DK0700399T3 - Derivater i 36-stilling af rifamyciner og anvendelse af sådanne som antimikrobemidler - Google Patents
Derivater i 36-stilling af rifamyciner og anvendelse af sådanne som antimikrobemidlerInfo
- Publication number
- DK0700399T3 DK0700399T3 DK94916937T DK94916937T DK0700399T3 DK 0700399 T3 DK0700399 T3 DK 0700399T3 DK 94916937 T DK94916937 T DK 94916937T DK 94916937 T DK94916937 T DK 94916937T DK 0700399 T3 DK0700399 T3 DK 0700399T3
- Authority
- DK
- Denmark
- Prior art keywords
- pct
- image
- alkylamino
- sec
- date
- Prior art date
Links
- 229930189077 Rifamycin Natural products 0.000 title abstract 3
- 239000004599 antimicrobial Substances 0.000 title abstract 2
- BTVYFIMKUHNOBZ-QXMMDKDBSA-N rifamycin s Chemical group O=C1C(C(O)=C2C)=C3C(=O)C=C1NC(=O)\C(C)=C/C=C\C(C)C(O)C(C)C(O)C(C)C(OC(C)=O)C(C)C(OC)\C=C/OC1(C)OC2=C3C1=O BTVYFIMKUHNOBZ-QXMMDKDBSA-N 0.000 title 1
- 229940081192 rifamycins Drugs 0.000 title 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical class OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 229960003292 rifamycin Drugs 0.000 abstract 2
- HJYYPODYNSCCOU-ODRIEIDWSA-N rifamycin SV Chemical compound OC1=C(C(O)=C2C)C3=C(O)C=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O HJYYPODYNSCCOU-ODRIEIDWSA-N 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- -1 4-oxo-3-pyridinyl carbonyloxy Chemical group 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000192125 Firmicutes Species 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP93108337 | 1993-05-24 | ||
| EP93110315 | 1993-06-29 | ||
| PCT/EP1994/001428 WO1994028002A1 (en) | 1993-05-24 | 1994-05-05 | 36-derivatives of rifamycins and their use as antimicrobial agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0700399T3 true DK0700399T3 (da) | 2001-11-26 |
Family
ID=26133222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94916937T DK0700399T3 (da) | 1993-05-24 | 1994-05-05 | Derivater i 36-stilling af rifamyciner og anvendelse af sådanne som antimikrobemidler |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5786350A (da) |
| JP (1) | JP3566962B2 (da) |
| KR (1) | KR100325562B1 (da) |
| AT (1) | ATE206427T1 (da) |
| AU (1) | AU687817B2 (da) |
| CA (1) | CA2160243C (da) |
| DE (1) | DE69428535T2 (da) |
| DK (1) | DK0700399T3 (da) |
| ES (1) | ES2164704T3 (da) |
| IL (1) | IL109691A (da) |
| PT (1) | PT700399E (da) |
| WO (1) | WO1994028002A1 (da) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2185168C1 (ru) * | 2001-01-26 | 2002-07-20 | Санкт-Петербургская Государственная Химико-Фармацевтическая Академия | Композиция для лечения туберкулеза |
| JP4202250B2 (ja) | 2001-07-25 | 2008-12-24 | バイオマリン ファーマシューティカル インコーポレイテッド | 血液脳関門輸送を調節するための組成物および方法 |
| AU2002360416A1 (en) * | 2001-11-21 | 2003-06-10 | Activbiotics, Inc. | Targeted therapeutics and uses thereof |
| US7820652B2 (en) * | 2003-09-24 | 2010-10-26 | Activbiotics Pharma, Llc | Regimen for the administration of rifamycin-class antibiotics |
| WO2005070940A2 (en) * | 2004-01-13 | 2005-08-04 | Cumbre Pharmaceuticals Inc. | Rifamycin derivatives effective against drug-resistant microbes |
| EP1723150A1 (en) * | 2004-01-13 | 2006-11-22 | Cumbre Pharmaceuticals Inc. | Rifamycin imino derivatives effective against drug-resistant microbes |
| US7265107B2 (en) | 2004-03-10 | 2007-09-04 | Cumbre Pharmaceuticals Inc. | Rifamycin C-11 oxime cyclo derivatives effective against drug-resistant microbes |
| US7256187B2 (en) | 2004-03-10 | 2007-08-14 | Cumbre Pharmaceuticals Inc. | Rifamycin C-11 oxime derivatives effective against drug-resistant microbes |
| US7250413B2 (en) * | 2004-04-26 | 2007-07-31 | Cumbre Pharmaceuticals Inc. | C-25 carbamate rifamycin derivatives with activity against drug-resistant microbes |
| EP1781670A1 (en) * | 2004-07-22 | 2007-05-09 | Cumbre Pharmaceuticals Inc. | Rifamycin derivatives for treating microbial infections |
| EP2671507A3 (en) | 2005-04-28 | 2014-02-19 | Proteus Digital Health, Inc. | Pharma-informatics system |
| MX2009002893A (es) | 2006-09-18 | 2009-07-10 | Raptor Pharmaceutical Inc | Tratamiento de trastornos hepaticos mediante la administracion de conjugados de la proteina asociada al receptor (rap). |
| CA2752373C (en) | 2009-02-20 | 2017-10-10 | To-Bbb Holding B.V. | Glutathione-based drug delivery system |
| IL255113B (en) | 2009-05-06 | 2022-09-01 | Laboratory Skin Care Inc | Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
| MX2015003108A (es) * | 2012-09-12 | 2015-09-10 | Salix Pharmaceuticals Inc | Metodos de administracion de rifaximina sin producir resistencia a los antibioticos. |
| CA3089236A1 (en) | 2018-01-24 | 2019-08-01 | The Rockefeller University | Antibacterial compounds, compositions thereof, and methods using same |
| WO2021016433A1 (en) | 2019-07-23 | 2021-01-28 | The Rockefeller University | Antibacterial compounds, compositions thereof, and methods using same |
| EP4594330A1 (en) | 2022-09-30 | 2025-08-06 | BioVersys AG | Rifabutin analogs for the treatment of disease |
-
1994
- 1994-05-05 DK DK94916937T patent/DK0700399T3/da active
- 1994-05-05 CA CA002160243A patent/CA2160243C/en not_active Expired - Lifetime
- 1994-05-05 PT PT94916937T patent/PT700399E/pt unknown
- 1994-05-05 AU AU68430/94A patent/AU687817B2/en not_active Expired
- 1994-05-05 KR KR1019950705232A patent/KR100325562B1/ko not_active Expired - Lifetime
- 1994-05-05 WO PCT/EP1994/001428 patent/WO1994028002A1/en not_active Ceased
- 1994-05-05 AT AT94916937T patent/ATE206427T1/de active
- 1994-05-05 DE DE69428535T patent/DE69428535T2/de not_active Expired - Lifetime
- 1994-05-05 ES ES94916937T patent/ES2164704T3/es not_active Expired - Lifetime
- 1994-05-05 US US08/792,035 patent/US5786350A/en not_active Expired - Lifetime
- 1994-05-05 JP JP50015095A patent/JP3566962B2/ja not_active Expired - Lifetime
- 1994-05-19 IL IL10969194A patent/IL109691A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2164704T3 (es) | 2002-03-01 |
| AU687817B2 (en) | 1998-03-05 |
| PT700399E (pt) | 2002-02-28 |
| DE69428535T2 (de) | 2002-08-01 |
| IL109691A (en) | 1998-10-30 |
| AU6843094A (en) | 1994-12-20 |
| DE69428535D1 (de) | 2001-11-08 |
| KR960702466A (ko) | 1996-04-27 |
| KR100325562B1 (ko) | 2002-07-22 |
| US5786350A (en) | 1998-07-28 |
| CA2160243A1 (en) | 1994-12-08 |
| WO1994028002A1 (en) | 1994-12-08 |
| JP3566962B2 (ja) | 2004-09-15 |
| JPH08511249A (ja) | 1996-11-26 |
| ATE206427T1 (de) | 2001-10-15 |
| IL109691A0 (en) | 1994-08-26 |
| CA2160243C (en) | 2007-08-28 |
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