DK0700914T3 - Campththecinderivater, deres fremstilling og antitumormidler - Google Patents

Campththecinderivater, deres fremstilling og antitumormidler

Info

Publication number: DK0700914T3
Authority: DK; Denmark
Prior art keywords: hydrogen; alkyl; antitumor agents; derivatives; campththecin
Prior art date: 1994-09-06

Application number

DK95113931T

Other languages

English (en)

Inventor

Takashi Yaegashi

Seigo Sawada

Tomio Furuta

Teruo Yokokura

Original Assignee

Daiichi Seiyaku Co

Yakult Honsha Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-09-06

Filing date

1995-09-05

Publication date

2000-07-31

1995-09-05 Application filed by Daiichi Seiyaku Co, Yakult Honsha Kk filed Critical Daiichi Seiyaku Co

2000-07-31 Application granted granted Critical

2000-07-31 Publication of DK0700914T3 publication Critical patent/DK0700914T3/da

Links

239000002246 antineoplastic agent Substances 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 1
VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
-1 methoxyethoxymethoxy group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000004417 unsaturated alkyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)

DK95113931T 1994-09-06 1995-09-05 Campththecinderivater, deres fremstilling og antitumormidler DK0700914T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP6246660A JPH0873461A (ja)	1994-09-06	1994-09-06	新規なカンプトテシン誘導体、その製造法および抗腫瘍剤

Publications (1)

Publication Number	Publication Date
DK0700914T3 true DK0700914T3 (da)	2000-07-31

Family

ID=17151729

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95113931T DK0700914T3 (da)	1994-09-06	1995-09-05	Campththecinderivater, deres fremstilling og antitumormidler

Country Status (17)

Country	Link
US (1)	US5843954A (da)
EP (1)	EP0700914B1 (da)
JP (1)	JPH0873461A (da)
KR (1)	KR100351952B1 (da)
CN (1)	CN1052482C (da)
AT (1)	ATE192447T1 (da)
AU (1)	AU688547B2 (da)
CA (1)	CA2157128C (da)
DE (1)	DE69516605T2 (da)
DK (1)	DK0700914T3 (da)
ES (1)	ES2146275T3 (da)
GR (1)	GR3033798T3 (da)
IL (1)	IL114989A (da)
NZ (1)	NZ272904A (da)
PT (1)	PT700914E (da)
RU (1)	RU2133748C1 (da)
ZA (1)	ZA957269B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4094710B2 (ja) *	1997-11-06	2008-06-04	株式会社ヤクルト本社	新規なカンプトテシン誘導体
FR2792937B1 (fr)	1999-04-27	2001-08-10	Cemaf	NOUVEAUX DERIVES DE PYRROLO-(3,4-b) QUINOLEINE, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION A TITRE DE MEDICAMENT
JP4776843B2 (ja)	1999-10-01	2011-09-21	イムノゲンインコーポレーティッド	免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
AR027687A1 (es)	2000-03-22	2003-04-09	Yakult Honsha Kk	Procedimiento para preparar camptotecina
CZ299329B6 (cs) *	2003-08-26	2008-06-18	Pliva-Lachema A.S.	Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu
CZ299593B6 (cs) *	2003-12-16	2008-09-10	Pliva-Lachema A. S.	Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
ITMI20051348A1 (it) *	2005-07-14	2007-01-15	Indena Spa	Analoghi della camptotecina loro processo di ottenimento loro uso e formulazioni che li contengono
CN100339377C (zh) *	2005-09-05	2007-09-26	合肥中科大生物技术有限公司	喜树碱衍生物及其制备
CN1319971C (zh) *	2005-09-09	2007-06-06	合肥中科大生物技术有限公司	喜树碱衍生物及其用途
CN102746314B (zh) *	2011-04-18	2016-07-06	华东师范大学	含有稳定7元内酯环的喜树碱类化合物、制备方法和用途
US11814394B2 (en)	2021-11-16	2023-11-14	Genequantum Healthcare (Suzhou) Co., Ltd.	Exatecan derivatives, linker-payloads, and conjugates and thereof
WO2024012566A2 (en)	2022-07-15	2024-01-18	Genequantum Healthcare (Suzhou) Co., Ltd.	Antibody, linkers, payload, conjugates and applications thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5839684A (ja) *	1981-09-04	1983-03-08	Yakult Honsha Co Ltd	１０−置換カンプテシン誘導体の製造法
JPS5951287A (ja) *	1982-09-17	1984-03-24	Yakult Honsha Co Ltd	新規なカンプトテシン誘導体
NZ219971A (en) *	1986-06-06	1989-08-29	Univ Princeton	Tetrahydropyrido (2,3-d pyrimidine derivatives and pharmaceutical compositions
US4981968A (en) *	1987-03-31	1991-01-01	Research Triangle Institute	Synthesis of camptothecin and analogs thereof
US5049668A (en) *	1989-09-15	1991-09-17	Research Triangle Institute	10,11-methylenedioxy-20(RS)-camptothecin analogs
US5122606A (en) *	1987-04-14	1992-06-16	Research Triangle Institute	10,11-methylenedioxy camptothecins
JP2540357B2 (ja) *	1987-06-24	1996-10-02	第一製薬株式会社	六環性化合物
JP2538792B2 (ja)	1987-06-25	1996-10-02	株式会社ヤクルト本社	新規なカンプトテシン誘導体
CA1332413C (en) *	1987-06-25	1994-10-11	Kabushiki Kaisha Yakult Honsha	Camptothecin derivatives and process for preparing same
JPH0615547B2 (ja) *	1988-01-20	1994-03-02	株式会社ヤクルト本社	新規なカンプトテシン誘導体
WO1991004260A2 (en) *	1989-09-15	1991-04-04	Research Triangle Institute	10,11-methylenedioxy-20(rs)-camptothecin and 10,11-methylenedioxy-20(s)-camptothecin analogs
US5162532A (en) *	1990-12-20	1992-11-10	North Carolina State University	Intermediates and method of making camptothecin and camptothecin analogs

1994
- 1994-09-06 JP JP6246660A patent/JPH0873461A/ja not_active Ceased
1995
- 1995-08-12 KR KR1019950025066A patent/KR100351952B1/ko not_active Expired - Fee Related
- 1995-08-17 IL IL11498995A patent/IL114989A/en not_active IP Right Cessation
- 1995-08-29 CA CA002157128A patent/CA2157128C/en not_active Expired - Fee Related
- 1995-08-30 ZA ZA957269A patent/ZA957269B/xx unknown
- 1995-08-31 NZ NZ272904A patent/NZ272904A/en unknown
- 1995-09-05 AT AT95113931T patent/ATE192447T1/de not_active IP Right Cessation
- 1995-09-05 AU AU30474/95A patent/AU688547B2/en not_active Ceased
- 1995-09-05 RU RU95115049A patent/RU2133748C1/ru not_active IP Right Cessation
- 1995-09-05 EP EP95113931A patent/EP0700914B1/en not_active Expired - Lifetime
- 1995-09-05 ES ES95113931T patent/ES2146275T3/es not_active Expired - Lifetime
- 1995-09-05 DE DE69516605T patent/DE69516605T2/de not_active Expired - Fee Related
- 1995-09-05 PT PT95113931T patent/PT700914E/pt unknown
- 1995-09-05 DK DK95113931T patent/DK0700914T3/da active
- 1995-09-06 CN CN95109535A patent/CN1052482C/zh not_active Expired - Fee Related
1997
- 1997-11-21 US US08/976,398 patent/US5843954A/en not_active Expired - Fee Related
2000
- 2000-06-28 GR GR20000401497T patent/GR3033798T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
ATE192447T1 (de)	2000-05-15
KR100351952B1 (ko)	2002-12-28
US5843954A (en)	1998-12-01
ZA957269B (en)	1996-03-25
DE69516605D1 (de)	2000-06-08
ES2146275T3 (es)	2000-08-01
DE69516605T2 (de)	2000-10-26
RU2133748C1 (ru)	1999-07-27
NZ272904A (en)	1996-08-27
KR960010644A (ko)	1996-04-20
GR3033798T3 (en)	2000-10-31
EP0700914A1 (en)	1996-03-13
CA2157128C (en)	2006-04-11
CN1052482C (zh)	2000-05-17
PT700914E (pt)	2000-09-29
AU3047495A (en)	1996-03-21
CN1126212A (zh)	1996-07-10
IL114989A (en)	1998-09-24
JPH0873461A (ja)	1996-03-19
EP0700914B1 (en)	2000-05-03
IL114989A0 (en)	1995-12-08
CA2157128A1 (en)	1996-03-07
AU688547B2 (en)	1998-03-12

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ATE89559T1 (de)	1993-06-15	Camptothecin-derivate und verfahren zu ihrer herstellung.
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