ATE171213T1 - Plasminogen-derivate die durch thrombin aktivierbar sind - Google Patents

Plasminogen-derivate die durch thrombin aktivierbar sind

Info

Publication number
ATE171213T1
ATE171213T1 AT93923634T AT93923634T ATE171213T1 AT E171213 T1 ATE171213 T1 AT E171213T1 AT 93923634 T AT93923634 T AT 93923634T AT 93923634 T AT93923634 T AT 93923634T AT E171213 T1 ATE171213 T1 AT E171213T1
Authority
AT
Austria
Prior art keywords
thrombin
activated
amino acid
acid residue
arg
Prior art date
Application number
AT93923634T
Other languages
English (en)
Inventor
Richard James Gilbert
Michael George Hunter
Keith Martyn Dawson
Original Assignee
British Biotech Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Biotech Pharm filed Critical British Biotech Pharm
Application granted granted Critical
Publication of ATE171213T1 publication Critical patent/ATE171213T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
AT93923634T 1992-10-29 1993-10-28 Plasminogen-derivate die durch thrombin aktivierbar sind ATE171213T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929222758A GB9222758D0 (en) 1992-10-29 1992-10-29 Proteins and nucleic acids

Publications (1)

Publication Number Publication Date
ATE171213T1 true ATE171213T1 (de) 1998-10-15

Family

ID=10724266

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93923634T ATE171213T1 (de) 1992-10-29 1993-10-28 Plasminogen-derivate die durch thrombin aktivierbar sind

Country Status (15)

Country Link
EP (1) EP0666920B1 (de)
JP (1) JP3329340B2 (de)
AT (1) ATE171213T1 (de)
AU (1) AU674180B2 (de)
CA (1) CA2145749C (de)
DE (1) DE69321134T2 (de)
DK (1) DK0666920T3 (de)
ES (1) ES2123669T3 (de)
FI (1) FI114102B (de)
GB (1) GB9222758D0 (de)
HK (1) HK1008047A1 (de)
NO (1) NO317661B1 (de)
NZ (1) NZ257175A (de)
WO (1) WO1994010318A1 (de)
ZA (1) ZA938120B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9412131D0 (en) * 1994-06-17 1994-08-10 British Bio Technology Thrombolytic composition
BR9711015A (pt) * 1996-08-02 1999-08-17 Boehringer Mannheim Gmbh Ativador de plasminog-nio capaz de ser ativado por trombina
US7445775B2 (en) 2000-12-21 2008-11-04 Thromb-X Nv Yeast expression vector and a method of making a recombinant protein by expression in a yeast cell
WO2003066842A2 (de) * 2002-02-06 2003-08-14 Trommsdorff Gmbh & Co. Kg Arzneimittel Verfahren zur herstellung von rekombinanten proteinen in mikroorganismen
FR2841904B1 (fr) * 2002-07-03 2004-08-20 Inst Nat Sante Rech Med Analogues de facteurs x clivables par la thrombine
PL213309B1 (pl) 2006-02-09 2013-02-28 Polska Akademia Nauk Inst Biochemii I Biofizyki Sposób hydrolizy wiazania peptydowego

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids

Also Published As

Publication number Publication date
WO1994010318A1 (en) 1994-05-11
JPH08504575A (ja) 1996-05-21
EP0666920B1 (de) 1998-09-16
AU5343294A (en) 1994-05-24
GB9222758D0 (en) 1992-12-09
NZ257175A (en) 1996-07-26
DE69321134T2 (de) 1999-02-25
FI114102B (fi) 2004-08-13
ES2123669T3 (es) 1999-01-16
FI952071A0 (fi) 1995-04-28
JP3329340B2 (ja) 2002-09-30
CA2145749C (en) 2005-06-21
DK0666920T3 (da) 1999-06-14
NO951648D0 (no) 1995-04-28
DE69321134D1 (de) 1998-10-22
NO951648L (no) 1995-04-28
AU674180B2 (en) 1996-12-12
NO317661B1 (no) 2004-11-29
CA2145749A1 (en) 1994-05-11
ZA938120B (en) 1994-08-01
HK1008047A1 (en) 1999-04-30
FI952071L (fi) 1995-04-28
EP0666920A1 (de) 1995-08-16

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee