DK0666920T3 - Trombinaktiverbare plasminogenderivater - Google Patents

Trombinaktiverbare plasminogenderivater

Info

Publication number
DK0666920T3
DK0666920T3 DK93923634T DK93923634T DK0666920T3 DK 0666920 T3 DK0666920 T3 DK 0666920T3 DK 93923634 T DK93923634 T DK 93923634T DK 93923634 T DK93923634 T DK 93923634T DK 0666920 T3 DK0666920 T3 DK 0666920T3
Authority
DK
Denmark
Prior art keywords
thrombin
amino acid
acid residue
activatable
activatable plasminogen
Prior art date
Application number
DK93923634T
Other languages
English (en)
Inventor
James Gilbert Richard
Michael George Hunter
Keith Martyn Dawson
Original Assignee
British Biotech Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Biotech Pharm filed Critical British Biotech Pharm
Application granted granted Critical
Publication of DK0666920T3 publication Critical patent/DK0666920T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
DK93923634T 1992-10-29 1993-10-28 Trombinaktiverbare plasminogenderivater DK0666920T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929222758A GB9222758D0 (en) 1992-10-29 1992-10-29 Proteins and nucleic acids
PCT/GB1993/002219 WO1994010318A1 (en) 1992-10-29 1993-10-28 Thrombin activatable plasminogen derivatives

Publications (1)

Publication Number Publication Date
DK0666920T3 true DK0666920T3 (da) 1999-06-14

Family

ID=10724266

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93923634T DK0666920T3 (da) 1992-10-29 1993-10-28 Trombinaktiverbare plasminogenderivater

Country Status (15)

Country Link
EP (1) EP0666920B1 (da)
JP (1) JP3329340B2 (da)
AT (1) ATE171213T1 (da)
AU (1) AU674180B2 (da)
CA (1) CA2145749C (da)
DE (1) DE69321134T2 (da)
DK (1) DK0666920T3 (da)
ES (1) ES2123669T3 (da)
FI (1) FI114102B (da)
GB (1) GB9222758D0 (da)
HK (1) HK1008047A1 (da)
NO (1) NO317661B1 (da)
NZ (1) NZ257175A (da)
WO (1) WO1994010318A1 (da)
ZA (1) ZA938120B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9412131D0 (en) * 1994-06-17 1994-08-10 British Bio Technology Thrombolytic composition
CA2262751A1 (en) * 1996-08-02 1998-02-12 Roche Diagnostics Gmbh Plasminogen activator capable of being activated by thrombin
JP4047170B2 (ja) 2000-12-21 2008-02-13 トロム−イクス・ナムローゼ・フエンノートシャップ 酵母発現ベクターおよび酵母細胞における発現による組換えタンパク質の製造方法
AU2003210137A1 (en) * 2002-02-06 2003-09-02 N-Zyme Biotec Gmbh Method for producing recombinant proteins in micro-organisms
FR2841904B1 (fr) * 2002-07-03 2004-08-20 Inst Nat Sante Rech Med Analogues de facteurs x clivables par la thrombine
PL213309B1 (pl) 2006-02-09 2013-02-28 Polska Akademia Nauk Inst Biochemii I Biofizyki Sposób hydrolizy wiazania peptydowego

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids

Also Published As

Publication number Publication date
NZ257175A (en) 1996-07-26
NO951648D0 (no) 1995-04-28
CA2145749A1 (en) 1994-05-11
ATE171213T1 (de) 1998-10-15
CA2145749C (en) 2005-06-21
ES2123669T3 (es) 1999-01-16
DE69321134D1 (de) 1998-10-22
GB9222758D0 (en) 1992-12-09
NO317661B1 (no) 2004-11-29
AU5343294A (en) 1994-05-24
DE69321134T2 (de) 1999-02-25
FI952071L (fi) 1995-04-28
HK1008047A1 (en) 1999-04-30
WO1994010318A1 (en) 1994-05-11
FI952071A0 (fi) 1995-04-28
JP3329340B2 (ja) 2002-09-30
FI114102B (fi) 2004-08-13
ZA938120B (en) 1994-08-01
AU674180B2 (en) 1996-12-12
JPH08504575A (ja) 1996-05-21
EP0666920A1 (en) 1995-08-16
NO951648L (no) 1995-04-28
EP0666920B1 (en) 1998-09-16

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