DK0699204T3 - Anvendelse af indolocarbazolderivater til behandling af en patologisk tilstand i prostata - Google Patents

Anvendelse af indolocarbazolderivater til behandling af en patologisk tilstand i prostata

Info

Publication number: DK0699204T3
Authority: DK; Denmark
Prior art keywords: treatment; halogen; prostate; indolocarbazole derivatives; co2ch3
Prior art date: 1993-05-28

Application number

DK94918168T

Other languages

English (en)

Inventor

Chikara Murakata

Craig A Dionne

Patricia C Contreras

Original Assignee

Cephalon Inc

Kyowa Hakko Kogyo Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-05-28

Filing date

1994-05-27

Publication date

1999-02-22

1994-05-27 Application filed by Cephalon Inc, Kyowa Hakko Kogyo Kk filed Critical Cephalon Inc

1999-02-22 Application granted granted Critical

1999-02-22 Publication of DK0699204T3 publication Critical patent/DK0699204T3/da

Links

VVVPGLRKXQSQSZ-UHFFFAOYSA-N indolo[3,2-c]carbazole Chemical class C1=CC=CC2=NC3=C4C5=CC=CC=C5N=C4C=CC3=C21 VVVPGLRKXQSQSZ-UHFFFAOYSA-N 0.000 title abstract 2
230000001575 pathological effect Effects 0.000 title abstract 2
210000002307 prostate Anatomy 0.000 title abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 4
150000002367 halogens Chemical class 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical group 0.000 abstract 2
CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Genetics & Genomics (AREA)
Epidemiology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK94918168T 1993-05-28 1994-05-27 Anvendelse af indolocarbazolderivater til behandling af en patologisk tilstand i prostata DK0699204T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US6917893A	1993-05-28	1993-05-28
US9662293A	1993-07-22	1993-07-22
PCT/US1994/006082 WO1994027982A1 (en)	1993-05-28	1994-05-27	Use of indolocarbazole derivatives to treat a pathological condition of the prostate

Publications (1)

Publication Number	Publication Date
DK0699204T3 true DK0699204T3 (da)	1999-02-22

Family

ID=26749764

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94918168T DK0699204T3 (da)	1993-05-28	1994-05-27	Anvendelse af indolocarbazolderivater til behandling af en patologisk tilstand i prostata

Country Status (14)

Country	Link
US (2)	US5516771A (da)
EP (2)	EP0699204B1 (da)
JP (2)	JP3344586B2 (da)
KR (1)	KR100201343B1 (da)
AT (1)	ATE165097T1 (da)
AU (1)	AU679752B2 (da)
CA (1)	CA2163904C (da)
DE (1)	DE69409641T2 (da)
DK (1)	DK0699204T3 (da)
ES (1)	ES2118414T3 (da)
FI (2)	FI113537B (da)
NO (1)	NO306902B1 (da)
NZ (1)	NZ267337A (da)
WO (1)	WO1994027982A1 (da)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5756494A (en) *	1992-07-24	1998-05-26	Cephalon, Inc.	Protein kinase inhibitors for treatment of neurological disorders
DE4243321A1 (de) *	1992-12-21	1994-06-23	Goedecke Ag	Aminosäurederivate von Heterocyclen als PKC-Inhibitoren
ES2123873T3 (es) *	1994-08-04	1999-01-16	Hoffmann La Roche	Pirrolocarbazol.
US5650407A (en) *	1995-04-05	1997-07-22	Cephalon, Inc.	Selected soluble esters of hydroxyl-containing indolocarbazoles
US5686444A (en)	1995-04-05	1997-11-11	Cephalon, Inc.	Selected soluble esters of hydroxyl-containing indolocarbazoles
US6676935B2 (en)	1995-06-27	2004-01-13	Cell Genesys, Inc.	Tissue specific adenoviral vectors
US6197293B1 (en)	1997-03-03	2001-03-06	Calydon, Inc.	Adenovirus vectors specific for cells expressing androgen receptor and methods of use thereof
US5808060A (en) *	1995-12-11	1998-09-15	Cephalon, Inc.	Fused isoindolones
BR9710706A (pt) *	1996-05-01	1999-08-17	Lilly Co Eli	Tratamento terap-utico para doen-as relacionadas a vegf
UA67725C2 (en)	1996-06-03	2004-07-15	Cephalon Inc	K-252a derivatives and a method for improvement of functioning and cell survival enhancement
US6875865B1 (en)	1996-06-03	2005-04-05	Cephalon, Inc.	Selected derivatives of K-252a
BR9710693A (pt)	1996-06-25	2000-01-11	Cephalon Inc	Uso de um derivado de k-252a para o tratamento do nervo central ou periférico e super produção de citoquinona.
EA002525B1 (ru) *	1997-08-15	2002-06-27	Сефалон Инк.	Сочетание ингибитора тирозинкиназы и химической стерилизации для лечения рака предстательной железы
DK1044203T3 (da)	1997-12-31	2003-07-14	Cephalon Inc	3'-epimere K-252a-derivater
US6127401A (en)	1998-06-05	2000-10-03	Cephalon, Inc.	Bridged indenopyrrolocarbazoles
US6013646A (en)	1998-07-02	2000-01-11	Bayer Corporation	Indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer
US6200968B1 (en) *	1998-08-06	2001-03-13	Cephalon, Inc.	Particle-forming compositions containing fused pyrrolocarbazoles
US7795246B2 (en) *	1998-08-06	2010-09-14	Cephalon, Inc.	Particle-forming compositions containing fused pyrrolocarbazoles
CN1329034C (zh)	1998-09-25	2007-08-01	赛福伦公司	预防/治疗感觉毛细胞和耳蜗神经元损伤的药物
ATE406907T1 (de) *	1998-10-28	2008-09-15	Cornell Res Foundation Inc	Methoden zur regulierung der angiogenese und vaskuläre integrität mittels trk rezeptor liganden bdnf, nt-3 und nt-4
US6841567B1 (en) *	1999-02-12	2005-01-11	Cephalon, Inc.	Cyclic substituted fused pyrrolocarbazoles and isoindolones
WO2001010440A1 (en) *	1999-08-09	2001-02-15	Trustees Of Dartmouth College	COMPOSITIONS AND METHODS TO ENHANCE CANCER CHEMOTHERAPY IN p53 DEFECTIVE TUMORS
US6399780B1 (en) *	1999-08-20	2002-06-04	Cephalon, Inc.	Isomeric fused pyrrolocarbazoles and isoindolones
US7129250B2 (en)	2000-05-19	2006-10-31	Aegera Therapeutics Inc.	Neuroprotective and anti-proliferative compounds
AR035971A1 (es) *	2001-05-16	2004-07-28	Cephalon Inc	Metodos para el tratamiento y la prevencion del dolor
IL144583A0 (en) *	2001-07-26	2002-05-23	Peptor Ltd	Chimeric protein kinase inhibitors
IL156429A0 (en) *	2003-06-12	2004-01-04	Peptor Ltd	Cell permeable conjugates of peptides for inhibition of protein kinases
CN101283275A (zh)	2005-10-11	2008-10-08	默克专利有限公司	趋化因子表达的依赖egfr的调控和对肿瘤的诊断和治疗的影响及其副作用
US20080021013A1 (en) *	2006-07-21	2008-01-24	Cephalon, Inc.	JAK inhibitors for treatment of myeloproliferative disorders
US20090155352A1 (en) *	2007-11-20	2009-06-18	Cephalon, Inc.	Microemulsion containing indolocarbazole compound and dosage forms containing the same
AU2013362134B2 (en)	2012-12-21	2018-07-05	Sykehuset Sorlandet Hf	EGFR targeted therapy of neurological disorders and pain

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS62155285A (ja) *	1985-12-27	1987-07-10	Kyowa Hakko Kogyo Co Ltd	生理活性物質ｋ−２５２の誘導体
JPS62155284A (ja) *	1985-12-27	1987-07-10	Kyowa Hakko Kogyo Co Ltd	生理活性物質ｋ−２５２の誘導体
JPS62240689A (ja) *	1986-04-07	1987-10-21	Meiji Seika Kaisha Ltd	Ｓｆ−２３７０物質誘導体及びその製法
JPH0826037B2 (ja) *	1987-01-22	1996-03-13	協和醗酵工業株式会社	生理活性物質ｋ−２５２の誘導体
JPH0826036B2 (ja) *	1987-01-22	1996-03-13	協和醗酵工業株式会社	生理活性物質ｋ−２５２の誘導体
US4923986A (en) *	1987-03-09	1990-05-08	Kyowa Hakko Kogyo Co., Ltd.	Derivatives of physiologically active substance K-252
JPH07113027B2 (ja) *	1987-12-24	1995-12-06	協和醗酵工業株式会社	Ｋ−２５２誘導体
DE3803620A1 (de) *	1988-02-06	1989-08-17	Goedecke Ag	Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel
US5073633A (en) *	1989-03-23	1991-12-17	Bristol-Myers Company	BMY-41950 antitumor antibiotic
DE3924538A1 (de) *	1989-07-25	1991-01-31	Goedecke Ag	Indolocarbazol und dessen verwendung
CA2112799A1 (en) *	1991-07-03	1993-01-21	Stephen P. Squinto	Method and assay system for neurotrophin activity
WO1993008809A1 (en) *	1991-11-08	1993-05-13	The University Of Southern California	Compositions containing k-252 compounds for potentiation of neurotrophin activity
US6271242B1 (en) *	1992-02-10	2001-08-07	Bristol-Myers Squibb Co.	Method for treating cancer using a tyrosine protein kinase inhibitor
US5461146A (en) *	1992-07-24	1995-10-24	Cephalon, Inc.	Selected protein kinase inhibitors for the treatment of neurological disorders

1994
- 1994-05-27 EP EP94918168A patent/EP0699204B1/en not_active Expired - Lifetime
- 1994-05-27 WO PCT/US1994/006082 patent/WO1994027982A1/en not_active Ceased
- 1994-05-27 DK DK94918168T patent/DK0699204T3/da active
- 1994-05-27 DE DE69409641T patent/DE69409641T2/de not_active Expired - Lifetime
- 1994-05-27 CA CA002163904A patent/CA2163904C/en not_active Expired - Fee Related
- 1994-05-27 EP EP98200023A patent/EP0839814A3/en not_active Withdrawn
- 1994-05-27 NZ NZ267337A patent/NZ267337A/en not_active IP Right Cessation
- 1994-05-27 JP JP50102695A patent/JP3344586B2/ja not_active Expired - Fee Related
- 1994-05-27 AT AT94918168T patent/ATE165097T1/de not_active IP Right Cessation
- 1994-05-27 AU AU69607/94A patent/AU679752B2/en not_active Ceased
- 1994-05-27 KR KR1019950705338A patent/KR100201343B1/ko not_active Expired - Fee Related
- 1994-05-27 US US08/250,175 patent/US5516771A/en not_active Expired - Lifetime
- 1994-05-27 ES ES94918168T patent/ES2118414T3/es not_active Expired - Lifetime
1995
- 1995-06-05 US US08/463,680 patent/US5654427A/en not_active Expired - Lifetime
- 1995-11-27 NO NO954816A patent/NO306902B1/no not_active IP Right Cessation
- 1995-11-27 FI FI955709A patent/FI113537B/fi not_active IP Right Cessation
2002
- 2002-05-27 JP JP2002153049A patent/JP3727613B2/ja not_active Expired - Fee Related
2003
- 2003-10-16 FI FI20031516A patent/FI114864B/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2163904C (en)	2000-01-25
JP3344586B2 (ja)	2002-11-11
NO954816L (no)	1996-01-26
WO1994027982A1 (en)	1994-12-08
FI114864B (fi)	2005-01-14
NO954816D0 (no)	1995-11-27
EP0699204A4 (en)	1996-01-10
AU6960794A (en)	1994-12-20
EP0839814A2 (en)	1998-05-06
EP0699204B1 (en)	1998-04-15
JP2002504064A (ja)	2002-02-05
KR100201343B1 (ko)	1999-06-15
DE69409641T2 (de)	1998-11-26
EP0839814A3 (en)	1998-09-16
NO306902B1 (no)	2000-01-10
US5654427A (en)	1997-08-05
FI955709L (fi)	1996-01-03
DE69409641D1 (de)	1998-05-20
JP2002356487A (ja)	2002-12-13
FI20031516A7 (fi)	2003-10-16
FI113537B (fi)	2004-05-14
EP0699204A1 (en)	1996-03-06
JP3727613B2 (ja)	2005-12-14
KR960702838A (ko)	1996-05-23
AU679752B2 (en)	1997-07-10
NZ267337A (en)	2005-01-28
CA2163904A1 (en)	1994-12-08
US5516771A (en)	1996-05-14
ATE165097T1 (de)	1998-05-15
ES2118414T3 (es)	1998-09-16
FI955709A0 (fi)	1995-11-27

Publication	Publication Date	Title
FI955709A0 (fi)	1995-11-27	Indolokarbatsolijohdannaisten käyttö eturauhasen patologisten tilojen hoidossa
FI911443A0 (fi)	1991-03-25	Foerfarande foer framstaellning av 3,5-di-tert.butyl-4-hydroxifenylmetylenderivat av 2-substituerade tiazolidinoner, oxazolidinoner och imidazolidinoner med antiinflammatorisk aktivitet.
EP0704437A3 (en)	1996-10-23	Red-shifted tris-aryl-s-triazines and thus stabilized compositions
DE69728544D1 (de)	2004-05-13	Totalsynthese von acylfulvenen mit antitumorwirkung
DE69104593D1 (de)	1994-11-17	Herstellung und Verwendung von N-Jodopropargyl-oxycarbonylaminosäure-Estern als antimicrobielle Mittel.
DK129189A (da)	1989-09-19	Benzophenonderivater
CA2026778A1 (en)	1990-08-07	Dioxaphosphorinane compounds and polyolefin compositions stabilized therewith
AU2028097A (en)	1997-10-22	Amino- and hydroxysubstituted triphenyl-s-triazines as stabilizers
NO821348L (no)	1983-02-22	4`-halogensubstituerte sukrosederivater.
FI832353L (fi)	1983-12-29	Vid behandling av psoriasis anvaendbara polyolefina -alkylkarboxylsyror och deras derivat
DE3867652D1 (de)	1992-02-27	N-substituierte 3,4-dihydropyrimidinverbindungen als mittel zur behandlung von erkrankungen des kardiovaskularen systems.
FI810145L (fi)	1981-07-23	Nya substituerade 1,8-dihydroxi-9-(10h)antracenoner foerfarande foer deras framstaellning och dessa foereningar innehaollande laekemedel
ATE112768T1 (de)	1994-10-15	Triazinverbindungen.
ATE162045T1 (de)	1998-01-15	Polyquaternäre ammoniumverbindungen enthaltende antimikrobielle mittel
DK0963998T3 (da)	2004-08-16	Azasteroidforbindelse til behandling eller prævention af prostatacancer
FI852249A0 (fi)	1985-06-05	Foerfarande foer framstaellning av nya isoxazolokinolinoner.
ATE28876T1 (de)	1987-08-15	Triorganozinnacetylsalicylate und diese enthaltende biozide mittel.
MX9702211A (es)	1998-05-31	Hidroxifenil triazinas.