DK0683777T3 - Oxindol-1-N-(alkoxycarbonyl)carboxamider og -1-(N-carboxamido)carboxamider som antiinflammatoriske midler - Google Patents
Oxindol-1-N-(alkoxycarbonyl)carboxamider og -1-(N-carboxamido)carboxamider som antiinflammatoriske midlerInfo
- Publication number
- DK0683777T3 DK0683777T3 DK94903461.5T DK94903461T DK0683777T3 DK 0683777 T3 DK0683777 T3 DK 0683777T3 DK 94903461 T DK94903461 T DK 94903461T DK 0683777 T3 DK0683777 T3 DK 0683777T3
- Authority
- DK
- Denmark
- Prior art keywords
- carboxamides
- pct
- oxindole
- carboxamido
- alkoxycarbonyl
- Prior art date
Links
- 150000003857 carboxamides Chemical class 0.000 title 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 title 1
- 229940121363 anti-inflammatory agent Drugs 0.000 title 1
- 239000002260 anti-inflammatory agent Substances 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1511493A | 1993-02-09 | 1993-02-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0683777T3 true DK0683777T3 (da) | 1997-04-28 |
Family
ID=21769613
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94903461.5T DK0683777T3 (da) | 1993-02-09 | 1993-12-10 | Oxindol-1-N-(alkoxycarbonyl)carboxamider og -1-(N-carboxamido)carboxamider som antiinflammatoriske midler |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5607959A (fr) |
| EP (1) | EP0683777B1 (fr) |
| JP (1) | JP2709530B2 (fr) |
| AT (1) | ATE145206T1 (fr) |
| CA (1) | CA2155664C (fr) |
| DE (1) | DE69305999T2 (fr) |
| DK (1) | DK0683777T3 (fr) |
| ES (1) | ES2097025T3 (fr) |
| FI (1) | FI940568A7 (fr) |
| GR (1) | GR3021924T3 (fr) |
| WO (1) | WO1994018194A1 (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997013767A1 (fr) * | 1995-10-09 | 1997-04-17 | Chemisch Pharmazeutische Forschungsgesellschaft Mbh | 1-indolcarboxamides substitues heterocycliquement, s'utilisant comme inhibiteurs de la cyclo-oxygenase-2 |
| DE60041763D1 (de) * | 1999-04-23 | 2009-04-23 | Vertex Pharma | Inhibitoren von c-jun n-terminal kinasen (jnk) |
| US7612065B2 (en) | 2000-04-21 | 2009-11-03 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-JUN N-terminal kinases (JNK) |
| AU2002322720B2 (en) | 2001-07-25 | 2008-11-13 | Raptor Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
| CA2789262C (fr) | 2005-04-28 | 2016-10-04 | Proteus Digital Health, Inc. | Systeme pharma-informatique |
| EP2063905B1 (fr) | 2006-09-18 | 2014-07-30 | Raptor Pharmaceutical Inc | Traitement des troubles hépatiques par l'administration de conjugués de protéine associée au récepteur (rap) |
| TR201908314T4 (tr) | 2009-02-20 | 2019-06-21 | 2 Bbb Medicines B V | Glutatyon bazlı ilaç dağıtım sistemi. |
| KR101909711B1 (ko) | 2009-05-06 | 2018-12-19 | 라보라토리 스킨 케어, 인크. | 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법 |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN163263B (fr) * | 1984-02-07 | 1988-08-27 | Pfizer | |
| DE3582890D1 (de) * | 1984-02-07 | 1991-06-20 | Pfizer | 2-oxindolzwischenprodukte. |
| US4721712A (en) * | 1984-06-12 | 1988-01-26 | Pfizer Inc. | 1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory agents |
| US4556672A (en) * | 1984-03-19 | 1985-12-03 | Pfizer Inc. | 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents |
| US4569942A (en) * | 1984-05-04 | 1986-02-11 | Pfizer Inc. | N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents |
| EP0365194B1 (fr) * | 1988-10-18 | 1995-08-02 | Pfizer Inc. | Prodrogues de 3-aryl-2-oxindole-1-carboxamide antiinflammatoires |
| RO109195B1 (ro) * | 1988-10-18 | 1994-12-30 | Pfizer | Derivati de 3-acil-2-oxindol-1-carboxamide |
| US5047554A (en) * | 1989-04-18 | 1991-09-10 | Pfizer Inc. | 3-substituted-2-oxindole derivatives |
| US4952703A (en) * | 1989-05-25 | 1990-08-28 | Pfizer Inc. | Intermediates for making 2-oxindole-1-carboxamides |
| US5270331A (en) * | 1993-01-26 | 1993-12-14 | Pfizer, Inc. | Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides |
-
1993
- 1993-12-10 CA CA002155664A patent/CA2155664C/fr not_active Expired - Fee Related
- 1993-12-10 US US08/495,509 patent/US5607959A/en not_active Expired - Fee Related
- 1993-12-10 DE DE69305999T patent/DE69305999T2/de not_active Expired - Fee Related
- 1993-12-10 ES ES94903461T patent/ES2097025T3/es not_active Expired - Lifetime
- 1993-12-10 AT AT94903461T patent/ATE145206T1/de not_active IP Right Cessation
- 1993-12-10 EP EP94903461A patent/EP0683777B1/fr not_active Expired - Lifetime
- 1993-12-10 WO PCT/US1993/011792 patent/WO1994018194A1/fr not_active Ceased
- 1993-12-10 DK DK94903461.5T patent/DK0683777T3/da active
- 1993-12-10 JP JP6518013A patent/JP2709530B2/ja not_active Expired - Fee Related
-
1994
- 1994-02-08 FI FI940568A patent/FI940568A7/fi not_active Application Discontinuation
-
1996
- 1996-12-06 GR GR960403329T patent/GR3021924T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2155664A1 (fr) | 1994-08-18 |
| WO1994018194A1 (fr) | 1994-08-18 |
| US5607959A (en) | 1997-03-04 |
| CA2155664C (fr) | 1999-06-15 |
| EP0683777A1 (fr) | 1995-11-29 |
| FI940568L (fi) | 1994-08-10 |
| EP0683777B1 (fr) | 1996-11-13 |
| FI940568A0 (fi) | 1994-02-08 |
| GR3021924T3 (en) | 1997-03-31 |
| JP2709530B2 (ja) | 1998-02-04 |
| JPH08502517A (ja) | 1996-03-19 |
| ES2097025T3 (es) | 1997-03-16 |
| DE69305999D1 (en) | 1996-12-19 |
| DE69305999T2 (de) | 1997-03-06 |
| FI940568A7 (fi) | 1994-08-10 |
| ATE145206T1 (de) | 1996-11-15 |
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