DK0694542T3 - Fremgangsmåde til racemerisering af enantiomerer af alfa-liponsyre - Google Patents

Fremgangsmåde til racemerisering af enantiomerer af alfa-liponsyre

Info

Publication number
DK0694542T3
DK0694542T3 DK95108719T DK95108719T DK0694542T3 DK 0694542 T3 DK0694542 T3 DK 0694542T3 DK 95108719 T DK95108719 T DK 95108719T DK 95108719 T DK95108719 T DK 95108719T DK 0694542 T3 DK0694542 T3 DK 0694542T3
Authority
DK
Denmark
Prior art keywords
alpha
enantiomers
lipoic acid
racemization
organic
Prior art date
Application number
DK95108719T
Other languages
English (en)
Inventor
Horst Bethge
Roland Moeller
Gerhard Dr Sator
Stefan Merget
Thomas Dr Beisswenger
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Application granted granted Critical
Publication of DK0694542T3 publication Critical patent/DK0694542T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK95108719T 1994-07-30 1995-06-07 Fremgangsmåde til racemerisering af enantiomerer af alfa-liponsyre DK0694542T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4427079A DE4427079C2 (de) 1994-07-30 1994-07-30 Verfahren zur Racemisierung von Enantiomeren der alpha-Liponsäure

Publications (1)

Publication Number Publication Date
DK0694542T3 true DK0694542T3 (da) 1999-09-20

Family

ID=6524563

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95108719T DK0694542T3 (da) 1994-07-30 1995-06-07 Fremgangsmåde til racemerisering af enantiomerer af alfa-liponsyre

Country Status (9)

Country Link
US (1) US5621117A (da)
EP (1) EP0694542B1 (da)
JP (1) JPH0859653A (da)
AT (1) ATE176468T1 (da)
CA (1) CA2154910A1 (da)
DE (2) DE4427079C2 (da)
DK (1) DK0694542T3 (da)
ES (1) ES2128611T3 (da)
GR (1) GR3029909T3 (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4427079C2 (de) * 1994-07-30 2002-12-19 Viatris Gmbh Verfahren zur Racemisierung von Enantiomeren der alpha-Liponsäure
US6090842A (en) 1998-03-10 2000-07-18 The Regents Of The University Of California Lipoic acid analogs
IT1319195B1 (it) 2000-10-10 2003-09-26 Laboratorio Chimico Int Spa Processo per la produzione dell'acido r(+)alfa-lipoico.
US20020115710A1 (en) * 2000-10-31 2002-08-22 Zicker Steven Curtis Composition and method
US20090156658A1 (en) 2000-10-31 2009-06-18 Hill's Pet Nutrition, Inc. Antioxidant-Containing Food Composition For Use In Inhibiting Histamine Pathways In Companion Animals
US20020076470A1 (en) * 2000-10-31 2002-06-20 Colgate-Palmolive Company Composition and method
US8669282B2 (en) 2000-10-31 2014-03-11 Hill's Pet Nutrition, Inc. Companion animal compositions including lipoic acid and methods of use thereof
CN102784396B (zh) 2004-11-09 2015-07-29 希尔氏宠物营养品公司 抗氧化剂用于基因调节的用途
US20090176864A1 (en) * 2004-11-24 2009-07-09 Hill's Pet Nutrition, Inc. Methods For Improving Hepatic and Immune Function In An Animal
WO2006058278A2 (en) * 2004-11-24 2006-06-01 Hill's Pet Nutrition, Inc. Methods for improving liver clearance of xenobiotic substances in an animal
US8168161B2 (en) * 2004-12-22 2012-05-01 Hill's Pet Nutrition, Inc. Method to promote oral health in companion animals
DK1830883T3 (da) * 2004-12-29 2013-11-25 Hills Pet Nutrition Inc Fremgangsmåde til at hæmme en nedgang i indlæring og/eller hukommelse hos dyr
US8148325B2 (en) * 2004-12-30 2012-04-03 Hill's Pet Nutrition, Inc. Methods for enhancing the quality of life of a senior animal
US8252742B2 (en) * 2004-12-30 2012-08-28 Hill's Pet Nutrition, Inc. Methods for enhancing the quality of life of a senior animal
US7541355B2 (en) * 2005-05-23 2009-06-02 Vela Acquisition Corporation Conversion process for 2,3-benzodiazepine enantiomers
EP1906912B1 (en) * 2005-07-14 2012-08-15 Hill's Pet Nutrition, Inc. Method for prolonging the life of animals
US8492432B2 (en) * 2005-08-17 2013-07-23 Hill's Pet Nutrition, Inc. Methods for the treatment of kidney disease
US20080317884A1 (en) * 2007-06-22 2008-12-25 Jewell Dennis E Enhancing Disease Resistance In An Animal
US8512695B2 (en) * 2008-10-21 2013-08-20 The General Hospital Corporation Method of preventing fat graft resorption by administering fat-derived cells and poloxamer P 188
EP2389178A4 (en) * 2008-12-01 2012-06-06 Invasc Therapeutic Inc COMPOSITIONS CONTAINING INHIBITORS OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM AND LIPOIC ACID COMPOUNDS, AND THEIR USE FOR THE TREATMENT OF RENIN-ANGIOTENSIN-ALDOSTERONE ASSOCIATED DISORDERS
WO2010077935A1 (en) 2008-12-16 2010-07-08 Hill's Pet Nutrition, Inc. Antioxidant-containing food composition for use in inhibiting histamine pathways in companion animals
WO2010078319A1 (en) 2008-12-30 2010-07-08 Hill's Pet Nutrition, Inc. Lipoic acid containing compositions for use in the treatment and prevention of ki dney- related disorders in companion animals
ES2528758T3 (es) 2008-12-30 2015-02-12 Hill's Pet Nutrition, Inc. Métodos para aumentar la palatabilidad de composiciones alimenticias para animales de compañía
CA2750140C (en) 2008-12-30 2015-10-06 Hill's Pet Nutrition, Inc. Use of lipoic acid for treating or preventing degenerative joint conditions, osteoarthritis, cartilage damage, and related disorders in companion animals
RU2485795C2 (ru) 2009-01-16 2013-06-27 Хилл'С Пет Ньютришн, Инк. Композиции для домашних животных, содержащие пировиноградную кислоту и ее соли, и способы их применения
EP2453759B1 (en) 2009-07-14 2015-10-21 Hill's Pet Nutrition, Inc. Pet food compositions including a sustained-release lipoic acid and methods of manufacture and use thereof
WO2012019103A2 (en) 2010-08-06 2012-02-09 The General Hospital Corporation D/B/A System and apparatus for cell treatment
CN102442994B (zh) * 2011-10-31 2013-07-31 江苏同禾药业有限公司 一种s-硫辛酸外消旋化方法及r-硫辛酸的制备方法
CN114280173B (zh) * 2021-12-07 2023-04-28 河南润弘制药股份有限公司 一种硫辛酸注射液聚合物检测方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3629116A1 (de) 1986-08-27 1988-03-10 Asta Pharma Ag Verfahren zur herstellung enantiomerenreiner r-(+)-(alpha)-liponsaeure und s-(-)-(alpha)-liponsaeure (thioctsaeure) sowie nonen- beziehungsweise mesylderivate als zwischenprodukte hierfuer
DE59010810D1 (de) 1989-11-09 1998-04-16 Asta Medica Ag Arzneimittel enthaltend als Wirkstoff R-alpha-Liponsäure oder S-alpha-Liponsäure
DE4137773A1 (de) 1991-11-16 1993-05-19 Degussa Herstellung und verwendung von salzen der reinen enantiomere der (alpha)-liponsaeure
DE4427079C2 (de) * 1994-07-30 2002-12-19 Viatris Gmbh Verfahren zur Racemisierung von Enantiomeren der alpha-Liponsäure

Also Published As

Publication number Publication date
US5621117A (en) 1997-04-15
DE4427079A1 (de) 1996-02-08
EP0694542A1 (de) 1996-01-31
ES2128611T3 (es) 1999-05-16
EP0694542B1 (de) 1999-02-03
DE4427079C2 (de) 2002-12-19
DE59505022D1 (de) 1999-03-18
ATE176468T1 (de) 1999-02-15
GR3029909T3 (en) 1999-07-30
JPH0859653A (ja) 1996-03-05
CA2154910A1 (en) 1996-01-31

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