr) *	1990-05-22	1994-11-10	Sanofi Sa	Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux.

1990
- 1990-05-22 FR FR9006399A patent/FR2662355B1/fr not_active Expired - Lifetime
1991
- 1991-05-17 IL IL11216791A patent/IL112167A/en not_active IP Right Cessation
- 1991-05-17 IL IL9817591A patent/IL98175A/en not_active IP Right Cessation
- 1991-05-20 IE IE170791A patent/IE911707A1/en not_active IP Right Cessation
- 1991-05-20 TW TW080103889A patent/TW216771B/zh not_active IP Right Cessation
- 1991-05-21 AT AT91401311T patent/ATE132369T1/de not_active IP Right Cessation
- 1991-05-21 DK DK91401311.5T patent/DK0458696T3/da active
- 1991-05-21 US US07/703,835 patent/US5229389A/en not_active Expired - Lifetime
- 1991-05-21 EP EP91401311A patent/EP0458696B1/fr not_active Expired - Lifetime
- 1991-05-21 DK DK94403014T patent/DK0655247T3/da active
- 1991-05-21 AT AT94403014T patent/ATE207747T1/de not_active IP Right Cessation
- 1991-05-21 CA CA002042974A patent/CA2042974C/en not_active Expired - Lifetime
- 1991-05-21 EP EP94403014A patent/EP0655247B1/fr not_active Expired - Lifetime
- 1991-05-21 DE DE69115989T patent/DE69115989T2/de not_active Expired - Lifetime
- 1991-05-21 DE DE69132797T patent/DE69132797T2/de not_active Expired - Fee Related
- 1991-05-21 CA CA002365832A patent/CA2365832C/en not_active Expired - Fee Related
- 1991-05-22 HU HU911729A patent/HU208922B/hu unknown
- 1991-05-22 KR KR1019910008272A patent/KR0181330B1/ko not_active Expired - Lifetime
- 1991-05-22 JP JP3146949A patent/JP2618115B2/ja not_active Expired - Lifetime
- 1991-05-22 ZA ZA913865A patent/ZA913865B/xx unknown
- 1991-11-07 US US07/789,044 patent/US5270320A/en not_active Expired - Lifetime
- 1991-11-19 BR BR919105015A patent/BR9105015A/pt not_active Application Discontinuation
1993
- 1993-10-20 US US08/142,069 patent/US5468753A/en not_active Expired - Lifetime
1994
- 1994-12-27 IL IL11216794A patent/IL112167A0/xx unknown
1996
- 1996-08-20 JP JP8218926A patent/JP2954029B2/ja not_active Expired - Fee Related
2002
- 2002-05-15 CY CY0200037A patent/CY2283B1/xx unknown

Also Published As

Publication number	Publication date
ATE132369T1 (de)	1996-01-15
KR910019617A (ko)	1991-12-19
DE69115989T2 (de)	1996-08-22
CA2365832C (en)	2007-08-07
US5468753A (en)	1995-11-21
EP0655247B1 (fr)	2001-10-31
DE69115989D1 (de)	1996-02-15
CA2042974C (en)	2002-09-17
IE911707A1 (en)	1991-12-04
ATE207747T1 (de)	2001-11-15
ZA913865B (en)	1992-02-26
HK1001471A1 (en)	1998-06-19
AU7713391A (en)	1991-11-28
BR9105015A (pt)	1993-05-25
DE69132797D1 (de)	2001-12-06
DK0458696T3 (da)	1996-05-20
JP2618115B2 (ja)	1997-06-11
CY2283B1 (en)	2003-07-04
IL112167A (en)	1996-01-31
IL98175A (en)	1996-01-19
EP0458696B1 (fr)	1996-01-03
CA2042974A1 (en)	1991-11-22
DE69132797T2 (de)	2002-05-29
EP0655247A1 (fr)	1995-05-31
AU636488B2 (en)	1993-04-29
HU911729D0 (en)	1991-12-30
EP0458696A2 (fr)	1991-11-27
IL112167A0 (en)	1995-03-15
US5270320A (en)	1993-12-14
KR0181330B1 (ko)	1999-03-20
IL98175A0 (en)	1992-06-21
FR2662355A1 (fr)	1991-11-29
JP2954029B2 (ja)	1999-09-27
EP0458696A3 (en)	1992-03-18
IE20011078A1 (en)	2002-03-20
JPH09132535A (ja)	1997-05-20
FR2662355B1 (fr)	1994-11-10
HU208922B (en)	1994-02-28
CA2365832A1 (en)	1991-11-23
HUT59824A (en)	1992-07-28
US5229389A (en)	1993-07-20
TW216771B (da)	1993-12-01
JPH04226917A (ja)	1992-08-17

Publication	Publication Date	Title
DK0655247T3 (da)	2002-02-18	Anvendelse af vinkristin til bestemmelse af substanser på neuralt niveau
Munro et al.	1996	Correlation of structural class with no-observed-effect levels: a proposal for establishing a threshold of concern
DE69100547D1 (de)	1993-12-02	Methode und Vorrichtung zum elektrochemischen Bearbeiten der Spritzöffnungen von Brennstoff-Einspritzdüsen.
ATE110415T1 (de)	1994-09-15	Verbessertes verfahren und apparat, um biologische substanzen in lebenden zellen einzuführen.
DE69110437D1 (de)	1995-07-20	Vorrichtung zur zerstörungsfreien Prüfung von länglichen Elementen mit annähernd konstantem Querschnitt.
ATE4234T1 (de)	1983-08-15	Vorrichtung zur dosierten abgabe eines wirkstoffs.
DE3177194D1 (de)	1990-08-02	Verfahren zum gewinnen von kautschuk und nebenprodukten aus guayul und guayulaehnlichen straeuchern.
DE69021687D1 (de)	1995-09-21	Verfahren und Vorrichtung zur Zählung von Ereignissen unter Verwendung eines flüchtigen Speichers.
DE58903504D1 (de)	1993-03-25	Verfahren zur messung der konzentration optisch aktiver substanzen und anordnung zur durchfuehrung des verfahrens.
Rickson et al.	1987	Social bases of farmers' responses to land degradation.
DE59009364D1 (de)	1995-08-10	Verfahren zur quantitativen Bestimmung zumindest eines chemischen Parameters eines Probenmediums.
DE3780604D1 (de)	1992-08-27	Vorrichtung zur auswertung eines sauerstoffuehlers.
IT7821096A0 (it)	1978-03-10	Elementi d'usura sostituibili per un cingolo senza fine.
EP0057236A4 (en)	1982-10-14	METHOD FOR DETERMINING A SIDE CHAIN OF GLUCOSE ASSOCIATED WITH A TUMOR, METHOD FOR DIAGNOSING TUMORS, AND "KIT" FOR DIAGNOSING TUMORS.
Salanki	1979	Behavioural studies on mussels under changing environmental conditions
DE3879754D1 (de)	1993-05-06	Hydrophiler zusatz zum zuechten von pilzen und verfahren zu seiner verwendung.
ATE9343T1 (de)	1984-09-15	2,6-diethyl-3,5-dimethyl-2,3-dihydro-4h-pyran, verfahren zu seiner herstellung und seine verwendung zur frueherkennung, lokalisierung und bekaempfung von lasioderma serricorne f.
PT74139B (de)	1983-07-21	Verfahren und vorrichtung zum herstellen von litzen aus draeh ten bzw.von seilen aus litzen
Greenwald	1981	Prediction of Songbird Responses to Habitat Alteration Resulting from Waste Water Irrigation
Ehler et al.	1976	Water Quality Guidance: Development of Residuals Management Strategies. An Executive Summary
DE59103597D1 (de)	1995-01-05	Verfahren zum ermitteln der kraftstoffeinspritzmenge.
DE3768202D1 (de)	1991-04-04	Verfahren und geraet zur ausfuehrung von die beurteilung des fliessverhaltens von thermoplasten ermoeglichenden messungen.
McFarland	1983	Behavioural transitions: A reply to Roper and Crossland.
EHLER et al.	1976	Water quality guidance: Development of residuals management strategies. An executive summary[Socioeconomic Environmental Studies Series]
Robinson	1981	Chesapeake Bay Low Freshwater Inflow Study