DK0701443T4 - Terfenadinmetabolitter og deres optisk rene isomerer til behandling af allergiske lidelser - Google Patents

Terfenadinmetabolitter og deres optisk rene isomerer til behandling af allergiske lidelser

Info

Publication number
DK0701443T4
DK0701443T4 DK93918584T DK93918584T DK0701443T4 DK 0701443 T4 DK0701443 T4 DK 0701443T4 DK 93918584 T DK93918584 T DK 93918584T DK 93918584 T DK93918584 T DK 93918584T DK 0701443 T4 DK0701443 T4 DK 0701443T4
Authority
DK
Denmark
Prior art keywords
treatment
optically pure
allergic disorders
pure isomers
terfenadine metabolites
Prior art date
Application number
DK93918584T
Other languages
English (en)
Other versions
DK0701443T3 (da
Inventor
W Young James
M Gray Nancy
L Woosley Raymond
Yiwang Chen
Original Assignee
Sepracor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27129882&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0701443(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sepracor Inc filed Critical Sepracor Inc
Application granted granted Critical
Publication of DK0701443T3 publication Critical patent/DK0701443T3/da
Publication of DK0701443T4 publication Critical patent/DK0701443T4/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Epoxy Compounds (AREA)
DK93918584T 1992-08-03 1993-08-03 Terfenadinmetabolitter og deres optisk rene isomerer til behandling af allergiske lidelser DK0701443T4 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92415692A 1992-08-03 1992-08-03
US92418292A 1992-08-03 1992-08-03
PCT/US1993/007260 WO1994003170A1 (en) 1992-08-03 1993-08-03 Terfenadine metabolites and their optically pure isomers for treating allergic disorders

Publications (2)

Publication Number Publication Date
DK0701443T3 DK0701443T3 (da) 1998-02-09
DK0701443T4 true DK0701443T4 (da) 2000-12-18

Family

ID=27129882

Family Applications (3)

Application Number Title Priority Date Filing Date
DK97104837T DK0815860T3 (da) 1992-08-03 1993-08-03 Terfenadincarboxylat og behandlingen af allergiske lidelser
DK02006356T DK1214937T3 (da) 1992-08-03 1993-08-03 Terfenadincarboxylat og behandling af hudirritation
DK93918584T DK0701443T4 (da) 1992-08-03 1993-08-03 Terfenadinmetabolitter og deres optisk rene isomerer til behandling af allergiske lidelser

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DK97104837T DK0815860T3 (da) 1992-08-03 1993-08-03 Terfenadincarboxylat og behandlingen af allergiske lidelser
DK02006356T DK1214937T3 (da) 1992-08-03 1993-08-03 Terfenadincarboxylat og behandling af hudirritation

Country Status (24)

Country Link
US (1) US5375693A (da)
EP (4) EP1214937B1 (da)
JP (6) JP3041954B2 (da)
KR (1) KR950702420A (da)
AT (3) ATE162399T1 (da)
AU (3) AU675240B2 (da)
BR (1) BR9306841A (da)
CA (1) CA2141572C (da)
CZ (1) CZ27495A3 (da)
DE (5) DE701443T1 (da)
DK (3) DK0815860T3 (da)
ES (3) ES2086270T5 (da)
FI (1) FI950467A7 (da)
GB (1) GB2284351B (da)
GR (3) GR960300024T1 (da)
HK (1) HK1045806B (da)
HU (1) HU226242B1 (da)
NO (1) NO310644B1 (da)
PL (1) PL174373B1 (da)
PT (2) PT815860E (da)
RO (1) RO116043B1 (da)
RU (1) RU2167657C2 (da)
SK (1) SK12495A3 (da)
WO (1) WO1994003170A1 (da)

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WO1993023047A1 (en) * 1992-05-11 1993-11-25 Merrell Dow Pharmaceuticals Inc. Use of terfenadine derivatives as antihistaminics in a hepatically impaired patient
FI950467A7 (fi) 1992-08-03 1995-03-31 Sepracor Inc Terfenadiinin metaboliitit ja niiden optisesti puhtaat isomeerit aller gisten sairauksien hoitamiseksi
HU226559B1 (en) * 1993-06-24 2009-03-30 Amr Technology Process for the production of piperidine derivatives
US20020007068A1 (en) 1999-07-16 2002-01-17 D'ambra Thomas E. Piperidine derivatives and process for their production
WO1995010278A1 (en) * 1993-10-15 1995-04-20 Hoechst Marion Roussel, Inc. Treatment of allergic disorders with terfenadine carboxylate
CA2449419C (en) 1994-05-18 2011-09-06 Aventis Pharmaceuticals Inc. Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof
US20030045722A1 (en) * 1994-05-18 2003-03-06 Henton Daniel R. Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof
US5455049A (en) * 1995-01-04 1995-10-03 Ascent Pharmaceuticals, Inc. Terfenadine oral powder
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US5906747A (en) * 1995-11-13 1999-05-25 Biosepra Inc. Separation of molecules from dilute solutions using composite chromatography media having high dynamic sorptive capacity at high flow rates
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US5837284A (en) * 1995-12-04 1998-11-17 Mehta; Atul M. Delivery of multiple doses of medications
US5922736A (en) * 1995-12-04 1999-07-13 Celegene Corporation Chronic, bolus administration of D-threo methylphenidate
US5733756A (en) * 1996-01-05 1998-03-31 Celgene Corporation Lactams and processes for stereoselective enrichment of lactams, amides, and esters
US5908850A (en) * 1995-12-04 1999-06-01 Celgene Corporation Method of treating attention deficit disorders with d-threo methylphenidate
US6355656B1 (en) 1995-12-04 2002-03-12 Celgene Corporation Phenidate drug formulations having diminished abuse potential
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ES2124167B1 (es) * 1996-06-04 1999-09-16 Espanola Prod Quimicos Nuevos derivados del bencimidazol con actividad antihistaminica.
US5925761A (en) * 1997-02-04 1999-07-20 Sepracor Inc. Synthesis of terfenadine and derivatives
US6962997B1 (en) * 1997-05-22 2005-11-08 Celgene Corporation Process and intermediates for resolving piperidyl acetamide steroisomers
NZ501248A (en) * 1997-08-26 2001-06-29 Aventis Pharma Inc Pharmaceutical composition for combination of piperidinoalkanol-decongestant
US6194431B1 (en) 1998-04-14 2001-02-27 Paul D. Rubin Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors
DE19913862C2 (de) * 1999-03-26 2003-04-10 Forschungszentrum Juelich Gmbh Verfahren zur biokatalysierten Umsetzung schlecht wasserlöslicher Substanzen
DE10007203A1 (de) * 2000-02-17 2001-08-23 Asta Medica Ag Neue Kombination nichtsedierender Antihistaminika mit Substanzen, die die Leukotrienwirkung beeinflussen, zur Behandlung der Rhinitis/Konjunktivitis
US6613907B2 (en) 2000-11-08 2003-09-02 Amr Technology, Inc. Process for the production of piperidine derivatives with microorganisms
CZ20033019A3 (cs) * 2001-04-09 2004-07-14 Teva Pharmaceutical Industries Ltd. Polymorfní formy chloridu fexofenadinu
US20030021849A1 (en) * 2001-04-09 2003-01-30 Ben-Zion Dolitzky Polymorphs of fexofenadine hydrochloride
CA2450858C (en) * 2001-06-18 2009-04-07 Dr. Reddy's Laboratories Limited Novel crystalline forms of 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-.alpha.,.alpha.-dimethylbenzene acetic acid and its hydrochloride
WO2003020274A1 (en) * 2001-08-30 2003-03-13 Aventis Pharmaceuticals Inc. Treatment of atopic dermatitis
EP1474392A1 (en) * 2002-06-10 2004-11-10 Teva Pharmaceutical Industries Ltd. Polymorphic form xvi of fexofenadine hydrochloride
TWI326214B (en) * 2002-07-17 2010-06-21 Avanir Pharmaceuticals Inc Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders
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US20050239830A1 (en) * 2004-04-26 2005-10-27 Vikram Khetani Methods of diminishing co-abuse potential
US7498345B2 (en) 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US7498443B2 (en) 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of carebastine
JP2008514641A (ja) * 2004-09-28 2008-05-08 テバ ファーマシューティカル インダストリーズ リミティド 結晶形フェキソフェナジン、およびその調製方法
JP2008523097A (ja) * 2004-12-09 2008-07-03 セルジーン・コーポレーション Ｄ−トレオメチルフェニデートを用いた治療
ZA200804550B (en) 2005-11-09 2009-08-26 Combinatorx Inc Methods, compositions, and kits for the treatment of medical conditions
KR101519028B1 (ko) * 2007-04-13 2015-05-11 써던 리서취 인스티튜트 항혈관형성제 및 사용방법
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KR102597910B1 (ko) 2015-03-26 2023-11-02 재클린 엠. 이베르센 숙취상태와 연관된 증상들을 억제하기 위한 방법 및 조성물
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WO1993023047A1 (en) 1992-05-11 1993-11-25 Merrell Dow Pharmaceuticals Inc. Use of terfenadine derivatives as antihistaminics in a hepatically impaired patient
FI950467A7 (fi) 1992-08-03 1995-03-31 Sepracor Inc Terfenadiinin metaboliitit ja niiden optisesti puhtaat isomeerit aller gisten sairauksien hoitamiseksi
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Also Published As

Publication number Publication date
DE69316660T3 (de) 2001-04-05
WO1994003170A1 (en) 1994-02-17
DK1214937T3 (da) 2007-09-17
ATE322899T1 (de) 2006-04-15
NO310644B1 (no) 2001-08-06
HUT71889A (en) 1996-02-28
HU226242B1 (en) 2008-07-28
GB2284351B (en) 1996-11-27
JP3037697B2 (ja) 2000-04-24
DE69334008T2 (de) 2006-10-19
ATE162399T1 (de) 1998-02-15
JP2000086512A (ja) 2000-03-28
DE69316660D1 (de) 1998-02-26
DE69334008D1 (de) 2006-05-24
NO950374D0 (no) 1995-02-01
ES2086270T1 (es) 1996-07-01
AU7182296A (en) 1997-01-30
JP3288660B2 (ja) 2002-06-04
DK0815860T3 (da) 2006-08-14
EP0701443B1 (en) 1998-01-21
DE701443T1 (de) 1997-01-30
DE69334145T2 (de) 2008-01-24
GR3035417T3 (en) 2001-05-31
EP0815860A2 (en) 1998-01-07
EP0701443B2 (en) 2000-11-22
JP3288661B2 (ja) 2002-06-04
GB2284351A (en) 1995-06-07
GR3026530T3 (en) 1998-07-31
JP3288662B2 (ja) 2002-06-04
EP0815860B1 (en) 2006-04-12
ATE363283T1 (de) 2007-06-15
FI950467L (fi) 1995-03-31
AU675240B2 (en) 1997-01-30
RU2167657C2 (ru) 2001-05-27
ES2086270T5 (es) 2001-02-01
EP1214937B1 (en) 2007-05-30
PL307339A1 (en) 1995-05-15
FI950467A7 (fi) 1995-03-31
DE69334145D1 (de) 2007-07-12
JPH08500348A (ja) 1996-01-16
JP2000086513A (ja) 2000-03-28
JP2000086516A (ja) 2000-03-28
ES2086270T3 (es) 1998-03-01
JP2000086515A (ja) 2000-03-28
AU1842999A (en) 1999-04-29
HK1045806A1 (en) 2002-12-13
EP0701443A1 (en) 1996-03-20
CA2141572A1 (en) 1994-02-17
GB9502183D0 (en) 1995-03-22
PT815860E (pt) 2006-08-31
GR960300024T1 (en) 1996-05-31
DK0701443T3 (da) 1998-02-09
AU4798693A (en) 1994-03-03
ES2257757T3 (es) 2006-08-01
HK1045806B (en) 2008-03-14
BR9306841A (pt) 1998-12-08
EP1688142A1 (en) 2006-08-09
PL174373B1 (pl) 1998-07-31
CZ27495A3 (en) 1996-09-11
EP0815860A3 (en) 1998-01-14
JP3041954B2 (ja) 2000-05-15
DE9320925U1 (de) 1995-08-31
RU95107881A (ru) 1996-11-27
EP1214937A3 (en) 2002-10-30
NO950374L (no) 1995-03-29
KR950702420A (ko) 1995-07-29
PT1214937E (pt) 2007-07-25
RO116043B1 (ro) 2000-10-30
CA2141572C (en) 2001-02-06
ES2284740T3 (es) 2007-11-16
SK12495A3 (en) 1997-01-08
FI950467A0 (fi) 1995-02-02
JP2000086514A (ja) 2000-03-28
HU9500313D0 (en) 1995-03-28
US5375693A (en) 1994-12-27
DE69316660T2 (de) 1998-05-07
EP1214937A2 (en) 2002-06-19

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