DK0678089T3 - N-Acylpyrrolidiner og lægemidler til behandling eller forebyggelse af cholecystokinin- og gastrin-relaterede forstyrrelser - Google Patents

N-Acylpyrrolidiner og lægemidler til behandling eller forebyggelse af cholecystokinin- og gastrin-relaterede forstyrrelser

Info

Publication number: DK0678089T3
Authority: DK; Denmark
Prior art keywords: acylpyrrolidines; cholecystokinin; gastrin; drugs; prevention
Prior art date: 1993-01-07

Application number

DK94903940.8T

Other languages

English (en)

Inventor

Marc Capet

Franco Manfre

Marie-Christine Dubroeucq

Original Assignee

Rhone Poulenc Rorer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-01-07

Filing date

1994-01-03

Publication date

1996-11-18

1994-01-03 Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa

1996-11-18 Application granted granted Critical

1996-11-18 Publication of DK0678089T3 publication Critical patent/DK0678089T3/da

Links

239000003814 drug Substances 0.000 title abstract 2
102100025841 Cholecystokinin Human genes 0.000 title 1
101800001982 Cholecystokinin Proteins 0.000 title 1
102100021022 Gastrin Human genes 0.000 title 1
108010052343 Gastrins Proteins 0.000 title 1
AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 title 1
229940107137 cholecystokinin Drugs 0.000 title 1
229940079593 drug Drugs 0.000 title 1
230000002265 prevention Effects 0.000 title 1
IZTQOLKUZKXIRV-YRVFCXMDSA-N sincalide Chemical compound C([C@@H](C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](N)CC(O)=O)C1=CC=C(OS(O)(=O)=O)C=C1 IZTQOLKUZKXIRV-YRVFCXMDSA-N 0.000 title 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Anesthesiology (AREA)
Ophthalmology & Optometry (AREA)
Addiction (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

DK94903940.8T 1993-01-07 1994-01-03 N-Acylpyrrolidiner og lægemidler til behandling eller forebyggelse af cholecystokinin- og gastrin-relaterede forstyrrelser DK0678089T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9300078A FR2700166B1 (fr)	1993-01-07	1993-01-07	Dérivés de pyrrolidine, leur préparation et les médicaments les contenant.

Publications (1)

Publication Number	Publication Date
DK0678089T3 true DK0678089T3 (da)	1996-11-18

Family

ID=9442867

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94903940.8T DK0678089T3 (da)	1993-01-07	1994-01-03	N-Acylpyrrolidiner og lægemidler til behandling eller forebyggelse af cholecystokinin- og gastrin-relaterede forstyrrelser

Country Status (18)

Country	Link
US (1)	US5707991A (da)
EP (1)	EP0678089B1 (da)
JP (1)	JPH08505849A (da)
KR (1)	KR960700229A (da)
AT (1)	ATE143947T1 (da)
AU (1)	AU5819394A (da)
CA (1)	CA2152185A1 (da)
DE (1)	DE69400704T2 (da)
DK (1)	DK0678089T3 (da)
ES (1)	ES2094638T3 (da)
FR (1)	FR2700166B1 (da)
GR (1)	GR3021314T3 (da)
HU (1)	HUT74094A (da)
IL (1)	IL108288A0 (da)
NO (1)	NO952688L (da)
NZ (1)	NZ259399A (da)
WO (1)	WO1994015915A1 (da)
ZA (1)	ZA9429B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2721608B1 (fr) *	1994-06-22	1996-07-19	Rhone Poulenc Rorer Sa	Dérivés de thiazolidine, leur préparation et les médicaments les contenant.
FR2734724B1 (fr) *	1995-06-01	1997-07-04	Rhone Poulenc Rorer Sa	Application de derives de pyrrolidine a la preparation de medicaments destines au traitement de l'alcoolisme
FR2744362B1 (fr) *	1996-02-07	1998-02-27	Rhone Poulenc Rorer Sa	Application de derives de pyrrolidine a la preparation de medicaments destines au traitement de l'abus de drogues ou de substances donnant lieu a des pharmacomanies ou a un usage excessif
AR021803A1 (es) *	1998-09-23	2002-08-07	Merck & Co Inc	Proceso estereoselectivo perfeccionado para enalapril.
ITRM20020014A1 (it) *	2002-01-15	2003-07-15	Sigma Tau Ind Farmaceuti	Derivati di acidi a-feniltiocarbossilici e a-fenilossicarbossilici utili per il trattamento di patologie che rispondono all'attivazione del
AU2003291227A1 (en)	2002-11-05	2004-06-07	Smithkline Beecham Corporation	Antibacterial agents
DK1966130T3 (da) *	2005-12-23	2014-02-10	Zealand Pharma As	Modificerede lysin-mimetiske forbindelser
WO2008079266A2 (en)	2006-12-21	2008-07-03	Wyeth	Synthesis of pyrrolidine compounds
JP6989864B2 (ja)	2017-05-05	2022-02-03	ジーランドファーマ，アー／エス	ギャップ結合細胞間コミュニケーションモジュレータ及び糖尿病性眼疾患の治療のためのそれらの使用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0124317B1 (en) *	1983-04-27	1990-04-11	Ici Americas Inc.	Proline derivatives
FR2667864B2 (fr) *	1990-03-07	1994-08-05	Rhone Poulenc Sante	Derives de n-phenyl glycinamides, leur preparation et les medicaments les contenant.
FR2678938B1 (fr) *	1991-07-10	1993-10-08	Rhone Poulenc Rorer Sa	Derives de pyrrolidine, leur preparation et les medicaments les contenant.

1993
- 1993-01-07 FR FR9300078A patent/FR2700166B1/fr not_active Expired - Fee Related
1994
- 1994-01-03 JP JP6515748A patent/JPH08505849A/ja active Pending
- 1994-01-03 DE DE69400704T patent/DE69400704T2/de not_active Expired - Fee Related
- 1994-01-03 WO PCT/FR1994/000009 patent/WO1994015915A1/fr not_active Ceased
- 1994-01-03 ES ES94903940T patent/ES2094638T3/es not_active Expired - Lifetime
- 1994-01-03 AU AU58193/94A patent/AU5819394A/en not_active Abandoned
- 1994-01-03 EP EP94903940A patent/EP0678089B1/fr not_active Expired - Lifetime
- 1994-01-03 NZ NZ259399A patent/NZ259399A/en unknown
- 1994-01-03 KR KR1019950702824A patent/KR960700229A/ko not_active Withdrawn
- 1994-01-03 CA CA002152185A patent/CA2152185A1/fr not_active Abandoned
- 1994-01-03 US US08/448,401 patent/US5707991A/en not_active Expired - Fee Related
- 1994-01-03 HU HU9502068A patent/HUT74094A/hu unknown
- 1994-01-03 AT AT94903940T patent/ATE143947T1/de not_active IP Right Cessation
- 1994-01-03 DK DK94903940.8T patent/DK0678089T3/da active
- 1994-01-04 ZA ZA9429A patent/ZA9429B/xx unknown
- 1994-01-06 IL IL10828894A patent/IL108288A0/xx unknown
1995
- 1995-07-06 NO NO952688A patent/NO952688L/no unknown
1996
- 1996-10-10 GR GR960401907T patent/GR3021314T3/el unknown

Also Published As

Publication number	Publication date
GR3021314T3 (en)	1997-01-31
US5707991A (en)	1998-01-13
NO952688D0 (no)	1995-07-06
HUT74094A (en)	1996-11-28
IL108288A0 (en)	1994-04-12
KR960700229A (ko)	1996-01-19
ES2094638T3 (es)	1997-01-16
AU5819394A (en)	1994-08-15
ATE143947T1 (de)	1996-10-15
ZA9429B (en)	1994-08-11
EP0678089A1 (fr)	1995-10-25
DE69400704D1 (de)	1996-11-14
CA2152185A1 (fr)	1994-07-21
FR2700166A1 (fr)	1994-07-08
HU9502068D0 (en)	1995-09-28
DE69400704T2 (de)	1997-03-13
NZ259399A (en)	1996-07-26
WO1994015915A1 (fr)	1994-07-21
EP0678089B1 (fr)	1996-10-09
FR2700166B1 (fr)	1995-02-17
JPH08505849A (ja)	1996-06-25
NO952688L (no)	1995-08-29

Publication	Publication Date	Title
NO304889B1 (no)	1999-03-01	Imidazopyridiner og deres anvendelse ved fremstilling av legemidler til behandling av mave-tarm-sykdommer
DZ1794A1 (fr)	2002-02-17	Nouvelle formule pharmaceutique.
ATE195117T1 (de)	2000-08-15	1-amdinophenyl-pyrrolidone/piperidinone als blutblättchen-aggregations inhibitoren
DK0833644T3 (da)	2003-07-21	Farmaceutisk og diætetiske sammensætninger til forebyggelse og behandling af gastrointestinale sygdomme
ES2122637T3 (es)	1998-12-16	Derivados de tiazolidina, su preparacion y los medicamentos que les contienen.
NO964121L (no)	1996-11-26	Pyrimidin- eller triazin-karboksylsyrederivater for anvendelse som legemidler
ATE213633T1 (de)	2002-03-15	Lamotrigin haltiges arzneimittel
DK0748314T3 (da)	2002-08-26	Tetrasubstituerede imidazolderivater, fremgangsmåde til deres fremstilling, deres anvendelse som lægemidler og farmaceutiske præparater med indhold deraf
NO308654B1 (no)	2000-10-09	Amid-derivater, fremgangsmÕter og mellomprodukter for fremstilling derav, deres anvendelse og farmasøytiske blandinger som inneholdende dem
DK0711283T3 (da)	1999-11-22	Tetrahydro-1H-benzazepinoner og hexahydroazepinoner som selektive cholecystokinin-B-receptorantagonister
NO952688D0 (no)	1995-07-06	N-acyl-pyrrolidiner og medikamenter for behandling eller prevensjon av cholecystokinin- og eller gastrin-relaterte tilstander
DK0866711T3 (da)	2006-11-27	Anvendelse af 6-methyl-5-oxo-3-thiomorpholinylcarbonyl-L-histidyl-L-prolinamid til fremstilling af et farmaceutisk præparat til modvirkning af sövnapnö
DK0678088T3 (da)	1996-11-18	N-acylpyrrolidiner og lægemidler til behandling og forebyggelse af cholecystokinin- og gastrinrelaterede sygdomme
BR9306870A (pt)	1998-12-08	Derivados farmacologicamente ativos de (aminometila terciária) - benzenometanol
DK0675895T3 (da)	1998-02-23	Etoposidderivater, fremgangsmåde til fremstilling deraf, anvendelse deraf som lægemiddel og anvendelse deraf til fremstilling af et lægemiddel til anticancerbehandling
ES2099973T3 (es)	1997-06-01	Derivados de ureido-acetamida su preparacion y los medicamentos que los contienen.
DK0678022T3 (da)	1996-12-02	Anvendelse af riluzol ved fremstilling af lægemidler, som er anvendelige til behandling af stråleskader