ATE110415T1 - Verbessertes verfahren und apparat, um biologische substanzen in lebenden zellen einzuführen. - Google Patents

Verbessertes verfahren und apparat, um biologische substanzen in lebenden zellen einzuführen.

Info

Publication number
ATE110415T1
ATE110415T1 AT91909768T AT91909768T ATE110415T1 AT E110415 T1 ATE110415 T1 AT E110415T1 AT 91909768 T AT91909768 T AT 91909768T AT 91909768 T AT91909768 T AT 91909768T AT E110415 T1 ATE110415 T1 AT E110415T1
Authority
AT
Austria
Prior art keywords
improved method
living cells
biological substances
introducing biological
introducing
Prior art date
Application number
AT91909768T
Other languages
English (en)
Inventor
Ronald F Bruner
Vit Michael J De
Stephen A Johnston
John C Sanford
Original Assignee
Du Pont
Cornell Res Foundation Inc
Univ Duke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont, Cornell Res Foundation Inc, Univ Duke filed Critical Du Pont
Application granted granted Critical
Publication of ATE110415T1 publication Critical patent/ATE110415T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8206—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by physical or chemical, i.e. non-biological, means, e.g. electroporation, PEG mediated
    • C12N15/8207—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by physical or chemical, i.e. non-biological, means, e.g. electroporation, PEG mediated by mechanical means, e.g. microinjection, particle bombardment, silicon whiskers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Sustainable Development (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Mechanical Engineering (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AT91909768T 1990-05-29 1991-04-29 Verbessertes verfahren und apparat, um biologische substanzen in lebenden zellen einzuführen. ATE110415T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/529,989 US5204253A (en) 1990-05-29 1990-05-29 Method and apparatus for introducing biological substances into living cells

Publications (1)

Publication Number Publication Date
ATE110415T1 true ATE110415T1 (de) 1994-09-15

Family

ID=24112008

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91909768T ATE110415T1 (de) 1990-05-29 1991-04-29 Verbessertes verfahren und apparat, um biologische substanzen in lebenden zellen einzuführen.

Country Status (13)

Country Link
US (1) US5204253A (de)
EP (1) EP0535005B1 (de)
JP (1) JP2517813B2 (de)
KR (1) KR960008270B1 (de)
AR (1) AR243603A1 (de)
AT (1) ATE110415T1 (de)
AU (1) AU7878891A (de)
CA (1) CA2083816C (de)
DE (1) DE69103631T2 (de)
DK (1) DK0535005T3 (de)
ES (1) ES2059140T3 (de)
HU (1) HU216738B (de)
WO (1) WO1991018991A1 (de)

Families Citing this family (377)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0500799B1 (de) * 1989-11-16 1998-01-14 Duke University Transformation von tierischen Hautzellen mit hilfe von Partikeln
JP3135969B2 (ja) 1992-01-18 2001-02-19 科学技術振興事業団 微粒子発射装置
JP3368603B2 (ja) 1992-02-28 2003-01-20 オリンパス光学工業株式会社 遺伝子治療用処置具
GB9211107D0 (en) * 1992-05-26 1992-07-08 British Tech Group Diamond film deposition
AU2146092A (en) * 1992-05-28 1993-12-30 Scientific Dimensions Usa, Inc. Transgenic animal production with biolistically transformed spermatozoa
TW404844B (en) 1993-04-08 2000-09-11 Oxford Biosciences Ltd Needleless syringe
US5405779A (en) * 1993-04-09 1995-04-11 Agracetus, Inc. Apparatus for genetic transformation
GB9321183D0 (en) * 1993-10-14 1993-12-01 Zeneca Ltd A method of plant transformation
US5506125A (en) * 1993-12-22 1996-04-09 Agracetus, Inc. Gene delivery instrument with replaceable cartridges
JP3221683B2 (ja) * 1994-01-21 2001-10-22 パウダージェクト ヴァクシンズ， インコーポレイテッド ガス駆動型遺伝子搬入装置
US5899880A (en) * 1994-04-08 1999-05-04 Powderject Research Limited Needleless syringe using supersonic gas flow for particle delivery
US6287850B1 (en) * 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
DE69527585T2 (de) * 1994-06-08 2003-04-03 Affymetrix, Inc. Verfahren und Vorrichtung zum Verpacken von Chips
GB9416663D0 (en) 1994-08-17 1994-10-12 Oxford Bioscience Limited Particle delivery
US5648598A (en) * 1994-12-20 1997-07-15 Institut National De La Recherche Agronomique Ornamental character of scented geraniums by genetic transformation
GB9426379D0 (en) 1994-12-23 1995-03-01 Oxford Biosciences Ltd Particle delivery
GB9502879D0 (en) * 1995-02-14 1995-04-05 Oxford Biosciences Ltd Particle delivery
DE19510696A1 (de) * 1995-03-14 1996-09-19 Soft Gene Gmbh Vorrichtung zur Druckverteilung im Kopfstück einer Apparatur zum ballistischen Transfer von Zellen
US5780100A (en) * 1995-05-18 1998-07-14 Powderject Vaccines, Inc. Method and apparatus for preparing sample cartridges for particle acceleration device
US5525510A (en) * 1995-06-02 1996-06-11 Agracetus, Inc. Coanda effect gene delivery instrument
US6720149B1 (en) * 1995-06-07 2004-04-13 Affymetrix, Inc. Methods for concurrently processing multiple biological chip assays
US7223739B1 (en) 1995-06-07 2007-05-29 Powderject Vaccines, Inc. Adjuvanted genetic vaccines
US6013050A (en) * 1995-10-20 2000-01-11 Powderject Research Limited Particle delivery
JP2786139B2 (ja) 1995-12-05 1998-08-13 株式会社日本医化器械製作所 生物学的物質又は生理活性物質を導入する打込装置
US6893664B1 (en) * 1996-06-17 2005-05-17 Powderject Research Limited Particle delivery techniques
US5850026A (en) * 1996-07-03 1998-12-15 Cargill, Incorporated Canola oil having increased oleic acid and decreased linolenic acid content
US5733600A (en) 1996-11-13 1998-03-31 Powderject Vaccines, Inc. Method and apparatus for preparing sample cartridges for a particle acceleration device
DE19648656B4 (de) * 1996-11-14 2005-08-11 Hiper Ceramics Gmbh Vorrichtung zum Beschleunigen von Partikeln auf Zellen zum ballistischen Transfer
US6587578B2 (en) 1997-03-21 2003-07-01 Dobi Medical Systems, Inc. Dynamic-functional imaging of biological objects using a non-rigid object holder
DE69838670D1 (de) 1997-03-21 2007-12-20 Dobi Medical Systems Inc Dynamische und funktionelle bilderzeugung von biologischen objekten mittels einer verformbaren halterung
US5749337A (en) * 1997-03-31 1998-05-12 Palatov; Dennis Barrel type internal combustion engine
US6307128B1 (en) 1997-06-03 2001-10-23 Miami University Fatty acid elongases
US6433154B1 (en) 1997-06-12 2002-08-13 Bristol-Myers Squibb Company Functional receptor/kinase chimera in yeast cells
US6586661B1 (en) * 1997-06-12 2003-07-01 North Carolina State University Regulation of quinolate phosphoribosyl transferase expression by transformation with a tobacco quinolate phosphoribosyl transferase nucleic acid
US6074360A (en) * 1997-07-21 2000-06-13 Boehringer Mannheim Gmbh Electromagnetic transdermal injection device and methods related thereto
EP1007712A4 (de) * 1997-08-05 2004-06-30 Kimeragen Inc Verwendung von duplex-oligonukleotiden zur beeinflussung lokaler genetischer veränderungen in pflanzen
US5994624A (en) * 1997-10-20 1999-11-30 Cotton Incorporated In planta method for the production of transgenic plants
WO1999026653A1 (en) 1997-11-20 1999-06-03 United States Army Medical Research And Material Command Dna vaccines against tick-borne flaviviruses
US6369201B1 (en) 1998-02-19 2002-04-09 Metamorphix International, Inc. Myostatin multimers
US5973227A (en) * 1998-05-06 1999-10-26 University Of Saskatchewan Flax transformation
KR20010052345A (ko) 1998-05-12 2001-06-25 수잔 씨 복 인간 항트롬빈 3 및 그에 관련된 방법
US7094953B2 (en) 1998-05-29 2006-08-22 Iowa State University Research Foundation, Inc. Plant retroelements and methods related thereto
US6720479B1 (en) * 1998-05-29 2004-04-13 Iowa State University Research Foundation, Inc. Plant retroelements and methods related thereto
EP1975175A3 (de) 1998-06-02 2008-10-29 Nihon University IgA-Nierenleiden-bezogene DNA
CA2330824A1 (en) 1998-06-17 1999-12-23 Epimmune Inc. Hla binding peptides and their uses
US6281375B1 (en) 1998-08-03 2001-08-28 Cargill, Incorporated Biodegradable high oxidative stability oils
US6602678B2 (en) 1998-09-04 2003-08-05 Powderject Research Limited Non- or minimally invasive monitoring methods
NZ510923A (en) 1998-09-04 2003-09-26 Powderject Res Ltd Monitoring methods using particle delivery methods
US6713117B1 (en) * 1998-10-02 2004-03-30 Dharma Kodali Vegetable oil having elevated stearic acid content
ES2259846T3 (es) * 1998-10-19 2006-10-16 Powderject Vaccines, Inc. Promotores minimo y uso de los mismos.
US6881723B1 (en) 1998-11-05 2005-04-19 Powderject Vaccines, Inc. Nucleic acid constructs
US7510841B2 (en) * 1998-12-28 2009-03-31 Illumina, Inc. Methods of making and using composite arrays for the detection of a plurality of target analytes
WO2000047227A2 (en) 1999-02-09 2000-08-17 Powderject Vaccines, Inc. Mycobacterium tuberculosis, immunization
US6987025B1 (en) * 1999-02-11 2006-01-17 The Arizona Board Of Regents On Behalf Of The University Of Arizona Dwf4 polynucleotides, polypeptides and uses thereof
EP1586645A3 (de) * 1999-02-25 2006-02-22 Ceres Incorporated DNA-Fragmente mit bestimmter Sequenz und die dadurch kodierte Polypeptide
GB9905933D0 (en) * 1999-03-15 1999-05-05 Powderject Res Ltd Neeedleless syringe
US20040029167A1 (en) * 1999-03-22 2004-02-12 Bernard Fritig Inducible COMT_II promoter, chimeric gene containing same and plants transformed therewith
US6995301B1 (en) 1999-05-04 2006-02-07 Cargill, Incorporated Plant acyltransferases
DE19926216A1 (de) * 1999-06-09 2001-02-22 Metallgesellschaft Ag Verfahren zur Herstellung von Bariumsulfat, Bariumsulfat und Verwendung des Bariumsulfats
US7485715B2 (en) * 1999-06-18 2009-02-03 Ceres, Inc. Sequence-determined DNA encoding AP2 domain polypeptides
US7399850B2 (en) * 1999-06-18 2008-07-15 Ceres, Inc. Sequence-determined DNA fragments encoding AP2 domain proteins
EP1194449B1 (de) * 1999-06-28 2010-09-22 Oklahoma Medical Research Foundation Inhibitoren des memapsin 2 und ihre verwendung
US7479555B2 (en) * 1999-07-21 2009-01-20 Ceres, Inc. Polynucleotides having a nucleotide sequence that encodes a polypeptide having MOV34 family activity
GB9918061D0 (en) * 1999-07-30 1999-10-06 Univ Bath Modified plants
DE19946059A1 (de) * 1999-09-25 2001-03-29 Roche Diagnostics Gmbh System zur transdermalen Gewinnung von Körperflüssigkeit
GB9923306D0 (en) * 1999-10-01 1999-12-08 Isis Innovation Diagnostic and therapeutic epitope, and transgenic plant
AR025996A1 (es) * 1999-10-07 2002-12-26 Valigen Us Inc Plantas no transgenicas resistentes a los herbicidas.
US20040234539A1 (en) * 1999-11-03 2004-11-25 Powderject Research Limited Nucleic acid vaccine compositions having a mammalian cd80/cd86 gene promoter driving antigen expression
US7196066B1 (en) * 1999-11-03 2007-03-27 Powderject Vaccines, Inc. DNA-vaccines based on constructs derived from the genomes of human and animal pathogens
US20040109874A1 (en) * 1999-11-10 2004-06-10 Powderject Vaccines, Inc. Induction of mucosal immunity by vaccination via the skin route
US20060194958A1 (en) * 1999-11-10 2006-08-31 Nickolai Alexandrov Sequence-determined DNA fragments encoding AN1-like zinc finger proteins
JP4776131B2 (ja) 1999-11-18 2011-09-21 エピミューン インコーポレイテッド ヘテロクリティックアナログおよび関連方法
FR2802102B1 (fr) * 1999-12-08 2002-07-12 Poudres & Explosifs Ste Nale Seringue sans aiguille munie d'un tube d'ejection a section constante
JP4623825B2 (ja) 1999-12-16 2011-02-02 協和発酵バイオ株式会社 新規ポリヌクレオチド
JP3365500B2 (ja) * 2000-01-19 2003-01-14 ウシオ電機株式会社 狭帯化ＡｒＦエキシマレーザ装置
FR2804329B1 (fr) * 2000-02-02 2002-12-13 Poudres & Explosifs Ste Nale Seringue sans aiguille munie d'un opercule contenant le principe actif
JP2003527604A (ja) 2000-03-10 2003-09-16 ワシントン・ユニバーシティ 個々の細胞の標識方法
GB0008494D0 (en) 2000-04-07 2000-05-24 Secr Defence Microprojectile delivery system
US7691991B2 (en) * 2000-04-17 2010-04-06 Ceres, Inc. Sequence-determined DNA fragments encoding cytochrome P450 proteins
AU5929101A (en) * 2000-04-28 2001-11-12 Us Gov Health & Human Serv Improved immunogenicity using a combination of dna and vaccinia virus vector vaccines
WO2001087491A1 (en) 2000-05-16 2001-11-22 Regents Of The University Of Minnesota High mass throughput particle generation using multiple nozzle spraying
CA2705366A1 (en) 2000-08-28 2002-03-07 Agensys, Inc. Nucleic acid and corresponding protein entitled 85p1b3 useful in treatment and detection of cancer
AU2001286843A1 (en) * 2000-08-30 2002-03-13 North Carolina State University Transgenic plants containing molecular decoys that alter protein content therein
CN102311986B (zh) 2000-10-06 2015-08-19 协和发酵麒麟株式会社 产生抗体组合物的细胞
GB0025710D0 (en) * 2000-10-20 2000-12-06 Medical Res Council Biolistic device
FR2815969B1 (fr) 2000-10-30 2004-12-10 Aventis Cropscience Sa Plantes tolerantes aux herbicides par contournement de voie metabolique
DE60128149D1 (en) * 2000-11-07 2007-06-06 Univ North Carolina State Putrescin-n-methyltransferasepromotor
US20050260699A1 (en) * 2000-11-22 2005-11-24 Desouza Mervyn L Carotenoid biosynthesis
US7385046B2 (en) * 2001-01-03 2008-06-10 Ceres, Inc. Sequence-determined DNA fragments encoding ethylene responsive element binding proteins
US20050003474A1 (en) * 2001-01-26 2005-01-06 Desouza Mervyn L. Carotenoid biosynthesis
US20040078846A1 (en) * 2002-01-25 2004-04-22 Desouza Mervyn L. Carotenoid biosynthesis
EP1363487A4 (de) * 2001-01-29 2005-08-17 Cargill Inc Pilzresistente transgene pflanzen
ATE332367T1 (de) * 2001-02-09 2006-07-15 Bbk Bio Corp Verfahren zur übertragung ausgewählter moleküle
US6924358B2 (en) 2001-03-05 2005-08-02 Agensys, Inc. 121P1F1: a tissue specific protein highly expressed in various cancers
US7271240B2 (en) 2001-03-14 2007-09-18 Agensys, Inc. 125P5C8: a tissue specific protein highly expressed in various cancers
EP2280030A3 (de) 2001-04-10 2011-06-15 Agensys, Inc. Nukleinsäuren und zugehörige Proteine für die Behandlung und den Nachweis von Krebs
US20030191073A1 (en) 2001-11-07 2003-10-09 Challita-Eid Pia M. Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer
WO2002092824A1 (en) * 2001-05-15 2002-11-21 Wilkinson Thesesa C Method for producing transgenic monocotyledonous plants
US7247338B2 (en) * 2001-05-16 2007-07-24 Regents Of The University Of Minnesota Coating medical devices
CN1638655A (zh) * 2001-06-08 2005-07-13 韦克多烟草有限公司 修饰烟草中烟碱和亚硝胺的水平
US20060157072A1 (en) * 2001-06-08 2006-07-20 Anthony Albino Method of reducing the harmful effects of orally or transdermally delivered nicotine
EP1409514A4 (de) * 2001-06-22 2005-02-02 Ceres Inc Chimere histon-acetyltransferase-polypeptide
EP1900815B1 (de) 2001-07-12 2016-09-07 University of Massachusetts In-vivo-Herstellung kleiner interferierender und Genverstummung vermittelnder RNAs
IL159756A0 (en) 2001-07-12 2004-06-20 Univ Massachusetts IN VIVO PRODUCTION OF SMALL INTERFERING RNAs THAT MEDIATE GENE SILENCING
US8061006B2 (en) * 2001-07-26 2011-11-22 Powderject Research Limited Particle cassette, method and kit therefor
US20030084473A1 (en) * 2001-08-09 2003-05-01 Valigen Non-transgenic herbicide resistant plants
EP2287186B1 (de) 2001-09-06 2014-12-31 Agensys, Inc. Nucleinsäure und entsprechendes Protein, STEAP-1, bei der Behandlung und zum Nachweis von Krebs
RU2532104C2 (ru) 2001-10-19 2014-10-27 Сумитомо Кемикал Компани, Лимитед Метаболизирующий гербицид белок, его ген и их применение
US20030166190A1 (en) * 2001-12-10 2003-09-04 Wright David A. Nucleic acids related to plant retroelements
JP2005513428A (ja) 2001-12-17 2005-05-12 パウダージェクト リサーチ リミテッド 非侵襲的または最小侵襲的モニタリング方法
WO2003104428A2 (en) 2002-01-21 2003-12-18 Vaccinex, Inc. Gene differentially expressed in breast and bladder cancer and encoded polypeptides
EP1499188A4 (de) * 2002-04-09 2007-11-14 Vector Tobacco Ltd Tabak mit weniger nikotin und nitrosaminen
WO2004041997A2 (en) * 2002-05-01 2004-05-21 National Institutes Of Health Immunotherapy regimens in hiv-infected patients
DE10223196B4 (de) * 2002-05-24 2004-05-13 Dornier Medtech Systems Gmbh Verfahren und Einrichtung zum Transferieren von Molekülen in Zellen
CA2487901A1 (en) * 2002-05-31 2003-12-11 University Of Utah Research Foundation Variants of antithrombin iii
GB0212885D0 (en) * 2002-06-05 2002-07-17 Isis Innovation Therapeutic epitopes and uses thereof
US20060194959A1 (en) * 2002-07-15 2006-08-31 Nickolai Alexandrov Sequence-determined DNA fragments encoding SRF-type transcription factors
US7364901B2 (en) * 2002-07-15 2008-04-29 University Of Kentucky Research Foundation Recombinant Stokesia epoxygenase gene
US20040081653A1 (en) 2002-08-16 2004-04-29 Raitano Arthur B. Nucleic acids and corresponding proteins entitled 251P5G2 useful in treatment and detection of cancer
EP1548105A4 (de) 2002-08-30 2006-03-01 Japan Science & Tech Agency Verfahren zur gezielten genunterbrechung, genom eines hyperthermostabilen bakteriums und genom-chip damit
US7476777B2 (en) * 2002-09-17 2009-01-13 Ceres, Inc. Biological containment system
AU2003295333A1 (en) * 2002-09-17 2004-04-08 Ceres, Inc. Biological containment system
EP1545593A1 (de) * 2002-09-27 2005-06-29 PowderJect Research Limited Mit nukleinsäure überzogene partikel
CA2500715A1 (en) 2002-10-03 2004-04-15 Epimmune Inc. Hla binding peptides and their uses
JP2006508163A (ja) 2002-11-27 2006-03-09 アジェンシス， インコーポレイテッド 癌の処置および検出において有用な２４ｐ４ｃ１２と称される、核酸および対応タンパク質
EP1903056A3 (de) 2002-12-10 2008-05-07 Idm Pharma, Inc. HLA-A1, -A2, -A3, -A24, -B7 and -B44 bindende Peptide die Tumorassoziiert-Antigen Epitopen enthalten, und Zusammensetzungen davon
CA2511553C (en) 2002-12-26 2013-07-30 Shin-Ichi Hashimoto Process for producing dipeptides
WO2004071168A2 (en) * 2003-02-05 2004-08-26 Divergence, Inc. Nucleic acids encoding anthelmintic agents and plants made therefrom
CA2860151A1 (en) 2003-02-10 2004-08-26 Agensys, Inc. Nucleic acid and corresponding protein named 158p1d7 useful in the treatment and detection of bladder and other cancers
EP1462801A3 (de) * 2003-03-24 2005-01-05 Tepnel Lifecodes Methoden zur messung der negativkontrolle in mehrfachanalyt-assays
CA2526274C (en) 2003-05-30 2015-12-01 Agensys, Inc. Prostate stem cell antigen (psca) variants and subsequences thereof
US20040241659A1 (en) * 2003-05-30 2004-12-02 Applera Corporation Apparatus and method for hybridization and SPR detection
US7459547B2 (en) 2003-06-02 2008-12-02 University Of Massachusetts Methods and compositions for controlling efficacy of RNA silencing
ATE485394T1 (de) 2003-06-02 2010-11-15 Univ Massachusetts Verfahren und zusammensetzungen zur verbesserung der wirksamkeit und spezifität von fnai
US7892205B2 (en) * 2003-06-06 2011-02-22 Boston Scientific Scimed, Inc. Device and method for delivering micronized therapeutic agents in the body
US7663017B2 (en) 2003-07-30 2010-02-16 Institut Pasteur Transgenic mice having a human major histocompatability complex (MHC) phenotype, experimental uses and applications
US20050081261A1 (en) * 2003-10-14 2005-04-14 Pennell Roger I. Methods and compositions for altering seed phenotypes
US8147426B2 (en) * 2003-12-31 2012-04-03 Nipro Diagnostics, Inc. Integrated diagnostic test system
CA2552894A1 (en) * 2004-01-09 2005-08-04 University Of Utah Research Foundation Methods of using high affinity atiii variants
EP1709188A1 (de) * 2004-01-16 2006-10-11 Ceres, Inc. Pflanzenzellen enthaltend rezepture polypeptide
US7368629B2 (en) * 2004-02-04 2008-05-06 Divergence, Inc. Nucleic acids encoding anthelmintic agents and plants made therefrom
US7241937B2 (en) * 2004-04-23 2007-07-10 Ceres, Inc. Methods and materials for improving plant drought tolerance
CN104056251B (zh) 2004-04-28 2019-09-17 英国技术集团国际有限公司 与腹部疾病有关的表位
US10105437B2 (en) 2004-04-28 2018-10-23 Btg International Limited Epitopes related to coeliac disease
JP4736480B2 (ja) 2004-05-17 2011-07-27 住友化学株式会社 雑草防除方法
EP1753871B1 (de) 2004-05-28 2015-07-15 Agensys, Inc. An psca-proteine bindende antikörper und verwandte moleküle
WO2006023766A2 (en) * 2004-08-20 2006-03-02 Ceres Inc. P450 polynucleotides, polypeptides, and uses thereof
WO2006031859A2 (en) 2004-09-14 2006-03-23 Ceres Inc. Modulation of amino acid and sugar content in plants
US20060059585A1 (en) * 2004-09-14 2006-03-16 Boris Jankowski Modulating plant sugar levels
US7429692B2 (en) * 2004-10-14 2008-09-30 Ceres, Inc. Sucrose synthase 3 promoter from rice and uses thereof
WO2006062971A2 (en) * 2004-12-08 2006-06-15 Ceres Inc. Modulating plant carbon levels
WO2008076922A1 (en) * 2006-12-15 2008-06-26 Ceres, Inc. Modulation of plant protein levels
US9758790B2 (en) 2004-12-08 2017-09-12 Ceres, Inc. Modulating the level of components within plants
WO2007089610A1 (en) * 2006-01-26 2007-08-09 Ceres, Inc. Modulating plant oil levels
BRPI0519657A2 (pt) * 2004-12-16 2009-03-03 Ceres Inc modulaÇço dos nÍveis de nitrogÊnio em plantas
US7335760B2 (en) * 2004-12-22 2008-02-26 Ceres, Inc. Nucleic acid sequences encoding zinc finger proteins
GB0507997D0 (en) * 2005-02-01 2005-05-25 Powderject Vaccines Inc Nucleic acid constructs
WO2006091676A2 (en) * 2005-02-22 2006-08-31 Ceres Inc. Modulating plant alkaloids
EP3300739A3 (de) 2005-03-31 2018-07-18 Agensys, Inc. An 161p2f10b-proteine bindende antikörper und zugehörige moleküle
US20060246576A1 (en) 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
WO2006113481A1 (en) * 2005-04-14 2006-10-26 Ceres Inc. Secondary metabolite production via manipulation of genome methylation
US7312376B2 (en) * 2005-04-20 2007-12-25 Ceres, Inc. Regulatory regions from Papaveraceae
WO2006133461A1 (en) * 2005-06-08 2006-12-14 Ceres Inc. Identification of terpenoid-biosynthesis related regulatory protein-regulatory region associations
SG165385A1 (en) 2005-06-24 2010-10-28 Teijin Pharma Ltd Novel physiological substance nesfatin, substance relevant thereto, and use of the substances
AU2006279896A1 (en) * 2005-08-10 2007-02-22 Oklahoma Medical Research Foundation Truncated memapsin 2 for use for treating Alzheimer's disease
WO2007037245A1 (ja) 2005-09-29 2007-04-05 Shionogi & Co., Ltd. 血管新生抑制作用を有するポリペプチド
US20100062137A1 (en) * 2005-09-30 2010-03-11 Steven Craig Bobzin Modulating plant tocopherol levels
US20090178160A1 (en) * 2005-10-25 2009-07-09 Joon-Hyun Park Modulation of Triterpenoid Content in Plants
EP2923563B1 (de) 2006-01-12 2024-09-18 Cibus Europe B.V. EPSPS-Mutanten
US20090304901A1 (en) * 2006-01-25 2009-12-10 Steven Craig Bobzin Modulating plant protein levels
EP1988941A2 (de) * 2006-01-31 2008-11-12 Nanocopoeia, Inc. Oberflächenbeschichtung mit nanoteilchen
CA2637883C (en) 2006-01-31 2015-07-07 Regents Of The University Of Minnesota Electrospray coating of objects
US9108217B2 (en) 2006-01-31 2015-08-18 Nanocopoeia, Inc. Nanoparticle coating of surfaces
US20070199090A1 (en) * 2006-02-22 2007-08-23 Nestor Apuya Modulating alkaloid biosynthesis
WO2007120989A2 (en) * 2006-02-24 2007-10-25 Ceres, Inc. Shade regulatory regions
WO2007117693A2 (en) * 2006-04-07 2007-10-18 Ceres, Inc. Regulatory protein-regulatory region associations related to alkaloid biosynthesis
JP5242382B2 (ja) 2006-04-14 2013-07-24 株式会社医学生物学研究所 エフェクター機能を有するポリペプチド変異体
EP2018397A2 (de) * 2006-05-09 2009-01-28 Reliance Life Sciences Pvt., Ltd. Molekulare klonung und sequenzierung des acetyl-coa-carboxylase-gens aus jatropha curcas
US20100154082A1 (en) * 2006-05-10 2010-06-17 Ceres, Inc. Shade tolerance in plants
WO2007133804A2 (en) * 2006-05-15 2007-11-22 Ceres, Inc. Modulation of oil levels in plants
US20080003667A1 (en) * 2006-05-19 2008-01-03 Affymetrix, Inc. Consumable elements for use with fluid processing and detection systems
US20100005549A1 (en) * 2006-06-14 2010-01-07 Shing Kwok Increasing uv-b tolerance in plants
US20090320165A1 (en) * 2006-06-21 2009-12-24 Steven Craig Bobzin Modulation of protein levels in plants
CA2893168C (en) 2006-06-28 2017-11-07 Nucelis Inc. Fatty acid blends and uses therefor
US8344210B2 (en) * 2006-07-05 2013-01-01 Ceres, Inc. Increasing low light tolerance in plants
US20130191941A1 (en) 2006-07-05 2013-07-25 Shing Kwok Modulating light response pathways in plants, increasing light-related tolerances in plants, and increasing biomass in plants
US7939294B2 (en) 2006-09-25 2011-05-10 Kyowa Hakko Bio Co., Ltd. DNA encoding proteins having dipeptide-synthesizing activity and methods of using the same
US8362322B2 (en) 2006-10-27 2013-01-29 Ceres, Inc. Modulating lignin in plants
US20100199378A1 (en) * 2006-11-20 2010-08-05 Shing Kwok Shade tolerance in plants
US8222388B2 (en) * 2006-11-22 2012-07-17 Ceres, Inc. Broadly expressing regulatory regions
US9040816B2 (en) * 2006-12-08 2015-05-26 Nanocopoeia, Inc. Methods and apparatus for forming photovoltaic cells using electrospray
CN101679966B (zh) 2007-01-24 2014-03-12 协和发酵麒麟株式会社 具有增强的效应子活性的遗传重组抗体组合物
EP2107115A1 (de) 2007-01-24 2009-10-07 Kyowa Hakko Kirin Co., Ltd. Genetisch rekombinante antikörperzusammensetzung zur anbindung insbesondere an gangliosid gm2
EP2316939A2 (de) 2007-01-25 2011-05-04 Kyowa Hakko Kirin Co., Ltd. Neues Peptid
JP5550041B2 (ja) 2007-09-27 2014-07-16 塩野義製薬株式会社 チトクロームｐ４５０を用いたアダマンタン水酸化体の製造方法
CN108342376A (zh) * 2007-10-05 2018-07-31 赛布斯欧洲公司 芸苔属中突变的乙酰羟酸合酶基因
JP5620106B2 (ja) 2007-10-24 2014-11-05 株式会社糖鎖工学研究所 増強されたエフェクター機能を有するポリペプチド
WO2009059011A2 (en) 2007-11-01 2009-05-07 Mayo Foundation For Medical Education And Research Hla-dr binding peptides and their uses
JP2011508047A (ja) * 2007-12-27 2011-03-10 サイバス，エルエルシー アルキルエステル脂肪酸配合物およびその用途
US9839772B2 (en) 2008-05-06 2017-12-12 Cook Medical Technologies Llc Apparatus and methods for delivering therapeutic agents
WO2009143167A2 (en) 2008-05-19 2009-11-26 Advaxis Dual delivery system for heterologous antigens
US9650639B2 (en) 2008-05-19 2017-05-16 Advaxis, Inc. Dual delivery system for heterologous antigens
US9017660B2 (en) 2009-11-11 2015-04-28 Advaxis, Inc. Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors
AU2009248852B9 (en) 2008-05-23 2015-08-13 Cibus Europe B.V. Production of squalene using yeast
US8419145B2 (en) * 2008-07-25 2013-04-16 Eastman Kodak Company Inkjet printhead and method of printing with multiple drop volumes
EP2311864A4 (de) 2008-08-13 2013-07-31 Kyowa Hakko Kirin Co Ltd Rekombinante protein-s-zusammensetzung
CA2739881A1 (en) 2008-10-09 2010-04-15 Kyowa Medex Co., Ltd. Novel fructosyl peptide oxidase
US8298794B2 (en) * 2008-10-09 2012-10-30 Ceres, Inc. Cinnamyl-alcohol dehydrogenases
CA2747390C (en) * 2008-12-23 2016-10-04 Wilson-Cook Medical Inc. Apparatus and methods for containing and delivering therapeutic agents
US20110239315A1 (en) 2009-01-12 2011-09-29 Ulla Bonas Modular dna-binding domains and methods of use
EP2206723A1 (de) 2009-01-12 2010-07-14 Bonas, Ulla Modulare DNA-bindende Domänen
US9101744B2 (en) 2009-05-29 2015-08-11 Cook Medical Technologies Llc Systems and methods for delivering therapeutic agents
US8118777B2 (en) 2009-05-29 2012-02-21 Cook Medical Technologies Llc Systems and methods for delivering therapeutic agents
PL2659771T3 (pl) 2009-07-20 2019-05-31 Ceres Inc Rośliny transgeniczne o zwiększonej biomasie
US10016617B2 (en) 2009-11-11 2018-07-10 The Trustees Of The University Of Pennsylvania Combination immuno therapy and radiotherapy for the treatment of Her-2-positive cancers
CN107058145A (zh) * 2009-11-23 2017-08-18 纽塞利斯公司 使用酵母产生角鲨烯的方法和组合物
EP3456826B1 (de) 2009-12-10 2023-06-28 Regents of the University of Minnesota Tal-effektor-vermittelte dna-modifizierung
CN102762724A (zh) 2009-12-23 2012-10-31 拜尔知识产权有限公司 对hppd抑制剂型除草剂耐受的植物
CA2785126C (en) 2009-12-23 2019-07-02 Bayer Intellectual Property Gmbh Plants tolerant to hppd inhibitor herbicides
AR079883A1 (es) 2009-12-23 2012-02-29 Bayer Cropscience Ag Plantas tolerantes a herbicidas inhibidores de las hppd
CA2785225C (en) 2009-12-23 2019-01-22 Bayer Intellectual Property Gmbh Plants tolerant to hppd inhibitor herbicides.
UY33140A (es) 2009-12-23 2011-07-29 Bayer Cropscience Ag Plantas tolerantes a herbicidas inhibidores de las hppd
US20110159577A1 (en) * 2009-12-30 2011-06-30 E. I. Du Pont De Nemours And Company Divider for use with biolistic bombardment device
US9371538B2 (en) 2010-02-04 2016-06-21 Bayer Intellectual Property Gmbh Method for increasing photosynthetic carbon fixation using glycolate dehydrogenase multi-subunit fusion protein
US20130052221A1 (en) 2010-02-26 2013-02-28 The Govt. of the U.S, as represented by The Sec. of The Dept. of Health and Human Services Dna-protein vaccination protocols
CA2791652C (en) 2010-03-02 2018-06-12 Kyowa Kirin Co., Ltd. Modified antibody composition
JP5767207B2 (ja) 2010-03-26 2015-08-19 協和発酵キリン株式会社 新規修飾部位導入抗体および抗体フラグメント
WO2011140329A1 (en) 2010-05-06 2011-11-10 Ceres, Inc. Transgenic plants having increased biomass
EP2569633B1 (de) 2010-05-14 2016-02-10 The General Hospital Corporation Zusammensetzungen und verfahren zur identifikation tumorspezifischer neoantigene
JP6208580B2 (ja) 2010-05-17 2017-10-04 サンガモ セラピューティクス， インコーポレイテッド 新規のｄｎａ結合タンパク質及びその使用
MY185668A (en) 2010-06-02 2021-05-28 Evolva Inc Recombinant production of steviol glycosides
JP5058332B2 (ja) 2010-07-14 2012-10-24 住友ゴム工業株式会社 イソプレンオリゴマー、ポリイソプレン、及びこれらの製造方法、ゴム組成物、並びに空気入りタイヤ
UA112969C2 (uk) 2010-08-03 2016-11-25 Сібас Юс Ллс Рослина, стійка до одного або більше ррх-інгібуючих гербіцидів, яка містить мутантний ген протопорфіриноген ix оксидази (ррх)
US20120122223A1 (en) 2010-08-03 2012-05-17 Cibus Us Llc Mutated protoporphyrinogen ix oxidase (ppx) genes
CN107412756A (zh) 2010-10-01 2017-12-01 宾夕法尼亚大学理事会 李斯特菌疫苗载体用于在寄生虫感染的个体中扭转免疫无应答的用途
BR112013010278B1 (pt) 2010-10-27 2020-12-29 Ceres, Inc método para produzir uma planta, método para modular a composição de biomassa em uma planta, ácido nucleico isolado e método para alterar a composição de biomassa em uma planta
WO2012125551A1 (en) 2011-03-11 2012-09-20 Advaxis Listeria-based adjuvants
US9556448B2 (en) 2011-04-11 2017-01-31 Targeted Growth, Inc. Identification and the use of KRP mutants in plants
KR102114493B1 (ko) 2011-08-08 2020-05-26 에볼바 에스아 스테비올 글리코시드의 재조합 생산
KR101815063B1 (ko) 2011-08-08 2018-01-05 에볼바 에스아 사프란 화합물의 재조합 생성을 위한 방법 및 물질
WO2013022881A1 (en) 2011-08-08 2013-02-14 International Flavors & Fragrances Inc. Compositions and methods for the biosynthesis of vanillin or vanillin beta-d-glucoside
WO2013025485A1 (en) 2011-08-12 2013-02-21 Ceres, Inc. Transcription terminators
BR122020026837B1 (pt) 2011-11-02 2021-04-13 Ceres, Inc Método de aumento do rendimento de planta em solo contendo níveis elevados de al3+, método de aumento da tolerância de uma planta
ES2894724T3 (es) 2011-12-02 2022-02-15 Rhode Island Hospital Vacuna contra la malaria falciparum
US10323256B2 (en) 2011-12-09 2019-06-18 Ceres, Inc. Transgenic plants having altered biomass composition
SG10201700392UA (en) 2012-03-12 2017-03-30 Advaxis Inc Suppressor cell function inhibition following listeria vaccine treatment
EP2861737B1 (de) 2012-06-19 2019-04-17 Regents Of The University Of Minnesota Gen-targeting in pflanzen durch dns-viren
EP2895601A1 (de) 2012-09-14 2015-07-22 Bayer Cropscience LP Hppd-varianten und verfahren zur verwendung
EP2905290B1 (de) 2012-10-05 2019-12-04 Kyowa Kirin Co., Ltd. Heterodimere proteinzusammensetzung
CN104968193B (zh) 2012-11-01 2021-02-09 塞尔克蒂斯股份有限公司 用于生成治疗性蛋白质的植物
JP6594205B2 (ja) 2012-11-05 2019-10-23 エヴォルヴァ エスアー． バニリンシンターゼ
US20140178561A1 (en) 2012-12-21 2014-06-26 Cellectis Potatoes with reduced cold-induced sweetening
CN105051195B (zh) 2013-02-06 2019-09-06 埃沃尔瓦公司 用于提高莱鲍迪苷d和莱鲍迪苷m之产生的方法
CN105189771B (zh) 2013-02-11 2019-11-05 埃沃尔瓦公司 在重组宿主中有效产生甜菊醇糖苷
CA2942826A1 (en) 2013-03-14 2014-09-25 Evolutionary Genomics, Inc. Identification and use of tomato genes controlling salt/drought tolerance and fruit sweetness
US9790515B2 (en) 2013-03-14 2017-10-17 Cibus Us Llc Mutated allene oxide synthase 2 (AOS2) genes
EA201591447A1 (ru) 2013-03-15 2016-05-31 Сибас Юс Ллс Способы и композиции для повышения эффективности направленной модификации генов с применением опосредованной олигонуклеотидами репарации генов
US9867931B2 (en) 2013-10-02 2018-01-16 Cook Medical Technologies Llc Therapeutic agents for delivery using a catheter and pressure source
US12331303B2 (en) 2013-03-15 2025-06-17 Cibus Us Llc Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
UA120033C2 (uk) 2013-03-15 2019-09-25 Сібас Юс Ллс Спосіб підвищення ефективності спрямованої модифікації генів із застосуванням опосередкованої олігонуклеотидами репарації генів
US10113162B2 (en) 2013-03-15 2018-10-30 Cellectis Modifying soybean oil composition through targeted knockout of the FAD2-1A/1B genes
US9957515B2 (en) 2013-03-15 2018-05-01 Cibus Us Llc Methods and compositions for targeted gene modification
US11931227B2 (en) 2013-03-15 2024-03-19 Cook Medical Technologies Llc Bimodal treatment methods and compositions for gastrointestinal lesions with active bleeding
AU2014251207B2 (en) 2013-04-07 2019-06-13 Dana-Farber Cancer Institute, Inc. Compositions and methods for personalized neoplasia vaccines
US9944970B2 (en) 2013-07-09 2018-04-17 Kyowa Medex Co., Ltd. Glycated hexapeptide oxidase and use thereof
CN105745332A (zh) 2013-09-11 2016-07-06 非凡食品有限公司 含有血红素的多肽的分泌
CA2911168C (en) 2013-10-29 2018-08-14 Biotech Institute, Llc Production and use of specialty cannabis with bd/bt genotype and a beta caryophyllene-dominant terpene profile
US10801070B2 (en) 2013-11-25 2020-10-13 The Broad Institute, Inc. Compositions and methods for diagnosing, evaluating and treating cancer
US11725237B2 (en) 2013-12-05 2023-08-15 The Broad Institute Inc. Polymorphic gene typing and somatic change detection using sequencing data
JP7060324B2 (ja) 2013-12-20 2022-04-26 ザ・ブロード・インスティテュート・インコーポレイテッド ネオ抗原ワクチンによる併用療法
JP6448194B2 (ja) 2014-01-20 2019-01-09 住友ゴム工業株式会社 シス型プレニルトランスフェラーゼをコードする遺伝子、及び、ＮｏｇｏＢｒｅｃｅｐｔｏｒをコードする遺伝子を宿主に導入することにより、該宿主において、シス型プレニルトランスフェラーゼ及びＮｏｇｏＢｒｅｃｅｐｔｏｒを発現させた形質転換体、並びに該形質転換体を用いたポリイソプレノイドの製造方法
US10053717B2 (en) 2014-01-31 2018-08-21 University Of Copenhagen Biosynthesis of forskolin and related compounds
US20180037912A1 (en) 2014-01-31 2018-02-08 University Of Copenhagen Methods for Producing Diterpenes
BR112016020889B1 (pt) 2014-03-11 2022-10-04 BASF Agricultural Solutions Seed US LLC Molécula de ácido nucleico recombinante, célula hospedeira bacteriana, proteína hppd recombinante, uso do ácido nucleico recombinante e produto de base
AU2015229095B2 (en) 2014-03-14 2022-01-27 Cibus Europe B.V. Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
US9101100B1 (en) 2014-04-30 2015-08-11 Ceres, Inc. Methods and materials for high throughput testing of transgene combinations
US9737251B2 (en) 2014-05-28 2017-08-22 Verily Life Sciences Llc Needle-free blood draw
WO2015193858A1 (en) 2014-06-20 2015-12-23 Cellectis Potatoes with reduced granule-bound starch synthase
WO2015197075A1 (en) 2014-06-23 2015-12-30 University Of Copenhagen Methods and materials for production of terpenoids
US10480000B2 (en) 2014-07-15 2019-11-19 Ceres, Inc. Methods of increasing crop yield under abiotic stress
EP3179869A1 (de) 2014-08-11 2017-06-21 Evolva SA Erzeugung von steviolglycosiden in rekombinanten wirten
JP2017528134A (ja) 2014-09-09 2017-09-28 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． 組み換え宿主におけるステビオールグリコシドの生産
EP3215626A1 (de) 2014-11-07 2017-09-13 University of Copenhagen Biosynthese von oxidiertem 13r-mo und verwandte verbindungen
WO2016075302A1 (en) 2014-11-13 2016-05-19 Evolva Sa Methods and materials for biosynthesis of manoyl oxide
EP4636401A2 (de) 2014-12-19 2025-10-22 The Broad Institute, Inc. Verfahren zur profilierung des t-zell-rezeptor-repertoirs
WO2016100975A1 (en) 2014-12-19 2016-06-23 Massachsetts Institute Ot Technology Molecular biomarkers for cancer immunotherapy
EP3250686A1 (de) 2015-01-30 2017-12-06 Evolva SA Erzeugung von steviolglycosiden in rekombinanten wirten
JP6719174B2 (ja) 2015-02-23 2020-07-08 住友ゴム工業株式会社 特定のプロモーター及び特定の蛋白質をコードする遺伝子を含むベクター、該ベクターが導入された形質転換植物、並びに、該ベクターを植物に導入することにより、ポリイソプレノイドの生産量を向上させる方法
JP6557990B2 (ja) 2015-02-23 2019-08-14 住友ゴム工業株式会社 特定のプロモーター及び特定の蛋白質をコードする遺伝子を含むベクター、該ベクターが導入された形質転換植物、並びに、該ベクターを植物に導入することにより、ポリイソプレノイドの生産量を向上させる方法
JP6557989B2 (ja) 2015-02-23 2019-08-14 住友ゴム工業株式会社 特定のプロモーター及び特定の蛋白質をコードする遺伝子を含むベクター、該ベクターが導入された形質転換植物、並びに、該ベクターを植物に導入することにより、ポリイソプレノイドの生産量を向上させる方法
CN115851470B (zh) 2015-03-16 2025-09-02 帝斯曼知识产权资产管理有限公司 Udp-糖基转移酶
HRP20220299T1 (hr) 2015-05-11 2022-05-13 Impossible Foods Inc. Ekspresijski konstrukti i postupci za genetsku modifikaciju metilotrofnog kvasca
EP4276106A3 (de) 2015-05-13 2024-01-24 The United States of America as represented by the Secretary of the Department of Health and Human Services Methoden und zusammensetzungen beruhend auf konstruktenenthaltend konservierte elemente zur induktion einer immunantwort
MX2017014700A (es) 2015-05-20 2018-08-15 Broad Inst Inc Neoantigenos compartidos.
WO2016191315A1 (en) 2015-05-22 2016-12-01 Stcube & Co., Inc. Screening methods for targets for cancer therapy
TW202241500A (zh) 2015-06-09 2022-11-01 美商博德研究所有限公司 用於贅瘤疫苗之調配物及其製備方法
AU2016307066A1 (en) 2015-08-07 2018-02-08 Evolva Sa Production of steviol glycosides in recombinant hosts
US10837024B2 (en) 2015-09-17 2020-11-17 Cellectis Modifying messenger RNA stability in plant transformations
US20170199961A1 (en) 2015-12-16 2017-07-13 Gritstone Oncology, Inc. Neoantigen Identification, Manufacture, and Use
WO2017134601A1 (en) 2016-02-02 2017-08-10 Cellectis Modifying soybean oil composition through targeted knockout of the fad3a/b/c genes
BR112018016278A2 (pt) 2016-02-09 2019-01-02 Cibus Europe Bv métodos e composições para aumentar a eficiência da modificação do gene direcionada usando reparação de gene mediada por oligonucleotídeo
CN109310739A (zh) 2016-03-31 2019-02-05 内恩疗法公司 新抗原及其使用方法
MY198001A (en) 2016-04-13 2023-07-25 Evolva SA Production of steviol glycoside in recombinant hosts
EP3446119A1 (de) 2016-04-18 2019-02-27 The Broad Institute Inc. Verbesserte hla-epitopvorhersage
WO2017184727A1 (en) 2016-04-21 2017-10-26 Bayer Cropscience Lp Tal-effector mediated herbicide tolerance
US10815514B2 (en) 2016-05-16 2020-10-27 Evolva Sa Production of steviol glycosides in recombinant hosts
WO2018015512A1 (en) 2016-07-20 2018-01-25 Evolva Sa Biosynthesis of 13r-manoyl oxide derivatives
AU2017309313B2 (en) 2016-08-09 2023-11-02 River Stone Biotech, Inc. Biosynthesis of benzylisoquinoline alkaloids and benzylisoquinoline alkaloid precursors
US11396669B2 (en) 2016-11-07 2022-07-26 Evolva Sa Production of steviol glycosides in recombinant hosts
WO2018092072A1 (en) 2016-11-16 2018-05-24 Cellectis Methods for altering amino acid content in plants through frameshift mutations
MX2019006010A (es) 2016-11-23 2019-12-05 Gritstone Oncology Inc Administracion viral de neoantigenos.
AU2018208191B2 (en) 2017-01-10 2024-09-12 National Cancer Center Anti-GPC3 antibody
WO2018140391A1 (en) 2017-01-24 2018-08-02 The Broad Institute, Inc. Compositions and methods for detecting a mutant variant of a polynucleotide
BR112019018056A2 (pt) 2017-03-07 2020-08-11 BASF Agricultural Solutions Seed US LLC molécula de ácido nucleico recombinante, cassete de expressão, célula hospedeira, plantas, sementes transgênicas, polipeptídeo recombinante, métodos para conferir tolerância e para controlar ervas daninhas, produto de utilidade e uso da sequência de nucleotídeos
BR112019018059A2 (pt) 2017-03-07 2020-08-04 BASF Agricultural Solutions Seed US LLC molécula de ácido nucleico recombinante, célula hospedeira, plantas, sementes transgênicas, polipeptídeo recombinante, método para produzir um polipeptídeo, método de controle de ervas daninhas, uso do ácido nucleico e produto de utilidade
US11180770B2 (en) 2017-03-07 2021-11-23 BASF Agricultural Solutions Seed US LLC HPPD variants and methods of use
CN118370809A (zh) 2017-04-03 2024-07-23 百欧恩泰美国公司 蛋白质抗原及其用途
CA3060622A1 (en) 2017-04-25 2018-11-01 Cellectis Alfalfa with reduced lignin composition
MX2019013259A (es) 2017-05-08 2020-01-13 Gritstone Oncology Inc Vectores de neoantigeno de alfavirus.
WO2018213803A1 (en) 2017-05-19 2018-11-22 Neon Therapeutics, Inc. Immunogenic neoantigen identification
AU2018279627B2 (en) 2017-06-09 2023-08-10 Seattle Project Corp. Neoantigen identification, manufacture, and use
ES3029080T3 (en) 2017-10-10 2025-06-23 Seattle Project Corp Neoantigen identification using hotspots
US20210032651A1 (en) 2017-10-24 2021-02-04 Basf Se Improvement of herbicide tolerance to hppd inhibitors by down-regulation of putative 4-hydroxyphenylpyruvate reductases in soybean
US11279944B2 (en) 2017-10-24 2022-03-22 BASF Agricultural Solutions Seed US LLC Of herbicide tolerance to 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors by down-regulation of HPPD expression in soybean
US11885815B2 (en) 2017-11-22 2024-01-30 Gritstone Bio, Inc. Reducing junction epitope presentation for neoantigens
EP4495597A3 (de) 2018-01-04 2025-04-30 Iconic Therapeutics LLC Antikörper gegen den gewebefaktor, antikörper-wirkstoff-konjugate und zugehörige verfahren
WO2019140009A1 (en) 2018-01-09 2019-07-18 Cibus Us Llc Shatterproof genes and mutations
AU2019247403B2 (en) 2018-04-04 2025-04-10 Cibus Europe, B.V. FAD2 genes and mutations
US11866788B2 (en) 2018-05-08 2024-01-09 Sanford Burnham Prebys Medical Discovery Institute Role of PVT1 in the diagnosis and treatment of MYC-driven cancer
TW202000907A (zh) 2018-05-23 2020-01-01 美商葛利史東腫瘤科技公司 共有抗原
US20210380684A1 (en) 2018-09-28 2021-12-09 Kyowa Kirin Co., Ltd. Antibody composition
WO2020072700A1 (en) 2018-10-02 2020-04-09 Dana-Farber Cancer Institute, Inc. Hla single allele lines
KR102232757B1 (ko) * 2018-11-22 2021-03-26 (주)엑솔런스바이오테크놀로지 체외충격파를 이용한 표적물질 전달 장치
WO2020131586A2 (en) 2018-12-17 2020-06-25 The Broad Institute, Inc. Methods for identifying neoantigens
WO2020190363A1 (en) 2019-03-19 2020-09-24 Massachusetts Institute Of Technology Control of nitrogen fixation in rhizobia that associate with cereals
WO2020219972A1 (en) 2019-04-25 2020-10-29 Impossible Foods Inc. Strains and methods for production of heme-containing proteins
JP7457733B2 (ja) 2019-05-30 2024-03-28 グリットストーン バイオ インコーポレイテッド 改変アデノウイルス
JP2020195326A (ja) 2019-06-03 2020-12-10 住友ゴム工業株式会社 天然ゴムの製造方法、形質転換植物、空気入りタイヤの製造方法及びゴム製品の製造方法
US11473086B2 (en) 2019-06-19 2022-10-18 Ut-Battelle, Llc Loss of function alleles of PtEPSP-TF and its regulatory targets in rice
CN114746109A (zh) 2019-09-02 2022-07-12 居里研究所 靶向肿瘤新抗原性肽的免疫疗法
WO2021055846A1 (en) 2019-09-19 2021-03-25 Sanford Burnham Prebys Medical Discovery Institute Methods and compositions for treating myc-driven cancers
US12394502B2 (en) 2019-10-02 2025-08-19 The General Hospital Corporation Method for predicting HLA-binding peptides using protein structural features
WO2021078910A1 (en) 2019-10-22 2021-04-29 Institut Curie Immunotherapy targeting tumor neoantigenic peptides
CN120242238A (zh) * 2019-10-30 2025-07-04 株式会社大赛璐 基因枪
JP2021080204A (ja) 2019-11-19 2021-05-27 住友ゴム工業株式会社 融合タンパク質、物質製造方法、ベクター、形質転換細胞、空気入りタイヤの製造方法及びゴム製品の製造方法
WO2021177074A1 (ja) 2020-03-05 2021-09-10 住友ゴム工業株式会社 ポリイソプレノイドの製造方法、ベクター、形質転換植物、空気入りタイヤの製造方法及びゴム製品の製造方法
JP7744330B2 (ja) 2020-04-01 2025-09-25 協和キリン株式会社 抗体組成物
EP4149952A1 (de) 2020-05-12 2023-03-22 Institut Curie Neoantigene epitope in zusammenhang mit sf3b1-mutationen
BR112022023464A2 (pt) 2020-06-05 2022-12-20 Cook Medical Technologies Llc Endoscópios médicos para entregar agentes terapêuticos
EP4192496A4 (de) 2020-08-06 2025-01-01 Gritstone bio, Inc. Multiepitop-impfstoffkassetten
WO2022072833A2 (en) 2020-10-02 2022-04-07 Impossible Foods Inc. Expression constructs and methods of genetically engineering cells
WO2022072846A2 (en) 2020-10-02 2022-04-07 Impossible Foods Inc. Transgenic plants with altered fatty acid profiles and upregulated heme biosynthesis
WO2022074098A1 (en) 2020-10-08 2022-04-14 Fundació Privada Institut D'investigació Oncològica De Vall Hebron Method for the identification of cancer neoantigens
US11530419B2 (en) 2020-10-30 2022-12-20 Fortiphyte, Inc. Pathogen resistance in plants
WO2022098936A1 (en) 2020-11-06 2022-05-12 Amazon Technologies, Inc. Selecting neoantigens for personalized cancer vaccine
MX2023007003A (es) 2020-12-14 2023-08-18 Biontech Us Inc Antigenos especificos de tejidos para la inmunoterapia del cancer.
WO2022159176A1 (en) 2021-01-19 2022-07-28 Amazon Technologies, Inc. A deep learning model for predicting tumor-specific neoantigen mhc class i or class ii immunogenicity
CN117157713A (zh) 2021-02-05 2023-12-01 亚马逊科技公司 对用于个性化癌症疫苗的新抗原进行排序
CA3212964A1 (en) 2021-03-11 2022-09-15 Mnemo Therapeutics Tumor neoantigenic peptides
CA3213004A1 (en) 2021-03-11 2022-09-15 Mnemo Therapeutics Tumor neoantigenic peptides and uses thereof
MX2023010640A (es) 2021-03-11 2024-02-07 Inst Curie Péptidos neoantigénicos transmembranales.
WO2022197630A1 (en) 2021-03-15 2022-09-22 Amazon Technologies, Inc. Methods for optimizing tumor vaccine antigen coverage for heterogenous malignancies
EP4346884A1 (de) 2021-05-27 2024-04-10 Amazon Technologies, Inc. Chemische mehrkomponentenzusammensetzung eines neoantigenimpfstoffs auf peptidbasis
US12543936B2 (en) 2021-07-14 2026-02-10 Cook Medical Technologies Llc Systems and methods for preventing clogging of a delivery system
JP7829849B2 (ja) 2021-09-10 2026-03-16 住友ゴム工業株式会社 トランス型ポリイソプレノイドの製造方法、ベクター、形質転換生物、空気入りタイヤの製造方法及びゴム製品の製造方法
JP7799273B2 (ja) 2022-03-02 2026-01-15 住友ゴム工業株式会社 変異シス型プレニルトランスフェラーゼ（ｃｐｔ）ファミリー蛋白質、ポリイソプレノイドの製造方法、ベクター、形質転換植物、空気入りタイヤの製造方法及びゴム製品の製造方法
JP7799272B2 (ja) 2022-03-02 2026-01-15 住友ゴム工業株式会社 変異シス型プレニルトランスフェラーゼ（ｃｐｔ）ファミリー蛋白質、ポリイソプレノイドの製造方法、ベクター、形質転換植物、空気入りタイヤの製造方法及びゴム製品の製造方法
JP7799274B2 (ja) 2022-03-02 2026-01-15 住友ゴム工業株式会社 変異シス型プレニルトランスフェラーゼ（ｃｐｔ）ファミリー蛋白質、ポリイソプレノイドの製造方法、ベクター、形質転換植物、空気入りタイヤの製造方法及びゴム製品の製造方法
US20240360515A1 (en) 2022-03-16 2024-10-31 Amazon Technologies, Inc. Monitoring circulating tumor dna to improve subclone penetration of follow-up neoantigen cancer vaccines
EP4499134A1 (de) 2022-03-24 2025-02-05 Institut Curie Gegen tumortransponierbare elementabgeleitete neoantigene peptide in glioblastomen gerichtete immuntherapie
US20250003004A1 (en) 2022-07-15 2025-01-02 Amazon Technologies, Inc. Personalized Longitudinal Analysis of Circulating Material to Monitor and Adapt Neoantigen Cancer Vaccines
AU2023337091A1 (en) 2022-09-09 2025-03-06 Eidgenössische Technische Hochschule Zürich Plant regulatory elements and uses thereof
US12496429B2 (en) 2022-10-18 2025-12-16 Cook Medical Technologies Llc Systems and methods for delivering pressurized fluid to a target site alone or in conjunction with therapeutic agents
US12239091B2 (en) 2023-03-27 2025-03-04 Redsea Science And Technology Inc. Tomato plant designated ‘MX20-06’
WO2025030048A2 (en) 2023-08-03 2025-02-06 J.R. Simplot Company Fusarium wilt resistance genes
US20250075226A1 (en) 2023-08-29 2025-03-06 University Of Freiburg Proteins for regulation of symbiotic infection and associated regulatory elements
EP4702988A1 (de) 2024-08-28 2026-03-04 Biotechnology Assets S.A. Kombinationsprodukt zur behandlung von leishmaniose

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4945050A (en) * 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US5015580A (en) * 1987-07-29 1991-05-14 Agracetus Particle-mediated transformation of soybean plants and lines
IL84459A (en) * 1986-12-05 1993-07-08 Agracetus Apparatus and method for the injection of carrier particles carrying genetic material into living cells
ATE119569T1 (de) * 1988-02-29 1995-03-15 Du Pont Vorrichtung für das liefern von substanzen in zellen und gewebe auf eine nichtletale weise.

Also Published As

Publication number Publication date
DE69103631D1 (de) 1994-09-29
HU9203554D0 (en) 1993-03-29
US5204253A (en) 1993-04-20
HUT67533A (en) 1995-04-28
CA2083816C (en) 2005-06-28
EP0535005B1 (de) 1994-08-24
HU216738B (hu) 1999-08-30
AR243603A1 (es) 1993-08-31
ES2059140T3 (es) 1994-11-01
EP0535005A1 (de) 1993-04-07
JP2517813B2 (ja) 1996-07-24
KR960008270B1 (ko) 1996-06-21
WO1991018991A1 (en) 1991-12-12
DE69103631T2 (de) 1995-02-23
DK0535005T3 (da) 1994-09-26
CA2083816A1 (en) 1991-11-30
JPH05508316A (ja) 1993-11-25
AU7878891A (en) 1991-12-31

Similar Documents

Publication Publication Date Title
ATE110415T1 (de) Verbessertes verfahren und apparat, um biologische substanzen in lebenden zellen einzuführen.
DE3788026D1 (de) Verfahren und Vorrichtung zur Kultivierung von Zellen.
DK475386D0 (da) Fremgangsmaade og apparat til fremstilling af biologiske stoffer
DE69803344D1 (de) Vorrichtung zum nachweis von strahlung und verfahren zu ihrer herstellung
DE69740113D1 (de) Vorrichtung und verfahren zur inkubation von zellen
DE3788058D1 (de) Zelltoxischer antikörperkomplex und verfahren zu seiner herstellung.
DE69931085D1 (de) System und Verfahren zum Separieren von biologischen Zellen
DE69636398D1 (de) Blutbehandlungssystem und Verfahren zur Gewinnung von mononuklearen Zellen
ATE538205T1 (de) Verfahren, medien und vorrichtung zur einführung von molekülen in pflanzenzellen und bakterien mittels aerosolstrahlen
DK1088212T3 (da) Apparat og fremgangsmåde til indsamling og førstebehandling af vævsprøver til molekylærgenetisk diagnostik
DE3783103D1 (de) Elektrochemischer gassensor und verfahren zu seiner herstellung.
DE3382359D1 (de) Verfahren zur kultivierung und isolierung von zellen.
DE69837440D1 (de) Apparat, geeignet zum transport und lagerung von kernbrennstoffstäben und verfahren zur verwendung des apparats
FI931303A7 (fi) Menetelmät vieraan DNA:n viemiseksi soluihin
DE69816272D1 (de) Cyanidfreie lytische reagenzzusammensetzung und verfahren zur hämoglobin- und zellanalyse
DE69507689D1 (de) Verfahren zur mehrstufigen pflanzenzucht und dazu geeigneter apparat
DE69735547D1 (de) Verfahren zur induzierung von immunsupprimierten zellen und vorrichtung zu deren kultivierung
ATE214612T1 (de) Biologisch aktive substanzen, verfahren zur herstellung und sie enthaltende zusammensetzungen
DE3482594D1 (de) Analytische testzusammensetzung, vorrichtung, verfahren zu ihrer herstellung und zur bestimmung von peroxidatisch wirkenden substanzen.
DE3483934D1 (de) Verfahren und apparat zum einpflanzen eines fremdstoffes in lebende zelle.
DE68919256D1 (de) Verfahren und Vorrichtung zur Ermittlung von Zelleigenschaften.
DE69534698D1 (de) Verfahren und Vorrichtung zum Vermittlen von Zellen
DE69005987D1 (de) Dichtung, Vorrichtung und Verfahren zur ihrer Herstellung.
DE68912661D1 (de) Verfahren und Vorrichtung für Zellkultur.
DE68909997D1 (de) Vorrichtung zur Kultur von tierischen Zellen, Kulturmethode und Mittel zum Nachweis der Kultur.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties