DK0694039T3 - Derivater af 1,5-benzodiazepin med CCK-antagonistisk og agonistisk virkning - Google Patents

Derivater af 1,5-benzodiazepin med CCK-antagonistisk og agonistisk virkning

Info

Publication number
DK0694039T3
DK0694039T3 DK94913580T DK94913580T DK0694039T3 DK 0694039 T3 DK0694039 T3 DK 0694039T3 DK 94913580 T DK94913580 T DK 94913580T DK 94913580 T DK94913580 T DK 94913580T DK 0694039 T3 DK0694039 T3 DK 0694039T3
Authority
DK
Denmark
Prior art keywords
benzodiazepine
derivatives
agonistic effect
cck
antagonistic
Prior art date
Application number
DK94913580T
Other languages
Danish (da)
English (en)
Inventor
Elizabeth Ellen Sugg
Christopher Joseph Aquino
Jerzy Ryszard Szewczyk
Harry Finch
Robin Arthur Ellis Carr
Original Assignee
Glaxo Wellcome Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Wellcome Inc filed Critical Glaxo Wellcome Inc
Application granted granted Critical
Publication of DK0694039T3 publication Critical patent/DK0694039T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
DK94913580T 1993-04-15 1994-04-14 Derivater af 1,5-benzodiazepin med CCK-antagonistisk og agonistisk virkning DK0694039T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939307833A GB9307833D0 (en) 1993-04-15 1993-04-15 Modulators of cholecystokinin and gastrin
PCT/EP1994/001131 WO1994024149A1 (en) 1993-04-15 1994-04-14 1,5-benzodiazepine derivatives having cck antagonistic or agonistic activity

Publications (1)

Publication Number Publication Date
DK0694039T3 true DK0694039T3 (da) 2001-05-21

Family

ID=10733915

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94913580T DK0694039T3 (da) 1993-04-15 1994-04-14 Derivater af 1,5-benzodiazepin med CCK-antagonistisk og agonistisk virkning

Country Status (33)

Country Link
US (2) US5646140A (es)
EP (1) EP0694039B1 (es)
JP (1) JP3406317B2 (es)
KR (1) KR100364948B1 (es)
CN (1) CN1058487C (es)
AP (2) AP512A (es)
AT (1) ATE198894T1 (es)
AU (1) AU681139B2 (es)
CA (1) CA2158973C (es)
CZ (1) CZ286695B6 (es)
DE (1) DE69426624T2 (es)
DK (1) DK0694039T3 (es)
EC (1) ECSP941066A (es)
ES (1) ES2154674T3 (es)
FI (1) FI954853A7 (es)
GB (1) GB9307833D0 (es)
GR (1) GR3035641T3 (es)
HU (1) HU223467B1 (es)
IL (2) IL109316A (es)
IS (2) IS4148A (es)
MY (2) MY131569A (es)
NO (1) NO311133B1 (es)
NZ (1) NZ265272A (es)
OA (1) OA10355A (es)
PE (2) PE50594A1 (es)
PH (1) PH30897A (es)
PL (1) PL178790B1 (es)
PT (1) PT694039E (es)
RU (1) RU2135486C1 (es)
SK (1) SK281211B6 (es)
TW (1) TW487703B (es)
WO (1) WO1994024149A1 (es)
ZA (2) ZA942570B (es)

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US5739129A (en) * 1994-04-14 1998-04-14 Glaxo Wellcome Inc. CCK or gastrin modulating 5-heterocyclic-1, 5 benzodiazepines
EP0755394A1 (en) * 1994-04-15 1997-01-29 Glaxo Wellcome Inc. A method of inducing cholecystokinin agonist activity using 1,4-benzodiazepine compounds
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GB9420763D0 (en) * 1994-10-14 1994-11-30 Glaxo Inc Acetamide derivatives
GB9420747D0 (en) * 1994-10-14 1994-11-30 Glaxo Inc 1,5 benzodiazepine derivatives
US5780464A (en) * 1994-10-14 1998-07-14 Glaxo Wellcome Inc. Enteric coated compositions of 1,5-benzodiazepine derivatives having CCK antagonistic or agonistic activity
US5910495A (en) * 1994-10-14 1999-06-08 Glaxo Wellcome Inc. Use of 1,5-benzo b!1,4-diazepines to control gastric emptying
CA2239293A1 (en) 1995-12-11 1997-06-19 New England Medical Center Hosptials, Inc. Assay for and uses of peptide hormone receptor ligands
US5750353A (en) * 1995-12-11 1998-05-12 New England Medical Center Hospitals, Inc. Assay for non-peptide agonists to peptide hormone receptors
ES2206754T3 (es) * 1996-12-10 2004-05-16 Zeria Pharmaceutical Co., Ltd. Derivados de 1,5 - benzodiazepina.
ATE422359T1 (de) 1997-04-15 2009-02-15 Csir Verbindungen und pharmazeutische zusammensetzungen mit appetitunterdrückender aktivität
AR022044A1 (es) * 1999-05-06 2002-09-04 Glaxo Group Ltd Derivados de 1,5-benzodiazepina
GB2396815B (en) 1999-10-27 2004-09-08 Phytopharm Plc A composition comprising a pregnenone derivative and an NSAID
GB2363985B (en) 2000-06-30 2004-09-29 Phytopharm Plc Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
US6768024B1 (en) 2000-08-04 2004-07-27 Lion Bioscience Ag Triamine derivative melanocortin receptor ligands and methods of using same
US20020180095A1 (en) * 2001-05-29 2002-12-05 Berard Steven O. Thermally conductive carbon fiber extrusion compounder and method of using same
CA2476936A1 (en) * 2002-02-20 2003-08-28 Chih-Hung Lee Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (vr1) receptor
US7074805B2 (en) * 2002-02-20 2006-07-11 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
US6933311B2 (en) * 2003-02-11 2005-08-23 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
US7015233B2 (en) * 2003-06-12 2006-03-21 Abbott Laboratories Fused compounds that inhibit vanilloid subtype 1 (VR1) receptor
RU2261246C1 (ru) * 2004-04-15 2005-09-27 Общество с ограниченной ответственностью "Исследовательский Институт Химического Разнообразия" (ООО "Исследовательский Институт Химического Разнообразия") Замещенные 7-сульфонил бензо[b][1,4]диазепины (варианты), способы их получения (варианты), фокусированная библиотека и фармацевтическая композиция
EA010888B1 (ru) * 2004-05-25 2008-12-30 Пфайзер Продактс, Инк. Тетраазабензо[е]азуленовые производные и их аналоги
CN1333077C (zh) * 2005-04-15 2007-08-22 华南农业大学 缩胆囊素活性片段的串联表达及其应用
RU2303597C1 (ru) * 2006-05-12 2007-07-27 Иващенко Андрей Александрович Фармацевтическая композиция, способы ее получения и применения
TW200824687A (en) * 2006-08-25 2008-06-16 Abbott Lab Compounds that inhibit TRPV1 and uses thereof
US8030504B2 (en) * 2006-12-20 2011-10-04 Abbott Laboratories Antagonists of the TRPV1 receptor and uses thereof
MX2010010262A (es) * 2008-03-20 2010-12-06 Abbott Lab Metodos para la elaboracion de agentes para el sistema nervioso central que son antagonistas del trpv1.
CN103102285B (zh) * 2013-01-30 2015-07-29 淮阴师范学院 对氨基苯乙腈的制备方法
WO2015074081A1 (en) 2013-11-18 2015-05-21 Bair Kenneth W Benzopiperazine compositions as bet bromodomain inhibitors
PT3071203T (pt) 2013-11-18 2021-03-11 Forma Therapeutics Inc Composições de tetra-hidroquinolina como inibidores de bromodomínio bet
MY197231A (en) 2015-07-22 2023-06-06 Enanta Pharm Inc Benzodiazepine derivatives as rsv inhibitors
SG10201913587WA (en) 2016-02-05 2020-02-27 Denali Therapeutics Inc Inhibitors of receptor-interacting protein kinase 1
DK3552017T3 (da) 2016-12-09 2022-05-16 Denali Therapeutics Inc Forbindelser, der er anvendelige som ripk1-inhibitorer
AU2018221820B2 (en) 2017-02-16 2023-11-02 Enanta Pharmaceuticals, Inc. Processes for the preparation of benzodiazepine derivatives
US10752598B2 (en) * 2017-06-07 2020-08-25 Enanta Pharmaceuticals, Inc. Aryldiazepine derivatives as RSV inhibitors
WO2019006291A1 (en) 2017-06-30 2019-01-03 Enanta Pharmaceuticals, Inc. HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS
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FR2641280B1 (fr) * 1988-12-29 1994-01-21 Roussel Uclaf Nouveaux derives de la 2,4-dioxo 2,3,4,5-tetrahydro 1h-1,5-benzodiazepine, leur procede de preparation et leur application comme medicaments
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FR2659653B1 (fr) * 1990-03-13 1992-05-22 Rhone Poulenc Sante Derives de l'uree, leur preparation et les medicaments les contenant.
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Also Published As

Publication number Publication date
PE50594A1 (es) 1995-01-06
AP512A (en) 1996-07-29
GB9307833D0 (en) 1993-06-02
ES2154674T3 (es) 2001-04-16
CA2158973A1 (en) 1994-10-27
IL109316A0 (en) 1994-07-31
FI954853A0 (fi) 1995-10-12
PT694039E (pt) 2001-06-29
JP3406317B2 (ja) 2003-05-12
CN1058487C (zh) 2000-11-15
IS4147A (is) 1994-10-16
NZ265272A (en) 1997-07-27
IL109316A (en) 1999-03-12
FI954853L (fi) 1995-10-12
ZA942571B (en) 1994-11-11
KR100364948B1 (ko) 2003-03-29
NO311133B1 (no) 2001-10-15
CN1120843A (zh) 1996-04-17
AU6567694A (en) 1994-11-08
AP9400635A0 (en) 1994-04-30
ATE198894T1 (de) 2001-02-15
US5646140A (en) 1997-07-08
SK281211B6 (sk) 2001-01-18
PH30897A (en) 1997-12-23
ZA942570B (en) 1994-11-11
EP0694039B1 (en) 2001-01-24
HK1003943A1 (en) 1998-11-13
DE69426624T2 (de) 2001-06-21
RU2135486C1 (ru) 1999-08-27
ECSP941066A (es) 1994-11-16
SK125395A3 (en) 1996-06-05
AP9400634A0 (en) 1994-04-30
EP0694039A1 (en) 1996-01-31
CZ267595A3 (en) 1996-04-17
PL178790B1 (pl) 2000-06-30
CA2158973C (en) 2006-06-06
DE69426624D1 (de) 2001-03-01
OA10355A (en) 2001-10-19
MY131569A (en) 2007-08-30
HUT74102A (en) 1996-11-28
FI954853A7 (fi) 1995-10-12
TW487703B (en) 2002-05-21
NO954090D0 (no) 1995-10-13
AU681139B2 (en) 1997-08-21
PE50994A1 (es) 1995-01-06
HU223467B1 (hu) 2004-07-28
US5585376A (en) 1996-12-17
IL109315A0 (en) 1994-07-31
IS4148A (is) 1994-10-16
CZ286695B6 (en) 2000-06-14
NO954090L (no) 1995-12-13
WO1994024149A1 (en) 1994-10-27
HU9502978D0 (en) 1995-12-28
MY112237A (en) 2001-05-31
JPH08508744A (ja) 1996-09-17
PL311084A1 (en) 1996-02-05
AP462A (en) 1996-02-19
GR3035641T3 (en) 2001-06-29

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