DK0705831T3 - Cycloalkano-indol- og -azaindol-derivater - Google Patents

Cycloalkano-indol- og -azaindol-derivater

Info

Publication number: DK0705831T3
Authority: DK; Denmark
Prior art keywords: opt; substd; alkyl; phenyl; alkoxy
Prior art date: 1994-10-04

Application number

DK95114877T

Other languages

English (en)

Inventor

Siegfried Dr Goldmann

Stefan Dr Wohlfeil

Hilmar Dr Bischoff

Ulrich Dr Mueller

Dirk Dr Denzer

Richard Dr Connell

Rudi Dr Gruetzmann

Martin Dr Beuck

Anke Dr Domdey-Bette

Original Assignee

Bayer Healthcare Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-04

Filing date

1995-09-21

Publication date

2004-04-05

1995-09-21 Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag

2004-04-05 Application granted granted Critical

2004-04-05 Publication of DK0705831T3 publication Critical patent/DK0705831T3/da

Links

125000005334 azaindolyl group Chemical class N1N=C(C2=CC=CC=C12)* 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 9
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 6
125000003545 alkoxy group Chemical group 0.000 abstract 5
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 4
125000002252 acyl group Chemical group 0.000 abstract 3
125000003342 alkenyl group Chemical group 0.000 abstract 3
125000005843 halogen group Chemical group 0.000 abstract 3
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
150000001925 cycloalkenes Chemical class 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/02—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with only hydrogen, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Obesity (AREA)
Hematology (AREA)
Child & Adolescent Psychology (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)

DK95114877T 1994-10-04 1995-09-21 Cycloalkano-indol- og -azaindol-derivater DK0705831T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4435477A DE4435477A1 (de)	1994-10-04	1994-10-04	Cycloalkano-indol- und -azaindol-derivate

Publications (1)

Publication Number	Publication Date
DK0705831T3 true DK0705831T3 (da)	2004-04-05

Family

ID=6529939

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95114877T DK0705831T3 (da)	1994-10-04	1995-09-21	Cycloalkano-indol- og -azaindol-derivater

Country Status (35)

Country	Link
US (6)	US5684014A (da)
EP (1)	EP0705831B1 (da)
JP (1)	JP3901234B2 (da)
KR (1)	KR100355986B1 (da)
CN (2)	CN1050605C (da)
AT (1)	ATE255580T1 (da)
AU (1)	AU700609B2 (da)
CA (1)	CA2159546C (da)
CZ (1)	CZ291348B6 (da)
DE (2)	DE4435477A1 (da)
DK (1)	DK0705831T3 (da)
DZ (1)	DZ1934A1 (da)
EE (1)	EE03527B1 (da)
ES (1)	ES2211890T3 (da)
FI (2)	FI113048B (da)
HN (1)	HN1995009160A (da)
HR (1)	HRP950505B1 (da)
HU (1)	HU225052B1 (da)
IL (3)	IL115493A (da)
MA (1)	MA23683A1 (da)
MY (1)	MY117282A (da)
NO (1)	NO305365B1 (da)
NZ (1)	NZ280130A (da)
PH (1)	PH31400A (da)
PL (1)	PL183154B1 (da)
PT (1)	PT705831E (da)
RU (1)	RU2157803C2 (da)
SG (1)	SG63528A1 (da)
SI (1)	SI0705831T1 (da)
SK (1)	SK284260B6 (da)
SV (1)	SV1995000062A (da)
TN (1)	TNSN95098A1 (da)
TW (1)	TW448175B (da)
UA (1)	UA44700C2 (da)
ZA (1)	ZA958297B (da)

Families Citing this family (55)

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DE4435477A1 (de) *	1994-10-04	1996-04-11	Bayer Ag	Cycloalkano-indol- und -azaindol-derivate
DE19525028A1 (de) *	1995-07-10	1997-01-16	Bayer Ag	Amide und Sulfonamide von heterocyclisch substituierten Benzylaminen
US6774236B1 (en)	1996-04-04	2004-08-10	Bayer Aktiengesellschaft	Process for the preparation of enantiomerically pure cycloalkano-indol -and azaindol -and pyrimido [1,2A]indolcarbocyclic acids and their activated derivatives
DE19613549A1 (de) *	1996-04-04	1997-10-09	Bayer Ag	Verfahren zur Herstellung von enantiomerenreinen Cycloalkano-indol- und azaindol-carbonsäuren und deren aktivierte Derivate
DE19619950A1 (de)	1996-04-17	1997-10-23	Bayer Ag	Heterocyclisch-substituierte Phenylglycinolamide
EP0802192A1 (de) *	1996-04-17	1997-10-22	Bayer Ag	Heterocyclisch-substituierte Phenylglycinolamide mit antiatherosklerotischer Wirkung und Verfahren zu ihrer Herstellung
DE19615119A1 (de) *	1996-04-17	1997-10-23	Bayer Ag	Neue Arylessigsäureamide
DE19615265A1 (de) *	1996-04-18	1997-12-04	Bayer Ag	Neue Pyridazino-, Pyrimido-, Pyrazino- und Triazino-indole
ID27812A (id) *	1998-05-01	2001-04-26	Lilly Co Eli	ESTER PENGHAMBAT sPLA2
ES2213984T3 (es)	1998-10-30	2004-09-01	Eli Lilly And Company	Derivados de azaindol y su uso como agentes antitrombicos.
AU4616200A (en) *	1999-05-25	2000-12-12	Yamanouchi Pharmaceutical Co., Ltd.	Hydrazide derivatives
DE19929065A1 (de) *	1999-06-25	2000-12-28	Bayer Ag	Kombination von MTP-Inhibitoren und HMG-CoA-Reduktase-Inhibitoren und ihre Verwendung in Arzneimitteln
DE19934610A1 (de) *	1999-07-23	2001-01-25	Bayer Ag	Schnellfreisetzende Extrudate und Verfahren zu ihrer Herstellung sowie daraus erhältliche Zubereitungen
EP1134221A1 (en) *	2000-03-15	2001-09-19	Aventis Pharma Deutschland GmbH	Substituted beta-carbolines as lkB kinase inhibitors
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WO2001074817A1 (en) *	2000-03-30	2001-10-11	Yamanouchi Pharmaceutical Co., Ltd.	Hydrazide derivatives
DE10030375A1 (de) *	2000-06-21	2002-01-03	Bayer Ag	Verwendung von MTP-Inhibitoren zur Senkung von ppTRL
BR0206844A (pt) *	2001-01-31	2005-07-12	Synaptic Pharma Corp	Uso de antagonistas do receptor gal3 para o tratamento de depressão e/ou ansiedade e compostos usados em tais métodos
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BR0306292A (pt) *	2002-02-28	2004-08-24	Japan Tobacco Inc	Composto de éster e uso medicinal do mesmo
WO2003101983A1 (en) *	2002-05-31	2003-12-11	Yamanouchi Pharmaceutical Co., Ltd.	Tetrahydropyran derivative
RU2342362C2 (ru) *	2002-11-26	2008-12-27	Шэньчжэнь Чипскрин Байосайенсиз Лтд.	Замещенные производные арилалкановой кислоты как пан агонисты рапп с высокой антигипергликемической и антигиперлипидемической активностью
WO2004063156A1 (en) *	2003-01-08	2004-07-29	Biovitrum Ab	Novel indole derivates as fabp-4 inhibitors
WO2005051382A1 (ja) *	2003-11-28	2005-06-09	Astellas Pharma Inc.	脂質低下作用増強剤
US7649002B2 (en)	2004-02-04	2010-01-19	Pfizer Inc	(3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists
US7932268B2 (en)	2004-03-05	2011-04-26	The Trustees Of The University Of Pennsylvania	Methods for treating disorders or diseases associated with hyperlipidemia and hypercholesterolemia while minimizing side effects
US7262318B2 (en) *	2004-03-10	2007-08-28	Pfizer, Inc.	Substituted heteroaryl- and phenylsulfamoyl compounds
AU2005230397B2 (en) *	2004-04-09	2010-04-08	Elanco Animal Health Ireland Limited	Intermittent dosing regimen for the treatment of overweight with MTP-inhibitors
US20050288340A1 (en) *	2004-06-29	2005-12-29	Pfizer Inc	Substituted heteroaryl- and phenylsulfamoyl compounds
US20060030623A1 (en) *	2004-07-16	2006-02-09	Noboru Furukawa	Agent for the treatment or prevention of diabetes, obesity or arteriosclerosis
FR2873694B1 (fr) *	2004-07-27	2006-12-08	Merck Sante Soc Par Actions Si	Nouveaux aza-indoles inhibiteurs de la mtp et apob
US8101774B2 (en) *	2004-10-18	2012-01-24	Japan Tobacco Inc.	Ester derivatives and medicinal use thereof
AU2005297923B2 (en) *	2004-10-25	2010-12-23	Japan Tobacco Inc.	Solid medicinal preparation improved in solubility and stability and process for producing the same
PA8660701A1 (es)	2005-02-04	2006-09-22	Pfizer Prod Inc	Agonistas de pyy y sus usos
JP2008542255A (ja) *	2005-05-27	2008-11-27	ファイザー・プロダクツ・インク	肥満症の治療または体重減量の維持のためのカンナビノイド−１受容体アンタゴニストおよびミクロソームトリグリセリド輸送タンパク質阻害物質の併用
WO2007015162A1 (en) *	2005-08-04	2007-02-08	Pfizer Limited	Piperidinoyl-pyrrolidine and piperidinoyl-piperidine compounds
EP1951220A2 (en) *	2005-10-18	2008-08-06	Aegerion Pharmaceuticals	Compositions for lowering serum cholesterol and/or triglycerides
US7741317B2 (en)	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
US7888376B2 (en)	2005-11-23	2011-02-15	Bristol-Myers Squibb Company	Heterocyclic CETP inhibitors
ES2402581T3 (es) *	2006-02-23	2013-05-06	Pfizer Limited	Piperidinoilpirrolidinas como agonistas del receptor de melanocortina tipo 4
US8383660B2 (en)	2006-03-10	2013-02-26	Pfizer Inc.	Dibenzyl amine compounds and derivatives
AU2007252994A1 (en) *	2006-05-18	2007-11-29	Bayer Healthcare Ag	Pharmaceutical compositions comprising implitapide and methods of using same
MX2009004314A (es)	2006-11-13	2009-05-05	Pfizer Prod Inc	Diaril, dipiridinil y arilpiridinilderivados y usos de los mismos.
CN101663262B (zh)	2006-12-01	2014-03-26	百时美施贵宝公司	用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
CA2673290A1 (en) *	2006-12-21	2008-07-03	Aegerion Pharmaceuticals, Inc.	Methods for treating obesity with a combination comprising a mtp inhibitor and a cholesterol absorption inhibitor
RU2338745C1 (ru) *	2007-03-21	2008-11-20	Андрей Александрович Иващенко	ЗАМЕЩЕННЫЕ 2,3,4,5-ТЕТРАГИДРО-1Н-ПИРИДО[4,3-b]ИНДОЛЫ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
WO2008124384A2 (en) *	2007-04-03	2008-10-16	Aegerion Pharmaceuticals, Inc.	Combinations of mtp inhibitors with cholesterol absorption inhibitors or interferon for treating hepatitis c
JP5530438B2 (ja) *	2008-08-06	2014-06-25	ファイザー・リミテッド	Ｍｃ４作動薬としてのジアゼピンおよびジアゾカン化合物
CN105120863B (zh)	2013-03-14	2021-06-04	奥斯特克有限公司	促进骨生长的烷基胺骆驼蓬碱衍生物
WO2016037106A1 (en) *	2014-09-05	2016-03-10	Allosteros Therapeutics, Inc	CaMKII INHIBITORS AND USES THEREOF
CN108218862B (zh) *	2018-02-07	2020-06-23	贵州医科大学	α-卡波林类衍生物在制备抗心肌缺氧复氧损伤药物中的应用
CN110467560B (zh) *	2018-05-09	2025-11-25	深圳微芯生物科技股份有限公司	一种苯基氨基丙酸钠衍生物、其制备方法和应用
CA3108714A1 (en)	2018-08-14	2020-02-20	Osteoqc Inc.	Pyrrolo - dipyridine compounds
CA3109104A1 (en)	2018-08-14	2020-02-20	Osteoqc Inc.	Fluoro .beta.-carboline compounds
US20230285376A1 (en)	2020-07-29	2023-09-14	Amryt Pharmaceuticals Inc.	Lomitapide for use in methods of treating hyperlipidemia and hypercholesterolemia in pediatric patients

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DE4435477A1 (de) *	1994-10-04	1996-04-11	Bayer Ag	Cycloalkano-indol- und -azaindol-derivate
DE19613549A1 (de)	1996-04-04	1997-10-09	Bayer Ag	Verfahren zur Herstellung von enantiomerenreinen Cycloalkano-indol- und azaindol-carbonsäuren und deren aktivierte Derivate
DE19615119A1 (de) *	1996-04-17	1997-10-23	Bayer Ag	Neue Arylessigsäureamide

1994
- 1994-10-04 DE DE4435477A patent/DE4435477A1/de not_active Withdrawn
1995
- 1995-02-07 HN HN1995009160A patent/HN1995009160A/es unknown
- 1995-09-21 SI SI9530693T patent/SI0705831T1/xx unknown
- 1995-09-21 PT PT95114877T patent/PT705831E/pt unknown
- 1995-09-21 ES ES95114877T patent/ES2211890T3/es not_active Expired - Lifetime
- 1995-09-21 DK DK95114877T patent/DK0705831T3/da active
- 1995-09-21 EP EP95114877A patent/EP0705831B1/de not_active Expired - Lifetime
- 1995-09-21 DE DE59510839T patent/DE59510839D1/de not_active Expired - Lifetime
- 1995-09-21 AT AT95114877T patent/ATE255580T1/de not_active IP Right Cessation
- 1995-09-27 AU AU32920/95A patent/AU700609B2/en not_active Ceased
- 1995-09-27 HR HR950505A patent/HRP950505B1/xx not_active IP Right Cessation
- 1995-09-28 US US08/535,698 patent/US5684014A/en not_active Expired - Lifetime
- 1995-09-29 NZ NZ280130A patent/NZ280130A/en not_active IP Right Cessation
- 1995-09-29 CA CA2159546A patent/CA2159546C/en not_active Expired - Fee Related
- 1995-10-02 TW TW084110247A patent/TW448175B/zh active
- 1995-10-02 IL IL11549395A patent/IL115493A/xx not_active IP Right Cessation
- 1995-10-02 IL IL12964199A patent/IL129641A0/xx unknown
- 1995-10-02 FI FI954681A patent/FI113048B/fi active
- 1995-10-02 DZ DZ950116A patent/DZ1934A1/fr active
- 1995-10-02 KR KR1019950033651A patent/KR100355986B1/ko not_active Expired - Fee Related
- 1995-10-02 TN TNTNSN95098A patent/TNSN95098A1/fr unknown
- 1995-10-02 MA MA24027A patent/MA23683A1/fr unknown
- 1995-10-02 IL IL12964195A patent/IL129641A/xx not_active IP Right Cessation
- 1995-10-03 RU RU95117070/04A patent/RU2157803C2/ru not_active IP Right Cessation
- 1995-10-03 HU HU9502891A patent/HU225052B1/hu not_active IP Right Cessation
- 1995-10-03 SK SK1239-95A patent/SK284260B6/sk not_active IP Right Cessation
- 1995-10-03 ZA ZA958297A patent/ZA958297B/xx unknown
- 1995-10-03 EE EE9500071A patent/EE03527B1/xx not_active IP Right Cessation
- 1995-10-03 PL PL95310756A patent/PL183154B1/pl not_active IP Right Cessation
- 1995-10-03 JP JP27966495A patent/JP3901234B2/ja not_active Expired - Fee Related
- 1995-10-03 NO NO953930A patent/NO305365B1/no not_active IP Right Cessation
- 1995-10-03 PH PH51415A patent/PH31400A/en unknown
- 1995-10-03 CZ CZ19952567A patent/CZ291348B6/cs not_active IP Right Cessation
- 1995-10-03 UA UA95104372A patent/UA44700C2/uk unknown
- 1995-10-03 SG SG1995001478A patent/SG63528A1/en unknown
- 1995-10-04 CN CN95117117A patent/CN1050605C/zh not_active Expired - Fee Related
- 1995-10-04 SV SV1995000062A patent/SV1995000062A/es active IP Right Grant
- 1995-10-04 MY MYPI95002964A patent/MY117282A/en unknown
- 1995-10-04 CN CNB981260853A patent/CN1183111C/zh not_active Expired - Fee Related
1997
- 1997-07-03 US US08/887,781 patent/US6245775B1/en not_active Expired - Lifetime
1999
- 1999-05-17 US US09/313,035 patent/US6265431B1/en not_active Expired - Lifetime
2000
- 2000-12-08 FI FI20002693A patent/FI108791B/fi active
- 2000-12-11 US US09/734,955 patent/US20020147209A1/en not_active Abandoned
2001
- 2001-03-21 US US09/814,263 patent/US6479503B2/en not_active Expired - Lifetime
2002
- 2002-07-18 US US10/198,315 patent/US6858622B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
FI20002693L (fi)	2000-12-08
US6858622B2 (en)	2005-02-22
EP0705831A2 (de)	1996-04-10
PL183154B1 (pl)	2002-05-31
TW448175B (en)	2001-08-01
CN1130631A (zh)	1996-09-11
US20030149073A1 (en)	2003-08-07
RU2157803C2 (ru)	2000-10-20
JPH08225526A (ja)	1996-09-03
IL129641A (en)	2000-08-31
KR960014126A (ko)	1996-05-22
FI954681A0 (fi)	1995-10-02
DE59510839D1 (de)	2004-01-15
SK284260B6 (sk)	2004-12-01
NZ280130A (en)	1996-05-28
EE03527B1 (et)	2001-10-15
HN1995009160A (es)	2000-04-24
DE4435477A1 (de)	1996-04-11
NO953930D0 (no)	1995-10-03
CA2159546C (en)	2010-12-14
FI113048B (fi)	2004-02-27
DZ1934A1 (fr)	2002-02-17
HRP950505B1 (en)	2002-04-30
CA2159546A1 (en)	1996-04-05
MY117282A (en)	2004-06-30
US6265431B1 (en)	2001-07-24
HU9502891D0 (en)	1995-11-28
CN1224715A (zh)	1999-08-04
IL115493A (en)	1999-10-28
UA44700C2 (uk)	2002-03-15
SI0705831T1 (en)	2004-02-29
PH31400A (en)	1998-10-29
US20020147209A1 (en)	2002-10-10
ZA958297B (en)	1996-05-06
AU700609B2 (en)	1999-01-07
SG63528A1 (en)	1999-03-30
IL129641A0 (en)	2000-02-29
PL310756A1 (en)	1996-04-15
JP3901234B2 (ja)	2007-04-04
HUT73240A (en)	1996-07-29
HRP950505A2 (en)	1997-08-31
CZ291348B6 (cs)	2003-02-12
FI954681A7 (fi)	1996-04-05
CN1050605C (zh)	2000-03-22
ES2211890T3 (es)	2004-07-16
HK1005139A1 (en)	1998-12-24
MA23683A1 (fr)	1996-07-01
NO953930L (no)	1996-04-09
NO305365B1 (no)	1999-05-18
CZ256795A3 (en)	1996-04-17
EP0705831A3 (de)	1997-01-22
PT705831E (pt)	2004-04-30
TNSN95098A1 (fr)	1996-02-06
SK123995A3 (en)	1996-06-05
US6479503B2 (en)	2002-11-12
EE9500071A (et)	1996-04-15
US6245775B1 (en)	2001-06-12
ATE255580T1 (de)	2003-12-15
AU3292095A (en)	1996-04-18
HU225052B1 (en)	2006-05-29
KR100355986B1 (ko)	2003-01-06
SV1995000062A (es)	1996-07-10
EP0705831B1 (de)	2003-12-03
CN1183111C (zh)	2005-01-05
FI108791B (fi)	2002-03-28
US5684014A (en)	1997-11-04
US20020055635A1 (en)	2002-05-09
IL115493A0 (en)	1996-01-19

Publication	Publication Date	Title
ATE255580T1 (de)	2003-12-15	Cycloalkano-indol- und -azaindol-derivate
PL310460A1 (en)	1996-03-18	Novel derivatives of imidazopyridine, method of obtaining them and drugs containing such derivatives
AU2819992A (en)	1993-05-13	Hiv protease inhibitors useful for the treatment of aids
FR2619111B1 (fr)	1991-01-11	Derives de (piperidinyl-4)methyl-2 tetrahydro-1,2,3,4 9h-pyrido (3,4-b) indole, leur preparation et leur application en therapeutique
HU9600914D0 (en)	1996-05-28	4-indolylpiperazinyl derivatives
ATE197794T1 (de)	2000-12-15	Benzyloxy-substituierte phenylglycinolamide als arzneimittel
AU6193196A (en)	1997-02-20	Substituted 4H-pyrans