FI20002693L - Menetelmä karboksyylihappojen valmistamiseksi - Google Patents

Menetelmä karboksyylihappojen valmistamiseksi Download PDF

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Publication number
FI20002693L
FI20002693L FI20002693A FI20002693A FI20002693L FI 20002693 L FI20002693 L FI 20002693L FI 20002693 A FI20002693 A FI 20002693A FI 20002693 A FI20002693 A FI 20002693A FI 20002693 L FI20002693 L FI 20002693L
Authority
FI
Finland
Prior art keywords
carboxylic acids
preparing carboxylic
preparing
acids
carboxylic
Prior art date
Application number
FI20002693A
Other languages
English (en)
Swedish (sv)
Other versions
FI108791B (fi
Inventor
Ulrich Mueller
Richard Connell
Siegfried Goldmann
Rudi Gruetzmann
Martin Beuck
Hilmar Bischoff
Dirk Denzer
Anke Domdey-Bette
Stefan Wohlfeil
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of FI20002693L publication Critical patent/FI20002693L/fi
Application granted granted Critical
Publication of FI108791B publication Critical patent/FI108791B/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10Laxatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D219/00Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/02Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with only hydrogen, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
FI20002693A 1994-10-04 2000-12-08 Menetelmä karboksyylihappojen valmistamiseksi FI108791B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4435477 1994-10-04
DE4435477A DE4435477A1 (de) 1994-10-04 1994-10-04 Cycloalkano-indol- und -azaindol-derivate

Publications (2)

Publication Number Publication Date
FI20002693L true FI20002693L (fi) 2000-12-08
FI108791B FI108791B (fi) 2002-03-28

Family

ID=6529939

Family Applications (2)

Application Number Title Priority Date Filing Date
FI954681A FI113048B (fi) 1994-10-04 1995-10-02 Karboliini- ja karbatsolijohdannaisia, menetelmä niiden valmistamiseksi ja menetelmässä käytettäviä välituotteita
FI20002693A FI108791B (fi) 1994-10-04 2000-12-08 Menetelmä karboksyylihappojen valmistamiseksi

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI954681A FI113048B (fi) 1994-10-04 1995-10-02 Karboliini- ja karbatsolijohdannaisia, menetelmä niiden valmistamiseksi ja menetelmässä käytettäviä välituotteita

Country Status (35)

Country Link
US (6) US5684014A (fi)
EP (1) EP0705831B1 (fi)
JP (1) JP3901234B2 (fi)
KR (1) KR100355986B1 (fi)
CN (2) CN1183111C (fi)
AT (1) ATE255580T1 (fi)
AU (1) AU700609B2 (fi)
CA (1) CA2159546C (fi)
CZ (1) CZ291348B6 (fi)
DE (2) DE4435477A1 (fi)
DK (1) DK0705831T3 (fi)
DZ (1) DZ1934A1 (fi)
EE (1) EE03527B1 (fi)
ES (1) ES2211890T3 (fi)
FI (2) FI113048B (fi)
HN (1) HN1995009160A (fi)
HR (1) HRP950505B1 (fi)
HU (1) HU225052B1 (fi)
IL (3) IL129641A0 (fi)
MA (1) MA23683A1 (fi)
MY (1) MY117282A (fi)
NO (1) NO305365B1 (fi)
NZ (1) NZ280130A (fi)
PH (1) PH31400A (fi)
PL (1) PL183154B1 (fi)
PT (1) PT705831E (fi)
RU (1) RU2157803C2 (fi)
SG (1) SG63528A1 (fi)
SI (1) SI0705831T1 (fi)
SK (1) SK284260B6 (fi)
SV (1) SV1995000062A (fi)
TN (1) TNSN95098A1 (fi)
TW (1) TW448175B (fi)
UA (1) UA44700C2 (fi)
ZA (1) ZA958297B (fi)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4435477A1 (de) * 1994-10-04 1996-04-11 Bayer Ag Cycloalkano-indol- und -azaindol-derivate
DE19525028A1 (de) * 1995-07-10 1997-01-16 Bayer Ag Amide und Sulfonamide von heterocyclisch substituierten Benzylaminen
DE19613549A1 (de) * 1996-04-04 1997-10-09 Bayer Ag Verfahren zur Herstellung von enantiomerenreinen Cycloalkano-indol- und azaindol-carbonsäuren und deren aktivierte Derivate
US6774236B1 (en) 1996-04-04 2004-08-10 Bayer Aktiengesellschaft Process for the preparation of enantiomerically pure cycloalkano-indol -and azaindol -and pyrimido [1,2A]indolcarbocyclic acids and their activated derivatives
DE19615119A1 (de) 1996-04-17 1997-10-23 Bayer Ag Neue Arylessigsäureamide
DE19619950A1 (de) 1996-04-17 1997-10-23 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide
EP0802192A1 (de) * 1996-04-17 1997-10-22 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide mit antiatherosklerotischer Wirkung und Verfahren zu ihrer Herstellung
DE19615265A1 (de) * 1996-04-18 1997-12-04 Bayer Ag Neue Pyridazino-, Pyrimido-, Pyrazino- und Triazino-indole
CN1303290A (zh) * 1998-05-01 2001-07-11 伊莱利利公司 sPLA2抑制剂酯
ES2213984T3 (es) 1998-10-30 2004-09-01 Eli Lilly And Company Derivados de azaindol y su uso como agentes antitrombicos.
AU4616200A (en) * 1999-05-25 2000-12-12 Yamanouchi Pharmaceutical Co., Ltd. Hydrazide derivatives
DE19929065A1 (de) * 1999-06-25 2000-12-28 Bayer Ag Kombination von MTP-Inhibitoren und HMG-CoA-Reduktase-Inhibitoren und ihre Verwendung in Arzneimitteln
DE19934610A1 (de) * 1999-07-23 2001-01-25 Bayer Ag Schnellfreisetzende Extrudate und Verfahren zu ihrer Herstellung sowie daraus erhältliche Zubereitungen
MEP28108A (en) * 2000-03-15 2010-10-10 Sanofi Aventis Deutschland Substituted beta-carbolines with ikb-kinase inhibiting activity
EP1134221A1 (en) * 2000-03-15 2001-09-19 Aventis Pharma Deutschland GmbH Substituted beta-carbolines as lkB kinase inhibitors
AU2001244635A1 (en) * 2000-03-30 2001-10-15 Yamanouchi Pharmaceutical Co..Ltd. Hydrazide derivatives
DE10030375A1 (de) * 2000-06-21 2002-01-03 Bayer Ag Verwendung von MTP-Inhibitoren zur Senkung von ppTRL
CA2672805A1 (en) * 2001-01-31 2002-08-08 H. Lundbeck A/S Pyrimidine derivatives
GB0115109D0 (en) * 2001-06-21 2001-08-15 Aventis Pharma Ltd Chemical compounds
CN1630629B (zh) * 2002-02-28 2010-05-05 日本烟草产业株式会社 酯化合物及其医药用途
JPWO2003101983A1 (ja) * 2002-05-31 2005-09-29 アステラス製薬株式会社 テトラヒドロピラン誘導体
RU2342362C2 (ru) * 2002-11-26 2008-12-27 Шэньчжэнь Чипскрин Байосайенсиз Лтд. Замещенные производные арилалкановой кислоты как пан агонисты рапп с высокой антигипергликемической и антигиперлипидемической активностью
WO2004063156A1 (en) * 2003-01-08 2004-07-29 Biovitrum Ab Novel indole derivates as fabp-4 inhibitors
WO2005051382A1 (ja) * 2003-11-28 2005-06-09 Astellas Pharma Inc. 脂質低下作用増強剤
US7649002B2 (en) 2004-02-04 2010-01-19 Pfizer Inc (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists
NZ549721A (en) 2004-03-05 2010-08-27 Univ Pennsylvania Methods for treating disorders or diseases associated with hyperlipidemia and hypercholesterolemia while minimizing side-effects
US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
US20080280922A1 (en) * 2004-04-09 2008-11-13 Marc Alois Celine Maria Engelen Intermittent Dosing Regimen For Overweight and Obese Subjects
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
US20060030623A1 (en) * 2004-07-16 2006-02-09 Noboru Furukawa Agent for the treatment or prevention of diabetes, obesity or arteriosclerosis
FR2873694B1 (fr) * 2004-07-27 2006-12-08 Merck Sante Soc Par Actions Si Nouveaux aza-indoles inhibiteurs de la mtp et apob
US8101774B2 (en) * 2004-10-18 2012-01-24 Japan Tobacco Inc. Ester derivatives and medicinal use thereof
BRPI0516772A (pt) * 2004-10-25 2008-09-23 Japan Tobacco Inc formulação sólida com solubilidade e estabilidade melhoradas e método para produção da referida formulação
PA8660701A1 (es) 2005-02-04 2006-09-22 Pfizer Prod Inc Agonistas de pyy y sus usos
JP2008542255A (ja) * 2005-05-27 2008-11-27 ファイザー・プロダクツ・インク 肥満症の治療または体重減量の維持のためのカンナビノイド−1受容体アンタゴニストおよびミクロソームトリグリセリド輸送タンパク質阻害物質の併用
WO2007015162A1 (en) * 2005-08-04 2007-02-08 Pfizer Limited Piperidinoyl-pyrrolidine and piperidinoyl-piperidine compounds
JP2009511635A (ja) * 2005-10-18 2009-03-19 エージェリオン ファーマシューティカルズ 哺乳動物における高脂血症に関連する障害を治療するための方法
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
AP2008004602A0 (en) * 2006-02-23 2008-10-31 Pfizer Ltd Melanocortin type 4 receptor agonist piperidinoylpyrrolidines
US8383660B2 (en) 2006-03-10 2013-02-26 Pfizer Inc. Dibenzyl amine compounds and derivatives
US20080051427A1 (en) * 2006-05-18 2008-02-28 Fritz Schuckler Pharmaceutical Compositions and Methods of Using Same
CA2669311C (en) 2006-11-13 2011-09-20 Pfizer Products Inc. Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof
JP5498168B2 (ja) 2006-12-01 2014-05-21 ブリストル−マイヤーズ スクイブ カンパニー アテローム性動脈硬化および循環器疾患の治療のためのcetp阻害剤としてのn−((3−ベンジル)−2,2−(ビス−フェニル)−プロパン−1−アミン誘導体
US20080161279A1 (en) * 2006-12-21 2008-07-03 Wisler Gerald L Methods of Treating Obesity
RU2338745C1 (ru) * 2007-03-21 2008-11-20 Андрей Александрович Иващенко ЗАМЕЩЕННЫЕ 2,3,4,5-ТЕТРАГИДРО-1Н-ПИРИДО[4,3-b]ИНДОЛЫ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
WO2008124384A2 (en) * 2007-04-03 2008-10-16 Aegerion Pharmaceuticals, Inc. Combinations of mtp inhibitors with cholesterol absorption inhibitors or interferon for treating hepatitis c
CA2731897C (en) * 2008-08-06 2013-07-02 Pfizer Limited Diazepine and diazocane compounds as mc4 agonists
CN113416187B (zh) 2013-03-14 2024-07-19 奥斯菲治疗有限公司 促进骨生长的烷基胺骆驼蓬碱衍生物
AU2015311730A1 (en) * 2014-09-05 2017-04-20 Allosteros Therapeutics, Inc Camkii inhibitors and uses thereof
CN108218862B (zh) * 2018-02-07 2020-06-23 贵州医科大学 α-卡波林类衍生物在制备抗心肌缺氧复氧损伤药物中的应用
CN110467560B (zh) 2018-05-09 2025-11-25 深圳微芯生物科技股份有限公司 一种苯基氨基丙酸钠衍生物、其制备方法和应用
JP7695496B2 (ja) 2018-08-14 2025-06-19 オシフィ セラピューティクス リミティド ライアビリティ カンパニー フルオロβ-カルボリン化合物
ES3004565T3 (en) 2018-08-14 2025-03-12 Ossifi Therapeutics Llc Pyrrolo - dipyridine compounds for the treatment of bone loss
EP4188372A1 (en) 2020-07-29 2023-06-07 Amryt Pharmaceuticals Inc. Lomitapide for use in methods of treating hyperlipidemia and hypercholesterolemia in pediatric patients

Family Cites Families (13)

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Publication number Priority date Publication date Assignee Title
CH501623A (de) * 1967-12-18 1971-01-15 Ruetgerswerke Ag Verfahren zur Herstellung von 2-Chlorpyridin und seinen Derivaten
IL81325A (en) * 1986-01-23 1990-11-29 Merck Frosst Canada Inc Tetrahydrocarbazole 1-alkanoic acids and pharmaceutical compositions containing them
US4808608A (en) * 1986-01-23 1989-02-28 Merck & Co., Inc. Tetrahydrocarbazole 1-alkanoic acids, pharmaceutical compositions and use
US4940719A (en) * 1986-03-27 1990-07-10 Merck Frosst Canada, Inc. Tetrahydrocarbazole esters, pharmaceutical compositions and use
US4775680A (en) * 1987-07-21 1988-10-04 Merck & Co., Inc. Cyclohept[b]indolealkanoic acids, pharmaceutical compositions and use
CA1326030C (en) * 1987-07-21 1994-01-11 John W. Gillard Cyclohept[b]indolealkanoic acids
GB9101375D0 (en) * 1991-01-22 1991-03-06 Erba Carlo Spa N-imidazolyl derivatives of substituted tetrahydrocarbazole and cyclohepht(b)indole
DE4112533A1 (de) * 1991-04-17 1992-10-22 Bayer Ag Verfahren zur herstellung von enantiomerenreinen substituierten (chinolin-2-yl-methoxy)phenyl-essigsaeuren
DE4200954A1 (de) 1991-04-26 1992-10-29 Bayer Ag Heterocyclisch substituierte phenylessigsaeurederivate
DE4308788A1 (de) * 1993-03-18 1994-09-22 Bayer Ag Hetero-tricyclisch-substituierte Phenyl-cyclohexan-carbonsäurederivate
DE4435477A1 (de) * 1994-10-04 1996-04-11 Bayer Ag Cycloalkano-indol- und -azaindol-derivate
DE19613549A1 (de) 1996-04-04 1997-10-09 Bayer Ag Verfahren zur Herstellung von enantiomerenreinen Cycloalkano-indol- und azaindol-carbonsäuren und deren aktivierte Derivate
DE19615119A1 (de) * 1996-04-17 1997-10-23 Bayer Ag Neue Arylessigsäureamide

Also Published As

Publication number Publication date
IL129641A0 (en) 2000-02-29
DE4435477A1 (de) 1996-04-11
NO953930L (no) 1996-04-09
HU225052B1 (en) 2006-05-29
HRP950505A2 (en) 1997-08-31
PT705831E (pt) 2004-04-30
JP3901234B2 (ja) 2007-04-04
SV1995000062A (es) 1996-07-10
IL115493A (en) 1999-10-28
US6265431B1 (en) 2001-07-24
NZ280130A (en) 1996-05-28
US20020147209A1 (en) 2002-10-10
SK123995A3 (en) 1996-06-05
IL115493A0 (en) 1996-01-19
PL183154B1 (pl) 2002-05-31
FI954681A0 (fi) 1995-10-02
CZ291348B6 (cs) 2003-02-12
US6858622B2 (en) 2005-02-22
CN1224715A (zh) 1999-08-04
NO953930D0 (no) 1995-10-03
CN1050605C (zh) 2000-03-22
KR960014126A (ko) 1996-05-22
MA23683A1 (fr) 1996-07-01
FI113048B (fi) 2004-02-27
SI0705831T1 (en) 2004-02-29
EP0705831A3 (de) 1997-01-22
EP0705831B1 (de) 2003-12-03
DK0705831T3 (da) 2004-04-05
TNSN95098A1 (fr) 1996-02-06
HN1995009160A (es) 2000-04-24
NO305365B1 (no) 1999-05-18
UA44700C2 (uk) 2002-03-15
JPH08225526A (ja) 1996-09-03
CA2159546C (en) 2010-12-14
EP0705831A2 (de) 1996-04-10
CN1183111C (zh) 2005-01-05
PL310756A1 (en) 1996-04-15
KR100355986B1 (ko) 2003-01-06
ATE255580T1 (de) 2003-12-15
SK284260B6 (sk) 2004-12-01
TW448175B (en) 2001-08-01
US5684014A (en) 1997-11-04
DE59510839D1 (de) 2004-01-15
ES2211890T3 (es) 2004-07-16
AU3292095A (en) 1996-04-18
EE9500071A (et) 1996-04-15
EE03527B1 (et) 2001-10-15
US20030149073A1 (en) 2003-08-07
AU700609B2 (en) 1999-01-07
HU9502891D0 (en) 1995-11-28
ZA958297B (en) 1996-05-06
CA2159546A1 (en) 1996-04-05
US20020055635A1 (en) 2002-05-09
DZ1934A1 (fr) 2002-02-17
SG63528A1 (en) 1999-03-30
FI108791B (fi) 2002-03-28
HK1005139A1 (en) 1998-12-24
US6479503B2 (en) 2002-11-12
FI954681A7 (fi) 1996-04-05
HUT73240A (en) 1996-07-29
PH31400A (en) 1998-10-29
HRP950505B1 (en) 2002-04-30
CZ256795A3 (en) 1996-04-17
IL129641A (en) 2000-08-31
MY117282A (en) 2004-06-30
RU2157803C2 (ru) 2000-10-20
US6245775B1 (en) 2001-06-12
CN1130631A (zh) 1996-09-11

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