DK0694542T3 - Fremgangsmåde til racemerisering af enantiomerer af alfa-liponsyre - Google Patents

Fremgangsmåde til racemerisering af enantiomerer af alfa-liponsyre

Info

Publication number
DK0694542T3
DK0694542T3 DK95108719T DK95108719T DK0694542T3 DK 0694542 T3 DK0694542 T3 DK 0694542T3 DK 95108719 T DK95108719 T DK 95108719T DK 95108719 T DK95108719 T DK 95108719T DK 0694542 T3 DK0694542 T3 DK 0694542T3
Authority
DK
Denmark
Prior art keywords
alpha
enantiomers
lipoic acid
racemization
organic
Prior art date
Application number
DK95108719T
Other languages
English (en)
Inventor
Horst Bethge
Roland Moeller
Gerhard Dr Sator
Stefan Merget
Thomas Dr Beisswenger
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Application granted granted Critical
Publication of DK0694542T3 publication Critical patent/DK0694542T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK95108719T 1994-07-30 1995-06-07 Fremgangsmåde til racemerisering af enantiomerer af alfa-liponsyre DK0694542T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4427079A DE4427079C2 (de) 1994-07-30 1994-07-30 Verfahren zur Racemisierung von Enantiomeren der alpha-Liponsäure

Publications (1)

Publication Number Publication Date
DK0694542T3 true DK0694542T3 (da) 1999-09-20

Family

ID=6524563

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95108719T DK0694542T3 (da) 1994-07-30 1995-06-07 Fremgangsmåde til racemerisering af enantiomerer af alfa-liponsyre

Country Status (9)

Country Link
US (1) US5621117A (da)
EP (1) EP0694542B1 (da)
JP (1) JPH0859653A (da)
AT (1) ATE176468T1 (da)
CA (1) CA2154910A1 (da)
DE (2) DE4427079C2 (da)
DK (1) DK0694542T3 (da)
ES (1) ES2128611T3 (da)
GR (1) GR3029909T3 (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4427079C2 (de) * 1994-07-30 2002-12-19 Viatris Gmbh Verfahren zur Racemisierung von Enantiomeren der alpha-Liponsäure
US6090842A (en) 1998-03-10 2000-07-18 The Regents Of The University Of California Lipoic acid analogs
IT1319195B1 (it) * 2000-10-10 2003-09-26 Laboratorio Chimico Int Spa Processo per la produzione dell'acido r(+)alfa-lipoico.
US8669282B2 (en) 2000-10-31 2014-03-11 Hill's Pet Nutrition, Inc. Companion animal compositions including lipoic acid and methods of use thereof
US20090156658A1 (en) 2000-10-31 2009-06-18 Hill's Pet Nutrition, Inc. Antioxidant-Containing Food Composition For Use In Inhibiting Histamine Pathways In Companion Animals
US20020076470A1 (en) * 2000-10-31 2002-06-20 Colgate-Palmolive Company Composition and method
US20020115710A1 (en) * 2000-10-31 2002-08-22 Zicker Steven Curtis Composition and method
WO2006053010A2 (en) 2004-11-09 2006-05-18 Hill's Pet Nutrition, Inc. Use of antioxidants for gene modulation
US20090176864A1 (en) * 2004-11-24 2009-07-09 Hill's Pet Nutrition, Inc. Methods For Improving Hepatic and Immune Function In An Animal
ES2550952T3 (es) * 2004-11-24 2015-11-13 Hill's Pet Nutrition, Inc. Composición para su uso en la mejora del aclaramiento hepático de sustancias xenobióticas en un animal
US8168161B2 (en) * 2004-12-22 2012-05-01 Hill's Pet Nutrition, Inc. Method to promote oral health in companion animals
BRPI0519642A8 (pt) * 2004-12-29 2017-10-03 Hill´S Pet Nutrition Inc Método para inibir um declínio em aprendizagem e/ou memória, kit apropriado para administrar um ou mais antioxidantes a um animal, meio para transmitir informação, e, uso de uma composição
AU2005322887B2 (en) * 2004-12-30 2010-03-11 Hill's Pet Nutrition, Inc. Methods for enhancing the quality of life of a senior animal
US8252742B2 (en) 2004-12-30 2012-08-28 Hill's Pet Nutrition, Inc. Methods for enhancing the quality of life of a senior animal
US7541355B2 (en) * 2005-05-23 2009-06-02 Vela Acquisition Corporation Conversion process for 2,3-benzodiazepine enantiomers
BRPI0613000A2 (pt) * 2005-07-14 2012-12-04 Hills Pet Nutrition Inc método para aumentar a longevidade de um animal, artigo de fabricação, kit, e, meio de comunicação de informação acerca de ou instruções para a administração a um animal velho de uma composição
RU2377980C2 (ru) 2005-08-17 2010-01-10 Хилл`С Пет Ньютришн, Инк. Способы и композиции для профилактики и лечения заболеваний почек
US20080317884A1 (en) * 2007-06-22 2008-12-25 Jewell Dennis E Enhancing Disease Resistance In An Animal
AU2009308152B2 (en) * 2008-10-21 2015-05-21 The General Hospital Corporation Cell transplantation
BRPI0916476A2 (pt) * 2008-12-01 2016-02-16 Invasc Therapeutics Inc composição, método de tratamento para um distúrbio relacionado ao sistema renina-angiotensina-aldosterona, método para reduzir a resistência à insulina, método para tratar um distúrbio relacionado à síndrome metabólica
JP5791515B2 (ja) 2008-12-16 2015-10-07 ヒルズ・ペット・ニュートリシャン・インコーポレーテッド 愛玩動物においてヒスタミン関連経路を阻害する際に使用するための、抗酸化剤を含有する食物組成物
WO2010078319A1 (en) 2008-12-30 2010-07-08 Hill's Pet Nutrition, Inc. Lipoic acid containing compositions for use in the treatment and prevention of ki dney- related disorders in companion animals
DK2367549T3 (da) 2008-12-30 2013-11-04 Hills Pet Nutrition Inc Anvendelse af alfalipoinsyre til behandling eller forebyggelse af nedbrydende ledsygdomme, osteoarthritis, bruskskade, og relaterede lidelser hos kæledyr
CA2750192C (en) 2008-12-30 2016-11-08 Hill's Pet Nutrition, Inc. Methods for increasing the palatability of companion animal food compositions
CN102281768A (zh) 2009-01-16 2011-12-14 希尔氏宠物营养品公司 包含丙酮酸及其盐的陪伴动物组合物及其使用方法
EP2453759B1 (en) 2009-07-14 2015-10-21 Hill's Pet Nutrition, Inc. Pet food compositions including a sustained-release lipoic acid and methods of manufacture and use thereof
JP6072684B2 (ja) 2010-08-06 2017-02-01 ザ ジェネラル ホスピタル コーポレーション ディー／ビー／エイ マサチューセッツ ジェネラル ホスピタル 細胞処置システムおよび細胞処置装置
CN102442994B (zh) * 2011-10-31 2013-07-31 江苏同禾药业有限公司 一种s-硫辛酸外消旋化方法及r-硫辛酸的制备方法
CN114280173B (zh) * 2021-12-07 2023-04-28 河南润弘制药股份有限公司 一种硫辛酸注射液聚合物检测方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3629116A1 (de) * 1986-08-27 1988-03-10 Asta Pharma Ag Verfahren zur herstellung enantiomerenreiner r-(+)-(alpha)-liponsaeure und s-(-)-(alpha)-liponsaeure (thioctsaeure) sowie nonen- beziehungsweise mesylderivate als zwischenprodukte hierfuer
PT95826B (pt) 1989-11-09 1997-11-28 Asta Medica Ag Processo para a preparacao de composicoes farmaceuticas contendo como ingrediente activo acido r-alfa-liponico ou acido s-alfa-liponico
DE4137773A1 (de) * 1991-11-16 1993-05-19 Degussa Herstellung und verwendung von salzen der reinen enantiomere der (alpha)-liponsaeure
DE4427079C2 (de) * 1994-07-30 2002-12-19 Viatris Gmbh Verfahren zur Racemisierung von Enantiomeren der alpha-Liponsäure

Also Published As

Publication number Publication date
ES2128611T3 (es) 1999-05-16
DE4427079C2 (de) 2002-12-19
DE4427079A1 (de) 1996-02-08
US5621117A (en) 1997-04-15
ATE176468T1 (de) 1999-02-15
JPH0859653A (ja) 1996-03-05
EP0694542A1 (de) 1996-01-31
GR3029909T3 (en) 1999-07-30
DE59505022D1 (de) 1999-03-18
EP0694542B1 (de) 1999-02-03
CA2154910A1 (en) 1996-01-31

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