DK0669342T3 - Fremgangsmåde til isolering og rensning af vitamin K-afhængige proteiner - Google Patents

Fremgangsmåde til isolering og rensning af vitamin K-afhængige proteiner

Info

Publication number
DK0669342T3
DK0669342T3 DK95102504T DK95102504T DK0669342T3 DK 0669342 T3 DK0669342 T3 DK 0669342T3 DK 95102504 T DK95102504 T DK 95102504T DK 95102504 T DK95102504 T DK 95102504T DK 0669342 T3 DK0669342 T3 DK 0669342T3
Authority
DK
Denmark
Prior art keywords
isolating
vitamin
dependent proteins
proteins
dependent
Prior art date
Application number
DK95102504T
Other languages
English (en)
Inventor
Friedrich Prof Dorner
Artur Dr Mitterer
Bernhard Dr Fischer
Original Assignee
Baxter Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Ag filed Critical Baxter Ag
Application granted granted Critical
Publication of DK0669342T3 publication Critical patent/DK0669342T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
DK95102504T 1994-02-28 1995-02-22 Fremgangsmåde til isolering og rensning af vitamin K-afhængige proteiner DK0669342T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4406515A DE4406515C1 (de) 1994-02-28 1994-02-28 Verfahren zur Isolierung und Reinigung Vitamin K-abhängiger Proteine

Publications (1)

Publication Number Publication Date
DK0669342T3 true DK0669342T3 (da) 2001-11-12

Family

ID=6511421

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95102504T DK0669342T3 (da) 1994-02-28 1995-02-22 Fremgangsmåde til isolering og rensning af vitamin K-afhængige proteiner

Country Status (13)

Country Link
US (1) US5633350A (da)
EP (1) EP0669342B1 (da)
JP (1) JPH07258286A (da)
AT (1) ATE205218T1 (da)
CA (1) CA2143510C (da)
CZ (1) CZ290471B6 (da)
DE (1) DE4406515C1 (da)
DK (1) DK0669342T3 (da)
ES (1) ES2161790T3 (da)
FI (1) FI116526B (da)
HU (1) HU219828B (da)
NO (1) NO322372B1 (da)
SK (1) SK22695A3 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69926226T2 (de) * 1998-04-15 2006-05-24 Novo Nordisk A/S Neues verfahren zur trennung von proteinen unter verwendung eines ca++ enthaltenden elutionsmittels
DE60138111D1 (de) * 2000-07-21 2009-05-07 Chemo Sero Therapeut Res Inst Verfahren zur reinigung eines kalziumionen-bindenden proteins
US7897734B2 (en) 2003-03-26 2011-03-01 Novo Nordisk Healthcare Ag Method for the production of proteins
JP2008525381A (ja) * 2004-12-23 2008-07-17 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 関心のあるビタミンｋ依存性タンパク質を含んでなる組成物中におけるタンパク質混入物の量の減少
US20090047723A1 (en) * 2005-01-14 2009-02-19 Bayer Healthcare Llc Method for purification of factor vii
RU2440810C2 (ru) * 2005-04-28 2012-01-27 Ново Нордиск Хелс Кеа Аг Закрытый контейнер, содержащий активированный полипептид фактора vii, способы его получения и набор и способ применения набора
US7375084B2 (en) 2006-03-07 2008-05-20 Baxter International Inc. Highly phosphorylated and sulfated recombinant factor IX
DK2125866T3 (da) * 2007-02-28 2013-07-29 Baxter Int Fremgangsmåde til rensning af rekombinant blodkoagulationsfaktor IX, som er beriget med sulfaterede og/eller phosphorylerede molekyler
EP2526115B1 (en) * 2010-01-18 2018-08-01 Novo Nordisk Health Care AG Purification of blood coagulation factors
JP5883849B2 (ja) 2010-04-29 2016-03-15 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ 陰イオン交換樹脂を用いる二価カチオン結合タンパク質の精製方法
WO2012104339A1 (en) 2011-02-01 2012-08-09 Novo Nordisk A/S Purification of insulin
EP2748180B1 (en) 2011-10-14 2018-08-15 Baxalta GmbH Protein purification by anion exchange chromatography
LT2748179T (lt) * 2011-10-14 2022-04-11 Takeda Pharmaceutical Company Limited Baltymų gryninimas anijonų mainų chromatografija
TR201808584T4 (tr) * 2013-03-15 2018-07-23 Baxalta GmbH Anyon değişimi kromotografisi aracılığıyla k vitaminine bağlı proteinler için saflaştırma yöntemi.
JP7606185B2 (ja) * 2020-09-03 2024-12-25 日機装株式会社 フェノールレッド吸着剤およびフェノールレッドの除去方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3101752A1 (de) * 1981-01-21 1982-08-26 Behringwerke Ag, 3550 Marburg "verfahren zur reinigung der blutgerinnungsfaktoren ii, vii, ix und/oder x und danach hergestellte praeparationen"
EP0317376B2 (fr) * 1987-10-23 1996-04-03 Centre Regional De Transfusion Sanguine De Lille Préparation de concentré de facteur IX humain de haute pureté et d'autres protéines plasmatiques
US4981952A (en) * 1988-10-04 1991-01-01 Eli Lilly And Company Method for the purification of vitamin K-dependent proteins
AT395596B (de) * 1991-06-20 1993-01-25 Immuno Ag Verfahren zur herstellung von aktiviertem protein c

Also Published As

Publication number Publication date
CZ290471B6 (cs) 2002-07-17
NO322372B1 (no) 2006-09-25
EP0669342A2 (de) 1995-08-30
CA2143510C (en) 1999-12-21
SK22695A3 (en) 1995-09-13
FI950888A0 (fi) 1995-02-27
FI116526B (fi) 2005-12-15
CA2143510A1 (en) 1995-08-29
EP0669342B1 (de) 2001-09-05
HU219828B (hu) 2001-08-28
US5633350A (en) 1997-05-27
NO950733L (no) 1995-08-29
HU9500594D0 (en) 1995-04-28
HUT72844A (en) 1996-05-28
ATE205218T1 (de) 2001-09-15
CZ53995A3 (en) 1995-09-13
JPH07258286A (ja) 1995-10-09
DE4406515C1 (de) 1995-10-19
ES2161790T3 (es) 2001-12-16
NO950733D0 (no) 1995-02-27
EP0669342A3 (de) 1997-04-16
FI950888L (fi) 1995-08-29

Similar Documents

Publication Publication Date Title
NO950733L (no) Fremgangsmåte for isolering og rensing av proteiner som er avhengig av vitamin K
DE3685386D1 (de) Vorrichtung zum polieren von halbleiterscheiben.
DE3852591D1 (de) Vorrichtung zum Montieren von Chips.
DK395184D0 (da) Indretning til regulerbar aendring af friktionsgrebet mellem en bils hjl og et underlag, saasom en vejbane
DE3667921D1 (de) Druckwechseladsorptionsverfahren.
FI853604A7 (fi) Menetelmä fosforihapon puhdistamiseksi.
DE3886490D1 (de) Halbleitende Hochleistungsverstärker-Vorrichtung.
NO920351L (no) Anvendelser av interleukin-4 og fremgangsmaate for rensingav det
FR2522680B1 (fr) Oxydase d'acide l-glutamique (productrice de h2o2), sa production et methode d'analyse l'utilisant
FR2473929B1 (fr) Procede et dispositif d'usinage par decharges electriques
DE3685563D1 (de) Vorrichtung zum abspielen von videoplatten.
FI863069A7 (fi) Menetelmä lignoselluloosan liuottamiseksi.
FI830754L (fi) Foerfarande foer framstaellning av 1-substituerade n-(8 -ergolinyl-n',n'-dietylkarbamider
FR2509215B1 (fr) Procede et dispositif d'usinage par decharges electriques
FI862363A7 (fi) Menetelmä lastulevyjen valmistamiseksi.
FR2563829B1 (fr) Procede de production de n-(4-(3-aminopropyl)aminobutyl)-2,2-dihydroxyethanamide
IT8321708A0 (it) Procedimento e dispositivo per produrre granulato di silicio di elevata purezza.
DE3576783D1 (de) Vorrichtung zum bestuecken von komponenten.
JPS5721906A (en) Method of concentrating suspension of valve slurry, etc. and device used for said method
IT8323152A0 (it) Dispositivo di registrazione e centraggio per servofreni.
FI840120A7 (fi) Betonin ominaisuuksien säätelymenetelmä.
DE3771997D1 (de) Trennverfahren mittels kristallisation.
SU903802A1 (ru) Регул тор
SU877058A1 (ru) Устройство дл управлени перемещением базы механизированной крепи
FI854340A7 (fi) Menetelmä bakampisilliinihydrokloridin stabiloimiseksi.