DK0693285T3 - Farmaceutiske præparater, der indeholder et bisphosphonat og et antiresorberende middel til inhibering af knogletab - Google Patents

Farmaceutiske præparater, der indeholder et bisphosphonat og et antiresorberende middel til inhibering af knogletab

Info

Publication number: DK0693285T3
Authority: DK; Denmark
Prior art keywords: bisphosphonate; bone loss; antiresorbent; inhibiting bone; pharmaceutical compositions
Prior art date: 1994-07-22

Application number

DK95305083T

Other languages

English (en)

Inventor

George Joseph Cullinan

Larry John Black

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-07-22

Filing date

1995-07-20

Publication date

2002-05-27

1995-07-20 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2002-05-27 Application granted granted Critical

2002-05-27 Publication of DK0693285T3 publication Critical patent/DK0693285T3/da

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Physical Education & Sports Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Diabetes (AREA)
Obesity (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Control Of Motors That Do Not Use Commutators (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK95305083T 1994-07-22 1995-07-20 Farmaceutiske præparater, der indeholder et bisphosphonat og et antiresorberende middel til inhibering af knogletab DK0693285T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US27936394A	1994-07-22	1994-07-22

Publications (1)

Publication Number	Publication Date
DK0693285T3 true DK0693285T3 (da)	2002-05-27

Family

ID=23068631

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95305083T DK0693285T3 (da)	1994-07-22	1995-07-20	Farmaceutiske præparater, der indeholder et bisphosphonat og et antiresorberende middel til inhibering af knogletab

Country Status (23)

Country	Link
US (1)	US20010051636A1 (da)
EP (1)	EP0693285B1 (da)
JP (1)	JPH0840911A (da)
KR (1)	KR960003726A (da)
CN (1)	CN1079671C (da)
AT (1)	ATE212846T1 (da)
AU (1)	AU693235B2 (da)
BR (1)	BR9503406A (da)
CA (1)	CA2154414A1 (da)
CZ (1)	CZ189195A3 (da)
DE (1)	DE69525291T2 (da)
DK (1)	DK0693285T3 (da)
ES (1)	ES2168336T3 (da)
HU (1)	HUT72754A (da)
IL (1)	IL114683A (da)
NO (1)	NO308194B1 (da)
NZ (1)	NZ272608A (da)
PL (1)	PL181304B1 (da)
PT (1)	PT693285E (da)
RU (1)	RU2149631C1 (da)
TW (1)	TW398975B (da)
UA (1)	UA41909C2 (da)
ZA (1)	ZA956029B (da)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2206422A1 (en) *	1994-11-29	1996-06-06	Hoechst Marion Roussel, Inc.	Method of using triaryl-ethylene derivatives in the treatment and prevention of osteoporosis
AU712711B2 (en) *	1994-11-29	1999-11-11	Hoechst Marion Roussel, Inc.	Method of using triaryl-ethylene derivatives in the treatment and prevention of osteoporosis
EP0722727A1 (en) *	1995-01-20	1996-07-24	Eli Lilly And Company	Benzofuran derivatives for inhibiting uterine fibroid disease
US5554600A (en) *	1995-01-20	1996-09-10	Eli Lilly And Company	Methods for inhibiting endometriosis
US5512583A (en) *	1995-01-30	1996-04-30	Eli Lilly And Company	Methods of decreasing serum calcium levels
US6479517B1 (en) *	1995-02-28	2002-11-12	Eli Lilly And Company	Phosphorous-containing benzothiophenes
US5616571A (en) *	1995-06-06	1997-04-01	Merck & Co., Inc.	Bisphosphonates prevent bone loss associated with immunosuppressive therapy
US5958969A (en) *	1996-10-10	1999-09-28	Eli Lilly And Company	Benzo b!thiophene compounds, intermediates, formulations, and methods
GB2324726A (en) *	1997-05-01	1998-11-04	Merck & Co Inc	Combination Therapy for the Treatment of Osteoporosis
US7005428B1 (en)	1998-06-11	2006-02-28	Endorecherche, Inc.	Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US6465445B1 (en)	1998-06-11	2002-10-15	Endorecherche, Inc.	Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
AU2001272916A1 (en) *	2000-07-19	2002-02-05	Eli Lilly And Company	Method for enhancing bone mineral density gain by administration of raloxifene
CA2431515C (en) *	2001-01-23	2008-01-22	Gador S.A.	Composition comprising bisphosphonates for prevention and/or treatment of metabolic diseases of bones, process for preparing such composition, and use thereof
CA2438848C (en) *	2001-03-01	2011-05-03	Emisphere Technologies, Inc.	Compositions for delivering bisphosphonates
RU2192639C1 (ru) *	2001-04-05	2002-11-10	Дальневосточный государственный медицинский университет	Способ прогнозирования нарушений в постменопаузальном периоде
BR0308901A (pt) *	2002-05-10	2005-01-04	Hoffmann La Roche	ácidos bisfosfÈnicos para tratamento e prevenção de osteoporose
TR200300510A2 (tr) *	2003-04-18	2004-11-22	Sanovel �La� Sanay� Ve T�Caret A.�.	Dağılan alendronat mikropartikül formülasyonu
AR045637A1 (es) *	2003-09-12	2005-11-02	Amgen Inc	Formulacion de disolucion rapida de un compuesto activo frente a los receptores de calcio
KR100557086B1 (ko) *	2003-11-14	2006-03-03	한미약품 주식회사	랄록시펜과 비스포스포네이트의 상호 염
CN1921866A (zh) *	2004-02-19	2007-02-28	特瓦制药工业有限公司	使用雷洛昔芬和阿伦膦酸盐的改善的联合治疗
FR2875807B1 (fr) *	2004-09-30	2006-11-17	Servier Lab	Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
CN1304401C (zh) *	2004-12-28	2007-03-14	浙江工业大学	一种阿伦膦酸的制备方法
NZ556673A (en)	2005-02-03	2010-03-26	Gen Hospital Corp	Method for treating gefitinib and/or erlotinib resistant cancer with an EGFR inhibitor
GB0506708D0 (en) *	2005-04-01	2005-05-11	Queen Mary & Westfield College	Use of calcitonin as combined treatment therapy for the management of inflammatory disease conditions
EP3488866A1 (en)	2005-11-04	2019-05-29	Wyeth LLC	Antineoplastic combinations with mtor inhibitor, herceptin, and/or hki-272
US8022216B2 (en)	2007-10-17	2011-09-20	Wyeth Llc	Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
ES2531322T3 (es)	2008-06-17	2015-03-13	Wyeth Llc	Combinaciones antineoplásicas que contienen HKI-272 y vinorelbina
EP3175853B1 (en)	2008-08-04	2023-11-01	Wyeth LLC	Antineoplastic combinations of neratinib and capecitabine
PT3000467T (pt)	2009-04-06	2023-03-30	Wyeth Llc	Regime de tratamento utilizando neratinib para o cancro de mama
EP3205648A1 (en)	2010-06-10	2017-08-16	Seragon Pharmaceuticals, Inc.	Estrogen receptor modulators and uses thereof
EP2791132A4 (en)	2011-12-14	2015-08-05	Seragon Pharmaceuticals Inc	ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
US20210392934A1 (en) *	2016-03-10	2021-12-23	Enzymotec Ltd.	Lipid compositions and uses thereof

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2914563A (en)	1957-08-06	1959-11-24	Wm S Merrell Co	Therapeutic composition
US3274213A (en)	1961-09-05	1966-09-20	Upjohn Co	Alkoxy-substituted 2-phenyl-1-(tertiary-aminoalkoxy)phenyl-3, 4-dihydronaphthalenes
BE637389A (da)	1962-09-13
US4133814A (en) *	1975-10-28	1979-01-09	Eli Lilly And Company	2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4230862A (en)	1975-10-28	1980-10-28	Eli Lilly And Company	Antifertility compounds
US4323707A (en)	1975-10-28	1982-04-06	Eli Lilly And Company	Antifertility compounds
US4400543A (en)	1975-10-28	1983-08-23	Eli Lilly And Company	3-Phenyl-4-benzoyl-1,2-dihydronaphthalenes
DE3046719C2 (de)	1980-12-11	1983-02-17	Klinge Pharma GmbH, 8000 München	1,1,2-Triphenyl-but-1-en-Derivate, Verfahren zu ihrer Herstellung und Arzneimittel
US4418068A (en)	1981-04-03	1983-11-29	Eli Lilly And Company	Antiestrogenic and antiandrugenic benzothiophenes
US5139786A (en)	1989-07-07	1992-08-18	Ciba-Geigy Corporation	Topical formulations
DE69023844T2 (de)	1989-09-06	1996-06-20	Merck & Co Inc	Acyloxymethylester der Bisphonsäuren als Knochenresorptions-Inhibitoren.
DE69023906T2 (de)	1990-08-09	1996-04-11	Council Scient Ind Res	Benzopyrane und Verfahren zu deren Herstellung.
JPH04312526A (ja)	1991-04-09	1992-11-04	Fujisawa Pharmaceut Co Ltd	骨疾患治療剤
JP3157882B2 (ja) *	1991-11-15	2001-04-16	帝国臓器製薬株式会社	新規なベンゾチオフエン誘導体
TW366342B (en) *	1992-07-28	1999-08-11	Lilly Co Eli	The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
EP0675723A4 (en) *	1992-12-23	1998-08-05	Merck & Co Inc	THERAPY USING BISPHOSPHONATES AND STROGENS TO TREAT AND PREVENT BONE RESORPTION.
US5591753A (en) *	1994-01-28	1997-01-07	Eli Lilly And Company	Combination treatment for osteoporosis

1995
- 1995-07-19 UA UA95073400A patent/UA41909C2/uk unknown
- 1995-07-19 PL PL95309693A patent/PL181304B1/pl unknown
- 1995-07-19 NZ NZ272608A patent/NZ272608A/xx active IP Right Revival
- 1995-07-19 TW TW084107488A patent/TW398975B/zh not_active IP Right Cessation
- 1995-07-19 ZA ZA956029A patent/ZA956029B/xx unknown
- 1995-07-20 HU HU9502193A patent/HUT72754A/hu unknown
- 1995-07-20 CZ CZ951891A patent/CZ189195A3/cs unknown
- 1995-07-20 AU AU27112/95A patent/AU693235B2/en not_active Ceased
- 1995-07-20 RU RU95114385A patent/RU2149631C1/ru active
- 1995-07-20 IL IL11468395A patent/IL114683A/en not_active IP Right Cessation
- 1995-07-20 DE DE69525291T patent/DE69525291T2/de not_active Expired - Fee Related
- 1995-07-20 PT PT95305083T patent/PT693285E/pt unknown
- 1995-07-20 NO NO952890A patent/NO308194B1/no not_active IP Right Cessation
- 1995-07-20 DK DK95305083T patent/DK0693285T3/da active
- 1995-07-20 AT AT95305083T patent/ATE212846T1/de not_active IP Right Cessation
- 1995-07-20 KR KR1019950021267A patent/KR960003726A/ko not_active Ceased
- 1995-07-20 ES ES95305083T patent/ES2168336T3/es not_active Expired - Lifetime
- 1995-07-20 EP EP95305083A patent/EP0693285B1/en not_active Expired - Lifetime
- 1995-07-21 JP JP7185512A patent/JPH0840911A/ja not_active Withdrawn
- 1995-07-21 BR BR9503406A patent/BR9503406A/pt not_active Application Discontinuation
- 1995-07-21 CA CA002154414A patent/CA2154414A1/en not_active Abandoned
- 1995-07-21 CN CN95108916A patent/CN1079671C/zh not_active Expired - Fee Related
2000
- 2000-03-08 US US09/520,737 patent/US20010051636A1/en not_active Abandoned

Also Published As

Publication number	Publication date
KR960003726A (ko)	1996-02-23
NO952890D0 (no)	1995-07-20
EP0693285B1 (en)	2002-02-06
IL114683A0 (en)	1995-11-27
PL309693A1 (en)	1996-02-05
TW398975B (en)	2000-07-21
CN1119940A (zh)	1996-04-10
ZA956029B (en)	1997-01-20
IL114683A (en)	2001-06-14
PT693285E (pt)	2002-06-28
HU9502193D0 (en)	1995-09-28
DE69525291T2 (de)	2002-09-19
EP0693285A3 (en)	1998-05-06
CA2154414A1 (en)	1996-01-23
BR9503406A (pt)	1996-02-27
HUT72754A (en)	1996-05-28
EP0693285A2 (en)	1996-01-24
DE69525291D1 (de)	2002-03-21
CN1079671C (zh)	2002-02-27
UA41909C2 (uk)	2001-10-15
ATE212846T1 (de)	2002-02-15
RU2149631C1 (ru)	2000-05-27
AU2711295A (en)	1996-02-01
ES2168336T3 (es)	2002-06-16
PL181304B1 (pl)	2001-07-31
CZ189195A3 (en)	1996-06-12
US20010051636A1 (en)	2001-12-13
NO952890L (no)	1996-01-23
JPH0840911A (ja)	1996-02-13
AU693235B2 (en)	1998-06-25
NZ272608A (en)	2000-05-26
NO308194B1 (no)	2000-08-14

Publication	Publication Date	Title
ATE212846T1 (de)	2002-02-15	Bisphosphonat und anti-resorption agentien, enthaltende zusammensetzungen zur hemmung der knochenschwund
FR2702368B1 (fr)	1995-06-09	Implant tibial pour prothèse du genou.
PL303937A1 (en)	1995-01-09	Application of an antiestrogen compound and pharmaceutical agent
DK0530087T3 (da)	1995-10-02	Hidtil ukendte naphthylethylurinstof- og naphthylethylthiourinstofforbindelser, fremgangsmåde til fremstilling heraf og farmaceutiske midler, som indeholder dem
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NO981501L (no)	1998-06-02	Dimer-selektive RXR modulatorer og fremgangsmÕte for anvendelse derav
GR3018182T3 (en)	1996-02-29	Derivatives of amidinophenylalanine, procedure for their preparation, their utilisation and anticoagulant compositions comprising them.
PT1047406E (pt)	2003-08-29	Composicoes farmaceuticas autoclavaveis contendo um agente quelante
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DK0706348T3 (da)	1997-09-15	Kirurgisk instrument især til dental kirurgi.
MY101566A (en)	1991-12-17	Pharmaceutical compositions.
IL84844A0 (en)	1988-06-30	Pharmaceutical compositions comprising a certain carbazolone derivative or a salt thereof
IT1240336B (it)	1993-12-07	Composizioni farmaceutiche,dietetiche o veterinarie ad attivita' eumetabolica
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IL111580A (en)	1999-10-28	Use of melatonin derivatives in the preparation of pharmaceutical compositions for use in treating sleep disorders
IL105475A0 (en)	1993-08-18	Pharmaceutical compositions containing 1alpha,24(r)-dihydroxy-22(e)-dehydro-vitamin d3 for treating osteoporosis
IL111579A (en)	1999-10-28	Use of melatonin derivatives in the preparation of pharmaceutical compositions for use in treating desynchronization disorders
DK88087D0 (da)	1987-02-20	Tricyklisk 5-(3-chlor-6-methyl-5,5-dioxo-6,11-dihydro-dibenzo-(c,f)-(1,2)-thiazepin-11-yl)-amino-pentansyrederivat, fremgangsmaade til fremstilling deraf og farmaceutiske midler indeholdende dem
IL109866A (en)	2000-06-01	Crystalline 3-(4-hexyloxy-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyridine(+)L-hydrogentartrate its preparation and pharmaceutical compositions containing it
IL102895A0 (en)	1993-01-31	Pharmaceutical compositions for lowering blood lipid levels
NO972450L (no)	1997-05-29	Substituerte 2-(fosfinyloksymetyl)-1,2,5-tiadiazolidin-3-on 1,1-dioksider og preparater og metode for anvendelse derav
DK630088D0 (da)	1988-11-11	Azelastinembonat, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater med indhold af denne forbindelse som aktivt middel
FR2709662B1 (fr)	1995-11-24	Implant tibial pour prothèse du genou.
NO970784L (no)	1997-02-20	Fremgangsmåte for opprettholdelse av tenner og oralt ben