DK0675727T3 - Glycolipidenzympolymerkonjugater - Google Patents
GlycolipidenzympolymerkonjugaterInfo
- Publication number
- DK0675727T3 DK0675727T3 DK94903530T DK94903530T DK0675727T3 DK 0675727 T3 DK0675727 T3 DK 0675727T3 DK 94903530 T DK94903530 T DK 94903530T DK 94903530 T DK94903530 T DK 94903530T DK 0675727 T3 DK0675727 T3 DK 0675727T3
- Authority
- DK
- Denmark
- Prior art keywords
- polymer conjugates
- enzyme polymer
- glycolipid
- glycolipid enzyme
- conjugates
- Prior art date
Links
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 title 1
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
- 229930186217 Glycolipid Natural products 0.000 title 1
- 229920000642 polymer Polymers 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01045—Glucosylceramidase (3.2.1.45), i.e. beta-glucocerebrosidase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98980292A | 1992-12-10 | 1992-12-10 | |
| PCT/US1993/011920 WO1994013311A1 (en) | 1992-12-10 | 1993-12-08 | Glycolipid enzyme-polymer conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0675727T3 true DK0675727T3 (da) | 2002-08-05 |
Family
ID=25535471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94903530T DK0675727T3 (da) | 1992-12-10 | 1993-12-08 | Glycolipidenzympolymerkonjugater |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US5620884A (da) |
| EP (1) | EP0675727B1 (da) |
| JP (1) | JPH08507677A (da) |
| AU (1) | AU5743994A (da) |
| CA (1) | CA2150956A1 (da) |
| DE (1) | DE69331805T2 (da) |
| DK (1) | DK0675727T3 (da) |
| WO (1) | WO1994013311A1 (da) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995012413A1 (en) * | 1993-11-03 | 1995-05-11 | O'brien, Caroline, Jane | Cell control and suppression |
| EP0952841A4 (en) * | 1994-08-05 | 2000-11-02 | Molecular Structural Biotechno | BIOMOLECULAR COMPLEXES FOR TARGETED TRANSPORTATION OF MEDICINAL PRODUCTS IN SPECIAL REGIONS |
| WO1997009989A1 (en) * | 1995-09-14 | 1997-03-20 | Lxr Biotechnology Inc. | Compositions with anti-apoptotic activity, containing a mixture of phospholipids |
| SE9601817D0 (sv) | 1996-05-13 | 1996-05-13 | Karsten Buschard | Novel glycolipid complexex and their uses |
| WO1998002161A1 (en) * | 1996-07-15 | 1998-01-22 | Universiteit Van Amsterdam | Deoxynojirimycin derivatives and their uses as glucosylceramidase inhibitors |
| AU4648697A (en) | 1996-09-23 | 1998-04-14 | Chandrashekar Pathak | Methods and devices for preparing protein concentrates |
| AU5104098A (en) * | 1996-11-14 | 1998-06-03 | Polymer Technology Corporation | Use of water soluble enzyme-polymer conjugates for cleaning contact lenses |
| US6321909B1 (en) | 1997-02-13 | 2001-11-27 | Sky High, Llc | System for storing polyethylene glycol solutions |
| US6251866B1 (en) | 1997-08-05 | 2001-06-26 | Watson Laboratories, Inc. | Conjugates targeted to the interleukin-2 receptor |
| AU768765B2 (en) * | 1998-06-23 | 2004-01-08 | Novozymes A/S | A polypeptide-polymer conjugate |
| US6638526B1 (en) | 1998-06-23 | 2003-10-28 | Novozymes A/S | Polypeptides conjugated to copolymers of ethylene oxide and propylene oxide to reduce allergenicity |
| AU770911B2 (en) * | 1998-07-17 | 2004-03-04 | Novozymes A/S | A polypeptide-polymer conjugate with improved wash performance |
| JP2003505430A (ja) * | 1999-07-26 | 2003-02-12 | ジー・ディー・サール・アンド・カンパニー | デオキシノジリマイシンの長鎖ｎ−アルキル誘導体およびグルコセレブロシダーゼ酵素の糖脂質異常蓄積疾患の治療用の薬剤の製造のための使用 |
| WO2001049830A2 (en) * | 1999-12-30 | 2001-07-12 | Maxygen Aps | Improved lysosomal enzymes and lysosomal enzyme activators |
| US7138262B1 (en) | 2000-08-18 | 2006-11-21 | Shire Human Genetic Therapies, Inc. | High mannose proteins and methods of making high mannose proteins |
| WO2003017938A2 (en) * | 2001-08-22 | 2003-03-06 | Watson Pharmaceuticals, Inc. | Conjugates targeted to target receptors |
| US6887952B1 (en) | 2004-02-12 | 2005-05-03 | Biosite, Inc. | N-aryl-carbamic acid ester-derived and valeric acid ester-derived cross-linkers and conjugates, and methods for their synthesis and use |
| US7740861B2 (en) * | 2004-06-16 | 2010-06-22 | University Of Massachusetts | Drug delivery product and methods |
| WO2006031583A2 (en) * | 2004-09-09 | 2006-03-23 | Biosite Incorporated | Methods and compositions for measuring canine bnp and uses thereof |
| ES2375995T3 (es) * | 2004-09-17 | 2012-03-08 | University Of Massachusetts | Composiciones y sus usos para deficiencias de enzima lisosomal. |
| WO2006078813A2 (en) * | 2005-01-21 | 2006-07-27 | Biosite Incorporated | Arginine analogs, and methods for their synthesis and use |
| JP2008530305A (ja) | 2005-02-09 | 2008-08-07 | タイコ ヘルスケア グループ エルピー | 合成封止剤 |
| EP1948245B1 (en) * | 2005-10-24 | 2011-10-05 | University of Massachusetts | Compositions and their uses for gene therapy of bone conditions |
| RS52459B (sr) * | 2006-02-07 | 2013-02-28 | Shire Human Genetic Therapies Inc. | Stabilizovane kompozicije glukocerebrozidaze |
| WO2007097934A2 (en) * | 2006-02-17 | 2007-08-30 | Elusys Therapeutics, Inc. | Methods and compositions for using erythrocytes as carriers for delivery of drugs |
| EP2222283A2 (en) * | 2007-10-29 | 2010-09-01 | University of Massachusetts | Yeast cell wall protein (ycwp) encapsulated multilayered nanoparticles for nucleic acid delivery (sirna) |
| WO2010080720A2 (en) * | 2009-01-12 | 2010-07-15 | Nektar Therapeutics | Conjugates of a lysosomal enzyme moiety and a water soluble polymer |
| WO2010104883A1 (en) * | 2009-03-09 | 2010-09-16 | Molecular Express, Inc. | Methods and compositions for liposomal formulation of antigens and uses thereof |
| NZ623910A (en) | 2009-07-28 | 2016-06-24 | Shire Human Genetic Therapies | Compositions and methods for treating gaucher disease |
| US9194011B2 (en) | 2009-11-17 | 2015-11-24 | Protalix Ltd. | Stabilized alpha-galactosidase and uses thereof |
| WO2011107992A2 (en) * | 2010-03-02 | 2011-09-09 | Protalix Ltd. | Multimeric forms of therapeutic proteins and uses thereof |
| US9623090B2 (en) | 2012-03-02 | 2017-04-18 | Shire Human Genetic Therapies, Inc. | Compositions and methods for treating type III gaucher disease |
| AU2014239248B2 (en) | 2013-03-14 | 2017-02-23 | Alere San Diego, Inc. | 6-Acetylmorphine analogs, and methods for their synthesis and use |
| US10980892B2 (en) | 2015-06-15 | 2021-04-20 | Angiochem Inc. | Methods for the treatment of leptomeningeal carcinomatosis |
| EP3458439B1 (en) | 2016-05-18 | 2021-12-08 | Alere San Diego, Inc. | 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine analogs and methods for their synthesis and use |
| MY204084A (en) | 2017-06-11 | 2024-08-06 | Molecular Express Inc | Methods and compositions for substance use disorder vaccine formulations and uses thereof |
| IL297806A (en) | 2020-04-30 | 2022-12-01 | Sairopa B V | Anti-cd103 antibodies |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US3910822A (en) * | 1974-03-14 | 1975-10-07 | Us Health | Isolation of glucocerebrosidase from human placental tissue |
| US4749570A (en) * | 1981-12-31 | 1988-06-07 | The Governors Of The University Of Alberta | Targeting conjugates of albumin and therapeutic agents |
| GB8430252D0 (en) * | 1984-11-30 | 1985-01-09 | Beecham Group Plc | Compounds |
| JPS61275978A (ja) * | 1985-05-31 | 1986-12-06 | Toshiba Corp | 演算処理装置 |
| WO1989005850A1 (en) * | 1987-12-23 | 1989-06-29 | The United States Of America, As Represented By Th | Cloned dna for synthesizing unique glucocerebrosidase |
| ES2093642T3 (es) * | 1988-12-23 | 1997-01-01 | Genzyme Corp | Celulas cho que producen gluco-cerebrosidasa re-combinante enzimaticamente activa. |
| US5122614A (en) * | 1989-04-19 | 1992-06-16 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
| WO1992013067A1 (en) * | 1991-01-21 | 1992-08-06 | Genzyme Corporation | Production of enzymatically active glucocerebrosidase from recombinant cells |
-
1993
- 1993-12-08 WO PCT/US1993/011920 patent/WO1994013311A1/en not_active Ceased
- 1993-12-08 DK DK94903530T patent/DK0675727T3/da active
- 1993-12-08 EP EP94903530A patent/EP0675727B1/en not_active Expired - Lifetime
- 1993-12-08 CA CA002150956A patent/CA2150956A1/en not_active Abandoned
- 1993-12-08 DE DE69331805T patent/DE69331805T2/de not_active Expired - Fee Related
- 1993-12-08 JP JP6514367A patent/JPH08507677A/ja not_active Ceased
- 1993-12-08 AU AU57439/94A patent/AU5743994A/en not_active Abandoned
-
1994
- 1994-11-30 US US08/346,680 patent/US5620884A/en not_active Expired - Lifetime
-
1996
- 1996-10-23 US US08/735,961 patent/US5705153A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH08507677A (ja) | 1996-08-20 |
| EP0675727B1 (en) | 2002-04-10 |
| WO1994013311A1 (en) | 1994-06-23 |
| EP0675727A4 (en) | 1997-01-08 |
| US5620884A (en) | 1997-04-15 |
| EP0675727A1 (en) | 1995-10-11 |
| DE69331805T2 (de) | 2002-11-28 |
| US5705153A (en) | 1998-01-06 |
| DE69331805D1 (de) | 2002-05-16 |
| AU5743994A (en) | 1994-07-04 |
| CA2150956A1 (en) | 1994-06-23 |
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